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    • 1. 发明申请
    • SYSTEMS AND METHODS FOR MONITORING CROSS-LINKING ACTIVITY FOR CORNEAL TREATMENTS
    • 用于监测CORNEAL治疗的交联活动的系统和方法
    • WO2016191342A1
    • 2016-12-01
    • PCT/US2016/033718
    • 2016-05-23
    • AVEDRO, INC.FRIEDMAN, Marc, D.
    • FRIEDMAN, Marc, D.
    • A61F9/01G01N21/64
    • A61B3/145A61B5/004A61B5/0071A61B5/4836A61B5/4848A61F9/0079A61F9/008A61F2009/00872A61K31/525A61N5/062A61N2005/0643A61N2005/0661A61N2005/0662
    • A system for treatment of corneal tissue includes one or more light sources that generate excitation light delivered to corneal tissue treated with a cross-linking agent. The excitation light causes the cross-linking agent to fluoresce by emitting an emission light at a plurality of emission wavelengths. The system includes an image capture system that captures image(s) of the corneal tissue. The image(s) indicate at least two of the emission wavelengths. The system includes a controller that receives the image(s). The controller: identifies each of the at least two emission wavelengths in the image(s); determines, from the image(s), respective characteristics associated separately with each of the at least two emission wavelengths; and provides information relating to cross-linking activity generated by the cross-linking agent in the corneal tissue based on the respective characteristics associated with each of the at least two emission wavelengths.
    • 用于治疗角膜组织的系统包括产生激发光的一个或多个光源,所述光源传递给用交联剂处理的角膜组织。 通过发射多个发射波长的发射光,激发光使交联剂发荧光。 该系统包括捕获角膜组织的图像的图像捕获系统。 图像表示至少两个发射波长。 该系统包括接收图像的控制器。 控制器:识别图像中的至少两个发射波长中的每一个; 从所述图像确定与所述至少两个发射波长中的每一个分别相关联的各个特性; 并且基于与所述至少两个发射波长中的每一个相关联的相应特征,提供与所述交联剂在角膜组织中产生的交联活性有关的信息。
    • 10. 发明申请
    • EYE THERAPY
    • 眼睛治疗
    • WO2011050164A1
    • 2011-04-28
    • PCT/US2010/053551
    • 2010-10-21
    • AVEDRO, INC.MULLER, DavidMARSHALL, JohnFRIEDMAN, Marc, D.
    • MULLER, DavidMARSHALL, JohnFRIEDMAN, Marc, D.
    • A61F9/013
    • A61N5/062A61F9/0008A61F9/013A61K31/14
    • Embodiments apply a cross-linking agent to a region of corneal tissue. The cross-linking agent improves the ability of the corneal tissue to resist undesired structural changes. For example, the cross-linking agent may be Riboflavin or Rose Bengal, and the initiating element may be photoactivating light, such as ultraviolet (UV) light. In these embodiments, the photoactivating light initiates cross-linking activity by irradiating the applied cross-linking agent to release reactive oxygen radicals in the corneal tissue. The cross-linking agent acts as a sensitizer to convert O 2 into singlet oxygen which causes cross-linking within the corneal tissue. The rate of cross-linking in the cornea is related to the concentration of O 2 present when the cross-linking agent is irradiated with photoactivating light. Accordingly, the embodiments control the concentration of O 2 during irradiation to increase or decrease the rate of cross-linking and achieve a desired amount of cross-linking.
    • 实施例将交联剂应用于角膜组织的区域。 交联剂改善了角膜组织抵抗不良结构变化的能力。 例如,交联剂可以是核黄素或玫瑰红,并且起始元件可以是光活化的光,例如紫外(UV)光。 在这些实施方案中,光活化光通过照射所施加的交联剂以释放角膜组织中的活性氧自由基引发交联活性。 交联剂用作敏化剂以将O 2转化为单线态氧,其导致角膜组织内的交联。 角膜中的交联速率与交联剂用光活化光照射时存在的O 2浓度有关。 因此,实施例控制照射期间的O 2浓度以增加或降低交联速率并达到所需量的交联。