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1. 发明申请

WO2013014539A3 DEVICES FOR REDUCING LEFT ATRIAL PRESSURE HAVING BIODEGRADABLE CONSTRICTION, AND METHODS OF MAKING AND USING SAME 审中-公开
公开(公告)号：WO2013014539A3
公开(公告)日：2013-01-31
申请号：PCT/IB2012/001859
申请日：2012-07-27
申请人： V-WAVE LTD. , NITZAN, Yaacov , YACOBY, Menashe
发明人： NITZAN, Yaacov , YACOBY, Menashe
IPC分类号： A61B17/00 , A61F2/24
摘要： A device (100) for regulating blood pressure between a patient's left atrium and right atrium comprises an hourglass-shaped stent (110) comprising a neck region (104) and first and second flared end regions (102, 106), the neck region disposed between the first and second end regions and configured to engage the fossa ovalis of the patient's atrial septum; and a one-way tissue valve coupled to the first flared end region and configured to shunt blood from the left atrium to the right atrium when blood pressure in the left atrium exceeds blood pressure in the right atrium. The inventive device may include a biodegradable material that biodegrades to offset flow changes caused by tissue ingrowth. The inventive device may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits.

2. 发明申请

WO2009149462A3 LOW PROFILE TRANSCATHETER HEART VALVE 审中-公开
标题翻译：低剖面转盘心阀
公开(公告)号：WO2009149462A3
公开(公告)日：2010-02-04
申请号：PCT/US2009046646
申请日：2009-06-08
申请人： EDWARDS LIFESCIENCES CORP , HARITON ILIA , BENICHOU NETANEL , NITZAN YAACOV , FELSEN BELLLA , NGUYEN-THIEN-NH DIANA , KHANNA RAJESH , NGUYEN SON , LEVI TAMIR , PELLED ITAI
发明人： HARITON ILIA , BENICHOU NETANEL , NITZAN YAACOV , FELSEN BELLLA , NGUYEN-THIEN-NH DIANA , KHANNA RAJESH , NGUYEN SON , LEVI TAMIR , PELLED ITAI
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2002/9522 , A61F2220/0033 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , Y10T29/49863
摘要： An implantable prosthetic valve (10), according to one embodiment, comprises a frame (12), a leaflet structure (14), and a skirt member (16). The frame can have a plurality of axial struts (20) interconnected by a plurality of circumferential struts (22, 24). The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.
摘要翻译：根据一个实施例的可植入人造瓣膜（10）包括框架（12），小叶结构（14）和裙部构件（16）。框架可以具有通过多个圆周支柱（22,24）互连的多个轴向支柱（20）。小叶结构包括多个传单（例如，安排形成三尖瓣的三个小叶）。小叶结构具有固定到框架的扇形下边缘部分。裙部构件可以设置在小叶结构和框架之间。

3. 发明申请

WO2006129087A1 SURGICAL SYSTEM AND METHOD 审中-公开
标题翻译：外科系统与方法
公开(公告)号：WO2006129087A1
公开(公告)日：2006-12-07
申请号：PCT/GB2006/001985
申请日：2006-06-01
申请人： DEPUY INTERNATIONAL LTD , BIOSENSE WEBSTER INC , DEPUY ORTHOPÄDIE GMBH , REVIE, Ian , NITZAN, Yaacov , SLOMCZYKOWSKI, Mike , HAECHLER, Joerg
发明人： REVIE, Ian , NITZAN, Yaacov , SLOMCZYKOWSKI, Mike , HAECHLER, Joerg
IPC分类号： G06T17/40
CPC分类号： A61B90/36 , A61B34/10 , A61B34/20 , A61B2034/102 , A61B2034/105 , A61B2034/108 , A61B2034/2051 , A61B2034/2055 , A61F2002/4633
摘要： Methods, systems and data processing apparatus and methods are described for use in planning and carrying out a surgical procedure on a joint of a subject. The joint includes a first component and a second component, the first and second components being relatively movable. Joint data describing the configuration of the joint is captured while the joint is in a functional state in which the joint is undergoing its usual load bearing functional behaviour. The joint data is analysed to determine joint component orientation data specifying the relative orientation of the first and second components. The orientation of prosthetic implants to be used in the surgical procedure to recreate the joint is planned using the joint component orientation data. The planned orientation of the prosthetic implants improves the recreation of the functional state of the joint.
摘要翻译：描述了用于在受试者的关节上规划和执行外科手术的方法，系统和数据处理装置和方法。接头包括第一部件和第二部件，第一和第二部件是可相对移动的。在关节处于关节正在承受其通常的承载功能行为的功能状态下，捕获描述关节的构造的联合数据。分析联合数据以确定指定第一和第二组分的相对取向的联合分量取向数据。使用联合分量取向数据计划在外科手术中用于重建关节的假体植入物的取向。假体植入物的计划取向改善了关节功能状态的恢复。

4. 发明申请

WO2005084544A1 ORTHOPAEDIC MONITORING SYSTEM, METHODS AND APPARATUS 审中-公开
标题翻译： ORTHOPEDIC监测系统，方法和装置
公开(公告)号：WO2005084544A1
公开(公告)日：2005-09-15
申请号：PCT/GB2005/000854
申请日：2005-03-07
申请人： DEPUY INTERNATIONAL LTD , BIOSENSE WEBSTER, INC. , REVIE, Ian , ASHBY, Alan , REZNIK, Dudi , NITZAN, Yaacov
发明人： REVIE, Ian , ASHBY, Alan , REZNIK, Dudi , NITZAN, Yaacov
IPC分类号： A61B5/11
CPC分类号： A61B5/6878 , A61B5/0031 , A61B5/103 , A61B5/1118 , A61B5/1121 , A61B5/1127 , A61B5/4528 , A61B5/4571 , A61B5/4585 , A61B5/686 , A61B5/7246 , A61B5/7445 , A61B90/98 , A61B2090/3916 , A61B2090/3975 , A61F2002/3067
摘要： Methods, systems and apparatus for monitoring and assessing the orthopaedic performance of a patient are described. The method can comprise implanting at least a first and second RF wirelessly detectable markers in first and second bones associated with a site. A procedure can be carried out on the site and the positions of the first and second markers can be detected after the procedure has been completed. The detected positions can be used to assess the orthopaedic performance of the patient. An orthopaedic monitoring system comprises a monitoring station including a tracking system for RF wirelessly detecting the positions of markers within a working volume of the monitoring station. A computer control system is configured to determine a marker position for each of a plurality of markers implanted in a patient located in the working volume. The computer control system also generates an indication of the orthopaedic performance of the patient from the marker positions. The computer implemented method comprises identifying each of the plurality of markers, determining the positions of each of the markers and using the positions of the markers to generate a representation of the orthopaedic performance of the patient.
摘要翻译：描述了用于监测和评估患者的整形外科性能的方法，系统和装置。该方法可以包括在与位点相关联的第一和第二骨中植入至少第一和第二RF无线可检测标记。可以在现场执行程序，并且可以在程序完成后检测第一和第二标记的位置。检测到的位置可用于评估患者的整形外科表现。整形外科监测系统包括监测站，该监测站包括用于RF无线地检测监测站工作体积内标记位置的跟踪系统。计算机控制系统被配置为确定植入位于工作体积中的患者中的多个标记中的每一个的标记位置。计算机控制系统还从标记位置产生患者的整形外科表现。计算机实现的方法包括识别多个标记中的每一个，确定每个标记的位置，并使用标记的位置来生成患者的矫形表现的表示。

5. 发明申请

WO2006090134A2 IMPLANTABLE SENSOR 审中-公开
标题翻译：可植入传感器
公开(公告)号：WO2006090134A2
公开(公告)日：2006-08-31
申请号：PCT/GB2006/000600
申请日：2006-02-21
申请人： DEPUY INTERNATIONAL LIMITED , BIOSENSE WEBSTER INC , NITZAN, Yaacov , SPECTOR, Ben-Zion
发明人： NITZAN, Yaacov , SPECTOR, Ben-Zion
IPC分类号： G01D11/24 , A61B19/00
CPC分类号： A61B5/6864 , A61B5/06 , A61B5/062 , A61B5/4504 , A61B90/39 , A61B2090/3975 , G01D11/245
摘要： A sensor which can be implanted in a body part to collect data relating to the body part, the sensor includes a jacket which has a side wall which can be deformed inwardly, and first and second ends. A sensor part is contained within the jacket, and fastened to the jacket at or towards the first end of the jacket. The sensor part is at least partially isolated from compressive forces applied to the sensor which cause the side wall of the jacket to deform inwardly.
摘要翻译：传感器可植入身体部位以收集关于身体部位的数据，该传感器包括具有可向内变形的侧壁的护套以及第一端和第二端。传感器部件包含在护套内，并且在护套的第一端或朝向护套的第一端固定到护套上。传感器部分至少部分地与施加于传感器的压缩力隔离，这使得护套的侧壁向内变形。

6. 发明申请

WO2012085913A3 DEVICES FOR REDUCING LEFT ATRIAL PRESSURE, AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：用于降低左心房压力的装置，以及制造和使用该装置的方法
公开(公告)号：WO2012085913A3
公开(公告)日：2012-12-06
申请号：PCT/IL2011000958
申请日：2011-12-22
申请人： WAVE LTD V , NITZAN YAACOV , YACOBY MENASHE
发明人： NITZAN YAACOV , YACOBY MENASHE
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00623 , A61F2/2415 , A61F2/2418 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/001 , A61F2230/005 , A61F2230/0078
摘要： A device for regulating blood pressure between a patient's left atrium and right atrium comprises an hourglass-shaped stent comprising a neck region and first and second flared end regions, the neck region disposed between the first and second end regions and configured to engage the fossa ovalis of the patient's atrial septum; and a one-way tissue valve coupled to the first flared end region and configured to shunt blood from the left atrium to the right atrium when blood pressure in the left atrium exceeds blood pressure in the right atrium. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices may be used, for example, to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.
摘要翻译：一种用于调节患者的左心房和右心房之间的血压的装置包括沙漏形支架，该沙漏形支架包括颈部区域以及第一和第二喇叭形端部区域，所述颈部区域设置在第一和第二端部区域之间并且构造成接合卵圆窝的患者房间隔; 以及单向组织瓣膜，所述单向组织瓣膜联接至所述第一扩张端部区域并且配置为当左心房中的血压超过右心房中的血压时将血液从左心房分流至右心房。本发明的装置可以降低左心房压力和左心室舒张末期压力，并且可以增加心输出量，增加射血分数，减轻肺淤血和降低肺动脉压力等等。例如，本发明的装置可用于治疗具有心力衰竭，肺充血或心肌梗塞等病症的受试者。

7. 发明申请

WO2009149462A8 LOW PROFILE TRANSCATHETER HEART VALVE 审中-公开
标题翻译：低剖面转盘心阀
公开(公告)号：WO2009149462A8
公开(公告)日：2011-01-27
申请号：PCT/US2009046646
申请日：2009-06-08
申请人： EDWARDS LIFESCIENCES CORP , HARITON ILIA , BENICHOU NETANEL , NITZAN YAACOV , FELSEN BELLA , NGUYEN-THIEN-NH DIANA , KHANNA RAJESH , NGUYEN SON , LEVI TAMIR , PELLED ITAI
发明人： HARITON ILIA , BENICHOU NETANEL , NITZAN YAACOV , FELSEN BELLA , NGUYEN-THIEN-NH DIANA , KHANNA RAJESH , NGUYEN SON , LEVI TAMIR , PELLED ITAI
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2002/9522 , A61F2220/0033 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , Y10T29/49863
摘要： An implantable prosthetic valve (10), according to one embodiment, comprises a frame (12), a leaflet structure (14), and a skirt member (16). The frame can have a plurality of axial struts (20) interconnected by a plurality of circumferential struts (22, 24). The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.
摘要翻译：根据一个实施例的可植入人造瓣膜（10）包括框架（12），小叶结构（14）和裙部构件（16）。框架可以具有通过多个圆周支柱（22,24）互连的多个轴向支柱（20）。小叶结构包括多个传单（例如，安排形成三尖瓣的三个小叶）。小叶结构具有固定到框架的扇形下边缘部分。裙部构件可以设置在小叶结构和框架之间。

8. 发明申请

WO2010128501A1 DEVICE AND METHOD FOR REGULATING PRESSURE IN A HEART CHAMBER 审中-公开
标题翻译：用于调节心室压力的装置和方法
公开(公告)号：WO2010128501A1
公开(公告)日：2010-11-11
申请号：PCT/IL2010/000354
申请日：2010-05-04
申请人： V-WAVE LTD. , NITZAN, Yaacov , HARARI, Boaz , GLICK, Shmuel , SHMULEWITZ, Ascher , SIVAN, Tovy
发明人： NITZAN, Yaacov , HARARI, Boaz , GLICK, Shmuel , SHMULEWITZ, Ascher , SIVAN, Tovy
IPC分类号： A61F2/24
CPC分类号： A61M27/002 , A61F2/2412 , A61F2/2418 , A61F2002/249 , A61F2220/0058 , A61F2220/0066 , A61F2230/0013 , A61F2230/0078 , A61M27/006
摘要： A device for regulating blood pressure in a heart chamber is provided. The device includes a shunt positionable within a septum of the heart. The shunt is designed for enabling blood flow between a left heart chamber and a right heart chamber, wherein the flow rate capacity of the device is mostly a function of pressure in the left heart chamber.
摘要翻译：提供了一种用于调节心脏室中的血压的装置。该装置包括可定位在心脏隔膜内的分流器。分流器被设计用于使左心室和右心室之间的血液流动，其中装置的流量容量主要是左心室中的压力的函数。

9. 发明申请

WO2013014539A2 DEVICES FOR REDUCING LEFT ATRIAL PRESSURE HAVING BIODEGRADABLE CONSTRICTION, AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：用于减少具有生物可降解约束力的左心室压力的装置，以及制造和使用其的方法
公开(公告)号：WO2013014539A2
公开(公告)日：2013-01-31
申请号：PCT/IB2012001859
申请日：2012-07-27
申请人： WAVE LTD V , NITZAN YAACOV , YACOBY MENASHE
发明人： NITZAN YAACOV , YACOBY MENASHE
CPC分类号： A61F2/2412 , A61B17/0057 , A61B2017/00004 , A61B2017/00243 , A61B2017/00252 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61F2/2418 , A61F2210/0004 , A61F2230/001 , A61F2250/0039
摘要： A device for regulating blood pressure between a patient's left atrium and right atrium comprises an hourglass-shaped stent comprising a neck region and first and second flared end regions, the neck region disposed between the first and second end regions and configured to engage the fossa ovalis of the patient's atrial septum; and a one-way tissue valve coupled to the first flared end region and configured to shunt blood from the left atrium to the right atrium when blood pressure in the left atrium exceeds blood pressure in the right atrium. The inventive device may include a biodegradable material that biodegrades to offset flow changes caused by tissue ingrowth. The inventive device may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits.
摘要翻译：用于调节患者左心房和右心房之间的血压的装置包括沙漏形支架，其包括颈部区域和第一和第二扩张末端区域，所述颈部区域设置在第一和第二端部区域之间，并且被配置为接合卵圆窝的患者房间隔; 以及单向组织瓣膜，其联接到所述第一扩张末端区域并且构造成当左心房中的血压超过右心房中的血压时将血液从左心房分流到右心房。本发明的装置可以包括生物降解材料，其生物降解以抵消由组织向内生长引起的流动变化。本发明的装置可以减少左心房压力和左心室舒张末期压力，并且可以增加心输出量，增加射血分数，减轻肺部充血以及降低肺动脉压力等益处。

10. 发明申请

WO2012085913A2 DEVICES FOR REDUCING LEFT ATRIAL PRESSURE, AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：用于减少左心室压力的装置，以及制造和使用它们的方法
公开(公告)号：WO2012085913A2
公开(公告)日：2012-06-28
申请号：PCT/IL2011/000958
申请日：2011-12-22
申请人： V-WAVE LTD. , NITZAN, Yaacov , YACOBY, Menashe
发明人： NITZAN, Yaacov , YACOBY, Menashe
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00623 , A61F2/2415 , A61F2/2418 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/001 , A61F2230/005 , A61F2230/0078
摘要： A device for regulating blood pressure between a patient's left atrium and right atrium comprises an hourglass-shaped stent comprising a neck region and first and second flared end regions, the neck region disposed between the first and second end regions and configured to engage the fossa ovalis of the patient's atrial septum; and a one-way tissue valve coupled to the first flared end region and configured to shunt blood from the left atrium to the right atrium when blood pressure in the left atrium exceeds blood pressure in the right atrium. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices may be used, for example, to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.
摘要翻译：用于调节患者左心房和右心房之间的血压的装置包括沙漏形支架，其包括颈部区域和第一和第二扩张末端区域，所述颈部区域设置在第一和第二端部区域之间，并且被配置为接合卵圆窝的患者房间隔; 以及单向组织瓣膜，其联接到所述第一扩张末端区域并且构造成当左心房中的血压超过右心房中的血压时将血液从左心房分流到右心房。本发明的装置可以减少左心房压力和左心室舒张末期压力，并且可以增加心输出量，增加射血分数，缓解肺充血以及降低肺动脉压力等益处。本发明的装置可以用于例如治疗具有心力衰竭，肺充血或心肌梗死的受试者以及其它病症。

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