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1. 发明申请

WO2018106132A1 MICROFLUIDIC DEVICE FOR CELL CULTURE IN GRADIENT OF BIOACTIVE SUBSTANCE 审中-公开
公开(公告)号：WO2018106132A1
公开(公告)日：2018-06-14
申请号：PCT/PL2017/000122
申请日：2017-12-08
申请人： POLITECHNIKA WROCŁAWSKA , UNIWERSYTET MEDYCZNY IM. PIASTÓW ŚLĄSKICH
发明人： SZAFRAN, Roman , GĄSIOROWSKI, Kazimierz , GĘBCZAK, Katarzyna , WIATRAK, Benita
IPC分类号： C12M3/00 , C12M1/00 , B01L3/00 , B81B7/00
CPC分类号： C12M23/16 , C12M35/08
摘要： A multilayer microfluidic device for cell culture in the gradient of a bioactive substance characterised by three layers and two protective cups (3) of tanks, the top layer being a cover (6), which contains tanks of fluids feeding the culture chambers (1), reference points (4) and a millimetre graduation (5); in the middle functional layer (7), made of adhesive film, there is a set of channels serving as culture and indicator chambers (2) with semi-circular ends (8), at least one of which is intended for cell culture in concentration gradient of the active substance (culture chamber), one for cell culture without an active agent (blind test) and one to develop a concentration profile of the indicator substance (indicator chamber); and the bottom layer is the base (9).

2. 发明申请

WO2017099616A1 METHOD OF FILLING AND EMPTYING THE WORKING CHAMBER OF THE HYDRAULIC CYLINDER AND A HYDRAULIC CYLINDER TOGETHER WITH A CONTROL SYSTEM AND A HYDRAULIC CYLINDER FOR PERFORMING THE METHOD ACCORDING TO THE INVENTION 审中-公开
标题翻译：用于执行根据本发明的方法的液压缸和液压缸的工作室以及用于控制系统和液压缸的填充和放空方法
公开(公告)号：WO2017099616A1
公开(公告)日：2017-06-15
申请号：PCT/PL2016/000146
申请日：2016-12-08
申请人： POLITECHNIKA WROCŁAWSKA
发明人： SIWULSKI, Tomasz , WARZYŃSKA, Urszula
IPC分类号： F15B15/08 , F15B15/14
CPC分类号： F15B21/042 , F15B15/1485 , F15B15/149 , F15B2211/30575 , F15B2211/62 , F15B2211/66 , F15B2211/7053
摘要： A method of filling and emptying the working chamber of the hydraulic cylinder intended for universal use in industrial practice, in particular in heavy industry and intended in particular, for use in the systems operating at high temperatures or under high workload, distinctive by the fact that hydraulic fluid is fed to each working chamber (6, 7) of the hydraulic cylinder through a valve (12a,12b) via one supply hydraulic line (8, 9), and it is discharged via a second valve (12c, 12d), through a discharge hydraulic line (10,11). A hydraulic cylinder together with a control system built from a cylinder (1), in which a plunger (23) or piston (4) interconnected with a piston rod (3) is mounted, distinctive by the fact that two hydraulic lines, each with a valve (12a, 12b, 12c, 12d), are led to each working chamber (6, 7) of the cylinder, wherein one of them is a supply hydraulic line (8, 9) and the second one is a discharge hydraulic line (10, 11). A hydraulic cylinder made of a cylinder (1) in which a plunger (23) or a piston (4) interconnected with a piston rod (3) is mounted, distinctive by the fact that each of the working chambers (6, 7) of the cylinder s equipped with two connection pipes (18, 19, 20, 21), the first of which is intended for connecting the supply hydraulic line and the other one for connecting the discharge hydraulic line.
摘要翻译：一种填充和清空液压缸的工作室的方法，所述液压缸用于在工业实践中通用，特别是在重工业中并特别用于在高温或低温下运行的系统中由于液压流体通过阀（12a，12b）经由一个供应液压管线（8,9）供应到液压缸的每个工作室（6,7），并且其经由阀第二阀（12c，12d）通过排出液压管线（10,11）。液压缸连同由缸（1）构成的控制系统一起安装，其中安装有与活塞杆（3）相互连接的柱塞（23）或活塞（4），其特征在于两个液压管路将阀（12a，12b，12c，12d）引导到气缸的每个工作室（6,7），其中一个是供应液压管线（8,9），并且第二个是排出液压管线（10,11）。由安装有与活塞杆（3）相互连接的活塞（23）或活塞（4）的缸体（1）构成的液压缸被区别在于，每个工作室（6,7）的装有两个连接管（18,19,20,21）的缸体，其中第一个连接供应液压管路，另一个连接排出液压管路。

3. 发明申请

WO2017018893A1 METHOD AND DEVICE FOR DETERMINING THE QUALITY OF MOTOR-CAR FUEL 审中-公开
标题翻译：用于确定汽油燃料质量的方法和装置
公开(公告)号：WO2017018893A1
公开(公告)日：2017-02-02
申请号：PCT/PL2015/000120
申请日：2015-07-24
申请人： POLITECHNIKA WROCŁAWSKA
发明人： TETERYCZ, Helena , WIŚNIEWSKI, Kamil , KLUBIŃSKI, Grzegorz , SUCHORSKA-WOŹNIAK, Patrycja , RAC, Olga , FIEDOT, Marta
IPC分类号： G01N27/02 , G01R27/02 , G01R27/08 , G01R27/22 , G01N33/28
CPC分类号： G01N27/026 , G01N33/2835 , G01R27/02 , G01R27/08 , G01R27/22
摘要： Method of determining the quality of motor-car fuel in accordance with the invention is characterized by the fact that with experimental methods the impedance calibration curve is determined, after which the impedance as a function of the frequency of resonator element (2) submerged in the fuel tested and stimulated by electric signal from generator (1), then from the measured impedance characteristics as a function of frequency, the field of circle on the complex plane of Nyquist plot ('Z, Z") is determined characteristic for the composition of the fuel mixture tested on the basis of which the fuel composition is determined. The device is equipped with generator (1) connected to the resonator (2), which by vector voltmeter ammeter (3) and vector ammeter (4) is connected to arithmetic system (5) connected to micro-controller (12).
摘要翻译：根据本发明的确定汽车燃料质量的方法的特征在于，通过实验方法确定阻抗校准曲线，之后阻抗作为谐振器元件（2）的频率的函数淹没在燃料由发电机（1）的电信号进行测试和激励，然后根据测量的阻抗特性作为频率的函数，确定奈奎斯特图（'Z，Z“）复平面上的圆的场为燃料混合物在此基础上进行测试，确定燃料组成，该装置配备有连接到谐振器（2）的发电机（1），其通过矢量电压表电流表（3）和矢量电流表（4）连接到算术系统（5）连接到微控制器（12）。

4. 发明申请

WO2013115660A2 TEXTILE PRODUCT FOR ATTENUATION OF ELECTROMAGNETIC FIELD AND THE DEVICES FOR MANUFACTURING THE TEXTILE PRODUCT ATTENUATING ELECTROMAGNETIC FIELD 审中-公开
标题翻译：用于电磁场衰减的纺织产品和用于制造纺织产品的电磁场的装置
公开(公告)号：WO2013115660A2
公开(公告)日：2013-08-08
申请号：PCT/PL2013/000006
申请日：2013-01-25
申请人： INSTYTUT WŁÓKIENNICTWA , POLITECHNIKA WROCŁAWSKA
发明人： KOPROWSKA, Joanna , KUSIAKIEWICZ, Janusz , SZWUGIER, Arkadiusz , JEGIER, Grzegorz , ZIAJA, Jan
IPC分类号： D06M11/83
CPC分类号： D06M11/83 , C23C14/0036 , C23C14/205 , C23C14/3485 , C23C14/35 , C23C14/562 , C23C28/021 , C23C28/023 , C23C28/025 , C23C28/322 , C23C28/3225 , C23C28/345 , C23C28/3455 , C23C28/42 , D06M11/44 , D06M11/46 , H01J37/32761 , H01J37/3405 , H01J37/3467 , H05K9/0088
摘要： The subject of this invention is a textile product attenuating electromagnetic field and a device for manufacturing textile materials attenuating electromagnetic field by coating a textile material with coatings deposited by magnetron sputtering method, whereby the textile materials are intended for applications such as electromagnetic shields, used especially in hospitals, office blocks, dwelling houses and laboratories, and which may be used for manufacturing of wallpaper, curtains, blinds and roller blinds. The textile product has at least one layer (L 1 , L 2 , L 3 , L 4 ) of metal and/or at least one layer (L 1 , L 2 , L 3 , L 4 ) of metal oxide with the thickness below few micrometers, formula I, deposited on a substrate (S) alternately, where the number of the (L 1 , L 2 , L 3 , L 4 ) layers depends on the coefficient of shielding efficiency of electromagnetic field by the textile product. Inside a vacuum chamber, above the conveying device fixed to the base (10) there is a three-layer anode in a shape of a part of cylindrical surface, mounted with insulators (6) on the base (10) fixed to the chamber housing. The anode, on the side of the target (1 1), has a sliding layer (5) and under this layer, a layer of supporting structure (4) while on the bottom, there is a temperature stabilizer (3) to which a cooling system made of a set of pipes (2) transporting the cooling medium is mounted. Above the three-layer anode there is a magnetron sputtering device (1) equipped with a rectangular target (11), connected to a supplier (27) which is coupled through a control system (26) with a computer unit (25). The control system (26) is connected through a valve controller (28) with a control valve (29), an instrument for measuring the length of a coated fabric (30), and simultaneously, through a engine velocity governor (31) with a motor (32) driving a two-way drive (9) of the conveying device.
摘要翻译：本发明的主题是减弱电磁场的纺织产品和用于通过用通过磁控溅射方法沉积的涂层涂布纺织材料来制造纺织材料来制造电磁场的装置，由此纺织材料用于特别使用的电磁屏蔽在医院，办公楼，住宅和实验室，可用于壁纸，窗帘，百叶窗和卷帘的制造。纺织产品具有至少一层金属和/或至少一层厚度低于几微米的金属氧化物层（L1，L2，L3，L4），层I（L1，L2，L3，L4）沉积在（L1，L2，L3，L4）层的数量取决于纺织品的电磁场屏蔽效率的系数的衬底（S）。在真空室内部，固定在基座（10）上的传送装置上方有一个圆柱形表面的一部分形式的三层阳极，其上安装有固定在腔室（10）上的基座（10）上的绝缘体（6）。在靶（11）一侧上的阳极具有滑动层（5），并且在该层的下方具有一层支撑结构（4），而在底部上有一个温度稳定器（3）安装由一组输送冷却介质的管道（2）制成的冷却系统。在三层阳极上方有一个装有矩形靶（11）的磁控溅射装置（1），它连接到通过控制系统（26）与计算机单元（25）联接的供应器（27）。控制系统（26）通过阀控制器（28）连接有控制阀（29），用于测量涂覆织物（30）的长度的仪器，并且同时通过发动机调速器（31）马达（32）驱动输送装置的双向驱动（9）。

5. 发明申请

WO2017007347A1 A METHOD OF PRODUCING A PLANT PREPARATION FROM A CONE HOPS, KNOTWEED AND CRANBERRY, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS AND THEIR USAGE 审中-公开
标题翻译：一种生产来自果仁糖，牛奶和干酪的植物制剂的方法，含有这些化合物的药物组合物及其用途
公开(公告)号：WO2017007347A1
公开(公告)日：2017-01-12
申请号：PCT/PL2015/050029
申请日：2015-07-08
申请人： POLITECHNIKA WROCŁAWSKA
发明人： GANCARZ, Roman , KLEPACZ, Ewa
IPC分类号： A61K36/185 , A61K36/45 , A61K36/704 , A61P13/04
CPC分类号： A61K36/185 , A61K36/45 , A61K36/704 , A61K2236/00 , A61K2300/00
摘要： The invention relates to a method of producing a plant extracts with cone hops, knotweed and American cranberry, characterized in that the cones of hops (Humulus lupulus L.), St. John's knotweed (Polygonum aviculare L.) and fruit cranberry (Vaccinium macrocarpon L.) is extracted with carbon dioxide in a supercritical state, and then the solvent is evaporated. The present invention also relates to the preparation of plant extracts as pharmaceutical composition comprising the formulation of the plant, and the use of a preparation plant for the treatment of kidney stones and the use of extraction with carbon dioxide in supercritical conditions for preparing the plant formulations of the cone hops, knotweed and cranberry.
摘要翻译：本发明涉及一种用锥形啤酒花，藜和美洲蔓越莓生产植物提取物的方法，其特征在于啤酒花（葎草），圣约翰氏草（Polygonum aviculare L.）和水果蔓越莓（Vaccinium macrocarpon L.）用超临界状态的二氧化碳萃取，然后蒸发溶剂。本发明还涉及作为包含植物制剂的药物组合物的植物提取物的制备以及用于治疗肾结石的制备植物的使用以及在超临界条件下用二氧化碳提取制备植物制剂的用途的锥形啤酒花，藜和蔓越莓。

6. 发明申请

WO2017007346A1 PHENOL GLYCOSIDES AND THEIR USE IN THE TREATMENT OF UROLITHIASIS 审中-公开
标题翻译：酚醛糖苷及其在治疗尿崩症中的应用
公开(公告)号：WO2017007346A1
公开(公告)日：2017-01-12
申请号：PCT/PL2015/050028
申请日：2015-07-06
申请人： POLITECHNIKA WROCŁAWSKA
发明人： GANCARZ, Roman , KUBAS, Karolina
IPC分类号： C07H15/203 , A61K31/7034 , A61P13/04
CPC分类号： C07H15/203
摘要： The present invention relates to novel derivatives of polyphenol glycoside or polyalcohols of formula (1), wherein R1, R2, R3 is selected from the group consisting of H, OH, C(O)R4, C(0) OR4, 0 (Gly H3)n, wherein n = 0 1, 2, 3, and R4 is selected from the group consisting of H, alkyl, and Gly is a mono- or disaccharide residue. The present invention also relates to novel derivatives of glycoside polyphenols or polyalcohols, as pharmaceutical composition comprising a novel polyphenol glycoside or polyalcohols and the use of novel polyphenol glycoside or polyalcohols for the treatment of urolithiasis.
摘要翻译：本发明涉及式（1）的多酚糖苷或多元醇的新衍生物，其中R1，R2，R3选自H，OH，C（O）R4，C（O）OR4,0（Gly H3）n，其中n = 0,1,2,3和R4选自H，烷基，Gly是单糖或二糖残基。本发明还涉及作为包含新型多酚糖苷或多元醇的药物组合物以及用于治疗尿石症的新型多酚糖苷或多元醇的糖苷多酚或多元醇的新衍生物。

7. 发明申请

WO2016003301A1 METHOD FOR PREPARING OF THIN AND ULTRATHIN POLYMER FILMS ON SOLID SUBSTRATES 审中-公开
标题翻译：在固体基底上制备薄层和超薄聚合物薄膜的方法
公开(公告)号：WO2016003301A1
公开(公告)日：2016-01-07
申请号：PCT/PL2015/000110
申请日：2015-07-02
申请人： POLITECHNIKA WROCŁAWSKA
发明人： JANUS, Krzysztof , SWORAKOWSKI, Juliusz , SANISZEWSKI, Adam , BIELECKA, Urszula
IPC分类号： B05D3/06 , B23K26/073 , C03C17/32
CPC分类号： B05D3/06 , B05D3/0263 , C03C17/328 , C03C17/42 , C03C2217/75 , C03C2217/76 , C03C2217/948
摘要： The invention relates to method for preparing thin and ultrathin polymer films on solid substrates, in particular: glass, quartz, ITO coated glass, mica, comprising deposition of a layer of solution or suspension of polymer, followed by fabrication of solid layer by using a laser light forming a line with uniform light intensity, which is moving in a direction perpendicular to its axis.
摘要翻译：本发明涉及在固体基质上制备薄和超薄聚合物膜的方法，特别是玻璃，石英，ITO涂覆的玻璃，云母，包括沉积聚合物溶液或悬浮液层，随后通过使用激光形成具有均匀光强度的线，其在垂直于其轴线的方向上移动。

8. 发明申请

WO2022025779A1 A METHOD FOR THE PRODUCTION OF FUNCTIONAL HUMIC AND FULVIC PRODUCTS FROM NATURAL ORGANIC RAW MATERIALS 审中-公开
公开(公告)号：WO2022025779A1
公开(公告)日：2022-02-03
申请号：PCT/PL2020/050056
申请日：2020-08-03
申请人： POLITECHNIKA WROCŁAWSKA
发明人： HOFFMANN, Józef , HUCULAK-MĄCZKA, Marta , NIEWEŚ, Dominik , HOFFMANN, Krystyna , KLEM-MARCINIAK, Ewelina , ZIELIŃSKI, Jakub , KANIEWSKI, Maciej , BRAUN-GIWERSKA, Magdalena , BIEGUN, Marcin
IPC分类号： C05F11/02
摘要： The subject of the invention is a method for the production of functional humic and fulvic products enriched with N, P, K nutrients, characterized in that in the first stage, the raw carboniferous material is activated with an H3PO4 solution or an HNO3 solution until the pH level of the mixture is lower than 3; in the second step, an H3PO4 solution or an HNO3 solution is added, while the ratio of the input material to the total amount of added solutions is maintained within in the range of 1:5-1:15; next the mixture is neutralized with a KOH solution or an ΝΗ3'H2Ο solution and extracted with a KOH solution or an ΝΗ3'H2Ο solution; next the sediment is separated from the actual extract of humic substances enriched with nutrients such as N, P, K, from which humic acids are precipitated by adding H3PO4 or HNO3 acid with the concentration of up to 50 wt.%, and the products in the form of humic and fulvic acids are separated, wherein the activation and/or extraction process is aided with ultrasounds.

9. 发明申请

WO2021246886A1 COMPOUNDS FOR THE TREATMENT OR DIAGNOSIS OF COVID-19 审中-公开
公开(公告)号：WO2021246886A1
公开(公告)日：2021-12-09
申请号：PCT/PL2021/050037
申请日：2021-06-04
申请人： POLITECHNIKA WROCŁAWSKA
发明人： DRĄG, Marcin , RUT, Wioletta
IPC分类号： A61K31/16 , A61K31/165 , A61K31/4025 , A61K31/404 , A61K31/4188 , A61K31/426 , A61K38/00 , A61P31/14
摘要： Disclosed are compounds for use in the treatment, prophylaxis or diagnosis of COVID-19.

10. 发明申请

WO2018143831A1 METHOD OF MANUFACTURING A MULTILAYER MICROFLUIDIC DEVICE FOR DYNAMIC TISSUE CULTURE 审中-公开
公开(公告)号：WO2018143831A1
公开(公告)日：2018-08-09
申请号：PCT/PL2018/000010
申请日：2018-01-26
申请人： POLITECHNIKA WROCŁAWSKA , UNIWERSYTET MEDYCZNY W LODZI
发明人： SZAFRAN, Roman , PAWŁOWSKA, Agnieszka , FICHNA, Jakub , LEWANDOWSKA, Urszula
IPC分类号： C12M3/00 , B81B1/00 , B81B7/00 , B32B3/10 , B32B33/00
摘要： The method of manufacturing a multilayer microfluidic device for the conduct of tissue culture under dynamic conditions is presented, which consists of at least six layers (these are: bottom and lid, adhesive layer, at least one auxiliary glass layer, at least one elastomeric functional layer and at least one hydrogel layer). The method is characterized by the fact that in the first stage, on the basis of pre-designed maps of each layer of the device, its elements (vascular and connecting channels and microchannels, inspection, positioning and through holes, culture chambers, partitions and tanks) are produced. For this purpose, elastomeric layers are prepared in such a way that the medium is coated with a layer of elastomer and fixed. Then the focused laser beam does the engraving and cuts the structures. The auxiliary glass layers, the adhesive layer and the bottom and lid of the microdevices are engraved and the structure are cut by means of a focused laser beam operating on material sheets. In the second stage, non-adhesive auxiliary glass layers and elastomeric functional layers are combined into sets. Each set consists of one glass layer and one elastomeric layer on a carrier which forms the temporary basis of the set. In the third stage, the previously prepared liquid hydrogel is introduced through inspection holes into the culture chambers of the sets where it is fixed and then disconnected from the temporary base of the unit. In this way, in the exposed hydrogel layer, vascular microchannels are engraved, whereas connecting channels are engraved in partitions, by means of a focused laser beam. In the fourth stage, without the use of glue, one or more sets are joined together or to the bottom or to the lid by means of an adhesive layer. In the fifth stage, the microsystem is combined with liquid supply and outlet hoses using an adhesive. In the sixth stage, the microsystem is cleaned and washed. In the seventh stage, suspension of cells of any type is introduced into the microsystem, once or several times, at intervals allowing their immobilization on the surface of microchannels. In the eighth stage, cell culture is carried out under flow conditions in order to form a network of capillary vessels within the artificial tissue.

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