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1. 发明申请

WO2012170793A8 BIOREFINERY PROCESS FOR THF PRODUCTION 审中-公开
标题翻译：用于生产THF的生物工艺
公开(公告)号：WO2012170793A8
公开(公告)日：2013-03-14
申请号：PCT/US2012041512
申请日：2012-06-08
申请人： METABOLIX INC , VAN WALSEM JOHAN , ANDERSON ERIK , LICATA JOHN , SPARKS KEVIN A , FARMER WILLIAM R , MIRLEY CHRISTOPHER , BICKMEIER JEFFREY A , D AMBRUOSO ANN , SKRALY FRANK , RAMSEIER THOMAS M , SIVASUBRAMANIAN M S , PEOPLES OLIVER P , SHABTAI YOSSEF
发明人： VAN WALSEM JOHAN , ANDERSON ERIK , LICATA JOHN , SPARKS KEVIN A , FARMER WILLIAM R , MIRLEY CHRISTOPHER , BICKMEIER JEFFREY A , D AMBRUOSO ANN , SKRALY FRANK , RAMSEIER THOMAS M , SIVASUBRAMANIAN M S , PEOPLES OLIVER P , SHABTAI YOSSEF
IPC分类号： C12P7/62 , C07D307/08 , C12P17/04
CPC分类号： C12P17/04 , C07D307/08 , C07D307/33 , C07D307/58 , C12P7/625
摘要： Processes and methods for making biobased tetrahydrofuran products from renewable carbon resources are described herein.
摘要翻译：本文描述了从可再生碳资源制备生物基四氢呋喃产物的方法和方法。

2. 发明申请

WO2012037324A3 INCREASING CARBON FLOW FOR POLYHYDROXYBUTYRATE PRODUCTION IN BIOMASS CROPS 审中-公开
公开(公告)号：WO2012037324A3
公开(公告)日：2012-03-22
申请号：PCT/US2011/051728
申请日：2011-09-15
申请人： METABOLIX, INC. , SOMLEVA, Mariya , TANG, Jihong , ALI, Aminat , BOHMERT-TATAREV, Karen , PATTERSON, Nii , CHINNAPEN, Himani , SNELL, Kristi, D. , PEOPLES, Oliver, P.
发明人： SOMLEVA, Mariya , TANG, Jihong , ALI, Aminat , BOHMERT-TATAREV, Karen , PATTERSON, Nii , CHINNAPEN, Himani , SNELL, Kristi, D. , PEOPLES, Oliver, P.
IPC分类号： C12N15/82 , A01H5/12 , C10L1/02 , C10G3/00 , C12P7/62
摘要： Transgenic plants, transgenic plant material, and transgenic plant cells for the improved synthesis of polyhydroxyalkanoates, preferably poly(3-hydroxybutyrate) (also referred to as PHB), have been developed. In one embodiment, carbon flow is modulated to increase production of PHB. Preferred plants that can be genetically engineered to produce PHB include plants that produce a large amount of lignocellulosic biomass that can be converted into biofuels, such as switchgrass, Miscanthus, Sorghum, sugarcane, millets, Napier grass and other forage and turf grasses. An exemplary plant that can be genetically engineered to produce PHB and produces lignocellulosic biomass is switchgrass, Panicum virgatum L. A preferred cultivar of switchgrass is Alamo. Other suitable cultivars of switchgrass include, but are not limited to, Blackwell, Kanlow, Nebraska 28, Pathfinder, Cave-in-Rock, Shelter and Trailblazer.

3. 发明申请

WO2011034946A9 GENERATION OF HIGH POLYHYDROXYBUTRATE PRODUCING OILSEEDS 审中-公开
公开(公告)号：WO2011034946A9
公开(公告)日：2011-03-24
申请号：PCT/US2010/048963
申请日：2010-09-15
申请人： METABOLIX, INC. , PATTERSON, Nii , TANG, Jihong , HAN, Jixiang , TAVVA, Venkata , HERTIG, Andrew , ZHANG, Zhigang , RAMSEIER, Thomas, Martin , BOHMERT-TATAREV, Karen , PEOPLES, Oliver, P. , SNELL, Kristi, D.
发明人： PATTERSON, Nii , TANG, Jihong , HAN, Jixiang , TAVVA, Venkata , HERTIG, Andrew , ZHANG, Zhigang , RAMSEIER, Thomas, Martin , BOHMERT-TATAREV, Karen , PEOPLES, Oliver, P. , SNELL, Kristi, D.
IPC分类号： C12N15/82 , C12P7/62 , A01H5/00
摘要： Transgenic plants, plant material, plant cells, and genetic constructs for synthesis of biopolymers, for example polyhydroxyalkanoates ("PHA") are provided. In one embodiment, the transgenic plants synthesize polyhydroxybutyrate ("PHB"). In one embodiment the transgenic plant encodes siRNA for one or more of the genes encoding enzymes for producing PHA. In a more preferred embodiment, the siRNA expression is under the control of an inducible regulatory element. In another embodiment, the transgenic plant contains transgenes that encode expression enzymes that will degrade the polymer. In a preferred embodiment, the expression of these enzymes is under the control of a germination specific, inducible, or minimal promoter. In another embodiment, the transgenic plant contains transgenes encoding enzymes that increase carbon flow for polymer synthesis. In a preferred embodiment, these transgenes encode enzymes that increase carbon flow in the Calvin Cycle.

4. 发明申请

WO2012149162A2 GREEN PROCESS FOR PRODUCING POLYHYDROXYALKANOATES AND CHEMICALS USING A RENEWABLE FEEDSTOCK 审中-公开
标题翻译：生产聚羟基烷酸酯和化学品的绿色工艺使用可再生料
公开(公告)号：WO2012149162A2
公开(公告)日：2012-11-01
申请号：PCT/US2012/035217
申请日：2012-04-26
申请人： METABOLIX, INC. , ZHANG, Zhigang , MCCHALICHER, Christopher, W.J. , VAN WALSEM, Johan , PEOPLES, Oliver, P. , ENO, Richard, P. , RAMSEIER, Thomas, M.
发明人： ZHANG, Zhigang , MCCHALICHER, Christopher, W.J. , VAN WALSEM, Johan , PEOPLES, Oliver, P. , ENO, Richard, P. , RAMSEIER, Thomas, M.
IPC分类号： C12N1/20
CPC分类号： C12N15/63 , C12N1/20 , C12N15/52 , C12P7/04 , C12P7/18 , C12P7/24 , C12P7/46 , C12P7/625
摘要： Disclosed are organisms genetically engineered to make useful products when grown on ethanol as a carbon source. The organisms are genetically engineered to produce various useful products such as polyhydroxyalkanoates, diols, diacids, higher alcohols, and other useful chemicals.
摘要翻译：公开的是在乙醇作为碳源生长时被遗传工程化以制备有用产物的生物。生物体被遗传工程化以产生各种有用的产物，例如聚羟基链烷酸酯，二醇，二酸，高级醇和其它有用的化学品。

5. 发明申请

WO2012037324A2 INCREASING CARBON FLOW FOR POLYHYDROXYBUTYRATE PRODUCTION IN BIOMASS CROPS 审中-公开
标题翻译：增加碳水化合物生物质废料中聚羟基丁酸酯的生产
公开(公告)号：WO2012037324A2
公开(公告)日：2012-03-22
申请号：PCT/US2011051728
申请日：2011-09-15
申请人： METABOLIX INC , SOMLEVA MARIYA , TANG JIHONG , ALI AMINAT , BOHMERT-TATAREV KAREN , PATTERSON NII , CHINNAPEN HIMANI , SNELL KRISTI D , PEOPLES OLIVER P
发明人： SOMLEVA MARIYA , TANG JIHONG , ALI AMINAT , BOHMERT-TATAREV KAREN , PATTERSON NII , CHINNAPEN HIMANI , SNELL KRISTI D , PEOPLES OLIVER P
IPC分类号： C12N15/82 , A01H5/12 , C10G3/00 , C10L1/02 , C12P7/62
CPC分类号： C12N15/8261 , C10B53/02 , C10G3/00 , C10G2300/1014 , C10J2300/0916 , C10J2300/092 , C10L5/44 , C12N15/8243 , C12N15/8246 , C12N15/8255 , C12N15/8269 , C12P7/625 , Y02A40/146 , Y02E50/10 , Y02E50/30 , Y02P30/20
摘要： Transgenic plants, transgenic plant material, and transgenic plant cells for the improved synthesis of polyhydroxyalkanoates, preferably poly(3-hydroxybutyrate) (also referred to as PHB), have been developed. In one embodiment, carbon flow is modulated to increase production of PHB. Preferred plants that can be genetically engineered to produce PHB include plants that produce a large amount of lignocellulosic biomass that can be converted into biofuels, such as switchgrass, Miscanthus, Sorghum, sugarcane, millets, Napier grass and other forage and turf grasses. An exemplary plant that can be genetically engineered to produce PHB and produces lignocellulosic biomass is switchgrass, Panicum virgatum L. A preferred cultivar of switchgrass is Alamo. Other suitable cultivars of switchgrass include, but are not limited to, Blackwell, Kanlow, Nebraska 28, Pathfinder, Cave-in-Rock, Shelter and Trailblazer.
摘要翻译：已经开发了转基因植物，转基因植物材料和用于改进合成聚羟基链烷酸酯，优选聚（3-羟基丁酸酯）（也称为PHB））的转基因植物细胞。在一个实施方案中，调节碳流以增加PHB的产生。可以遗传工程化生产PHB的优选植物包括产生大量木质纤维素生物质的植物，其可以转化成生物燃料，例如柳枝稷，芒草，高粱，甘蔗，米勒，纳皮尔草和其他草料和草坪草。可以遗传工程化生产PHB并生产木质纤维素生物质的示范性植物是柳枝稷（Panicum virgatum L.）。优选的柳枝稷品种是Alamo。柳枝稷的其他合适品种包括但不限于：Blackwell，Kanlow，Nebraska 28，Pathfinder，Cave-in-Rock，Shelter和Trailblazer。

6. 发明申请

WO2011034946A1 GENERATION OF HIGH POLYHYDROXYBUTRATE PRODUCING OILSEEDS 审中-公开
标题翻译：高聚羟基丁酸酯生产油脂的生成
公开(公告)号：WO2011034946A1
公开(公告)日：2011-03-24
申请号：PCT/US2010048963
申请日：2010-09-15
申请人： METABOLIX INC , PATTERSON NII , TANG JIHONG , HAN JIXIANG , TAVVA VENKATA , HERTIG ANDREW , ZHANG ZHIGANG , RAMSEIER THOMAS MARTIN , BOHMERT-TATAREV KAREN , PEOPLES OLIVER P , SNELL KRISTI D
发明人： PATTERSON NII , TANG JIHONG , HAN JIXIANG , TAVVA VENKATA , HERTIG ANDREW , ZHANG ZHIGANG , RAMSEIER THOMAS MARTIN , BOHMERT-TATAREV KAREN , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： C12N15/82 , A01H5/00 , C12P7/62
CPC分类号： C12N15/8214 , C12N15/8257
摘要： Transgenic plants, plant material, plant cells, and genetic constructs for synthesis of biopolymers, for example polyhydroxyalkanoates ("PHA") are provided. In one embodiment, the transgenic plants synthesize polyhydroxybutyrate ("PHB"). In one embodiment the transgenic plant encodes siRNA for one or more of the genes encoding enzymes for producing PHA. In a more preferred embodiment, the siRNA expression is under the control of an inducible regulatory element. In another embodiment, the transgenic plant contains transgenes that encode expression enzymes that will degrade the polymer. In a preferred embodiment, the expression of these enzymes is under the control of a germination specific, inducible, or minimal promoter. In another embodiment, the transgenic plant contains transgenes encoding enzymes that increase carbon flow for polymer synthesis. In a preferred embodiment, these transgenes encode enzymes that increase carbon flow in the Calvin Cycle.
摘要翻译：提供了用于合成生物聚合物的转基因植物，植物材料，植物细胞和遗传构建体，例如聚羟基链烷酸酯（“PHA”）。在一个实施方案中，转基因植物合成聚羟基丁酸酯（“PHB”）。在一个实施方案中，转基因植物编码一种或多种编码产生PHA的酶的基因的siRNA。在更优选的实施方案中，siRNA表达处于诱导型调节元件的控制下。在另一个实施方案中，转基因植物含有编码会降解聚合物的表达酶的转基因。在一个优选的实施方案中，这些酶的表达处于发芽特异性，诱导型或最小启动子的控制下。在另一个实施方案中，转基因植物含有编码增加聚合物合成碳流量的酶的转基因。在一个优选的实施方案中，这些转基因编码增加卡尔文循环中碳流量的酶。

7. 发明申请

WO2010102217A1 STABLE, FERTILE, HIGH POLYHYDROXYALKANOATE PRODUCING PLANTS AND METHODS OF PRODUCING THEM 审中-公开
标题翻译：稳定，有效的高聚羟基烷基酯生产植物及其生产方法
公开(公告)号：WO2010102217A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/026378
申请日：2010-03-05
申请人： METABOLIX, INC. , BOHMERT-TATAREV, Karen , MCAVOY, Susan , PEOPLES, Oliver, P. , SNELL, Kristi, D.
发明人： BOHMERT-TATAREV, Karen , MCAVOY, Susan , PEOPLES, Oliver, P. , SNELL, Kristi, D.
IPC分类号： C12N15/82
CPC分类号： C12N15/8214 , C12N15/8257
摘要： Transgenic plants that produce high levels of polyhydroxybutyrate and methods of producing them are provided. In a preferred embodiment the transgenic plants are produced using plastid transformation technologies and utilize genes which are codon optimized. Stably transformed plants able to produce greater than 10% dwt PHB in tissues are also provided.
摘要翻译：提供了产生高水平聚羟基丁酸的转基因植物及其生产方法。在优选的实施方案中，使用质体转化技术产生转基因植物并利用密码子优化的基因。还提供了能够在组织中产生大于10％dwt PHB的稳定转化的植物。

8. 发明申请

WO2006101983A3 CHEMICALLY INDUCIBLE EXPRESSION OF BIOSYNTHETIC PATHWAYS 审中-公开
公开(公告)号：WO2006101983A3
公开(公告)日：2006-09-28
申请号：PCT/US2006/009531
申请日：2006-03-16
申请人： METABOLIX, INC. , KOURTZ, Lauralynn , PEOPLES, Oliver, P. , SNELL, Kristi, D.
发明人： KOURTZ, Lauralynn , PEOPLES, Oliver, P. , SNELL, Kristi, D.
IPC分类号： C12N15/82 , C12P7/62 , A01H5/00
摘要： Methods and constructs for the introduction of multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway are provided. In one embodiment, the constructs contain two or more enzyme-encoding genes, each under the control of an inducible promoter and each with a polyadenylation signal. The constructs are used to produce transgenic plants, in which the expression of the enzymes are increased when a chemical inducing agent is applied, and a biosynthetic product of the series of enzymes encoded by the transgenes is produced. Constructs may be used which contain two or more enzyme-encoding genes under the control of one or more promoters activated by activator molecules or complexes expressed from a transgene or transgenes, which are themselves under the control of one or more inducible promoters and switched on following the external application of a chemical. The transgene or transgenes expressing the activator molecules or complexes may be included in the same construct containing multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway. Alternatively, the transgene or transgenes expressing the activator molecules or complexes may be on a different construct from the construct containing multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway. The activator molecule can be expressed using a constitutive promoter in an inactive form which is converted to the active form following application of the chemical inducing agent.

9. 发明申请

WO2006101983A2 CHEMICALLY INDUCIBLE EXPRESSION OF BIOSYNTHETIC PATHWAYS 审中-公开
标题翻译：化学途径的化学诱导表达
公开(公告)号：WO2006101983A2
公开(公告)日：2006-09-28
申请号：PCT/US2006009531
申请日：2006-03-16
申请人： METABOLIX INC , KOURTZ LAURALYNN , PEOPLES OLIVER P , SNELL KRISTI D
发明人： KOURTZ LAURALYNN , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： C12N15/82 , A01H5/00 , C12P7/62
CPC分类号： C12N15/8247 , C12N15/8237 , C12N15/8243
摘要： Methods and constructs for the introduction of multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway are provided. In one embodiment, the constructs contain two or more enzyme-encoding genes, each under the control of an inducible promoter and each with a polyadenylation signal. The constructs are used to produce transgenic plants, in which the expression of the enzymes are increased when a chemical inducing agent is applied, and a biosynthetic product of the series of enzymes encoded by the transgenes is produced. Constructs may be used which contain two or more enzyme-encoding genes under the control of one or more promoters activated by activator molecules or complexes expressed from a transgene or transgenes, which are themselves under the control of one or more inducible promoters and switched on following the external application of a chemical. The transgene or transgenes expressing the activator molecules or complexes may be included in the same construct containing multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway. Alternatively, the transgene or transgenes expressing the activator molecules or complexes may be on a different construct from the construct containing multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway. The activator molecule can be expressed using a constitutive promoter in an inactive form which is converted to the active form following application of the chemical inducing agent.
摘要翻译：提供了在多酶生物合成途径中引入编码酶的多个基因的方法和构建体。在一个实施方案中，构建体含有两个或更多个酶编码基因，每个基因在诱导型启动子的控制下并且各自具有多聚腺苷酸化信号。构建体用于产生转基因植物，其中当施用化学诱导剂时酶的表达增加，并且产生由转基因编码的一系列酶的生物合成产物。可以使用含有两个或更多个酶编码基因的构建体，所述两个或多个酶编码基因在一个或多个由活化剂分子或由转基因或转基因表达的复合物所激活的启动子的控制下，所述启动子本身处于一个或多个诱导型启动子的控制下，化学品的外部应用。表达活化剂分子或复合物的转基因或转基因可以包含在含有多酶生物合成途径中的酶的多个基因的相同构建体中。或者，表达活化剂分子或复合物的转基因或转基因可以与含有多酶生物合成途径中的酶的多个基因的构建体在不同的构建体上。可以使用非活性形式的组成型启动子来表达活化剂分子，其在施用化学诱导剂之后转化为活性形式。

10. 发明申请

WO2012149162A3 GREEN PROCESS FOR PRODUCING POLYHYDROXYALKANOATES AND CHEMICALS USING A RENEWABLE FEEDSTOCK 审中-公开
标题翻译：生产聚羟基烷酸酯和化学品的绿色工艺使用可再生料
公开(公告)号：WO2012149162A3
公开(公告)日：2013-01-17
申请号：PCT/US2012035217
申请日：2012-04-26
申请人： METABOLIX INC , ZHANG ZHIGANG , MCCHALICHER CHRISTOPHER W J , VAN WALSEM JOHAN , PEOPLES OLIVER P , ENO RICHARD P , RAMSEIER THOMAS M
发明人： ZHANG ZHIGANG , MCCHALICHER CHRISTOPHER W J , VAN WALSEM JOHAN , PEOPLES OLIVER P , ENO RICHARD P , RAMSEIER THOMAS M
IPC分类号： C12N1/20 , C12N15/52
CPC分类号： C12N15/63 , C12N1/20 , C12N15/52 , C12P7/04 , C12P7/18 , C12P7/24 , C12P7/46 , C12P7/625
摘要： Disclosed are organisms genetically engineered to make useful products when grown on ethanol as a carbon source. The organisms are genetically engineered to produce various useful products such as polyhydroxyalkanoates, diols, diacids, higher alcohols, and other useful chemicals.
摘要翻译：公开的是当在乙醇作为碳源生长时被遗传工程化以制备有用产物的生物。生物体被遗传工程化以产生各种有用的产物，例如聚羟基链烷酸酯，二醇，二酸，高级醇和其它有用的化学品。

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