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1. 发明申请

WO2009018394A1 DEVICE AND METHOD FOR HYPERTENSION TREATMENT BY NON-INVASIVE STIMULATION TO VASCULAR BARORECEPTORS 审中-公开
标题翻译：通过非侵入性刺激对血管闭锁器进行高血压治疗的装置和方法
公开(公告)号：WO2009018394A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/071664
申请日：2008-07-30
申请人： SCHNEIDER, M., Bret , PARTSCH, Michael, J. , MISHELEVICH, David
发明人： SCHNEIDER, M., Bret , PARTSCH, Michael, J. , MISHELEVICH, David
IPC分类号： A61N7/00 , A61N1/36
CPC分类号： A61N7/00 , A61N1/0492 , A61N1/36014
摘要： The treatment of hypertension may be accomplished by stimulation of the carotid baroreceptors. In the present application the inventors disclose methods in which non- invasively-delivered mechanical perturbations caused by sound, ultrasound, or electrical perturbations caused by magnetic, or direct current stimulation may be used to stimulate the carotid baroreceptors, triggering physiological responses that treat medical disorders including hypertension.
摘要翻译：高血压的治疗可以通过刺激颈动脉压力感受器来实现。在本申请中，发明人公开了一种方法，其中由磁性或直流刺激引起的声音，超声波或电气扰动引起的非侵入式传递的机械扰动可用于刺激颈动脉压力感受器，引发治疗医学病症的生理反应包括高血压。

2. 发明申请

WO2009018393A2 DEVICE AND METHOD FOR TREATING HYPERTENSION VIA NON-INVASIVE NEUROMODULATION 审中-公开
标题翻译：通过非侵入式神经修复治疗高血压的装置和方法
公开(公告)号：WO2009018393A2
公开(公告)日：2009-02-05
申请号：PCT/US2008/071663
申请日：2008-07-30
申请人： NEOSTIM, INC. , PARTSCH, Michael, J. , SCHNEIDER, M., Bret , MISHELEVICH, David
发明人： PARTSCH, Michael, J. , SCHNEIDER, M., Bret , MISHELEVICH, David
IPC分类号： A61N2/00 , A61N2/02 , A61N1/36
CPC分类号： A61N2/006 , A61N1/36025 , A61N2/02

3. 发明申请

WO2009055780A1 TRANSCRANIAL MAGNETIC STIMULATION WITH PROTECTION OF MAGNET-ADJACENT STRUCTURES 审中-公开
标题翻译：具有保护磁铁结构的交叉磁化刺激
公开(公告)号：WO2009055780A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081307
申请日：2008-10-27
申请人： NEOSTIM, INC. , MISHELEVICH, David , SCHNEIDER, M., Bret
发明人： MISHELEVICH, David , SCHNEIDER, M., Bret
IPC分类号： A61N2/02
CPC分类号： A61N2/006 , A61N2/02
摘要： System and methods for Transcranial Magnetic Stimulation (TMS) are described in which regions adjacent (e.g., to the sides and behind the TMS electromagnet) are protected from the high magnetic fields emitted by the TMS electromagnet. Thus, adjacent muscle or neural structures are protected and undesirable side effects are avoid or minimized, allowing stimulation from previously unavailable sites such as the mouth and pharynx.
摘要翻译：描述了经颅磁刺激（TMS）的系统和方法，其中保护与TMS电磁体发射的高磁场相邻（例如，到TMS电磁体的两侧和后面）的区域。因此，相邻的肌肉或神经结构被保护并且不期望的副作用被避免或最小化，从而允许从先前不可用的部位（例如口腔和咽部）进行刺激。

4. 发明申请

WO2009033144A3 FOCUSING MAGNETIC FIELDS WITH ATTRACTOR MAGNETS AND CONCENTRATOR DEVICES 审中-公开
公开(公告)号：WO2009033144A3
公开(公告)日：2009-03-12
申请号：PCT/US2008/075575
申请日：2008-09-08
申请人： NEOSTIM, INC. , MISHELEVICH, David , SCHNEIDER, M., Bret
发明人： MISHELEVICH, David , SCHNEIDER, M., Bret
IPC分类号： A61N2/02 , A61N2/00
摘要： Described herein are Transcranial Magnetic Stimulation (TMS) systems and methods configured to focus the applied magnetic fields generated by one or more primary TMS electromagnets using attractor magnets and/or magnetic concentrators having high-permeability regions. An attractor magnet is typically a secondary, phase-complimentary magnet that is configured to shape the field of the primary TMS electromagnet. A magnetic concentrator typically includes a region of high magnetic permeability that may shape a TMS magnetic field. Attractor magnets and concentrator devices can be used independently or in combination. The profile of the TMS field can be made narrower or wider than for an unfocused field using these devices, systems and methods.

5. 发明申请

WO2009055634A1 INTRA-SESSION CONTROL OF TRANSCRANIAL MAGNETIC STIMULATION 审中-公开
标题翻译：转移磁性刺激的内分泌控制
公开(公告)号：WO2009055634A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081048
申请日：2008-10-24
申请人： NEOSTIM INC. , MISHELEVICH, David , SCHNEIDER, M., Bret
发明人： MISHELEVICH, David , SCHNEIDER, M., Bret
IPC分类号： A61N2/00
CPC分类号： A61N2/008 , A61N2/006 , A61N2/02
摘要： Described herein are methods for controlling Transcranial Magnetic Stimulation during or within a session, where direct immediate patient reported feedback is utilized to assess the effect and optimize the treatment in real time. These methods may be applicable to superficial repetitive Transcranial Magnet Stimulation (rTMS) or deep-brain stereotactic Transcranial Magnetic Stimulation (sTMS). Examples of therapies that may benefit from these methods include TMS treatment of: acute pain (e.g., during dental procedures or bunionectomies), depression, or Parkinson's Disease, to name only a few. TMS systems and devices including or more patient inputs that may be used to perform these methods are also described.
摘要翻译：这里描述的是在会话期间或期间控制经颅磁刺激的方法，其中直接立即使用患者报告的反馈来评估效果并实时优化治疗。这些方法可能适用于浅表重复经颅磁刺激（rTMS）或深脑立体定向经颅磁刺激（sTMS）。可以从这些方法中受益的疗法的实例包括：TMS治疗：急性疼痛（例如，在牙科手术或Bunionectomies期间），抑郁症或帕金森病，仅举几例。还描述了可以用于执行这些方法的TMS系统和包括或更多患者输入的设备。

6. 发明申请

WO2009023680A1 GANTRY AND SWITCHES FOR POSITION-BASED TRIGGERING OF TMS PULSES IN MOVING COILS 审中-公开
标题翻译：用于移动线圈中TMS脉冲位置触发的GANTRY AND SWITCHES
公开(公告)号：WO2009023680A1
公开(公告)日：2009-02-19
申请号：PCT/US2008/072930
申请日：2008-08-12
申请人： NEOSTIM, INC. , SCHNEIDER, M., Bret , MISHELEVICH, David
发明人： SCHNEIDER, M., Bret , MISHELEVICH, David
IPC分类号： A61N2/00 , A61N2/02
CPC分类号： A61N2/006 , A61N2/02
摘要： When a mechanical frame or gantry is used to move one or more electromagnets about a subject, the pulsed magnetic fields of the magnets need to be triggered, but only when the coil is in an appropriate physical position. Trigger points are established along the movement pathway (e.g., along the support frame) for the electromagnets that trigger the pulsation of the current being supplied to the given electromagnet. Use of the present invention allows firing of a magnetic coil to coordinate with the position of that coil, without need for expensive robotics or computerized motion control.
摘要翻译：当机械框架或龙门架用于围绕被摄体移动一个或多个电磁体时，磁体的脉冲磁场需要被触发，但是只有当线圈处于适当的物理位置时。触发点沿着运动路径（例如，沿着支撑框架）建立，用于触发被提供给给定电磁体的电流的脉动的电磁体。使用本发明允许点火线圈与该线圈的位置协调，而不需要昂贵的机器人或计算机化的运动控制。

7. 发明申请

WO2009049068A1 DISPLAY OF MODELED MAGNETIC FIELDS 审中-公开
标题翻译：模拟磁场的显示
公开(公告)号：WO2009049068A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079378
申请日：2008-10-09
申请人： NEOSTIM, INC. , MISHELEVICH, David , SCHNEIDER, M., Bret
发明人： MISHELEVICH, David , SCHNEIDER, M., Bret
IPC分类号： A61N2/02 , A61N2/00
CPC分类号： A61N2/02 , A61N1/08 , A61N2/006
摘要： Methods and systems for modeling and displaying magnetic field intensities during Transcranial Magnetic Stimulation (TMS) are described, particularly methods and system for modeling and displaying TMS using overlapping magnetic fields to stimulate deep brain regions.
摘要翻译：描述了经颅磁刺激（TMS）期间建模和显示磁场强度的方法和系统，特别是使用重叠磁场来建模和显示TMS以刺激深部脑区域的方法和系统。

8. 发明申请

WO2009036040A1 AUTOMATED MOVEMENT OF ELECTROMAGNETS TRACKING ECCENTRICITY OF THE HEAD 审中-公开
标题翻译：电动自动运动跟踪头部的偏心
公开(公告)号：WO2009036040A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/075824
申请日：2008-09-10
申请人： NEOSTIM, INC. , MISHELEVICH, David , SCHNEIDER, M., Bret
发明人： MISHELEVICH, David , SCHNEIDER, M., Bret
IPC分类号： A61N2/00 , A61N2/02
CPC分类号： A61N2/02 , A61N2/006
摘要： Methods and System for controlling the motion and position of one or more electromagnets during Transcranial Magnetic Stimulation (TMS) are described. In particular, described herein are systems and methods for rotating one or more electromagnet assemblies around a patient's head in an orbital path that follows the eccentricity of the head to maintain close proximity to the head.
摘要翻译：描述了在经颅磁刺激（TMS）期间控制一个或多个电磁体的运动和位置的方法和系统。特别地，这里所描述的系统和方法用于使一个或多个电磁体组件围绕患者头部在跟随头部偏心度的轨迹路径中旋转以保持与头部紧密接近的系统和方法。

9. 发明申请

WO2009033150A1 PITCH, ROLL, AND YAW MOTIONS FOR ELECTROMAGNET ARRAYS 审中-公开
标题翻译： PITCH，ROLL和YAW MOTIONS FOR ELECTROMAGNET ARRAYS
公开(公告)号：WO2009033150A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/075583
申请日：2008-09-08
申请人： NEOSTIM, INC. , SCHNEIDER, M., Bret , MISHELEVICH, David
发明人： SCHNEIDER, M., Bret , MISHELEVICH, David
IPC分类号： A61N2/02 , A61N2/00
CPC分类号： A61N2/006 , A61N2/02 , A61N2/12
摘要： A method for moving an array of electromagnetic coils used for Transcranial Magnetic Stimulation (TMS) in pitch, roll, or yaw modes or two or three of those in combination such that over successive firings of the magnets the neural tissues impacted are not over-stimulated and thus subject to undesirable side effects such as seizures.
摘要翻译：一种用于在俯仰，滚动或偏航模式中用于经颅磁刺激（TMS）的电磁线圈阵列的组合的方法，其中组合的神经组织的连续激发不会被过度刺激并因此受到不期望的副作用，例如发作。

10. 发明申请

WO2009026386A1 FIRING PATTERNS FOR DEEP BRAIN TRANSCRANIAL MAGNETIC STIMULATION 审中-公开
标题翻译：用于深层脑转移磁性刺激的模式
公开(公告)号：WO2009026386A1
公开(公告)日：2009-02-26
申请号：PCT/US2008/073751
申请日：2008-08-20
申请人： NEOSTIM, INC. , MISHELEVICH, David , SCHNEIDER, Bret, M.
发明人： MISHELEVICH, David , SCHNEIDER, Bret, M.
IPC分类号： A61N2/02
CPC分类号： A61N2/006 , A61N2/02
摘要： Methods, devices and systems for Transcranial Magnetic Stimulation (TMS) are provided for synchronous, asynchronous, or independent triggering the firing multiple of electromagnets from either a single power source or multiple energy sources. These methods are particularly useful for stimulation of deep (e.g., sub-cortical) brain regions, or for stimulation of multiple brain regions, since controlled magnetic pulses reaching the deep target location may combine to form a patterned pulse train that activates the desired volume of target tissue. Furthermore, the methods, devices and systems described herein may be used to control the rate of firing of action potentials in one or more brain regions, such as slow or fast rate rTMS. For example, described herein are multiple electromagnetic stimulation sources, each of which are activated independently to create a cumulative effect at the intersections of the electromagnetic stimulation trajectories, typically by means of a computerized calculation.
摘要翻译：用于经颅磁刺激（TMS）的方法，装置和系统被提供用于从单个电源或多个能量源同步，异步或独立地触发电磁体的点火倍数。这些方法对于刺激深部（例如亚皮质）脑区域或刺激多个脑区域特别有用，因为到达深靶位置的受控磁脉冲可以结合形成图案化的脉冲串，其激活所需体积的目标组织。此外，本文描述的方法，装置和系统可以用于控制一个或多个脑区域中的动作电位的发射速率，例如慢速或快速率rTMS。例如，这里描述的是多个电磁刺激源，每个电磁刺激源通常通过计算机化的计算独立地被激活以在电磁刺激轨迹的交叉处产生累积效应。

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