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1. 发明申请

WO1998036794A1 A SINGLE ELECTRICAL CATHETER FOR SEQUENTIAL CARDIAC STIMULATION 审中-公开
标题翻译：用于顺序性心脏刺激的单电导管
公开(公告)号：WO1998036794A1
公开(公告)日：1998-08-27
申请号：PCT/IB1998000203
申请日：1998-02-16
申请人： GRASSI, Gino , ALCIDI, Luciano
IPC分类号： A61N01/05
CPC分类号： A61N1/056
摘要： A single electrical catheter for temporary or permanent cardiac stimulation, whether VDD or DDD, includes atrial and ventricular electrodes mounted on the same catheter. The distance between the two electrode groups depends on heart dimensions. The electrodes A, B, C used for atrial sensing and stimulations are located and connected in such a way, that A and C are positioned symmetrically about the central electrode B; A and C are electrically connected to each other and to a terminal of the atrial pacing device, while B is connected to the other terminal. Said electrode configuration allows to decrease the stimulation threshold and to increase the recording sensitivity of the atrial signals.
摘要翻译：用于临时或永久性心脏刺激的单个电导管（无论是VDD还是DDD）包括安装在同一导管上的心房和心室电极。两个电极组之间的距离取决于心脏尺寸。用于心房感测和刺激的电极A，B，C以这样的方式定位和连接，使得A和C围绕中心电极B对称地定位; A和C彼此电连接到心房起搏装置的终端，而B连接到另一个终端。所述电极配置允许降低刺激阈值并增加心房信号的记录灵敏度。

2. 发明申请

WO1998024506A1 ELECTRODE LEAD WITH TEMPORARY INCREASED STIFFNESS DURING INGROWTH 审中-公开
标题翻译：电极导致在生长期间具有临时增加的强度
公开(公告)号：WO1998024506A1
公开(公告)日：1998-06-11
申请号：PCT/SE1997002002
申请日：1997-11-28
申请人： PACESETTER AB , HOLMSTRÖM, Nils , OBEL, Martin
发明人： PACESETTER AB
IPC分类号： A61N01/05
CPC分类号： A61N1/056
摘要： The invention relates to an implantable lead for an implantable active device, such as a pacemaker, having at least two electrodes, said lead having a proximal end adapted for electrical and mechanical connection to said active device, and a distal end opposite said proximal end, a ventricular electrode (4) carried at the distal end of said lead (3) for sensing and/or electrical interaction with the ventricle (2), an atrial electrode (5) carried on said lead (3) for sensing and/or electrical interaction with the atrium (1), said atrial electrode (5) disposed intermediate to the proximal end and said ventricular electrode (4). The lead has at the distal end a first part (C) having a first predetermined length, which is between 9-13 cm and exhibiting a first stiffness and adjacent thereto a second part (A) having a second predetermined length, which exceeds 15 cm, preferably 25 cm, and a second stiffness, said first stiffness of said first part (C) being such as to provide the lead a stiffness adapted to force the atrial electrode (1) in contact with the atrial wall when implanted, said second stiffness being greater than said first stiffness, a transition point (B) between part (A) and part (C) being situated at the proximal end of part (C).
摘要翻译：本发明涉及一种用于可植入有源装置（例如起搏器）的可植入引线，其具有至少两个电极，所述引线具有适于与所述有源器件电气和机械连接的近端以及与所述近端相对的远端，在所述引线（3）的远端处承载用于与心室（2）感测和/或电相互作用的心室电极（4），承载在所述引线（3）上用于感测和/或电气的心房电极与心房（1）的相互作用，所述心房电极（5）设置在近端和所述心室电极（4）的中间。引线在远端具有第一部分（C），第一部分（C）具有第一预定长度，该第一部分在9-13厘米之间并且呈现出第一刚度并与其相邻，具有第二预定长度的第二部分（A）超过15厘米所述第一部分（C）的所述第一刚度使所述第一刚度适于在植入时迫使所述心房电极（1）与所述心房壁接触，所述第二刚度大于所述第一刚度，部分（A）和部分（C）之间的转变点（B）位于部分（C）的近端处。

3. 发明申请

WO1997048439A1 LEAD INTRODUCER WITH DEFIBRILLATION ELECTRODE FOR ATRIAL DEFIBRILLATION 审中-公开
标题翻译：用于ATRIAL DEFRRILLING的引导电极
公开(公告)号：WO1997048439A1
公开(公告)日：1997-12-24
申请号：PCT/US1997008973
申请日：1997-05-28
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , RUTTEN, Jean , SMITS, Karel, F., A., A. , LINDEMANS, Fredric, W.
IPC分类号： A61N01/05
CPC分类号： A61N1/0563
摘要： There is provided a system and method for treating cardiac arrhythmias such as atrial defibrillation, and in particular a method for providing temporary atrial defibrillation which involves insertion of only one defibrillation lead. A lead introducer (20) is provided having a sheath (22) with an electrode configured around the outside of the sheath (22) and a lumen (24) for receiving therethrough a standard defibrillation lead. After insertion of the introducer into a patient's vein and positioning it so that the introducer electrode is placed within the vein, a defibrillation lead is passed through the introducer lumen. The defibrillation lead carries at least one electrode (15), suitably an electrode spaced from its distal end so that it can be positioned in the patient's coronary sinus. When the introducer electrode and the defibrillation lead electrode are optimally placed, they are electrically connected to a defibrillation unit for generation and delivery of a defibrillation pulse or pulses across the two electrodes, thereby providing therapy against the atrial fibrillation. In a preferred embodiment, the introducer electrode is a very flexible coil (25), and is positioned in the patient's subclavian vein; the defibrillation lead electrode is positioned in the patient's coronary sinus. Alternately, the electrode can be any other conductor configuration which provides the desired surface area and flexibility, e.g., a braid or woven wire configuration.
摘要翻译：提供了用于治疗心律失常的系统和方法，例如心房除颤，特别是提供暂时性心房除颤的方法，其涉及仅插入一个除颤引线。引线引导器（20）具有护套（22），护套（22）具有围绕护套（22）的外侧构造的电极和用于通过其接收标准除颤引线的管腔（24）。将引导器插入患者的静脉中并定位以使引导器电极置于静脉内时，除颤引线通过引导器内腔。除颤引线承载至少一个电极（15），适当地是与其远端间隔开的电极，使得其可以定位在患者的冠状窦中。当引导器电极和除颤引线电极被最佳地放置时，它们与除颤单元电连接，用于产生和递送穿过两个电极的除颤脉冲或脉冲，从而提供对心房颤动的治疗。在优选实施例中，导引器电极是非常柔性的线圈（25），并且位于患者锁骨下静脉中; 除颤引线电极位于患者的冠状窦内。或者，电极可以是提供期望的表面积和柔性的任何其它导体构造，例如编织线或编织线构造。

4. 发明申请

WO1997045158A1 DISTAL END DEVICE FOR AN IMPLANTABLE ELECTRICAL CONDUCTOR AND AN ELECTRICAL CONDUCTOR EQUIPPED WITH SUCH AN END DEVICE 审中-公开
标题翻译：用于可植入电导体的远端装置和装有这种端装置的电导体
公开(公告)号：WO1997045158A1
公开(公告)日：1997-12-04
申请号：PCT/SE1997000772
申请日：1997-05-12
申请人： PACESETTER AB , NEUBAUER, Heinz , LINDEGREN, Ulf
发明人： PACESETTER AB
IPC分类号： A61N01/05
CPC分类号： A61N1/0575
摘要： The invention relates to a device for preventing an anchoring means (26) on the distal end (10) of an implantable electrode cable from coming into contact, during introduction of the latter into a body cavity, with and damaging the cavity wall and to be compressible, while the anchoring means (26) is being screwed into a wall of the body cavity, in order to deliver medication to body tissue. For this purpose, the device is equipped with a body (30) made of a porous, resilient, spongy material, arranged coaxial to the helical anchoring means (26), the distal end of the body (30) projecting beyond the distal end (28) of the anchoring means and being at least partially filled with medication.
摘要翻译：本发明涉及一种用于防止可植入电极电缆的远端（10）上的锚固装置（26）在其将其引入体腔中并与腔体壁接触并且损坏腔壁时被接触的装置同时锚定装置（26）被旋入体腔的壁中，以将药物递送到身体组织。为此目的，该装置装备有由多孔弹性海绵材料构成的本体（30），其与螺旋锚定装置（26）同轴设置，该主体（30）的远端突出超过远端 28），并且至少部分地填充有药物。

5. 发明申请

WO1996040363A1 TRANSVENOUS DEFIBRILLATION LEAD WITH SIDE HOOKS 审中-公开
标题翻译：具有侧钩的变形引导
公开(公告)号：WO1996040363A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008176
申请日：1996-05-31
申请人： INTERMEDICS, INC.
发明人： INTERMEDICS, INC. , LIN, Jack, Hong-Zen
IPC分类号： A61N01/05
CPC分类号： A61N1/0573 , A61N1/0563
摘要： A transvenous implantable defibrillation lead (10) includes a conductor (12) and inner and outer coaxial cylindrical electrodes (16, 20). The inner electrode (16) is connected to the conductor (12), and the outer electrode (20) is connected to a sheath (18) overlying the conductor in rotatable relationship thereto. The sheath is fixed to the outer cylindrical electrode so that rotation of the sheath relative to the conductor results in rotation of the inner and outer cylindrical electrodes relative to each other. The inner electrode has a plurality of hooks (22) extending generally transversely and tangentially thereto, with the hooks being biased such that the terminal ends of the hooks tend to spring outwardly from the inner electrode. The hooks (22) are constrained against the inner cylindrical electrode (16) by the outer cylindrical electrode (20), except that a window (24) in the outer electrode permits the hooks (22) to spring outwardly therethrough upon rotation of the outer electrode (20) relative to the inner electrode (16). Once the hooks are so exposed, rotation of the inner and outer electrodes in unison permits the hooks to engage cardiac tissue. The hooks (22) provide fixation as well as conducting electrical stimulus to the cardiac tissue.
摘要翻译：经静脉植入式除颤引线（10）包括导体（12）和内外同轴圆柱形电极（16,20）。内部电极（16）连接到导体（12），并且外部电极（20）以可转动的关系连接到覆盖导体的护套（18）上。护套被固定到外圆柱形电极，使得护套相对于导体的旋转导致内部和外部圆柱形电极相对于彼此的旋转。内部电极具有大致横向和相切延伸的多个钩（22），钩被偏置，使得钩的终端倾向于从内部电极向外弹出。钩子（22）通过外圆柱形电极（20）被限制在内部圆柱形电极（16）上，除了外部电极中的窗口（24）允许钩子（22）在外部旋转之后向外弹簧电极（20）相对于内部电极（16）。一旦钩子如此暴露，内外电极的旋转一致就允许钩子接合心脏组织。钩（22）提供固定以及对心脏组织进行电刺激。

6. 发明申请

WO1996039221A1 MULTI-PHASIC MICROPHOTODIODE RETINAL IMPLANT AND ADAPTIVE IMAGING RETINAL STIMULATION SYSTEM 审中-公开
标题翻译：多相微胶原沉积物植入物和自适应成像诱导系统
公开(公告)号：WO1996039221A1
公开(公告)日：1996-12-12
申请号：PCT/US1996008734
申请日：1996-06-04
申请人： CHOW, Vincent , CHOW, Alan, Y.
IPC分类号： A61N01/05
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/05 , A61N1/36046
摘要： An artificial retina device and a method for stimulating and modulating its function is diclosed. The device is comprised of plural multi-phasic microphotodiode subunits, which, when surgically implanted into the subretinal space, may allow useful formed articifial vision to develop. One device, called an MMRI-4 (8), is configured in a flattened cubic shape and transduces light into electric currents to stimulate the retina. The MMRI-4 comprises two subunits in a PiN configuration (10a) and two subunits in an NiP configuration (10b), both present on each of the flattened sides, thereby allowing induced sensations regardless of which side faces incident light. Filter layers (20, 22) disposed on the PiN and NiP configurations allow for visible and infrared light respectively to induce currents. An Adaptive Imaging Retinal Stimulation System (AIRES), with a Projection and Tracking Optical System (PTOS), which may be worn as a headset, is also disclosed.
摘要翻译：一种人造视网膜装置及其功能的刺激和调节方法。该装置由多个多相微光二极管子单元组成，当手术植入视网膜内空间时，可以允许有用的形成的关节视力发展。称为MMRI-4（8）的一种器件被构造成扁平立方体，并将光转换成电流以刺激视网膜。 MMRI-4包括PiN构型（10a）中的两个亚基和NiP构型（10b）中的两个亚基，两个亚单位存在于每个平坦化侧上，从而允许诱导的感觉，而不管哪一侧面入射光。设置在PiN和NiP构造上的过滤层（20,22）分别允许可见光和红外光诱导电流。还公开了具有投影和跟踪光学系统（PTOS）的自适应成像视网膜刺激系统（AIRES），其可以作为耳机佩戴。

7. 发明申请

WO1996035475A1 MEDICAL LEAD WITH COMPRESSION LUMENS 审中-公开
标题翻译：医疗领导与压缩灯
公开(公告)号：WO1996035475A1
公开(公告)日：1996-11-14
申请号：PCT/US1996002803
申请日：1996-02-29
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , SHOBERG, Bret, R. , BORGERSEN, Svenn, E. , DOLLIMER, Michael, R.
IPC分类号： A61N01/05
CPC分类号： A61N1/056
摘要： A medical electrical lead having a multiple conductors located within an elongated lead body (10) which is provided with multiple conductor lumens (100, 102, 104) each containing a conductor (112, 114) and with at least one compression lumen (106, 108, 110) which does not contain a conductor. The conductor lumens (100, 102, 104) are spaced from one another by a first, minimum spacing and the compression lumen (106, 108, 110) or lumens are located intermediate the conductor lumens and are spaced from the conductor lumens by a second, minimal spacing of less than said first minimum spacing. The centers of the compression lumens (106, 108, 110) are located along lines which pass through both the center of a conductor lumen and the center of the lead body. The arrangement of the conductor and compression lumens enhances the lead's ability to survive crushing forces such as applied by the first rib and clavicle.
摘要翻译：一种具有位于细长引线体（10）内的多个导体的医用电引线，其具有多个导体管腔（100,102,104），每个导体腔体包含导体（112,114）和至少一个压缩内腔（106,104） 108,110），其不包含导体。导体腔（100,102,104）彼此隔开第一最小间隔，并且压缩腔（106,108,110）或管腔位于导体腔之间，并且与导体腔间隔第二，小于所述第一最小间距的最小间距。压缩腔（106,108,110）的中心沿着穿过导体内腔的中心和引线主体的中心的线定位。导体和压缩腔的布置增强了铅的存活力，例如由第一肋和锁骨施加的破碎力。

8. 发明申请

WO1996004040A1 LEAD WITH STYLET CAPTURE MEMBER 审中-公开
标题翻译：领导与收购成员
公开(公告)号：WO1996004040A1
公开(公告)日：1996-02-15
申请号：PCT/US1995009357
申请日：1995-07-24
申请人： MEDTRONIC, INC. , OTTEN, Lynn, M.
发明人： MEDTRONIC, INC.
IPC分类号： A61N01/05
CPC分类号： A61N1/05 , A61M25/01 , A61N1/0551
摘要： A lead having a capture member for releasably engaging the enlarged distal tip of a stylet. The capture member is connected to the flexible tubular casing of the lead near the distal end and includes an aperture having a necked down portion and a socket portion. The socket portion is shaped to accommodate the enlarged distal tip of the stylet. As the stylet is advanced towards the distal end of the lead the enlarged tip enters the necked down portion and is directed towards the socket portion until it pops into and is engaged within the socket portion. Once engaged the lead can be advanced, partially withdrawn, or turned by manipulating the stylet handle.
摘要翻译：具有用于可释放地接合探针的扩大的远端的捕获构件的引线。捕获构件在远端附近连接到引线的柔性管状壳体，并且包括具有颈缩部分和插座部分的孔。插座部分成形为容纳探针的扩大的远端。当探针推进到引线的远端时，扩大的尖端进入颈缩部分并且被引向插座部分，直到其进入插座部分并且被接合在插座部分内。一旦接合，可以通过操纵探针手柄来提前，部分撤回或转动。

9. 发明申请

WO1995024941A1 MEDICAL ELECTRICAL LEAD 审中-公开
标题翻译：医用电线
公开(公告)号：WO1995024941A1
公开(公告)日：1995-09-21
申请号：PCT/US1995002817
申请日：1995-03-06
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , BREYEN, Mark, D. , LESSAR, Joseph, F. , STOKES, Kenneth, B. , UPTON, James, E. , ISTEPHANOUS, Naim, S. , MILLER, Jennifer, P.
IPC分类号： A61N01/05
CPC分类号： A61N1/056
摘要： A medical electrical lead of the type which includes an electrode at a distal end of the lead, a connector at a proximal end of the lead and an elongated electrical conductor extending between the electrode and the connector. The conductor is comprised of a wire wound in a coil configuration with the wire comprised of a duplex titanium alloy. Materials of such composition have been found to have suitable conductivity for use with implantable pulse generators and suitable fatigue strength when used in endocardial lead placement. Moreover, such materials have been found to pass tests intended to detect metal ion oxidation (MIO) in susceptible polymeric materials.
摘要翻译：一种医用电引线，其包括在引线的远端处的电极，在引线的近端处的连接器和在电极和连接器之间延伸的细长电导体。导线由线圈构造的线组成，线由双相钛合金组成。已经发现这种组合物的材料具有适合的导电性，用于可植入的脉冲发生器，并且当用于心内膜引导放置时具有合适的疲劳强度。此外，已经发现这些材料通过旨在检测敏感聚合材料中的金属离子氧化（MIO）的测试。

10. 发明申请

WO1995011723A1 METHOD OF MANUFACTURING A MEDICAL ELECTRICAL LEAD 审中-公开
标题翻译：制造医用电线的方法
公开(公告)号：WO1995011723A1
公开(公告)日：1995-05-04
申请号：PCT/US1994011651
申请日：1994-10-14
申请人： MEDTRONIC, INC. , SCHILDGEN, Gary, R. , WAIT, Charles, R.
发明人： MEDTRONIC, INC.
IPC分类号： A61N01/05
CPC分类号： B22F3/225 , A61N1/056 , A61N1/0568 , B22F7/004 , B22F7/04 , B22F2998/00 , B22F2999/00 , Y10T29/49002 , Y10T29/49117 , B22F1/0048 , B22F3/22 , B22F2201/20 , B22F3/10
摘要： A method of manufacturing a medical electrical lead and, in particular, a method of manufacturing a sintered porous platinized electrode used in a steroid eluting pacing cardiac lead which offers increased dimensional and shape consistency over previously used manufacturing methods. The medical electrical lead comprises an electrical conductor covered by an insulating sleeve, a connector coupled to one end of said electrical conductor, an electrode coupled to the opposite end of the electrical conductor for conducting electrical energy to and from a body. The method of manufacturing the electrode consists primarily of mixing a conductive particulate material and a binder to form a slurry, introducing a distal end of a substrate into a mold, creating a negative pressure in the mold, injecting the slurry into the mold to form a mass of conductive particulate material on the substrate, and sintering the mold, substrate and conductive particulate material to form an electrode.
摘要翻译：一种医用电线的制造方法，特别是制造用于类固醇洗脱式起搏心脏引线的烧结多孔铂电极的方法，其提供了比以前使用的制造方法更大的尺寸和形状一致性。医疗电引线包括由绝缘套管覆盖的电导体，连接到所述电导体的一端的连接器，连接到电导体的相对端的电极，用于向身体传导电能。电极的制造方法主要包括将导电性颗粒材料和粘合剂混合以形成浆料，将基材的远端引入模具中，在模具中产生负压，将浆料注入模具中以形成导电颗粒材料的质量，并且烧结模具，衬底和导电颗粒材料以形成电极。

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