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1. 发明申请

WO2011123548A3 NEUROMODULATION OF DEEP-BRAIN TARGETS BY TRANSCRANIAL MAGNETIC STIMULATION ENHANCED BY TRANSCRANIAL DIRECT CURRENT STIMULATION 审中-公开
公开(公告)号：WO2011123548A3
公开(公告)日：2011-10-06
申请号：PCT/US2011/030550
申请日：2011-03-30
申请人： CERVEL NEUROTECH, INC. , SCHNEIDER, M., Bret , PARTSCH, Michael, J. , MISHELEVICH, David, J.
发明人： SCHNEIDER, M., Bret , PARTSCH, Michael, J. , MISHELEVICH, David, J.
IPC分类号： A61N2/02 , A61N2/08 , A61N1/36 , A61N1/04
摘要： Described herein are methods, devices and systems for neuromodulation of deep brain targets using a combination of transcranial magnetic stimulation (TMS) and transcranial direct current (DC) stimulation to reduce or eliminate side-effects when modulating one or more deep brain targets. For example, transcranial magnetic stimulation of a deep brain target may be synchronized with modulation of more superficially located cortical brain regions using transcranial direct current stimulation to prevent seizures and other side effects. Systems configured to regulate (or synchronize) the application of transcranial magnetic stimulation of deep brain targets and transcranial direct current stimulation are also described.

2. 发明申请

WO2012048319A2 TRANSVERSE TRANSCRANIAL MAGNETIC STIMULATION COIL PLACEMENT FOR IMPROVES ANALGESIA 审中-公开
标题翻译：横断面磁刺激线圈放置改善ANALGESIA
公开(公告)号：WO2012048319A2
公开(公告)日：2012-04-12
申请号：PCT/US2011/055594
申请日：2011-10-10
申请人： CERVEL NEUROTECH, INC. , SCHNEIDER, Bret, M. , MISHELEVICH, David, J.
发明人： SCHNEIDER, Bret, M. , MISHELEVICH, David, J.
IPC分类号： A61N2/02 , A61N2/04 , A61N1/34 , A61N1/36 , A61B18/18
CPC分类号： A61N2/006 , A61N1/40 , A61N2/008 , A61N2/02
摘要： Described herein are methods for neuromodulating brain activity of one or more target brain regions, the methods using Transcranial Magnetic Stimulation (TMS) to produce robust analgesia. In particular, described herein are systems for arranging one or more (e.g., a plurality) of TMS electromagnets oriented in a transverse direction, perpendicular to the posterior-anterior axis of the head, and applying sufficient energy to neuromodulate the target deep brain region.
摘要翻译：本文描述的是用于神经调节一个或多个靶脑区域的脑活动的方法，使用经颅磁刺激（TMS）产生强力镇痛的方法。特别地，本文所描述的是用于布置一个或多个（例如，多个）TMS电磁体的系统，所述TMS电磁体在横向方向上定向，垂直于头部的前后轴线，并且施加足够的能量来神经调节目标深部脑区域。

3. 发明申请

WO2009143503A2 TRANSCRANIAL MAGNETIC STIMULATION BY ENHANCED MAGNETIC FIELD PERTURBATIONS 审中-公开
标题翻译：通过增强磁场刺激的交叉磁性刺激
公开(公告)号：WO2009143503A2
公开(公告)日：2009-11-26
申请号：PCT/US2009/045109
申请日：2009-05-26
申请人： NEOSTIM, INC. , MISHELEVICH, David, J. , SCHNEIDER, M., Bret
发明人： MISHELEVICH, David, J. , SCHNEIDER, M., Bret
IPC分类号： A61N2/02 , A61N1/00 , A61B5/05
CPC分类号： A61N2/02 , A61N2/006
摘要： Described herein are devices, systems and methods to enhance the magnetic perturbation of a neuronal (e.g., brain) target during Transcranial Magnetic Stimulation (TMS), thereby enhancing the induced current in the target. In general, these devices, systems and methods enhance the magnetic perturbation (dB/dt) of the target by mechanically moving a TMS electromagnet (e.g., coil) at a frequency of greater than 1 kHz.
摘要翻译：本文描述了在经颅磁刺激（TMS）期间增强神经元（例如脑）靶的磁性扰动的装置，系统和方法，从而增强目标中的感应电流。通常，这些装置，系统和方法通过以大于1kHz的频率机械地移动TMS电磁体（例如，线圈）来增强目标的磁扰动（dB / dt）。

4. 发明申请

WO2008089003A3 SYSTEM FOR OPTICAL STIMULATION OF TARGET CELLS 审中-公开
公开(公告)号：WO2008089003A3
公开(公告)日：2008-07-24
申请号：PCT/US2008/050628
申请日：2008-01-09
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , ZHANG, Feng , DEISSEROTH, Karl , MISHELEVICH, David, J. , SCHNEIDER, M., Bret
发明人： ZHANG, Feng , DEISSEROTH, Karl , MISHELEVICH, David, J. , SCHNEIDER, M., Bret
IPC分类号： A61K48/00 , A61K38/00
摘要： Stimulation of target cells using light, e.g., in vivo , is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo . Other aspects and embodiments are directed to systems and methods for screening chemicals based screening chemicals to identify their effects on cell membrane ion channels and pumps, and to systems and methods for controlling an action potential of neuron (e.g., in vivo and in vitro environments).

5. 发明申请

WO2010080879A2 SHAPED COILS FOR TRANSCRANIAL MAGNETIC STIMULATION 审中-公开
标题翻译：用于经颅磁刺激的形状线圈
公开(公告)号：WO2010080879A2
公开(公告)日：2010-07-15
申请号：PCT/US2010/020324
申请日：2010-01-07
申请人： NEOSTIM, INC. , MISHELEVICH, David, J. , SCHNEIDER, M., Bret
发明人： MISHELEVICH, David, J. , SCHNEIDER, M., Bret
IPC分类号： A61N2/02 , A61B5/05 , A61B5/055
CPC分类号： A61N2/02 , A61N2/006
摘要： Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation.
摘要翻译：这里描述的是由两个弯曲的磁性线圈环形成的成形线圈TMS电磁体，所述两个弯曲的磁性线圈环在顶点处连接，所述顶点在线圈的外部线圈区域之间的角度通常小于120度（例如，在约45° 和大约70度，60度等）。顶点区域被整形以优化从TMS电磁体投射的磁场。例如，顶点区域可以是水平的或垂直的。在一些变型中，顶点区域通过重新布置形成两个线圈的导电绕组而形成，使得它们不再布置成与它们位于弯曲的磁性线圈环路的其他部分中的相同的柱状结构。这些TMS电磁体可能非常适合用于深脑经颅磁刺激。

6. 发明申请

WO2012108910A1 PORTABLE DIALYSIS MACHINE 审中-公开
标题翻译：便携式分析机
公开(公告)号：WO2012108910A1
公开(公告)日：2012-08-16
申请号：PCT/US2011/053184
申请日：2011-09-25
申请人： FRESENIUS MEDICAL CARE HOLDINGS, INC. , FULKERSON, Barry, Neil , BRAIG, James, Roswell , MISHELEVICH, David, J. , CLEMENS, Charles , FOSTER, Clark, Berg , GHIDOLI, Daniele , GURA, Victor , HERING, Martin , ISACKSON, Frank , JOSEPH, Russell, Thomas , ROBINSON, Thomas , SMITH, Mark, Forrest , TRCKA, Milan , ZWIERSTRA, Jan, Brian
发明人： FULKERSON, Barry, Neil , BRAIG, James, Roswell , MISHELEVICH, David, J. , CLEMENS, Charles , FOSTER, Clark, Berg , GHIDOLI, Daniele , GURA, Victor , HERING, Martin , ISACKSON, Frank , JOSEPH, Russell, Thomas , ROBINSON, Thomas , SMITH, Mark, Forrest , TRCKA, Milan , ZWIERSTRA, Jan, Brian
IPC分类号： B01D61/28 , B01D61/24
CPC分类号： A61M1/3413 , A61M1/1609 , A61M1/1645 , A61M1/166 , A61M1/1692 , A61M1/1696 , A61M1/3406 , A61M1/3626 , A61M1/3639 , A61M1/3641 , A61M1/3646 , A61M1/3656 , A61M1/3672 , A61M1/369 , A61M2205/10 , A61M2205/126 , A61M2205/13 , A61M2205/14 , A61M2205/15 , A61M2205/18 , A61M2205/3306 , A61M2205/3317 , A61M2205/3334 , A61M2205/3368 , A61M2205/3375 , A61M2205/3393 , A61M2205/3553 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/584 , A61M2205/6072 , A61M2209/084 , B01D61/18 , B01D61/30 , B01D2313/10 , B01D2313/105 , B01D2313/12 , B01D2313/125 , B01D2313/243
摘要： The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface, a heater in thermal communication with the planar surface, and a sodium sensor in electromagnetic communication with the planar surface. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features.
摘要翻译：本说明书公开了一种具有可拆卸控制器单元和基座单元的便携式透析机。控制器单元包括具有内表面的门，具有面板的壳体，其中壳体和面板限定了构造成接收门的内表面的凹陷区域，以及固定地连接到面板的歧管接收器。基座单元具有用于接收流体容器的平坦表面，与平坦表面集成的刻度，与平坦表面热连通的加热器和与平坦表面电磁连通的钠传感器。所公开的便携式透析系统的实施例具有改进的结构和功能特征，包括改进的模块性，易用性和安全特征。

7. 发明申请

WO2009020938A1 MONOPHASIC MULTI-COIL ARRAYS FOR TRANCRANIAL MAGNETIC STIMULATION 审中-公开
标题翻译：单向磁珠阵列用于急性磁刺激
公开(公告)号：WO2009020938A1
公开(公告)日：2009-02-12
申请号：PCT/US2008/072154
申请日：2008-08-04
申请人： NEOSTIM, INC. , SCHNEIDER, Bret, M. , MISHELEVICH, David, J.
发明人： SCHNEIDER, Bret, M. , MISHELEVICH, David, J.
IPC分类号： A61N1/00
CPC分类号： A61N2/004 , A61N2/02
摘要： Efficient use of multi-coil arrays for magnetic nerve stimulation depends upon coordinating the coil polarity, the pulse phase and the pulse timing. Monophasic magnetic nerve stimulators produce more precise and predictable results in the stimulation of nerves than biphasic and polyphasic machines, but are less electrically efficient, and consequently limited in terms of pulse train speed. The present invention concerns the coordination of pulse polarity, phase, timing, and strength between multiple magnetic stimulation coils. The goal is to optimize the manner in which multiple coils may be used synergistically to control the activity of underlying neural tissue.
摘要翻译：用于磁神经刺激的多线圈阵列的有效使用取决于线圈极性，脉冲相位和脉冲时序的协调。单相磁神经刺激器在双相和多相机器刺激神经方面产生更精确和可预测的结果，但电动效率较低，因此在脉冲列车速度方面受到限制。本发明涉及多个磁刺激线圈之间的脉冲极性，相位，定时和强度的协调。目的是优化多个线圈可以协同使用以控制潜在神经组织的活性的方式。

8. 发明申请

WO2005000105A2 COMPUTER-ASSISTED MANIPULATION OF CATHETERS AND GUIDE WIRES 审中-公开
标题翻译：电脑和导线的计算机辅助操作
公开(公告)号：WO2005000105A2
公开(公告)日：2005-01-06
申请号：PCT/US2004/020159
申请日：2004-06-22
申请人： TELECATH , SCHNEIDER, Michael, Bret , MISHELEVICH, David, J.
发明人： SCHNEIDER, Michael, Bret , MISHELEVICH, David, J.
IPC分类号： A61B
CPC分类号： A61M25/0105 , A61M25/0113
摘要： Computer-assisted methods and systems for manipulating elongate members during medical procedures are provided. Electromechanical devices are computer driven to manipulate the elongate members, which a user can direct through computer interfaces like graphical user interfaces and pointing devices.
摘要翻译：提供了用于在医疗过程中操纵细长构件的计算机辅助方法和系统。机电装置被计算机驱动以操纵细长构件，用户可以通过诸如图形用户界面和指示装置的计算机接口来引导。

9. 发明申请

WO2007130308A2 TRAJECTORY-BASED DEEP-BRAIN STEREOTACTIC TRANSCRANIAL MAGNETIC STIMULATION 审中-公开
标题翻译：基于TRAJECTORY的深层脑血管交叉神经刺激
公开(公告)号：WO2007130308A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/010262
申请日：2007-04-27
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , MISHELEVICH, David, J. , SCHNEIDER, Brett, M.
发明人： MISHELEVICH, David, J. , SCHNEIDER, Brett, M.
CPC分类号： A61N2/004 , A61N2/006 , A61N2/008 , A61N2/02
摘要： The present invention provides for Stereotactic Transcranial Magnetic Stimulation (sTMS) at predetermined locations with the brain or spinal cord and incorporates an array of electromagnets arranged in a specified configuration where selected coils in the array are pulsed simultaneously. Activation of foci demonstrated by functional MRI or other imaging techniques can be used to locate the neural region affected. Imaging techniques can also be utilized to determine the location of the designated targets.
摘要翻译：本发明提供了在具有脑或脊髓的预定位置处的立体定向经颅磁刺激（sTMS），并且包括以特定配置布置的电磁体阵列，其中阵列中的选定线圈同时脉冲。通过功能性MRI或其他成像技术证实的焦点活化可用于定位受影响的神经区。成像技术也可用于确定指定目标的位置。

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