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1. 发明申请

WO2013106563A1 APPLICATION OF ENERGY IN MEDICAL TREATMENTS 审中-公开
标题翻译：能源在医疗治疗中的应用
公开(公告)号：WO2013106563A1
公开(公告)日：2013-07-18
申请号：PCT/US2013/021021
申请日：2013-01-10
申请人： MULLER, David , MARSHALL, John
发明人： MULLER, David , MARSHALL, John
IPC分类号： A61F9/007 , A61N5/06
CPC分类号： A61F9/0079 , A61F9/00736 , A61F9/008 , A61F2009/0087 , A61F2009/00887 , A61N5/062 , A61N2005/0661
摘要： Embodiments apply light energy in medical treatments. To enhance or control the effect of the light energy, embodiments apply the light energy after tissue has been treated, e.g., with a photosensitizing agent. For example, embodiments may treat target tissue with riboflavin before exposure to ultraviolet light. For example, a system for cataract surgery includes a removal system configured to remove a first lens from an eye, wherein a capsular bag remains in the eye after removal of the first lens. The system includes an application system configured to treat lenticular epithelial cells in the capsular bag with the photosensitizing agent. The system includes a delivery system with a light source and an optical device. The optical device delivers light to the treated lenticular epithelial cells. Energy from the light destroys the lenticular epithelial cells in the capsular bag to reduce the growth of epithelial cells that cause posterior capsule opacification.
摘要翻译：实施例在光疗中应用光能。为了增强或控制光能的效果，实施例在组织被处理之后例如用光敏剂施加光能。例如，实施方案可以在暴露于紫外线之前用核黄素治疗靶组织。例如，用于白内障手术的系统包括被配置为从眼睛去除第一透镜的去除系统，其中在移除第一透镜之后，囊袋保留在眼睛中。该系统包括被配置成用光敏剂治疗囊袋中的透镜上皮细胞的应用系统。该系统包括具有光源和光学装置的传送系统。光学器件将光递送到经处理的透镜上皮细胞。来自光的能量破坏囊袋中的透镜上皮细胞以减少导致后囊不透明的上皮细胞的生长。

2. 发明申请

WO2012145159A1 CONTROLLED CROSS-LINKING INITIATION AND CORNEAL TOPOGRAPHY FEEDBACK SYSTEMS FOR DIRECTING CROSS-LINKING 审中-公开
标题翻译：控制交叉引导和导向交叉连接的角度反射系统
公开(公告)号：WO2012145159A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/032024
申请日：2012-04-03
申请人： AVEDRO, INC. , MULLER, David , MARSHALL, John , FRIEDMAN, Marc , BLINN, Stephen , SCHARF, Stephen , KAMAEV, Pavel , PERTAUB, Radha
发明人： MULLER, David , MARSHALL, John , FRIEDMAN, Marc , BLINN, Stephen , SCHARF, Stephen , KAMAEV, Pavel , PERTAUB, Radha
IPC分类号： A61F9/01 , A61F9/008
CPC分类号： A61N5/062 , A61B2018/00619 , A61F9/0079 , A61F2009/00844 , A61F2009/00872 , A61F2009/00882
摘要： Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.
摘要翻译：用于激活角膜组织内的交联以在眼睛治疗治疗之后稳定和加强角膜组织的装置和方法。提供反馈系统以获取测量并将反馈信息传递给控制器。反馈系统可以包括干涉仪系统，角膜偏振仪系统或用于监测角膜内的交联活动的其它构型。该控制器适用于分析反馈信息，并根据信息调整眼睛治疗。反馈系统的方面也可用于监测和诊断眼睛的特征。还提供了根据反馈系统提供的信息激活交联的方法，以提高交联疗法的准确性和安全性。

3. 发明申请

WO2011053768A3 SYSTEM AND METHOD FOR STABILIZING CORNEAL TISSUE AFTER TREATMENT 审中-公开
标题翻译：治疗后稳定角膜组织的系统和方法
公开(公告)号：WO2011053768A3
公开(公告)日：2011-11-24
申请号：PCT/US2010054673
申请日：2010-10-29
申请人： AVEDRO INC , MULLER DAVID , MARSHALL JOHN
发明人： MULLER DAVID , MARSHALL JOHN
IPC分类号： A61N5/02 , A61F7/00 , A61F9/007 , A61K38/18 , A61K38/20 , A61M35/00 , A61P27/02
CPC分类号： A61F9/007 , A61B18/1815 , A61B2018/00029 , A61F9/0079 , A61F9/013 , A61F2009/00872 , A61K38/1841 , A61M35/00 , A61M2210/0612
摘要： Embodiments according to aspects of the present invention provide systems and methods for stabilizing corneal tissue after treatment of the corneal tissue. For example, thermokeratoplasty may be applied to the corneal tissue to address disorders associated with abnormal shaping of the cornea. To stabilize the desired structural changes caused by the treatment, embodiments apply ophthalmic formulations that help to inhibit wound healing. Wound healing may occur in response to the application of the treatment and may produce further structural changes that mitigate or alter the desired effects of the treatment.
摘要翻译：根据本发明的方面的实施例提供了用于在角膜组织处理之后稳定角膜组织的系统和方法。例如，热角膜成形术可以应用于角膜组织以解决与角膜异常成形相关的疾病。为了稳定由治疗引起的期望的结构变化，实施方案应用有助于抑制伤口愈合的眼用制剂。伤口愈合可能会因应用治疗而发生，并可能产生进一步的结构变化，从而减轻或改变预期的治疗效果。

4. 发明申请

WO2011130356A9 SYSTEMS AND METHODS FOR ACTIVATING CROSS-LINKING IN AN EYE 审中-公开
公开(公告)号：WO2011130356A9
公开(公告)日：2011-10-20
申请号：PCT/US2011/032234
申请日：2011-04-13
申请人： AVEDRO, INC. , MULLER, David , MARSHALL, John , TROKEL, Stephen L. , HERSH, Peter , KAMAEV, Pavel
发明人： MULLER, David , MARSHALL, John , TROKEL, Stephen L. , HERSH, Peter , KAMAEV, Pavel
IPC分类号： A61F9/00 , A61N5/00 , A61K31/525 , A61P27/02 , A61N5/08

5. 发明申请

WO2010123581A3 MULTI-FUNCTION CONDIMENT CONTAINER 审中-公开
标题翻译：多功能连续容器
公开(公告)号：WO2010123581A3
公开(公告)日：2011-03-10
申请号：PCT/US2010001220
申请日：2010-04-23
申请人： HEINZ CO H J , CALDWELL CRAIG S , MARSHALL JOHN , RASILE WILLIAM F
发明人： CALDWELL CRAIG S , MARSHALL JOHN , RASILE WILLIAM F
IPC分类号： B65D75/36 , A23L27/60 , A47G19/32 , B65D25/22 , B65D75/62 , B65D77/38
CPC分类号： B65D77/2032 , B65D75/563 , B65D75/5811 , B65D75/5855 , B65D77/2036 , B65D77/204 , B65D85/72 , B65D2221/00
摘要： A container for condiments includes a container portion having generally planar bottom, a generally parallel flange, a discharge spout, and a sidewall extending between the bottom and the flange. A generally planar cover portion is secured to the flange by an adhesive such that there exists a non-bonded region between the cover and the flange. At least one section of the flange in the non-bonded region is bent downwardly away from the cover portion to form therebetween a finger-access gap. The sidewall includes a front portion disposed below the spout and extending downwardly with respect thereto. The sidewall front portion is configured to prevent the spout from becoming displaced upwardly in response to the sidewall front portion being contacted by the rear portion of another container in a package of the containers.
摘要翻译：用于调味品的容器包括具有大致平坦的底部的容器部分，大致平行的凸缘，排出口以及在底部和凸缘之间延伸的侧壁。大致平坦的盖部分通过粘合剂固定到凸缘上，使得在盖和凸缘之间存在非接合区域。非接合区域中的凸缘的至少一个部分从盖部分向下弯曲，从而在其间形成手指进入间隙。侧壁包括设置在喷嘴下方并相对于喷嘴向下延伸的前部。侧壁前部构造成防止喷口响应于侧壁前部与容器的包装中的另一容器的后部接触而向上移位。

6. 发明申请

WO2008030553A9 SYSTEMS AND METHODS FOR MANAGING TIPS AND GRATUITIES 审中-公开
标题翻译：用于管理提示和大小的系统和方法
公开(公告)号：WO2008030553A9
公开(公告)日：2009-02-26
申请号：PCT/US2007019516
申请日：2007-09-06
申请人： MARSHALL JOHN STEVEN
发明人： MARSHALL JOHN STEVEN
IPC分类号： G07B17/00 , G07F19/00
CPC分类号： G06Q10/10 , G06Q20/20 , G06Q40/12 , G06Q40/125 , G06Q99/00
摘要： Disclosed are systems and methods for recording, maintaining, and reporting tips and gratuities, optionally including details such as employee, task performed, and shift. In one aspect, inter-employee tip and gratuity transactions are tracked and verified. In another aspect, taxing authority forms and/or returns are automatically generated with substantially decreased administration time and cost, thereby facilitating a user's participation in voluntary taxing authority programs. Additionally, the training required by such programs is automatically monitored. In yet another aspect, tips and/or gratuities may be paid as wages. In another aspect of the present invention, employees are provided an opportunity to increase declared tips if the originally declared tips place employee in jeopardy of an audit. In another aspect, interfaces to third-party systems such as POS systems, payroll systems, and the like are provided to further minimize system administration time and data accuracy. In another aspect, Web-based systems are provided.
摘要翻译：公开了用于记录，维护和报告提示和小费的系统和方法，可选地包括诸如雇员，执行的任务和转移的细节。在一方面，追踪和验证员工之间的小费和酬金交易。另一方面，税务机关的形式和/或退货自动生成，管理时间和成本大大减少，从而方便用户参与自愿征税管理计划。此外，这些程序所需的培训也会自动监控。另一方面，技巧和/或小费可以作为工资支付。在本发明的另一方面，如果最初宣称的提示使员工处于审计的危险之中，员工将被提供机会来增加宣称的提示。在另一方面，提供与诸如POS系统，工资单系统等第三方系统的接口以进一步最小化系统管理时间和数据精度。另一方面，提供了基于Web的系统。

7. 发明申请

WO2008021325A3 LAYER SWITCHING FOR AN ULTRASOUND TRANSDUCER ARRAY 审中-公开
标题翻译：用于超声波传感器阵列的层切换
公开(公告)号：WO2008021325A3
公开(公告)日：2009-02-26
申请号：PCT/US2007017922
申请日：2007-08-13
申请人： SIEMENS MEDICAL SOLUTIONS , MARSHALL JOHN DOUGLAS , MO JIAN-HUA , USTUNER KUTAY F
发明人： MARSHALL JOHN DOUGLAS , MO JIAN-HUA , USTUNER KUTAY F
IPC分类号： B06B1/06
CPC分类号： G10K11/346 , B06B1/064 , G01S15/8906
摘要： A multi-layer transducer operates with only one system channel (24) per element (12). Passive switching connects the layers (14, 16) differently for transmit than for receive operation, such as connecting two layers (14, 16) in parallel for transmit and in series for receive. Any passive switching may be used, such as current and voltage limiting circuits (26, 28, 30). Tuning may be passively switched. Different tuning circuits (70, 72, 82, 84) are passively switched as a function of voltage level between transmit and receive operations.
摘要翻译：多层换能器仅对每个元件（12）仅具有一个系统通道（24）。无源开关将层（14,16）以不同于接收操作的方式连接层（14,16），例如并联连接两层（14,16）以进行传输并串联进行接收。可以使用任何无源开关，例如电流和电压限制电路（26,28,30）。调谐可能被动切换。作为发送和接收操作之间的电压电平的函数，不同的调谐电路（70,72,82,84）被动地切换。

8. 发明申请

WO2008121476A1 BIOLOGICALLY ACTIVE TAXANE ANALOGS AND METHODS OF TREATMENT BY ORAL ADMINISTRATION 审中-公开
标题翻译：生物活性的TAXANE模拟物和通过口服给药治疗的方法
公开(公告)号：WO2008121476A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/055384
申请日：2008-02-28
申请人： TAPESTRY PHARMACEUTICALS, INC. , MCCHESNEY, James, D. , TAPOLSKY, Gilles , EMERSON, David, E. , MARSHALL, John , AHMED, Tauseef , COHN, Allen , KURMAN, Michael , MODIANO, Manuel
发明人： MCCHESNEY, James, D. , TAPOLSKY, Gilles , EMERSON, David, E. , MARSHALL, John , AHMED, Tauseef , COHN, Allen , KURMAN, Michael , MODIANO, Manuel
IPC分类号： C07D493/06 , A61P35/00 , A61K31/337 , A61K31/357
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K39/3955 , A61K45/06
摘要： The present invention relates to a novel chemical compound of formula S-(I) for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.
摘要翻译：本发明涉及用于治疗癌症的新型式S-（I）化合物，含有所述化合物的组合物，制备方法和与其它治疗剂的组合。

9. 发明申请

WO2007061962A1 METHOD OF FABRICATING FLOW FIELD PLATES AND RELATED PRODUCTS AND METHODS 审中-公开
标题翻译：流动场板的制备方法及相关产品及方法
公开(公告)号：WO2007061962A1
公开(公告)日：2007-05-31
申请号：PCT/US2006/044918
申请日：2006-11-17
申请人： BALLARD POWER SYSTEMS INC. , BALLARD POWER SYSTEMS CORPORATION , FARRINGTON, Simon , GABRYS, Steven, D. , GRAY, William, D. , LEE, Wendy, J. , MARSHALL, John, Cameron
发明人： FARRINGTON, Simon , GABRYS, Steven, D. , GRAY, William, D. , LEE, Wendy, J. , MARSHALL, John, Cameron
IPC分类号： H01M8/02
CPC分类号： H01M8/0258 , H01M8/0213 , H01M8/0221 , H01M8/0228 , H01M8/0267 , H01M8/0271 , H01M8/2483 , H01M2008/1095 , Y02P70/56
摘要： Flow field plate and method related to the manufacture of the same. Flow field plates are at least partially coated with a low viscosity coating resin to increase mechanical strength and/or to decrease fluid permeability, and find particular utility for manufacturing thin, carbonaceous flow field plates for fuel cell stacks. .
摘要翻译：流场板及其制造方法相关。流场板至少部分地涂覆有低粘度涂层树脂以增加机械强度和/或降低流体渗透性，并且找到用于制造用于燃料电池堆的薄的碳质流动场板的特别实用性。。

10. 发明申请

WO2006124560A2 THERMAL IMAGING MEMBERS AND METHODS 审中-公开
标题翻译：热成像和方法
公开(公告)号：WO2006124560A2
公开(公告)日：2006-11-23
申请号：PCT/US2006/018386
申请日：2006-05-12
申请人： ZINK IMAGING, LLC , FILOSA, Michael, P. , TELFER, Stephen, J. , MARSHALL, John, L. , ALLEN, Richard, M. , HARDIN, John, M.
发明人： FILOSA, Michael, P. , TELFER, Stephen, J. , MARSHALL, John, L. , ALLEN, Richard, M. , HARDIN, John, M.
IPC分类号： B41M5/20
CPC分类号： B41M5/3275 , B41M5/3335 , B41M5/3375 , B41M5/38235 , B41M5/385 , C07D493/10 , C07D493/20 , C09B11/24 , C09B67/0025
摘要： There are described thermal imaging members and thermal imaging methods utilizing unsymmetrical rhodamine compounds. The rhodamine color- forming compounds exhibit a first color when in a crystalline form and a second color, different from the first color, when in an amorphous form.
摘要翻译：描述了使用不对称罗丹明化合物的热成像构件和热成像方法。当呈无定形形式时，当具有结晶形式和不同于第一种颜色的第二种颜色时，罗丹明成色化合物表现出第一种颜色。

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