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1. 发明申请

WO2016191342A1 SYSTEMS AND METHODS FOR MONITORING CROSS-LINKING ACTIVITY FOR CORNEAL TREATMENTS 审中-公开
标题翻译：用于监测CORNEAL治疗的交联活动的系统和方法
公开(公告)号：WO2016191342A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/033718
申请日：2016-05-23
申请人： AVEDRO, INC. , FRIEDMAN, Marc, D.
发明人： FRIEDMAN, Marc, D.
IPC分类号： A61F9/01 , G01N21/64
CPC分类号： A61B3/145 , A61B5/004 , A61B5/0071 , A61B5/4836 , A61B5/4848 , A61F9/0079 , A61F9/008 , A61F2009/00872 , A61K31/525 , A61N5/062 , A61N2005/0643 , A61N2005/0661 , A61N2005/0662
摘要： A system for treatment of corneal tissue includes one or more light sources that generate excitation light delivered to corneal tissue treated with a cross-linking agent. The excitation light causes the cross-linking agent to fluoresce by emitting an emission light at a plurality of emission wavelengths. The system includes an image capture system that captures image(s) of the corneal tissue. The image(s) indicate at least two of the emission wavelengths. The system includes a controller that receives the image(s). The controller: identifies each of the at least two emission wavelengths in the image(s); determines, from the image(s), respective characteristics associated separately with each of the at least two emission wavelengths; and provides information relating to cross-linking activity generated by the cross-linking agent in the corneal tissue based on the respective characteristics associated with each of the at least two emission wavelengths.
摘要翻译：用于治疗角膜组织的系统包括产生激发光的一个或多个光源，所述光源传递给用交联剂处理的角膜组织。通过发射多个发射波长的发射光，激发光使交联剂发荧光。该系统包括捕获角膜组织的图像的图像捕获系统。图像表示至少两个发射波长。该系统包括接收图像的控制器。控制器：识别图像中的至少两个发射波长中的每一个; 从所述图像确定与所述至少两个发射波长中的每一个分别相关联的各个特性; 并且基于与所述至少两个发射波长中的每一个相关联的相应特征，提供与所述交联剂在角膜组织中产生的交联活性有关的信息。

2. 发明申请

WO2012167260A2 SYSTEMS AND METHODS FOR MONITORING TIME BASED PHOTO ACTIVE AGENT DELIVERY OR PHOTO ACTIVE MARKER PRESENCE 审中-公开
标题翻译：用于监控基于时间的照片活动代理商交付或照片活动标记的系统和方法
公开(公告)号：WO2012167260A2
公开(公告)日：2012-12-06
申请号：PCT/US2012/040758
申请日：2012-06-04
申请人： AVEDRO, INC. , FRIEDMAN, Marc D. , KAMAEV, Pavel , MULLER, David , PERTAUB, Radha , SCHARF, Ronald , SHERR, Evan , USHER, David
发明人： FRIEDMAN, Marc D. , KAMAEV, Pavel , MULLER, David , PERTAUB, Radha , SCHARF, Ronald , SHERR, Evan , USHER, David
IPC分类号： A61B3/107 , A61B3/14
CPC分类号： A61M5/007 , A61B3/10 , A61B3/107 , A61B3/135 , A61B3/145 , A61B5/0066 , A61B5/0071 , A61F9/0079 , A61F9/008 , A61F2009/00851 , A61F2009/00872 , A61F2009/00893 , A61K49/006 , A61M37/0092 , A61N5/062 , A61N2005/0626 , A61N2005/0661 , A61N2005/067
摘要： Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.
摘要翻译：用于监测基于时间的光活性剂递送或光活性标记物在眼睛中的存在的装置和方法。提供一种监测系统，用于通过照亮眼睛来测量光活性标记物的存在，以激发光活性标记，然后观察来自光活性标记的特征发射。示例系统包括Scheimpflug光学系统或裂隙灯光学系统，以观察眼睛的横截面图像，以监测施加到眼睛上的光活性剂的瞬时分布，扩散模式和摄取速率。系统和方法还允许利用受监控的眼睛中的光活性剂的分布作为交联系统的反馈。

3. 发明申请

WO2008039252A3 MULTIMODAL OCULAR BIOMETRIC SYSTEM 审中-公开
标题翻译：多模态生物量系统
公开(公告)号：WO2008039252A3
公开(公告)日：2008-09-12
申请号：PCT/US2007011507
申请日：2007-05-14
申请人： RETICA SYSTEMS INC , FRIEDMAN MARC D , CASAVERDE PABLO , YANSEN DON , MCNERNEY TIM , TOSA YASUNARI , USHER DAVID , ACCOMANDO NICHOLAS A , MULLER DAVID , HEACOCK GREG , MARSHALL JOHN
发明人： FRIEDMAN MARC D , CASAVERDE PABLO , YANSEN DON , MCNERNEY TIM , TOSA YASUNARI , USHER DAVID , ACCOMANDO NICHOLAS A , MULLER DAVID , HEACOCK GREG , MARSHALL JOHN
IPC分类号： H04K1/10 , H04L9/00
CPC分类号： H04N7/18 , A61B3/1216 , A61B3/14 , G06K9/00597
摘要： A multimodal biometric identification system captures and processes images of both the iris and the retina for biometric identification. Another multimodal ocular system captures and processes images of the iris and/or the from both eyes of a subject. Biometrics based on data provided by these systems are more accurate and robust than using biometrics that include data from only the iris or only the retina from a single eye. An exemplary embodiment emits photons to the iris and the retina of both eyes, an iris image sensor that captures an image of the iris when the iris reflects the emitted light, a retina image sensor that captures an image of the retina when the retina reflects the emitted light, and a controller that controls the iris and the retina illumination sources, where the captured image of the iris and the captured image of the retina contain biometric data.
摘要翻译：多模式生物识别系统捕获并处理虹膜和视网膜的图像以进行生物识别。另一个多峰视觉系统捕获并处理虹膜的图像和/或来自对象双眼的图像。基于这些系统提供的数据的生物识别技术比使用仅来自虹膜的数据或仅来自单眼的视网膜的生物识别技术更准确和鲁棒。示例性实施例将光子发射到虹膜和双眼视网膜，虹膜图像传感器，当虹膜反射发射的光时捕获虹膜的图像;视网膜图像传感器，其在视网膜反射时捕获视网膜的图像以及控制光圈和视网膜照明源的控制器，其中所述虹膜的捕获图像和所述捕获的视网膜的图像包含生物特征数据。

4. 发明申请

WO2008039252A9 MULTIMODAL OCULAR BIOMETRIC SYSTEM 审中-公开
标题翻译：多模式眼睛生物测量系统
公开(公告)号：WO2008039252A9
公开(公告)日：2008-06-19
申请号：PCT/US2007011507
申请日：2007-05-14
申请人： RETICA SYSTEMS INC , FRIEDMAN MARC D , CASAVERDE PABLO , YANSEN DON , MCNERNEY TIM , TOSA YASUNARI , USHER DAVID , ACCOMANDO NICHOLAS A , MULLER DAVID , HEACOCK GREG , MARSHALL JOHN
发明人： FRIEDMAN MARC D , CASAVERDE PABLO , YANSEN DON , MCNERNEY TIM , TOSA YASUNARI , USHER DAVID , ACCOMANDO NICHOLAS A , MULLER DAVID , HEACOCK GREG , MARSHALL JOHN
IPC分类号： A61B3/14 , A61B3/15 , G06K9/62
CPC分类号： H04N7/18 , A61B3/1216 , A61B3/14 , G06K9/00597
摘要： A multimodal biometric identification system captures and processes images of both the iris and the retina for biometric identification. Another multimodal ocular system captures and processes images of the iris and/or the from both eyes of a subject. Biometrics based on data provided by these systems are more accurate and robust than using biometrics that include data from only the iris or only the retina from a single eye. An exemplary embodiment emits photons to the iris and the retina of both eyes, an iris image sensor that captures an image of the iris when the iris reflects the emitted light, a retina image sensor that captures an image of the retina when the retina reflects the emitted light, and a controller that controls the iris and the retina illumination sources, where the captured image of the iris and the captured image of the retina contain biometric data.
摘要翻译：多模式生物识别系统捕获和处理虹膜和视网膜的图像以用于生物识别。另一种多模式眼部系统捕捉和处理虹膜和/或来自对象双眼的图像。基于这些系统提供的数据的生物特征识别比使用生物特征识别更加准确和可靠，这些生物特征包括仅来自虹膜或仅来自单眼的视网膜的数据。示例性实施例向双眼的虹膜和视网膜发射光子，当虹膜反射发射的光时捕获虹膜图像的虹膜图像传感器，视网膜图像传感器，其在视网膜反射时捕获视网膜的图像发出的光线以及控制虹膜和视网膜照射源的控制器，其中虹膜的拍摄图像和视网膜的拍摄图像包含生物统计数据。

5. 发明申请

WO2005049131A1 PHOTOTHERAPY DEVICE AND SYSTEM 审中-公开
标题翻译：照相装置和系统
公开(公告)号：WO2005049131A1
公开(公告)日：2005-06-02
申请号：PCT/US2004/037559
申请日：2004-11-10
申请人： LUMERX, INC. , FRIEDMAN, Marc, D. , EVANS, Stephen , ZALESKY, Paul, J. , DAHM, Jon , LEVIN, Philip
发明人： FRIEDMAN, Marc, D. , EVANS, Stephen , ZALESKY, Paul, J. , DAHM, Jon , LEVIN, Philip
IPC分类号： A61N1/06
CPC分类号： A61N5/0603 , A61B2090/036 , A61M25/1011 , A61N5/0601 , A61N5/062 , A61N2005/005 , A61N2005/0602 , A61N2005/0609 , A61N2005/0652 , A61N2005/0661 , A61N2005/0662 , F21S4/20 , F21Y2115/10 , H01L33/62 , H01L2224/32245 , H01L2224/48091 , H01L2224/48247 , H01L2224/73265 , H01L2924/12044 , H01L2924/3025 , H01L2924/00014 , H01L2924/00
摘要： Physically flexible radiation-emitting probes and associated illumination methods and systems for delivering radiation or light to the interior of a lumen or cavity. Light-emitting devices are immersed in a flowing liquid coolant within a probe to provide high light output power, and convoluted electrical power buss structures provide physical flexibility of a probe about a longitudinal axis. The probes can be configured for delivering light to the interior of any lumen including for performing therapeutic medical procedures at locations in body lumens including the interior of the human gastrointestinal tract.
摘要翻译：物理上灵活的辐射发射探针和相关的照明方法和系统，用于将辐射或光传递到腔或腔的内部。发光器件浸入到探针内的流动的液体冷却剂中以提供高的光输出功率，并且卷积的电力总线结构提供探针围绕纵向轴线的物理灵活性。探针可以被配置为将光传送到任何腔的内部，包括用于在包括人胃肠道内部的体腔内的位置执行治疗性医学过程。

6. 发明申请

WO2005049127A1 INTRA-CAVITY CATHETERS AND EMTHODS OF USE 审中-公开
标题翻译：内腔导管和使用的功能
公开(公告)号：WO2005049127A1
公开(公告)日：2005-06-02
申请号：PCT/US2004/037846
申请日：2004-11-12
申请人： LUMERX, INC. , ZALESKY, Paul, J. , FRIEDMAN, Marc, D. , EVANS, Stephen
发明人： ZALESKY, Paul, J. , FRIEDMAN, Marc, D. , EVANS, Stephen
IPC分类号： A61M29/00
CPC分类号： A61N5/0603 , A61B2090/036 , A61M25/1011 , A61N5/0601 , A61N5/062 , A61N2005/005 , A61N2005/0602 , A61N2005/0609 , A61N2005/0652 , A61N2005/0661 , A61N2005/0662 , F21S4/20 , F21Y2115/10 , H01L33/62 , H01L2224/32245 , H01L2224/48091 , H01L2224/48247 , H01L2224/73265 , H01L2924/12044 , H01L2924/3025 , H01L2924/00014 , H01L2924/00
摘要： Catheters for performing therapeutic and diagnostic procedures within a body, including human or animal body cavities or lumens, and methods for use. One or more distancing member of the catheter can be used to position a sensor or a therapeutic device a minimum distance from a wall of a lumen or cavity. The catheter can include means for actively or passively controlling or modulating its position within the lumen or cavity during a procedure. Methods for using the catheter include nonocclusive deployment in the human gastrointestinal tract for phototherapy procedures, delivering electromagnetic radiation substantially homogeneously or in a desired pattern to the interior of a lumen.
摘要翻译：用于在体内执行治疗和诊断程序的导管，包括人或动物体腔或腔，以及使用方法。可以使用导管的一个或多个间隔构件来将传感器或治疗装置定位在距管腔或空腔的壁的最小距离处。导管可以包括用于在程序期间主动地或被动地控制或调节其在管腔或空腔内的位置的装置。使用导管的方法包括在人类胃肠道中进行非包容性部署以进行光疗法，将电磁辐射基本上均匀地或以期望的图案输送到内腔内部。

7. 发明申请

WO2008039252A2 MULTIMODAL OCULAR BIOMETRIC SYSTEM 审中-公开
标题翻译：多模式眼睛生物测量系统
公开(公告)号：WO2008039252A2
公开(公告)日：2008-04-03
申请号：PCT/US2007/011507
申请日：2007-05-14
申请人： RETICA SYSTEMS, INC. , FRIEDMAN, Marc, D. , CASAVERDE, Pablo , YANSEN, Don , MCNERNEY, Tim , TOSA, Yasunari , USHER, David , ACCOMANDO, Nicholas, A. , MULLER, David , HEACOCK, Greg , MARSHALL, John
发明人： FRIEDMAN, Marc, D. , CASAVERDE, Pablo , YANSEN, Don , MCNERNEY, Tim , TOSA, Yasunari , USHER, David , ACCOMANDO, Nicholas, A. , MULLER, David , HEACOCK, Greg , MARSHALL, John
IPC分类号： A61B3/14 , A61B3/15 , G06K9/62
CPC分类号： H04N7/18 , A61B3/1216 , A61B3/14 , G06K9/00597
摘要： A multimodal biometric identification system captures and processes images of both the iris and the retina for biometric identification. Another multimodal ocular system captures and processes images of the iris and/or the from both eyes of a subject. Biometrics based on data provided by these systems are more accurate and robust than using biometrics that include data from only the iris or only the retina from a single eye. An exemplary embodiment emits photons to the iris and the retina of both eyes, an iris image sensor that captures an image of the iris when the iris reflects the emitted light, a retina image sensor that captures an image of the retina when the retina reflects the emitted light, and a controller that controls the iris and the retina illumination sources, where the captured image of the iris and the captured image of the retina contain biometric data.
摘要翻译：多模式生物统计识别系统捕获并处理虹膜和视网膜的图像以进行生物统计识别。另一种多模式眼部系统捕捉和处理虹膜和/或来自对象双眼的图像。基于这些系统提供的数据的生物特征识别比使用生物特征识别更加准确和可靠，这些生物特征包括仅来自虹膜或仅来自单眼的视网膜的数据。示例性实施例向双眼的虹膜和视网膜发射光子，当虹膜反射发射的光时捕获虹膜图像的虹膜图像传感器，视网膜图像传感器，其在视网膜反射时捕获视网膜的图像发出的光线以及控制虹膜和视网膜照射源的控制器，其中虹膜的拍摄图像和视网膜的拍摄图像包含生物统计数据。

8. 发明申请

WO2011050164A1 EYE THERAPY 审中-公开
标题翻译：眼睛治疗
公开(公告)号：WO2011050164A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/053551
申请日：2010-10-21
申请人： AVEDRO, INC. , MULLER, David , MARSHALL, John , FRIEDMAN, Marc, D.
发明人： MULLER, David , MARSHALL, John , FRIEDMAN, Marc, D.
IPC分类号： A61F9/013
CPC分类号： A61N5/062 , A61F9/0008 , A61F9/013 , A61K31/14
摘要： Embodiments apply a cross-linking agent to a region of corneal tissue. The cross-linking agent improves the ability of the corneal tissue to resist undesired structural changes. For example, the cross-linking agent may be Riboflavin or Rose Bengal, and the initiating element may be photoactivating light, such as ultraviolet (UV) light. In these embodiments, the photoactivating light initiates cross-linking activity by irradiating the applied cross-linking agent to release reactive oxygen radicals in the corneal tissue. The cross-linking agent acts as a sensitizer to convert O 2 into singlet oxygen which causes cross-linking within the corneal tissue. The rate of cross-linking in the cornea is related to the concentration of O 2 present when the cross-linking agent is irradiated with photoactivating light. Accordingly, the embodiments control the concentration of O 2 during irradiation to increase or decrease the rate of cross-linking and achieve a desired amount of cross-linking.
摘要翻译：实施例将交联剂应用于角膜组织的区域。交联剂改善了角膜组织抵抗不良结构变化的能力。例如，交联剂可以是核黄素或玫瑰红，并且起始元件可以是光活化的光，例如紫外（UV）光。在这些实施方案中，光活化光通过照射所施加的交联剂以释放角膜组织中的活性氧自由基引发交联活性。交联剂用作敏化剂以将O 2转化为单线态氧，其导致角膜组织内的交联。角膜中的交联速率与交联剂用光活化光照射时存在的O 2浓度有关。因此，实施例控制照射期间的O 2浓度以增加或降低交联速率并达到所需量的交联。

9. 发明申请

WO2009036103A1 LONG DISTANCE MULTIMODAL BIOMETRIC SYSTEM AND METHOD 审中-公开
标题翻译：长距离多模态生物量系统和方法
公开(公告)号：WO2009036103A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/075910
申请日：2008-09-10
申请人： RETICA SYSTEMS, INC. , FRIEDMAN, Marc, D. , ACCOMANDO, Nicholas , BASHIR, Faisal , CASAVERDE, Pablo , DALY, Stephen, F. , HITCHCOCK, David, J. , JOSE, Romina Marie, Johnson , MCNERNEY, Tim , MULLER, David , RUZHITSKY, Vladimir , TOSA, Yasunari , USHER, David
发明人： FRIEDMAN, Marc, D. , ACCOMANDO, Nicholas , BASHIR, Faisal , CASAVERDE, Pablo , DALY, Stephen, F. , HITCHCOCK, David, J. , JOSE, Romina Marie, Johnson , MCNERNEY, Tim , MULLER, David , RUZHITSKY, Vladimir , TOSA, Yasunari , USHER, David
IPC分类号： G06K9/00
CPC分类号： G06K9/00771 , G06K9/00221 , G06K9/00597 , G06K9/00892 , G06K9/00973
摘要： A system for multimodal biometric identification has a first imaging system that detects one or more subjects in a first field of view, including a targeted subject having a first biometric characteristic and a second biometric characteristic; a second imaging system that captures a first image of the first biometric characteristic according to first photons, where the first biometric characteristic is positioned in a second field of view smaller than the first field of view, and the first image includes first data for biometric identification; a third imaging system that captures a second image of the second biometric characteristic according to second photons, where the second biometric characteristic is positioned in a third field of view which is smaller than the first and second fields of view, and the second image includes second data for biometric identification. At least one active illumination source emits the second photons.
摘要翻译：一种用于多模式生物识别的系统具有第一成像系统，其检测第一视场中的一个或多个被摄体，包括具有第一生物特征和第二生物特征的目标对象; 第二成像系统，其根据第一光子捕获第一生物特征的第一图像，其中第一生物特征位于小于第一视场的第二视野中，并且第一图像包括用于生物识别的第一数据 ; 第三成像系统，其根据第二光子捕获第二生物特征的第二图像，其中所述第二生物特征位于小于所述第一和第二视场的第三视场中，并且所述第二图像包括第二图像生物识别数据。至少一个有源照明源发射第二光子。

10. 发明申请

WO2008033784A2 LONG DISTANCE MULTIMODAL BIOMETRIC SYSTEM AND METHOD 审中-公开
标题翻译：长距离多模式生物统计系统和方法
公开(公告)号：WO2008033784A2
公开(公告)日：2008-03-20
申请号：PCT/US2007/078074
申请日：2007-09-10
申请人： RETICA SYSTEMS, INC. , FRIEDMAN, Marc D. , CASAVERDE, Pablo , MCNERNEY, Tim , TOSA, Yasunari , USHER, David , MULLER, David , BASHIR, Faisal , HITCHCOCK`, David J.
发明人： FRIEDMAN, Marc D. , CASAVERDE, Pablo , MCNERNEY, Tim , TOSA, Yasunari , USHER, David , MULLER, David , BASHIR, Faisal , HITCHCOCK`, David J.
IPC分类号： G06K9/00
CPC分类号： G06K9/00604 , G06K9/00255
摘要： A system for multimodal biometric identification has a first imaging system that detects one or more subjects in a first field of view, including a targeted subject having a first biometric characteristic and a second biometric characteristic; a second imaging system that captures a first image of the first biometric characteristic according to first photons, where the first biometric characteristic is positioned in a second field of view smaller than the first field of view, and the first image includes first data for biometric identification; a third imaging system that captures a second image of the second biometric characteristic according to second photons, where the second biometric characteristic is positioned in a third field of view which is smaller than the first and second fields of view, and the second image includes second data for biometric identification. At least one active illumination source emits the second photons.
摘要翻译：一种用于多模式生物识别的系统具有第一成像系统，其检测第一视野中的一个或多个对象，所述第一视野包括具有第一生物特征和第二生物特征的目标对象; 第二成像系统，其根据第一光子捕获第一生物识别特征的第一图像，其中第一生物识别特征位于小于第一视野的第二视野中，并且第一图像包括用于生物识别的第一数据 ; 第三成像系统，其根据第二光子捕获第二生物识别特征的第二图像，其中第二生物识别特征位于小于第一和第二视野的第三视野中，并且第二图像包括第二生物识别数据。至少有一个主动照明源发射第二个光子。

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