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1. 发明申请

WO2020086260A1 HIGHLY ACCURATE TEMPERATURE SENSORS, AND CALIBRATIONS THEREOF, FOR USE WITH IMPLANTABLE MEDICAL DEVICES 审中-公开
公开(公告)号：WO2020086260A1
公开(公告)日：2020-04-30
申请号：PCT/US2019/055228
申请日：2019-10-08
申请人： PACESETTER, INC.
发明人： OPRIS, Ion , ANDERSEN, Dean
IPC分类号： A61B5/01 , G01K7/01
摘要： Certain embodiments of the present technology relate to temperature sensors for using in an implantable medical device, and methods for use therewith. Such a method can include alternating between producing a first base-to-emitter voltage drop (VBE1) and a second base-to-emitter voltage drop (VBE2), and alternating between using a capacitor to store the VBE1, which is complimentary to absolute temperature (CTAT), and using the same capacitor to store a ΔVBE=VBE2-VBE1, which is proportion to absolute temperature (PTAT). The method also includes using a sigma-delta modulator that includes the capacitor to produce a signal having a duty cycle (dc) indicative of the ΔVBE stored using the capacitor, and producing a temperature measurement based on the signal having the duty cycle (dc) indicative of the ΔVBE.

2. 发明申请

WO2020061392A1 SYSTEMS AND METHODS FOR AUTOMATED CAPTURE THRESHOLD TESTING AND ASSOCIATED HIS BUNDLE PACING 审中-公开
公开(公告)号：WO2020061392A1
公开(公告)日：2020-03-26
申请号：PCT/US2019/052047
申请日：2019-09-20
申请人： PACESETTER, INC.
发明人： MANGUAL-SOTO, Jan, O. , LI, Wenwen , BADIE, Nima , MCSPADDEN, Luke, C.
IPC分类号： A61N1/05 , A61N1/362 , A61N1/37
摘要： Systems and methods for His bundle pacing using a stimulation device include applying an impulse to a His bundle of a patient heart using the stimulation device. The stimulation device then measures a response of the patient heart to application of the impulse that includes a response of a ventricle of the patient heart. The stimulation device calculates a ventricular delay as a time from application of the impulse to onset of the response of the ventricle and delivers, using a lead of the stimulation device, a backup impulse to the ventricle when at least the ventricular delay exceeds a delay value stored in a memory of the stimulation device. The stored delay may, for example, correspond to a previously determined value indicative of selective or other His bundle capture.

3. 发明申请

WO2019126101A1 LOW POWER ADVERTISEMENT SCHEDULE FOR IMPLANTABLE MEDICAL DEVICE AND METHOD 审中-公开
公开(公告)号：WO2019126101A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/066131
申请日：2018-12-18
申请人： PACESETTER, INC.
发明人： STOCKTON, John , LI, Perry
IPC分类号： A61N1/372
摘要： Methods and devices are provided for managing establishment of a communications link between an external instrument (EI) and an implantable medical device (IMD). The method stores, in the FMD, an advertisement schedule that includes first and second power schemes to be utilized with advertisement notices. The first and second power schemes define at least one of i) first and second power levels for transmitting the advertisement notices or ii) first and second receive sensitivities to scan for a connection request. The method manages at least one of a transmit or receive operation of the IMD, utilizing the first and second power schemes in connection with first and second advertisement notices, respectively. The method establishes a communication session between the IMD and the EI.

4. 发明申请

WO2019090256A1 BIOSTIMULATOR HAVING FIXATION ELEMENT 审中-公开
公开(公告)号：WO2019090256A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/059263
申请日：2018-11-05
申请人： PACESETTER, INC.
发明人： MAR, Craig E. , EBY, Thomas B. , PASPA, Paul , ORTS, Sondra , FISHLER, Matthew G. , LEE, Stephen , BOLING, Carl Lance , LUHRS, Thomas Robert
IPC分类号： A61N1/375 , A61N1/372
CPC分类号： A61N1/37518 , A61N1/057 , A61N1/37205 , A61N1/375 , A61N1/37512 , A61N1/3756
摘要： A biostimulator, such as a leadless cardiac pacemaker, including a fixation element to engage tissue and one or more backstop elements to resist back-out from the tissue, is described. The fixation element can be mounted on a housing of the biostimulator such that a helix of the fixation element extends distally to a leading point. The leading point can be located on a distal face of the helix at a position that is proximal from a center of the distal face. The backstop elements can include non-metallic filaments, such as sutures, or can include a pinch point of the biostimulator. The backstop features can grip the tissue to prevent unscrewing of the fixation element. Other embodiments are also described and claimed.

5. 发明申请

WO2018183646A1 METHOD AND DEVICE FOR MANAGING DISPLAY OF MULTIPLE DATA STREAMS 审中-公开
公开(公告)号：WO2018183646A1
公开(公告)日：2018-10-04
申请号：PCT/US2018/025094
申请日：2018-03-29
申请人： PACESETTER, INC.
发明人： SHANMUGAM, Muthuvale , BISEN, Pulkit , YOUNG, Chao-wen , WU, Yongjian , MILLER, Lisbet , PEI, Xing , SHAHANDEH, Reza
IPC分类号： A61N1/372 , A61B5/00 , A61B5/044
摘要： Methods and systems are provided to manage display of cardiac signals. The methods and systems receive a first data steam along a first communications path conveyed with first throughput and receiving a second data stream along a second communications path transmitted with second throughput. The first and second throughputs are asynchronous with respect to one another. The first and second data streams carry cardiac signals sensed by external and implanted electrodes, respectively, for one or more common events. The methods and systems store data from the first and second data streams in first and second memory buffers. The methods and systems synchronize the data stored in the first and second memory buffers with one another by performing at least one of: temporally offsetting activation of the storing operation for the first and second data streams with respect to one another; or managing an amount of the data maintained in at least one of the first memory buffer or the second memory buffer. The methods and systems co-display cardiac signals associated with the first and second data streams on a display by reading the data from the first and second memory buffers at a data display rate.

6. 发明申请

WO0187410A3 CARDIAC STIMULATION DEVICES AND METHODS FOR MEASURING IMPEDANCES ASSOCIATED WITH THE LEFT SIDE OF THE HEART 审中-公开
标题翻译：心脏刺激装置和测量与心脏左侧相关的阻力的方法
公开(公告)号：WO0187410A3
公开(公告)日：2002-03-21
申请号：PCT/US0115520
申请日：2001-05-14
申请人： PACESETTER INC
发明人： BRADLEY KERRY , BORNZIN GENE A , PARK EULJOON , KROLL MARK W
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： Methods of and systems for measuring at least one physiological parameter for assessing a patient's cardiac condition based on left heart impedance measurements are described. Various embodiments establish a current flow through a left side of the heart and measure a voltage between a first location on or in the left side of the heart and a second location within the human body while establishing the current flow. The inventive techniques and systems can be used for, among other things, measuring progression or regression of myocardial failure, dilation, or hypertrophy, pulmonary congestion, myocardial contractility, or ejection fraction. The measured voltage, related to left heart impedance, can be used to monitor patient condition for diagnostic purposes or to adapt pacing or defibrillation therapy. Therapy adaptation can include controlling pacing modes, pacing rates, or interchamber pacing delays, for example.
摘要翻译：描述了基于左心脏阻抗测量来测量用于评估患者心脏病状的至少一个生理参数的方法和系统。各种实施例建立通过心脏左侧的电流，并测量心脏左侧或左侧的第一位置与人体内的第二位置之间的电压，同时建立电流。本发明的技术和系统可以用于测量心肌衰竭，扩张或肥大，肺充血，心肌收缩力或射血分数的进展或消退。与左心脏阻抗相关的测量电压可用于监测患者状况以进行诊断或适应起搏或除颤治疗。治疗适应可以包括例如控制起搏模式，起搏速率或间隔起搏延迟。

7. 发明申请

WO1998014242A1 IMPEDANCE DEPENDENT IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR 审中-公开
标题翻译：阻抗相关的可植入式减速器
公开(公告)号：WO1998014242A1
公开(公告)日：1998-04-09
申请号：PCT/US1997017720
申请日：1997-10-02
申请人： PACESETTER, INC.
发明人： PACESETTER, INC. , AMELEY-VELEZ, Jorge, N.
IPC分类号： A61N01/39
CPC分类号： A61N1/3937 , A61N1/3912 , A61N1/3931
摘要： An implantable cardiac stimulation device (10) contains a high voltage defibrillating unit (16). A protection circuit (60) is connected to the defibrillating unit to guard against excessive current during a high voltage discharge. The protection circuit prevents damage to the defibrillation unit and to the associated heart tissue (12). The defibrillation current is monitored by the protection circuit and, if excessive, the defibrillation current is reduced by routing the current through an additional impedance. The protection circuit operates in real time to remove the additional impedance if the defibrillation current returns to a safe level. A memory device attached to the protection circuit records the event of an excessive defibrillation current.
摘要翻译：植入式心脏刺激装置（10）包含高压去纤颤装置（16）。保护电路（60）连接到除颤单元以防止高电压放电期间的过大电流。保护电路防止对除颤单元和相关联的心脏组织（12）的损伤。除颤电流由保护电路监控，如果过多，则通过将电流通过额外的阻抗进行布线来减小除颤电流。如果除颤电流恢复到安全水平，则保护电路实时工作以去除附加阻抗。连接到保护电路的存储器件记录过度除颤电流的事件。

8. 发明申请

WO1997036639A1 SINGLE-PASS A-V PACING LEAD 审中-公开
标题翻译：单通A-V PAC领先
公开(公告)号：WO1997036639A1
公开(公告)日：1997-10-09
申请号：PCT/US1997001254
申请日：1997-01-29
申请人： PACESETTER, INC.
发明人： PACESETTER, INC. , BORNZIN, Gene, A. , MORGAN, Kevin, L. , FLORIO, Joseph, J. , WOLSLEGER, Wendy, Kristine
IPC分类号： A61N01/05
CPC分类号： A61N1/056
摘要： A single-pass A-V pacing lead includes an elongated main lead body (32) having an atrial electrode (40) at the distal and thereof, and includes a ventricular branch (52) which departs from the main lead body just proximal to the tip of the atrial electrode (40). The ventricular branch has a ventricular electrode (60) at its distal tip. The main lead body (32) includes a preformed J-shaped portion (86) which, following proper implantation, projects the atrial electrode (40) against a wall of the atrial appendage. The ventricular branch includes a preformed bend (92) which curves in the opposite direction of the J-shaped portion so as to maintain the ventricular branch away from the wall of the atrial appendage (88).
摘要翻译：单程AV起搏引线包括细长的主引线体（32），其在远端具有心房电极（40），并且包括心室分支（52），所述心室分支离开主导体正好靠近尖端心房电极（40）。心室分支在其远端具有心室电极（60）。主引线体（32）包括预成形的J形部分（86），其在适当植入之后将心房电极（40）突出于心房壁的壁上。心室分支包括在J形部分的相反方向上弯曲的预成型弯曲部（92），以便使心室分支远离心房壁（88）的壁。

9. 发明申请

WO1997036638A1 SINGLE-PASS A-V LEAD FOR PACING WITH STIMULATION OF RIGHT VENTRICULAR OUTFLOW TRACT 审中-公开
标题翻译：单通道A-V引导用于激发右心室流出血栓
公开(公告)号：WO1997036638A1
公开(公告)日：1997-10-09
申请号：PCT/US1997000960
申请日：1997-01-29
申请人： PACESETTER, INC.
发明人： PACESETTER, INC. , BORNZIN, Gene, A. , MANN, Brian, M.
IPC分类号： A61N01/05
CPC分类号： A61N1/056
摘要： A single pass A-V lead for cardiac pacing comprises a lead body (32) having an atrial electrode (56) and a right ventricular outflow tract (RVOT) electrode (50). Preformed bends in the lead body are configured such that the atrial and RVOT electrodes are biased against the walls of the right atrium and RVOT respectively.
摘要翻译：用于心脏起搏的单程A-V引线包括具有心房电极（56）和右心室流出道（RVOT）电极（50）的引线体（32）。引线体中的预成形弯曲被配置成使得心房和RVOT电极分别偏压在右心房和RVOT的壁上。

10. 发明申请

WO1997035516A1 METHODS AND APPARATUS FOR STORING INTRACARDIAC ELECTROGRAMS 审中-公开
标题翻译：用于储存内皮细胞电泳的方法和装置
公开(公告)号：WO1997035516A1
公开(公告)日：1997-10-02
申请号：PCT/US1997004923
申请日：1997-03-25
申请人： PACESETTER, INC.
发明人： PACESETTER, INC. , VAN LAKE, Paul , ADINOLFI, David, W.
IPC分类号： A61B05/0432
CPC分类号： A61B5/0006 , A61B5/04325
摘要： Methods and apparatus are provided for storing intracardiac electrogram (IEGM) and other cardiac data in an implantable cardiac device (10). When a physician wishes to create a cardiac data record containing the IEGM and other cardiac data, the physician directs the cardiac device to store (14) the data on demand. A number of cardiac data records can be stored. Data records may also be stored after a delay period following a predetermined cardiac event. When the implantable cardiac device detects the predetermined cardiac event, the delay period begins. At the expiration of the delay period, the implantable cardiac device stores a cardiac data record. Cardiac data records can also be stored according to a predetermined schedule.
摘要翻译：提供了用于将心内电描记图（IEGM）和其他心脏数据存储在可植入心脏装置（10）中的方法和装置。当医生希望创建包含IEGM和其他心脏数据的心脏数据记录时，医师指示心脏装置按需存储数据（14）。可以存储许多心脏数据记录。数据记录也可以在预定的心脏事件之后的延迟时段之后存储。当可植入心脏装置检测到预定心脏事件时，延迟周期开始。在延迟期结束时，可植入心脏装置存储心脏数据记录。心脏数据记录也可以根据预定的时间表存储。

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