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1. 发明申请

WO2009143503A2 TRANSCRANIAL MAGNETIC STIMULATION BY ENHANCED MAGNETIC FIELD PERTURBATIONS 审中-公开
标题翻译：通过增强磁场刺激的交叉磁性刺激
公开(公告)号：WO2009143503A2
公开(公告)日：2009-11-26
申请号：PCT/US2009/045109
申请日：2009-05-26
申请人： NEOSTIM, INC. , MISHELEVICH, David, J. , SCHNEIDER, M., Bret
发明人： MISHELEVICH, David, J. , SCHNEIDER, M., Bret
IPC分类号： A61N2/02 , A61N1/00 , A61B5/05
CPC分类号： A61N2/02 , A61N2/006
摘要： Described herein are devices, systems and methods to enhance the magnetic perturbation of a neuronal (e.g., brain) target during Transcranial Magnetic Stimulation (TMS), thereby enhancing the induced current in the target. In general, these devices, systems and methods enhance the magnetic perturbation (dB/dt) of the target by mechanically moving a TMS electromagnet (e.g., coil) at a frequency of greater than 1 kHz.
摘要翻译：本文描述了在经颅磁刺激（TMS）期间增强神经元（例如脑）靶的磁性扰动的装置，系统和方法，从而增强目标中的感应电流。通常，这些装置，系统和方法通过以大于1kHz的频率机械地移动TMS电磁体（例如，线圈）来增强目标的磁扰动（dB / dt）。

2. 发明申请

WO2009055780A1 TRANSCRANIAL MAGNETIC STIMULATION WITH PROTECTION OF MAGNET-ADJACENT STRUCTURES 审中-公开
标题翻译：具有保护磁铁结构的交叉磁化刺激
公开(公告)号：WO2009055780A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081307
申请日：2008-10-27
申请人： NEOSTIM, INC. , MISHELEVICH, David , SCHNEIDER, M., Bret
发明人： MISHELEVICH, David , SCHNEIDER, M., Bret
IPC分类号： A61N2/02
CPC分类号： A61N2/006 , A61N2/02
摘要： System and methods for Transcranial Magnetic Stimulation (TMS) are described in which regions adjacent (e.g., to the sides and behind the TMS electromagnet) are protected from the high magnetic fields emitted by the TMS electromagnet. Thus, adjacent muscle or neural structures are protected and undesirable side effects are avoid or minimized, allowing stimulation from previously unavailable sites such as the mouth and pharynx.
摘要翻译：描述了经颅磁刺激（TMS）的系统和方法，其中保护与TMS电磁体发射的高磁场相邻（例如，到TMS电磁体的两侧和后面）的区域。因此，相邻的肌肉或神经结构被保护并且不期望的副作用被避免或最小化，从而允许从先前不可用的部位（例如口腔和咽部）进行刺激。

3. 发明申请

WO2009033144A3 FOCUSING MAGNETIC FIELDS WITH ATTRACTOR MAGNETS AND CONCENTRATOR DEVICES 审中-公开
公开(公告)号：WO2009033144A3
公开(公告)日：2009-03-12
申请号：PCT/US2008/075575
申请日：2008-09-08
申请人： NEOSTIM, INC. , MISHELEVICH, David , SCHNEIDER, M., Bret
发明人： MISHELEVICH, David , SCHNEIDER, M., Bret
IPC分类号： A61N2/02 , A61N2/00
摘要： Described herein are Transcranial Magnetic Stimulation (TMS) systems and methods configured to focus the applied magnetic fields generated by one or more primary TMS electromagnets using attractor magnets and/or magnetic concentrators having high-permeability regions. An attractor magnet is typically a secondary, phase-complimentary magnet that is configured to shape the field of the primary TMS electromagnet. A magnetic concentrator typically includes a region of high magnetic permeability that may shape a TMS magnetic field. Attractor magnets and concentrator devices can be used independently or in combination. The profile of the TMS field can be made narrower or wider than for an unfocused field using these devices, systems and methods.

4. 发明申请

WO2009026386A1 FIRING PATTERNS FOR DEEP BRAIN TRANSCRANIAL MAGNETIC STIMULATION 审中-公开
标题翻译：用于深层脑转移磁性刺激的模式
公开(公告)号：WO2009026386A1
公开(公告)日：2009-02-26
申请号：PCT/US2008/073751
申请日：2008-08-20
申请人： NEOSTIM, INC. , MISHELEVICH, David , SCHNEIDER, Bret, M.
发明人： MISHELEVICH, David , SCHNEIDER, Bret, M.
IPC分类号： A61N2/02
CPC分类号： A61N2/006 , A61N2/02
摘要： Methods, devices and systems for Transcranial Magnetic Stimulation (TMS) are provided for synchronous, asynchronous, or independent triggering the firing multiple of electromagnets from either a single power source or multiple energy sources. These methods are particularly useful for stimulation of deep (e.g., sub-cortical) brain regions, or for stimulation of multiple brain regions, since controlled magnetic pulses reaching the deep target location may combine to form a patterned pulse train that activates the desired volume of target tissue. Furthermore, the methods, devices and systems described herein may be used to control the rate of firing of action potentials in one or more brain regions, such as slow or fast rate rTMS. For example, described herein are multiple electromagnetic stimulation sources, each of which are activated independently to create a cumulative effect at the intersections of the electromagnetic stimulation trajectories, typically by means of a computerized calculation.
摘要翻译：用于经颅磁刺激（TMS）的方法，装置和系统被提供用于从单个电源或多个能量源同步，异步或独立地触发电磁体的点火倍数。这些方法对于刺激深部（例如亚皮质）脑区域或刺激多个脑区域特别有用，因为到达深靶位置的受控磁脉冲可以结合形成图案化的脉冲串，其激活所需体积的目标组织。此外，本文描述的方法，装置和系统可以用于控制一个或多个脑区域中的动作电位的发射速率，例如慢速或快速率rTMS。例如，这里描述的是多个电磁刺激源，每个电磁刺激源通常通过计算机化的计算独立地被激活以在电磁刺激轨迹的交叉处产生累积效应。

5. 发明申请

WO2011123548A3 NEUROMODULATION OF DEEP-BRAIN TARGETS BY TRANSCRANIAL MAGNETIC STIMULATION ENHANCED BY TRANSCRANIAL DIRECT CURRENT STIMULATION 审中-公开
公开(公告)号：WO2011123548A3
公开(公告)日：2011-10-06
申请号：PCT/US2011/030550
申请日：2011-03-30
申请人： CERVEL NEUROTECH, INC. , SCHNEIDER, M., Bret , PARTSCH, Michael, J. , MISHELEVICH, David, J.
发明人： SCHNEIDER, M., Bret , PARTSCH, Michael, J. , MISHELEVICH, David, J.
IPC分类号： A61N2/02 , A61N2/08 , A61N1/36 , A61N1/04
摘要： Described herein are methods, devices and systems for neuromodulation of deep brain targets using a combination of transcranial magnetic stimulation (TMS) and transcranial direct current (DC) stimulation to reduce or eliminate side-effects when modulating one or more deep brain targets. For example, transcranial magnetic stimulation of a deep brain target may be synchronized with modulation of more superficially located cortical brain regions using transcranial direct current stimulation to prevent seizures and other side effects. Systems configured to regulate (or synchronize) the application of transcranial magnetic stimulation of deep brain targets and transcranial direct current stimulation are also described.

6. 发明申请

WO2011123548A2 NEUROMODULATION OF DEEP-BRAIN TARGETS BY TRANSCRANIAL MAGNETIC STIMULATION ENHANCED BY TRANSCRANIAL DIRECT CURRENT STIMULATION 审中-公开
标题翻译：通过转移性直接电流刺激增强的转移性磁刺激对神经细胞的神经调节作用
公开(公告)号：WO2011123548A2
公开(公告)日：2011-10-06
申请号：PCT/US2011030550
申请日：2011-03-30
申请人： NEOSTIM INC , SCHNEIDER M BRET , PARTSCH MICHAEL J , MISHELEVICH DAVID J
发明人： SCHNEIDER M BRET , PARTSCH MICHAEL J , MISHELEVICH DAVID J
IPC分类号： A61N2/02 , A61N1/04 , A61N1/36 , A61N2/08
CPC分类号： A61N2/02 , A61N1/20 , A61N1/36021 , A61N1/40 , A61N2/006 , A61N2/008
摘要： Described herein are methods, devices and systems for neuromodulation of deep brain targets using a combination of transcranial magnetic stimulation (TMS) and transcranial direct current (DC) stimulation to reduce or eliminate side-effects when modulating one or more deep brain targets. For example, transcranial magnetic stimulation of a deep brain target may be synchronized with modulation of more superficially located cortical brain regions using transcranial direct current stimulation to prevent seizures and other side effects. Systems configured to regulate (or synchronize) the application of transcranial magnetic stimulation of deep brain targets and transcranial direct current stimulation are also described.
摘要翻译：本文描述的是使用经颅磁刺激（TMS）和经颅直流（DC）刺激的组合来神经调节深部脑靶标的方法，装置和系统，以在调节一个或多个深脑靶标时减少或消除副作用。例如，通过使用经颅直流刺激来预防癫痫发作和其他副作用，深脑靶的经颅磁刺激可以与更多表面定位的皮层脑区域的调制同步。还描述了被配置为调节（或同步）深脑靶和经颅直流刺激的经颅磁刺激的应用的系统。

7. 发明申请

WO2008089003A3 SYSTEM FOR OPTICAL STIMULATION OF TARGET CELLS 审中-公开
公开(公告)号：WO2008089003A3
公开(公告)日：2008-07-24
申请号：PCT/US2008/050628
申请日：2008-01-09
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , ZHANG, Feng , DEISSEROTH, Karl , MISHELEVICH, David, J. , SCHNEIDER, M., Bret
发明人： ZHANG, Feng , DEISSEROTH, Karl , MISHELEVICH, David, J. , SCHNEIDER, M., Bret
IPC分类号： A61K48/00 , A61K38/00
摘要： Stimulation of target cells using light, e.g., in vivo , is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo . Other aspects and embodiments are directed to systems and methods for screening chemicals based screening chemicals to identify their effects on cell membrane ion channels and pumps, and to systems and methods for controlling an action potential of neuron (e.g., in vivo and in vitro environments).

8. 发明申请

WO2007130308A3 TRAJECTORY-BASED DEEP-BRAIN STEREOTACTIC TRANSCRANIAL MAGNETIC STIMULATION 审中-公开
标题翻译：基于TRAJECTORY的深层脑血管交叉神经刺激
公开(公告)号：WO2007130308A3
公开(公告)日：2008-01-17
申请号：PCT/US2007010262
申请日：2007-04-27
申请人： UNIV LELAND STANFORD JUNIOR , MISHELEVICH DAVID J , SCHNEIDER BRETT M
发明人： MISHELEVICH DAVID J , SCHNEIDER BRETT M
IPC分类号： A61N2/00
CPC分类号： A61N2/004 , A61N2/006 , A61N2/008 , A61N2/02
摘要： The present invention provides for Stereotactic Transcranial Magnetic Stimulation (sTMS) at predetermined locations with the brain or spinal cord and incorporates an array of electromagnets arranged in a specified configuration where selected coils in the array are pulsed simultaneously. Activation of foci demonstrated by functional MRI or other imaging techniques can be used to locate the neural region affected. Imaging techniques can also be utilized to determine the location of the designated targets.
摘要翻译：本发明提供了在具有脑或脊髓的预定位置处的立体定向经颅磁刺激（sTMS），并且包括以特定配置布置的电磁体阵列，其中阵列中的选定线圈同时脉冲。通过功能性MRI或其他成像技术证实的焦点活化可用于定位受影响的神经区。成像技术也可用于确定指定目标的位置。

9. 发明申请

WO2012108910A1 PORTABLE DIALYSIS MACHINE 审中-公开
标题翻译：便携式分析机
公开(公告)号：WO2012108910A1
公开(公告)日：2012-08-16
申请号：PCT/US2011/053184
申请日：2011-09-25
申请人： FRESENIUS MEDICAL CARE HOLDINGS, INC. , FULKERSON, Barry, Neil , BRAIG, James, Roswell , MISHELEVICH, David, J. , CLEMENS, Charles , FOSTER, Clark, Berg , GHIDOLI, Daniele , GURA, Victor , HERING, Martin , ISACKSON, Frank , JOSEPH, Russell, Thomas , ROBINSON, Thomas , SMITH, Mark, Forrest , TRCKA, Milan , ZWIERSTRA, Jan, Brian
发明人： FULKERSON, Barry, Neil , BRAIG, James, Roswell , MISHELEVICH, David, J. , CLEMENS, Charles , FOSTER, Clark, Berg , GHIDOLI, Daniele , GURA, Victor , HERING, Martin , ISACKSON, Frank , JOSEPH, Russell, Thomas , ROBINSON, Thomas , SMITH, Mark, Forrest , TRCKA, Milan , ZWIERSTRA, Jan, Brian
IPC分类号： B01D61/28 , B01D61/24
CPC分类号： A61M1/3413 , A61M1/1609 , A61M1/1645 , A61M1/166 , A61M1/1692 , A61M1/1696 , A61M1/3406 , A61M1/3626 , A61M1/3639 , A61M1/3641 , A61M1/3646 , A61M1/3656 , A61M1/3672 , A61M1/369 , A61M2205/10 , A61M2205/126 , A61M2205/13 , A61M2205/14 , A61M2205/15 , A61M2205/18 , A61M2205/3306 , A61M2205/3317 , A61M2205/3334 , A61M2205/3368 , A61M2205/3375 , A61M2205/3393 , A61M2205/3553 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/584 , A61M2205/6072 , A61M2209/084 , B01D61/18 , B01D61/30 , B01D2313/10 , B01D2313/105 , B01D2313/12 , B01D2313/125 , B01D2313/243
摘要： The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface, a heater in thermal communication with the planar surface, and a sodium sensor in electromagnetic communication with the planar surface. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features.
摘要翻译：本说明书公开了一种具有可拆卸控制器单元和基座单元的便携式透析机。控制器单元包括具有内表面的门，具有面板的壳体，其中壳体和面板限定了构造成接收门的内表面的凹陷区域，以及固定地连接到面板的歧管接收器。基座单元具有用于接收流体容器的平坦表面，与平坦表面集成的刻度，与平坦表面热连通的加热器和与平坦表面电磁连通的钠传感器。所公开的便携式透析系统的实施例具有改进的结构和功能特征，包括改进的模块性，易用性和安全特征。

10. 发明申请

WO2010080879A2 SHAPED COILS FOR TRANSCRANIAL MAGNETIC STIMULATION 审中-公开
标题翻译：用于经颅磁刺激的形状线圈
公开(公告)号：WO2010080879A2
公开(公告)日：2010-07-15
申请号：PCT/US2010/020324
申请日：2010-01-07
申请人： NEOSTIM, INC. , MISHELEVICH, David, J. , SCHNEIDER, M., Bret
发明人： MISHELEVICH, David, J. , SCHNEIDER, M., Bret
IPC分类号： A61N2/02 , A61B5/05 , A61B5/055
CPC分类号： A61N2/02 , A61N2/006
摘要： Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation.
摘要翻译：这里描述的是由两个弯曲的磁性线圈环形成的成形线圈TMS电磁体，所述两个弯曲的磁性线圈环在顶点处连接，所述顶点在线圈的外部线圈区域之间的角度通常小于120度（例如，在约45° 和大约70度，60度等）。顶点区域被整形以优化从TMS电磁体投射的磁场。例如，顶点区域可以是水平的或垂直的。在一些变型中，顶点区域通过重新布置形成两个线圈的导电绕组而形成，使得它们不再布置成与它们位于弯曲的磁性线圈环路的其他部分中的相同的柱状结构。这些TMS电磁体可能非常适合用于深脑经颅磁刺激。

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