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1. 发明申请

WO2016164810A1 PLANTS WITH ENHANCED YIELD AND METHODS OF CONSTRUCTION 审中-公开
标题翻译：具有增强作用的植物和施工方法
公开(公告)号：WO2016164810A1
公开(公告)日：2016-10-13
申请号：PCT/US2016/026767
申请日：2016-04-08
申请人： METABOLIX, INC.
发明人： MALIK, Meghna , TANG, Jihong , SNELL, Kristi, D.
IPC分类号： C07K14/415 , C12N15/82
CPC分类号： C07K14/415 , C12N9/0006 , C12N15/52 , C12N15/8243 , C12N15/8247 , C12N15/8261 , C12Y101/01082 , Y02A40/146
摘要： Transgenic plants having enhanced yield and having enhanced seed yield are disclosed. The transgenic plants are transformed with a transgenic polynucleotide encoding one or more metabolic enzymes. The metabolic enzymes can be from any biological source. The transgenic polynucleotide(s) comprises a nucleic acid sequences encoding the metabolic enzymes under the control of functional plant promoters, the one or more metabolic enzymes are targeted to the plastids by the addition of plastid targeting signals. Optionally the functional plant promoters are seed specific promoters and the metabolic enzymes are targeted to the plastids by the addition of plastid targeting peptide heterologous to the metabolic enzymes. Methods of making the transgenic plants and transgenic polynucleotides are disclosed. The magnitude of the increases in seed yield achieved with these transgenic plants are simply unprecedented.
摘要翻译：公开了具有增加的产量并且具有增强的种子产量的转基因植物。用编码一种或多种代谢酶的转基因多核苷酸转化转基因植物。代谢酶可以来自任何生物来源。转基因多核苷酸包含编码在功能性植物启动子控制下的代谢酶的核酸序列，通过添加质体靶向信号将一种或多种代谢酶靶向质体。任选地，功能性植物启动子是种子特异性启动子，并且代谢酶通过加入与代谢酶异源的质体靶向肽靶向质体。公开了制备转基因植物和转基因多核苷酸的方法。这些转基因植物的种子产量增加的幅度是前所未有的。

2. 发明申请

WO2014210535A2 GENETICALLY ENGINEERED METHYLOTROPHS FOR THE PRODUCTION OF PHA BIOPOLYMERS AND C3, C4, AND C5 BIOCHEMICALS FROM METHANOL OR METHANE AS SOLE CARBON FEEDSTOCK 审中-公开
标题翻译：用于生产PHA生物聚合物的基因工程化甲基化物，作为纯碳源的甲醇或甲烷的C3，C4和C5生物化学
公开(公告)号：WO2014210535A2
公开(公告)日：2014-12-31
申请号：PCT/US2014/044706
申请日：2014-06-27
申请人： METABOLIX, INC.
发明人： RAMSEIER, Thomas, M. , CHANG, Dong-eun , GAO, Jian-rong , FARMER, William, R. , PEOPLES, Oliver, P.
IPC分类号： C12P7/18
CPC分类号： C12P7/625 , C12P7/18
摘要： Methods and genetically engineered hosts for the production of 3-carbon, 4- carbon and 5-carbon products, polymers and copolymers in methylotrophic bacteria are described herein.
摘要翻译：本文描述了在甲基营养细菌中生产3-碳，4-碳和5-碳产物，聚合物和共聚物的方法和基因工程的宿主。

3. 发明申请

WO2013184836A1 LOW GLASS TRANSITION POLYHYDROXYALKANOATES FOR MODIFICATION OF BIODEGRADABLE POLYMERS 审中-公开
标题翻译：用于改性生物可降解聚合物的低玻璃转变聚羟基烷基酯
公开(公告)号：WO2013184836A1
公开(公告)日：2013-12-12
申请号：PCT/US2013/044367
申请日：2013-06-05
申请人： METABOLIX, INC.
发明人： KRISHNASWAMY, Rajendra, K. , VAN WALSEM, Johan , PEOPLES, Oliver, P. , SHABTAI, Yossef , PADWA, Allen, R.
IPC分类号： C08L67/02
CPC分类号： C08L67/02 , C08J3/246 , C08J5/18 , C08J2367/02 , C08J2367/04 , C08J2467/04 , C08L67/04 , C08L2201/06 , C08L2205/02 , C08L2205/025 , C08L2205/24 , C08L2207/02 , Y10T428/1334 , Y10T442/3146 , Y10T442/637
摘要： Compositions of biobased polymer blends of polymers of polybutylene succinate (PBS) or polybutylene-adipate-terephthalate (PBAT) and a polyhydroxyalkanoate copolymer are described. In certain embodiments, the copolymer is a multiphase copolymer blend having one phase a glass transition temperature of about -5°C to about -50°C. Methods of making the compositions of the invention are also described. The invention also includes articles, films and laminates comprising the compositions.
摘要翻译：描述了聚丁二酸丁二醇酯（PBS）或聚丁二酸 - 己二酸酯 - 对苯二甲酸酯（PBAT）和聚羟基链烷酸酯共聚物的聚合物的生物基聚合物共混物的组合物。在某些实施方案中，共聚物是具有一相的多相共聚物共混物，玻璃化转变温度为约-5℃至约-50℃。还描述了制备本发明组合物的方法。本发明还包括包含组合物的制品，薄膜和层压材料。

4. 发明申请

WO2011160053A2 MELT STABLE POLYESTERS 审中-公开
标题翻译：熔融稳定聚酯
公开(公告)号：WO2011160053A2
公开(公告)日：2011-12-22
申请号：PCT/US2011/040934
申请日：2011-06-17
申请人： METABOLIX, INC. , KANN, Yelena , HUANG, Joseph , SUN, Xiudong , WHITEHOUSE, Robert, S.
发明人： KANN, Yelena , HUANG, Joseph , SUN, Xiudong , WHITEHOUSE, Robert, S.
IPC分类号： C08L67/02 , C08K5/29 , C08K5/14 , C08G63/06 , C08J5/00
CPC分类号： C08L67/04 , C08J3/226 , C08J2300/16 , C08J2467/04 , C08K5/29 , C08L67/02 , C08L79/00 , C08L2205/02 , C08L2666/18 , C08L2666/20
摘要： Compositions comprising melt stable polyesters and chain extenders are described.
摘要翻译：描述了包含熔融稳定聚酯和扩链剂的组合物。

5. 发明申请

WO2011146484A3 TOUGHENING POLYLACTIC ACID WITH POLYHYDROXYALKANOATES 审中-公开
公开(公告)号：WO2011146484A3
公开(公告)日：2011-11-24
申请号：PCT/US2011/036808
申请日：2011-05-17
申请人： METABOLIX, INC. , KRISHNASWAMY, Rajendra, K.
发明人： KRISHNASWAMY, Rajendra, K.
IPC分类号： C08L67/04 , C08G63/08 , C08K5/14 , C08J5/18 , B32B27/00
摘要： Compositions of polymer blends of polylactic acid (PLA) and polyhydroxyalkanoate are described. In certain embodiments, the PHA is a multiphase copolymer blend having one phase a fully amorphous phase with a glass transition temperature of below 20°C and is between about 5 to about 45% of the total PHA. Methods of making the compositions of the invention are also described. The invention also includes articles, films and laminates comprising the compositions.

6. 发明申请

WO2006031492A8 SINGLE SOLVENT POLYMER EXTRACTION METHODS 审中-公开
标题翻译：单溶剂聚合物萃取方法
公开(公告)号：WO2006031492A8
公开(公告)日：2007-07-05
申请号：PCT/US2005031624
申请日：2005-09-06
申请人： METABOLIX INC , ANDERSON ERIK , LICATA JOHN , WALSEM JOHAN VAN
发明人： ANDERSON ERIK , LICATA JOHN , WALSEM JOHAN VAN
IPC分类号： C08G63/02
CPC分类号： C08G63/89 , C08G63/06
摘要： This invention relates to single solvent polymer extraction methods.
摘要翻译：本发明涉及单一溶剂聚合物提取方法。

7. 发明申请

WO0216627A2 SULFUR CONTAINING POLYHYDROXYALKANOATE COMPOSITIONS AND METHOD OF PRODUCTION 审中-公开
标题翻译：含有聚羟基烷基酯组合物的硫磺和生产方法
公开(公告)号：WO0216627A2
公开(公告)日：2002-02-28
申请号：PCT/US0125826
申请日：2001-08-17
申请人： TEPHA INC , METABOLIX INC
发明人： STEINBUCHEL ALEXANDER , LUTKE-EVERSLOH TINA , EWERING CHRISTIAN
IPC分类号： C08G63/688 , C08G75/04 , C08G75/26 , C08L81/02 , C12P7/62 , C12P11/00 , C12P7/00
CPC分类号： C08G63/6882 , C08G75/045 , C08G75/26 , C08L81/02 , C12P7/625 , C12P11/00
摘要： A class of biopolymer including sulfur in the form of a thioester in the polymer backbone or a thioether in the polymer side chains has been developed. These are preferably produced by fermentation of bacteria with appropriate sulfur containing substrates, which are incorporated by a broad spectrum polyhydroxyalkanoate ("PHA") polymerase. The sulfur-containing PHAs allow various applications and uses in industry. Representative embodiments of the applications of the sulfur-containing PHAs include their uses in the packaging industry, medicine, pharmacy, agriculture or food industry, as active agents or as coatings, packaging, or carriers.
摘要翻译：已经开发了一类生物聚合物，其包括聚合物主链中硫酯形式的硫或聚合物侧链中的硫醚。这些优选通过用合适的含硫底物的细菌发酵来制备，其被广谱聚羟基链烷酸酯（“PHA”）聚合酶掺入。含硫PHA允许工业中的各种应用和用途。含硫PHA的应用的代表性实例包括其在包装工业，医药，制药，农业或食品工业中作为活性剂或作为涂料，包装或载体的用途。

8. 发明申请

WO0119361A3 THERAPEUTIC USES OF POLYMERS AND OLIGOMERS COMPRISING GAMMA-HYDROXYBUTYRATE 审中-公开
标题翻译：包含γ-羟基丁酸酯的聚合物和低聚物的治疗用途
公开(公告)号：WO0119361A3
公开(公告)日：2001-10-04
申请号：PCT/US0025261
申请日：2000-09-14
申请人： TEPHA INC , METABOLIX INC
发明人： WILLIAMS SIMON F , MARTIN DAVID P
IPC分类号： A61K31/19 , A61K31/765 , A61P5/00 , A61P9/10 , A61P9/12 , A61P15/00 , A61P21/02 , A61P23/00 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/32 , A61P29/00 , A61P35/00 , A61P43/00 , A61P25/00 , A61P25/26
CPC分类号： A61K31/19 , A61K31/765
摘要： Oligomers and polymer compositions are provided which comprise GHB and produce GHB after administration in vivo . Devices for the storage and delivery of these polymers and oligomers are also provided. These oligomers and polymer compositions are useful in a variety of applications. The compositions can be used therapeutically, for example, in the treatment of patients with narcolepsy, chronic schizophrenia, catatonic schizophrenia, atypical psychoses, chronic brain syndrome, neurosis, alcoholism, drug addiction and withdrawal, Parkinson's disease and other neuropharmacological illnesses, hypertension, ischemia, circulatory collapse, radiation exposure, cancer, and myocardial infarction. Other uses for the compositions include anesthesia induction, sedation, growth hormone production, heightened sexual desire, anorectic effects, euphoria, smooth muscle relaxation, muscle mass production, and sleep, including rapid eye movement sleep. In a still further embodiment, the oligomers and polymers may be used to produce absence seizures.
摘要翻译：提供了含有GHB并且在体内给药之后产生GHB的低聚物和聚合物组合物。还提供了用于储存和递送这些聚合物和低聚物的装置。这些低聚物和聚合物组合物可用于各种应用中。组合物可用于治疗例如发作性睡病，慢性精神分裂症，紧张性精神分裂症，非典型精神病，慢性脑综合征，神经症，酒精中毒，药物成瘾和戒断，帕金森病和其他神经药理学疾病，高血压，缺血的患者的治疗，循环衰竭，放射线暴露，癌症和心肌梗死。组合物的其它用途包括麻醉诱导，镇静，生长激素生成，性欲升高，厌食症，欣快，平滑肌松弛，肌肉量产和睡眠，包括快速眼动睡眠。在另一个实施方案中，低聚物和聚合物可以用于产生不发作的发作。

9. 发明申请

WO9961624A2 POLYHYDROXYALKANOATE BIOPOLYMER COMPOSITIONS 审中-公开
标题翻译：聚羟基烷基酯生物聚合物组合物
公开(公告)号：WO9961624A2
公开(公告)日：1999-12-02
申请号：PCT/US9911417
申请日：1999-05-21
申请人： METABOLIX INC
发明人： SKRALY FRANK A , PEOPLES OLIVER P
IPC分类号： C12N15/09 , C08G63/06 , C12N1/21 , C12N9/00 , C12N9/10 , C12P7/62 , C12R1/19 , C12N15/52 , C12N15/54 , C12N15/70
CPC分类号： C12N9/93 , C08G63/06 , C12N9/1029 , C12P7/625
摘要： Several novel PHA polymer compositions produced using biological sytems include monomers such as 3-hydroxybutyrate, 3-hydroxypropionate, 2-hydroxybutyrate, 3-hydroxyvalerate, 4-hydroxybutyrate, 4-hydroxyvalerate and 5-hydroxyvalerate. These PHA compositions can readily be extended to incorporate additional monomers including, for example, 3-hydroxyhexanoate, 4-hydroxyhexanoate, 6-hydroxyhexanoate or other longer chain 3-hydroxyacids containing seven or more carbons. This can be accomplished by taking natural PHA producers and mutating through chemical or transposon mutagenesis to delete or inactivate genes encoding undesirable activities. Alternatively, the strains can be genetically engineered to express only those enzymes required for the production of the desired polymer composition. Methods for genetically engineering PHA producing microbes are widely known in the art (Huisman and Madison, 1998, Microbiology and Molecular Biology Reviews, 63 : 21-53). These polymers have a variety of uses in medical, industrial and other commercial areas.
摘要翻译：使用生物系统生产的几种新型PHA聚合物组合物包括单体如3-羟基丁酸酯，3-羟基丙酸酯，2-羟基丁酸酯，3-羟基戊酸酯，4-羟基丁酸酯，4-羟基戊酸酯和5-羟基戊酸酯。这些PHA组合物可以容易地延伸以加入另外的单体，包括例如3-羟基己酸酯，4-羟基己酸酯，6-羟基己酸酯或其它含有7个或更多个碳的长链3-羟基酸。这可以通过使用天然PHA生产者和通过化学或转座子诱变进行突变来删除或灭活编码不期望的活性的基因来实现。或者，菌株可以被遗传工程化以仅表达生产所需聚合物组合物所需的那些酶。用于遗传工程化生产PHA的微生物的方法在本领域中是众所周知的（Huisman and Madison，1998，Microbiology and Molecular Biology Reviews， 63：21-53）。这些聚合物在医疗，工业和其他商业领域具有多种用途。

10. 发明申请

WO2014028943A8 BIOBASED RUBBER MODIFIERS FOR POLYMER BLENDS 审中-公开
标题翻译：用于聚合物混合物的生物橡胶改性剂
公开(公告)号：WO2014028943A8
公开(公告)日：2015-03-12
申请号：PCT/US2013055624
申请日：2013-08-19
申请人： METABOLIX INC
发明人： WEINLEIN ROGER , KANN YELENA
IPC分类号： C08J5/18 , C08L27/06 , C08L33/12 , C08L59/02
CPC分类号： C08J5/18 , C08J2327/06 , C08J2333/12 , C08J2359/02 , C08J2467/04 , C08L27/06 , C08L33/12 , C08L67/04
摘要： Compositions of polymer blends of polyvinylchloride (PVC) or polymethylmethacrylate (PMMA) or polyoxymethylene (POM) and polyhydroxyalkanoate (PHA) are described. In certain embodiments, the PHA is a poly-3-hydroxybutyrate-co-4-hydroxybutyrate copolymer having a weight percent 4-hydroxybutyrate of 30-45%. In other embodiments the PHA is a multiphase P3HB-4HB copolymer blend having one phase fully amorphous. The PHA is mixed with the PVC or PMMA or POM to optimize its optical, thermal and mechanical properties. In certain embodiments, the polymer is branched with optionally additives that improve properties. Methods of making the compositions of the invention are also described. The invention also includes articles, films and laminates comprising the compositions.
摘要翻译：描述了聚氯乙烯（PVC）或聚甲基丙烯酸甲酯（PMMA）或聚甲醛（POM）和聚羟基链烷酸酯（PHA）的聚合物共混物的组合物。在某些实施方案中，PHA是具有30-45％重量百分比的4-羟基丁酸酯的聚-3-羟基丁酸酯 - 共-4-羟基丁酸酯共聚物。在其它实施方案中，PHA是具有一相完全无定形的多相P3HB-4HB共聚物共混物。 PHA与PVC或PMMA或POM混合，以优化其光学，热学和机械性能。在某些实施方案中，聚合物用可任意改进性质的添加剂进行支化。还描述了制备本发明组合物的方法。本发明还包括包含组合物的制品，薄膜和层压材料。

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