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1. 发明申请

WO2018184717A2 FLUSSREDUKTOR 审中-公开
公开(公告)号：WO2018184717A2
公开(公告)日：2018-10-11
申请号：PCT/EP2018/000135
申请日：2018-03-29
申请人： CHRISTOPH MIETHKE GMBH & CO. KG
发明人： MIETHKE, Christoph
IPC分类号： A61M27/00
CPC分类号： A61M27/006
摘要： Die Erfindung betrifft ein Hydrocephalusventil zum Abfluss von Fluid aus Ventrikelsystemen von Patienten, dass mindestens ein Gehäuse mit Gehäuseinnenraum; und mindestens einen ersten Durchlass zum Einlassen und/oder Auslassen aufweist, und mindestens einen Körper; welcher im Gehäuseinnenraum angeordnet ist, wobei der Körper mindestens in einer Richtung bewegbar ausgebildet ist, wobei mindestens eine Einstelleinheit vorhanden ist. Die Erfindung hat sich gleichwohl einer Existenz bewährter Ventile die Aufgabe gestellt, Ventile zu verbessern. Sie löst dies dadurch, dass die Einstelleinheit ausgebildet ist, mindestens eine Abflussgeschwindigkeit im Durchlass einzustellen, und die Abflussgeschwindigkeit bei einem am Hydrocephalusventil anliegenden Druck von 20 cm Wassersäule die Abflussgeschwindigkeit zwischen 1 ml pro Stunde und 1000 ml pro Stunde einstellbar macht, um durch diese Einstellung eine aus dem Abfluss resultierende Änderung des Druckes im Ventrikelsystem zu verlangsamen oder zu beschleunigen.

2. 发明申请

WO2017143161A1 SYSTEMS AND METHODS FOR CONTROLLING A VOLUME OF FLUID WITHIN A PORTION OF A PATIENT'S BODY 审中-公开
标题翻译：用于在患者身体的一部分内控制一定体积的流体的系统和方法
公开(公告)号：WO2017143161A1
公开(公告)日：2017-08-24
申请号：PCT/US2017/018330
申请日：2017-02-17
申请人： LUCIANO, Mark
发明人： LUCIANO, Mark
IPC分类号： A61M25/00 , A61M1/00 , A61B5/00
CPC分类号： A61B5/00 , A61M1/0058 , A61M27/006
摘要： The present disclosure relates generally to controlling a volume of fluid within a portion of a patient's body. For example, the present disclosure can relate to the addition or removal of cerebral spinal fluid (CSF) from a portion of the patient's brain. The amount of fluid can be controlled by a system that includes a dual chamber probe and a volume control. One channel can include a drain element to drain the fluid from the portion of a patient's body. The other channel can include a volume changing element to facilitate the drainage of the fluid by changing a volume of the portion of the patient's body. The volume changing element can be coupled to a volume control, which can control the change of the volume of the portion of the patient's body (e.g., based on passive oscillation or active oscillation).
摘要翻译：本公开总体上涉及控制患者身体的一部分内的流体体积。例如，本公开可涉及从患者脑部的一部分添加或除去脑脊液（CSF）。流体的数量可以通过包括双室探头和音量控制的系统进行控制。一个通道可以包括排出元件以从患者身体的一部分排出流体。另一个通道可以包括体积改变元件，以通过改变患者身体部分的体积来促进流体的排出。体积改变元件可以耦合到音量控制器，该音量控制器可以控制病人身体部分的体积的改变（例如，基于被动振荡或主动振荡）。

3. 发明申请

WO2017117138A1 AN APPARATUS AND METHOD FOR CEREBRAL MICRODIALYSIS TO TREAT NEUROLOGICAL DISEASE, INCLUDING ALZHEIMER'S, PARKINSON'S OR MULTIPLE SCLEROSIS 审中-公开
标题翻译：用于脑微透析治疗神经系统疾病的装置和方法，包括阿尔茨海默氏病，帕金森氏病或多发性硬化症
公开(公告)号：WO2017117138A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/068725
申请日：2016-12-27
申请人： COGNOST THERAPEUTICS INC.
发明人： CHEN, Thomas , SHACHAR, Yehoshua , KORNBERG, Roger
IPC分类号： A61M1/14 , G01N33/53 , A61K39/395 , A61P25/28
CPC分类号： G01N33/6896 , A61M1/14 , A61M27/006 , A61M2202/0464 , A61M2210/0693 , C07K16/18 , G01N2333/4709 , G01N2800/2821 , G01N2800/2835 , G01N2800/52
摘要： An apparatus for performing cerebral micro-dialysis to treat neurological disease of a patient's brain includes a catheter for implantation in or near the patient's brain, an implantable pump communicated with the catheter to transport cerebrospinal fluid (CSF) from the patient, which CSF contains diseased cells or biomolecules associated with the neurological disease, and an implantable separation device communicated with the pump wherein the diseased cells or biomolecules are removed, where the separation apparatus includes a dialysis membrane impregnated with an antibody, a reversible electrostatic filter, and/or a magnetic field effect fractionation chamber wherein a magnetically-tagged antibody scavenges and aids in the removal of circulating diseased cells or biomolecules from the CSF,
摘要翻译：用于执行脑微透析以治疗患者脑部的神经疾病的装置包括用于植入患者脑内或患者脑部附近的导管，与导管连通以输送脑脊髓液（CSF）的可植入泵，来自患者，该CSF含有与神经疾病相关的患病细胞或生物分子，以及与泵连通的可移植分离装置，其中移除患病细胞或生物分子，其中分离装置包括浸渍有抗体的透析膜，可逆静电过滤器和/或磁场效应分级室，其中磁性标记抗体清除并有助于从CSF中去除循环病变细胞或生物分子，

4. 发明申请

WO2016200949A1 CEREBROSPINAL FLUID FLOW DIVERTER 审中-公开
标题翻译：脑脊液流量流
公开(公告)号：WO2016200949A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/036458
申请日：2016-06-08
申请人： HAUGHTON, Victor M.
发明人： HAUGHTON, Victor M.
IPC分类号： A61B5/03
CPC分类号： A61M27/006 , A61M25/10183 , A61M25/10185 , A61M39/06 , A61M2025/1081 , A61M2039/062 , A61M2210/0687 , A61M2210/0693 , A61M2230/005 , A61M2230/30
摘要： A device that can be placed within or near the cranial vault that fluctuates in size in response to changes in CSF pressure is disclosed. The device diminishes in size when CSF pressures rise and increases in size as CSF pressures diminish. The device has the effect of reducing the flow of CSF occurring in the foramen magnum and provides an alternative to craniovertebral decompression in Chiari I patients. The device may have applications in other neurologic illnesses associated with abnormal CSF flow, such as Idiopathic Syringomyelia, Normal Pressure Hydrocephalus, and CSF dural leaks.
摘要翻译：公开了一种能够放置在脑脊库内或附近的装置，该装置响应于CSF压力的变化而大小波动。当CSF压力升高时，该装置的尺寸减小，随着CSF压力的降低，尺寸增加。该装置具有减少在孔中发生的CSF的流动的作用，并提供了Chiari I患者颅骨减压的替代方案。该装置可能在与异常CSF流动相关的其他神经系统疾病中具有应用，例如特发性脊髓空洞症，正常压力脑积水和CSF硬脑膜渗漏。

5. 发明申请

WO2016196590A1 CATHETER ASSEMBLIES 审中-公开
标题翻译：导管总成
公开(公告)号：WO2016196590A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035211
申请日：2016-06-01
申请人： UNIVERSITY OF MASSACHUSETTS
发明人： CATALTEPE, Oguz
IPC分类号： A61M27/00
CPC分类号： A61M27/006 , A61M25/007 , A61M25/0097 , A61M27/00 , A61M39/02 , A61M39/10 , A61M2025/0681 , A61M2210/0687 , A61M2210/0693
摘要： A catheter assembly for transferring fluid into and out of a ventricle in the brain is disclosed. The catheter assembly include a sheath permanently installed in the brain, a catheter removably disposed in the sheath, and a connector. In some embodiments, the connector includes inner and outer connection portions, the inner connection portion connected to the sheath and catheter, respectively. A distal end of the catheter may include one or more lumens and/or one or more openings for transferring fluid. The catheter assembly may be connected to a shunt valve and distal (e.g., abdominal) catheter. The distal catheter may be removably disposed within a distal sheath that is permanently attached below the skin of the patient.
摘要翻译：公开了一种用于将流体输入和流出脑中的脑室的导管组件。导管组件包括永久安装在脑中的护套，可拆卸地设置在护套中的导管和连接器。在一些实施例中，连接器包括内部和外部连接部分，内部连接部分别分别连接到护套和导管。导管的远端可以包括用于传送流体的一个或多个腔和/或一个或多个开口。导管组件可以连接到分流阀和远端（例如腹部）导管。远侧导管可以可移除地设置在永久地附着在患者皮肤下方的远侧护套内。

6. 发明申请

WO2015140179A3 PERCUTANEOUS SYSTEM, DEVICES AND METHODS 审中-公开
标题翻译：经皮系统，装置和方法
公开(公告)号：WO2015140179A3
公开(公告)日：2015-12-17
申请号：PCT/EP2015055578
申请日：2015-03-17
申请人： NUHEART AS
发明人： TUSETH VEGARD
IPC分类号： A61M1/12
CPC分类号： A61M1/1008 , A61B17/00234 , A61B17/11 , A61B17/3468 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00685 , A61B2017/00867 , A61B2017/00876 , A61B2017/1107 , A61B2017/1139 , A61B2017/3488 , A61M1/10 , A61M1/101 , A61M1/1024 , A61M1/1029 , A61M1/1086 , A61M1/122 , A61M1/125 , A61M1/127 , A61M25/09 , A61M27/002 , A61M27/006 , A61M29/00 , A61M2205/8243
摘要： The present invention relates to a transcatheter method for providing fluid communication between two anatomical compartments. The present invention also relates to a transcatheter system comprising an intracorporeal connector for fluid communication between two anatomical compartments through at least one anatomical wall, wherein said connector is adapted to receive a flow regulating device, a connector, a flow regulating device and an insertion device.
摘要翻译：本发明涉及用于提供两个解剖室之间的流体连通的经导管方法。本发明还涉及一种经导管系统，其包括用于通过至少一个解剖壁在两个解剖室之间流体连通的体内连接器，其中所述连接器适于容纳流量调节装置，连接器，流量调节装置和插入装置。

7. 发明申请

WO2015161306A1 SYSTEMS AND METHODS FOR SHUNTING FLUID 审中-公开
标题翻译：用于流体流动的系统和方法
公开(公告)号：WO2015161306A1
公开(公告)日：2015-10-22
申请号：PCT/US2015/026555
申请日：2015-04-18
申请人： ALCYONE LIFESCIENCES, INC.
发明人： EAST, Andrew , BROPHY, Morgan , SINGH, Deep, Arjun , ANAND, PJ , DEGON, Robert , FALLON, Timothy , WALLER, Allison , ATTAR, Matthew
IPC分类号： A61M27/00
CPC分类号： A61M27/006 , A61M39/225 , A61M2027/004 , A61M2039/0018
摘要： Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system are also disclosed herein, as are various systems and methods for opening auxiliary fluid pathways through a shunt system.
摘要翻译：本文提供的系统和方法通常涉及分流流体，例如在治疗脑积水时分流脑脊液。提供了自清洁导管，其包括分开的尖端，其被配置为使得在其中插入导管的空腔中的脉动流动可导致尖端彼此撞击，从而清除障碍物。还提供了内置流量指示器的导管。示例性的流动指示器包括从导管的内表面径向向内延伸并且包括可成像部分（例如，在磁共振成像（MRI）下可见的部分）的突出部。可以使用MRI检测由流体流过导管引起的流动指示器的运动，从而提供导管是否部分或完全阻塞的可靠指示。本文还公开了用于冲洗分流系统的系统和方法，以及用于打开通过分流系统的辅助流体路径的各种系统和方法。

8. 发明申请

WO2015157334A1 PROGRAMMABLE CSF METERING SHUNT 审中-公开
标题翻译：可编程脑脊髓计量仪
公开(公告)号：WO2015157334A1
公开(公告)日：2015-10-15
申请号：PCT/US2015/024779
申请日：2015-04-07
申请人： CSF REFRESH LLC
发明人： SAUL, Tom , HOVATEN, Kristof
IPC分类号： A61M27/00
CPC分类号： A61M27/006 , A61M2205/3334 , A61M2205/3344 , A61M2205/52 , A61M2205/8206 , F16K99/0015 , F16K99/0057 , F16K2099/0088
摘要： An implantable body fluid drainage system includes a metering shunt having a housing with an internal chamber. A movable barrier divides the chamber into a first section and a second section, and the barrier can be displaced by a differential pressure. A first powered inlet valve providing a fill path to the first section of the chamber, and a first powered drain valve providing a drain path from the first section of the chamber. A CSF inlet conduit connects a CSF space to the first powered inlet valve. A CSF outlet conduit connects the first powered outlet valve to a discharge location. A controller opens the first powered inlet valve and close the first powered drain valve to fill the first section to a volume defined by the barrier and chamber geometry and closes the first powered inlet valve and opens the first powered drain valve to discharge the filled volume from the first section through the outlet conduit.
摘要翻译：可植入体液排出系统包括具有具有内室的壳体的计量分流器。可动挡板将腔室分成第一部分和第二部分，并且阻挡物可以通过压差移位。第一供电入口阀提供到腔室的第一部分的填充路径，以及第一动力排水阀，其从腔室的第一部分提供排出路径。 CSF入口导管将CSF空间连接到第一动力入口阀。 CSF出口导管将第一供电出口阀连接到排放位置。控制器打开第一个动力入口阀并关闭第一个动力排水阀，以将第一部分填充到由阻挡和室几何形状限定的体积上，并关闭第一个动力入口阀，并打开第一个动力排水阀，以将填充体积从第一部分通过出口管道。

9. 发明申请

WO2015116906A1 VENTRICULAR CATHETER 审中-公开
标题翻译：静电导管
公开(公告)号：WO2015116906A1
公开(公告)日：2015-08-06
申请号：PCT/US2015/013710
申请日：2015-01-30
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , RICHARDSON, Dusty , WINSTON, Ken
发明人： RICHARDSON, Dusty , WINSTON, Ken
IPC分类号： A61M25/00
CPC分类号： A61M25/007 , A61M25/0097 , A61M25/0102 , A61M27/006 , A61M2025/0063 , A61M2202/0464 , A61M2210/0693
摘要： The present invention provides a ventricular catheter designed to prevent or reduce CSF shunt obstruction. In particular, the ventricular catheter of the invention comprises a tube having a distal end and a tapered proximal end, in which the tapered proximal end comprises a plurality of slotted openings.
摘要翻译：本发明提供了设计用于预防或减少CSF分流阻塞的心室导管。特别地，本发明的心室导管包括具有远端和锥形近端的管，其中锥形近端包括多个开槽开口。

10. 发明申请

WO2015058085A1 WEARABLE EXTERNAL VENTRICULAR DRAIN SYSTEM 审中-公开
标题翻译：可靠的外部静脉排水系统
公开(公告)号：WO2015058085A1
公开(公告)日：2015-04-23
申请号：PCT/US2014/061137
申请日：2014-10-17
申请人： STEBBINS, Kristen , PENNELL, Thomas, J.
发明人： STEBBINS, Kristen , PENNELL, Thomas, J.
IPC分类号： A61M1/00
CPC分类号： A61M1/0035 , A61M1/0021 , A61M27/006 , A61M2205/3523 , A61M2205/3561 , A61M2209/088 , A61M2210/0693 , A61M2230/00 , F16K1/2071 , F16K1/38 , F16K5/10 , F16K15/063 , F16K17/04 , Y10T137/7932 , Y10T137/7935
摘要： A wearable EVD system having a ventricular catheter and transducer supported proximately to a patient's ear by a mount, such as supporting headband or ear clip. An adjustable orifice valve or a spring-loaded needle valve is used to control the amount of CSF that drains into a drip chamber suspended on the patient for periodic measurement and emptying into a similarly located drainage bag, thereby avoiding the need for an IV pole and allowing the patient more mobility without disrupting drainage of CSF.
摘要翻译：具有心室导管和换能器的穿戴式EVD系统，其通过诸如支撑头带或耳夹的安装座靠近患者的耳朵来支撑。使用可调节的节流阀或弹簧加载的针阀来控制排入到患者中的滴水室中的CSF的量，以便定期测量并排空到类似位置的排水袋中，从而避免需要IV极和使患者更容易移动，而不会中断CSF的引流。

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