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    • 1. 发明申请
    • NANOSCALE CALORIMETER ON CHIP AND RELATED METHODS AND DEVICES
    • NANOSCALE CALORIMETER ON CHIP及相关方法和设备
    • WO2013142384A2
    • 2013-09-26
    • PCT/US2013/032621
    • 2013-03-15
    • CALIFORNIA INSTITUTE OF TECHNOLOGYFON, Chung WahROUKES, Michael L.
    • FON, Chung WahROUKES, Michael L.
    • G01K17/00
    • G01N25/48G01K17/006
    • An article comprising: an array of calorimeter devices, wherein the device comprises: at least one fluidic enclosure disposed on a microfluidic chip, wherein the fluidic enclosure is substantially gas impermeable; at least one first chamber and at least one second chamber, wherein the first chamber and the second chamber are disposed within and enclosed by the fluidic enclosure, wherein the first chamber and the second chamber are not vacuum encapsulated; at least two microfluidic channels connected to the first chamber and at least two microfluidic channels connected to the second chamber; and at least one thermal sensor disposed between the chip and the first and second chambers, wherein the thermal sensor is adapted to measure a temperature differential between the first and second chambers. Examples include DSC and TSA devices. Biological binding and melting experiments can be done with high sensitivity.
    • 一种制品,包括:量热器装置阵列,其中所述装置包括:设置在微流体芯片上的至少一个流体外壳,其中所述流体外壳基本上不透气; 至少一个第一室和至少一个第二室,其中所述第一室和所述第二室设置在所述流体外壳内并由所述流体外壳围绕,其中所述第一室和所述第二室不被真空封装; 连接到第一室的至少两个微流体通道和连接到第二室的至少两个微流体通道; 以及设置在所述芯片和所述第一和第二腔室之间的至少一个热传感器,其中所述热传感器适于测量所述第一和第二腔室之间的温度差。 示例包括DSC和TSA设备。 生物结合和熔化实验可以灵敏度高。