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1. 发明申请

WO2012009603A3 TRANSCRANIAL MAGNETIC STIMULATION FOR ALTERING SUSCEPTIBILITY OF TISSUE TO PHARMACEUTICALS AND RADIATION 审中-公开
标题翻译：用于改变组织对药物和辐射的不适的转移磁性刺激
公开(公告)号：WO2012009603A3
公开(公告)日：2012-05-03
申请号：PCT/US2011044121
申请日：2011-07-15
申请人： CERVEL NEUROTECH INC , SCHNEIDER M BRET , PARTSCH MICHAEL J
发明人： SCHNEIDER M BRET , PARTSCH MICHAEL J
IPC分类号： A61N5/00 , A61M5/172 , A61N2/02
CPC分类号： A61N2/002 , A61N1/06 , A61N1/406 , A61N2/02 , H05K999/00
摘要： Described herein are methods for modulating the susceptibility of one or more target or tissue regions, and particularly one or more brain regions, to a therapeutic agent such as a drug, immune agent, compound, radiation, etc. In particular, the methods and systems described herein may include magnetic stimulation (including transcranial magnetic stimulation) of target or non-target regions to modulate the susceptibility of the one or more target or tissue regions to a therapeutic agent.
摘要翻译：本文描述的是调节一种或多种靶组织区域，特别是一个或多个脑区域对治疗剂如药物，免疫剂，化合物，辐射等的敏感性的方法。特别地，方法和系统本文描述的可以包括目标或非靶区域的磁刺激（包括经颅磁刺激），以调节一个或多个靶组织区域对治疗剂的敏感性。

2. 发明申请

WO2009018393A2 DEVICE AND METHOD FOR TREATING HYPERTENSION VIA NON-INVASIVE NEUROMODULATION 审中-公开
标题翻译：通过非侵入式神经修复治疗高血压的装置和方法
公开(公告)号：WO2009018393A2
公开(公告)日：2009-02-05
申请号：PCT/US2008/071663
申请日：2008-07-30
申请人： NEOSTIM, INC. , PARTSCH, Michael, J. , SCHNEIDER, M., Bret , MISHELEVICH, David
发明人： PARTSCH, Michael, J. , SCHNEIDER, M., Bret , MISHELEVICH, David
IPC分类号： A61N2/00 , A61N2/02 , A61N1/36
CPC分类号： A61N2/006 , A61N1/36025 , A61N2/02

3. 发明申请

WO2009018394A1 DEVICE AND METHOD FOR HYPERTENSION TREATMENT BY NON-INVASIVE STIMULATION TO VASCULAR BARORECEPTORS 审中-公开
标题翻译：通过非侵入性刺激对血管闭锁器进行高血压治疗的装置和方法
公开(公告)号：WO2009018394A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/071664
申请日：2008-07-30
申请人： SCHNEIDER, M., Bret , PARTSCH, Michael, J. , MISHELEVICH, David
发明人： SCHNEIDER, M., Bret , PARTSCH, Michael, J. , MISHELEVICH, David
IPC分类号： A61N7/00 , A61N1/36
CPC分类号： A61N7/00 , A61N1/0492 , A61N1/36014
摘要： The treatment of hypertension may be accomplished by stimulation of the carotid baroreceptors. In the present application the inventors disclose methods in which non- invasively-delivered mechanical perturbations caused by sound, ultrasound, or electrical perturbations caused by magnetic, or direct current stimulation may be used to stimulate the carotid baroreceptors, triggering physiological responses that treat medical disorders including hypertension.
摘要翻译：高血压的治疗可以通过刺激颈动脉压力感受器来实现。在本申请中，发明人公开了一种方法，其中由磁性或直流刺激引起的声音，超声波或电气扰动引起的非侵入式传递的机械扰动可用于刺激颈动脉压力感受器，引发治疗医学病症的生理反应包括高血压。

4. 发明申请

WO2011109080A2 A DEVICE FOR INTRANASAL AND EXTRANASAL NEUROMODULATION 审中-公开
标题翻译：一种用于经济和外部神经修复的装置
公开(公告)号：WO2011109080A2
公开(公告)日：2011-09-09
申请号：PCT/US2011000379
申请日：2011-02-28
申请人： PARTSCH MICHAEL J
发明人： PARTSCH MICHAEL J
CPC分类号： A61N1/36017 , A61N1/00 , A61N1/36075 , A61N1/36085
摘要： Systems, devices and methods for treating a subject by neuromodulation of a nerve or nerve cluster accessible from the nasal cavity and/or sinuses. Described herein are systems, devices and methods for treating a patient (or for allowing a patient treat themselves) by stimulation of a nerve, such as the olfactory nerve. In one example, the system, methods and devices are for the treatment of obesity by stimulation of the olfactory nerve to generate a percept such as nausea, satiety, hunger, thirst, pain, discomfort, exhaustion, tiredness, exhilaration, happiness, anxiety, restlessness, calmness, peacefulness, anger, disinterest, satisfaction, aversion, or any combination of the above.
摘要翻译：通过从鼻腔和/或鼻窦进入的神经或神经丛的神经调节来治疗受试者的系统，装置和方法。本文描述了通过刺激神经如嗅神经来治疗患者（或允许患者自己治疗）的系统，装置和方法。在一个示例中，系统，方法和装置用于通过刺激嗅觉神经来治疗肥胖，产生感觉，例如恶心，饱腹感，饥饿，口渴，疼痛，不适，疲惫，疲劳，疲劳，兴奋，幸福，焦虑，不安，冷静，和平，愤怒，不感兴趣，满足，厌恶或上述的任何组合。

5. 发明申请

WO2012009603A2 TRANSCRANIAL MAGNETIC STIMULATION FOR ALTERING SUSCEPTIBILITY OF TISSUE TO PHARMACEUTICALS AND RADIATION 审中-公开
标题翻译：经颅磁刺激改变组织对药物和辐射的敏感性
公开(公告)号：WO2012009603A2
公开(公告)日：2012-01-19
申请号：PCT/US2011/044121
申请日：2011-07-15
申请人： CERVEL NEUROTECH, INC. , SCHNEIDER, M., Bret , PARTSCH, Michael, J.
发明人： SCHNEIDER, M., Bret , PARTSCH, Michael, J.
IPC分类号： A61N5/00 , A61N2/02 , A61M5/172
CPC分类号： A61N2/002 , A61N1/06 , A61N1/406 , A61N2/02
摘要： Described herein are methods for modulating the susceptibility of one or more target or tissue regions, and particularly one or more brain regions, to a therapeutic agent such as a drug, immune agent, compound, radiation, etc. In particular, the methods and systems described herein may include magnetic stimulation (including transcranial magnetic stimulation) of target or non-target regions to modulate the susceptibility of the one or more target or tissue regions to a therapeutic agent.
摘要翻译：本文描述了用于调节一种或多种靶标或组织区域，特别是一个或多个脑区域对治疗剂例如药物，免疫剂，化合物，辐射等的易感性的方法特别地，本文描述的方法和系统可以包括目标或非目标区域的磁刺激（包括经颅磁刺激）以调节一个或多个目标或组织区域对治疗剂的敏感性。

6. 发明申请

WO2011109080A3 A DEVICE FOR INTRANASAL AND EXTRANASAL NEUROMODULATION 审中-公开
公开(公告)号：WO2011109080A3
公开(公告)日：2011-09-09
申请号：PCT/US2011/000379
申请日：2011-02-28
申请人： PARTSCH, Michael, J.
发明人： PARTSCH, Michael, J.
IPC分类号： A61N1/36 , A61N1/18 , A61N2/00 , A61N1/05 , A61N7/00 , A61N5/067
摘要： Systems, devices and methods for treating a subject by neuromodulation of a nerve or nerve cluster accessible from the nasal cavity and/or sinuses. Described herein are systems, devices and methods for treating a patient (or for allowing a patient treat themselves) by stimulation of a nerve, such as the olfactory nerve. In one example, the system, methods and devices are for the treatment of obesity by stimulation of the olfactory nerve to generate a percept such as nausea, satiety, hunger, thirst, pain, discomfort, exhaustion, tiredness, exhilaration, happiness, anxiety, restlessness, calmness, peacefulness, anger, disinterest, satisfaction, aversion, or any combination of the above.

7. 发明申请

WO2011123548A3 NEUROMODULATION OF DEEP-BRAIN TARGETS BY TRANSCRANIAL MAGNETIC STIMULATION ENHANCED BY TRANSCRANIAL DIRECT CURRENT STIMULATION 审中-公开
公开(公告)号：WO2011123548A3
公开(公告)日：2011-10-06
申请号：PCT/US2011/030550
申请日：2011-03-30
申请人： CERVEL NEUROTECH, INC. , SCHNEIDER, M., Bret , PARTSCH, Michael, J. , MISHELEVICH, David, J.
发明人： SCHNEIDER, M., Bret , PARTSCH, Michael, J. , MISHELEVICH, David, J.
IPC分类号： A61N2/02 , A61N2/08 , A61N1/36 , A61N1/04
摘要： Described herein are methods, devices and systems for neuromodulation of deep brain targets using a combination of transcranial magnetic stimulation (TMS) and transcranial direct current (DC) stimulation to reduce or eliminate side-effects when modulating one or more deep brain targets. For example, transcranial magnetic stimulation of a deep brain target may be synchronized with modulation of more superficially located cortical brain regions using transcranial direct current stimulation to prevent seizures and other side effects. Systems configured to regulate (or synchronize) the application of transcranial magnetic stimulation of deep brain targets and transcranial direct current stimulation are also described.

8. 发明申请

WO2011123548A2 NEUROMODULATION OF DEEP-BRAIN TARGETS BY TRANSCRANIAL MAGNETIC STIMULATION ENHANCED BY TRANSCRANIAL DIRECT CURRENT STIMULATION 审中-公开
标题翻译：通过转移性直接电流刺激增强的转移性磁刺激对神经细胞的神经调节作用
公开(公告)号：WO2011123548A2
公开(公告)日：2011-10-06
申请号：PCT/US2011030550
申请日：2011-03-30
申请人： NEOSTIM INC , SCHNEIDER M BRET , PARTSCH MICHAEL J , MISHELEVICH DAVID J
发明人： SCHNEIDER M BRET , PARTSCH MICHAEL J , MISHELEVICH DAVID J
IPC分类号： A61N2/02 , A61N1/04 , A61N1/36 , A61N2/08
CPC分类号： A61N2/02 , A61N1/20 , A61N1/36021 , A61N1/40 , A61N2/006 , A61N2/008
摘要： Described herein are methods, devices and systems for neuromodulation of deep brain targets using a combination of transcranial magnetic stimulation (TMS) and transcranial direct current (DC) stimulation to reduce or eliminate side-effects when modulating one or more deep brain targets. For example, transcranial magnetic stimulation of a deep brain target may be synchronized with modulation of more superficially located cortical brain regions using transcranial direct current stimulation to prevent seizures and other side effects. Systems configured to regulate (or synchronize) the application of transcranial magnetic stimulation of deep brain targets and transcranial direct current stimulation are also described.
摘要翻译：本文描述的是使用经颅磁刺激（TMS）和经颅直流（DC）刺激的组合来神经调节深部脑靶标的方法，装置和系统，以在调节一个或多个深脑靶标时减少或消除副作用。例如，通过使用经颅直流刺激来预防癫痫发作和其他副作用，深脑靶的经颅磁刺激可以与更多表面定位的皮层脑区域的调制同步。还描述了被配置为调节（或同步）深脑靶和经颅直流刺激的经颅磁刺激的应用的系统。

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