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1. 发明申请

WO2011133663A1 FUNCTIONALIZING BIOSENSORS USING A MULTIPLEXED DIP PEN ARRAY 审中-公开
标题翻译：使用多重DIP笔阵列功能化生物传感器
公开(公告)号：WO2011133663A1
公开(公告)日：2011-10-27
申请号：PCT/US2011/033239
申请日：2011-04-20
申请人： NANOINK, INC. , SMETANA, Alexander, B. , NETTIKADAN, Saju, R.
发明人： SMETANA, Alexander, B. , NETTIKADAN, Saju, R.
IPC分类号： G01N29/036 , G01N33/543 , G03F7/00 , B82Y10/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , G01N2291/0257
摘要： Multiplexed dip pen nanolithography for functionalizing sensors for biological applications, wherein multiple capture molecules are applied to sensor elements such as cantilevers. The sensor element can be a microcantilever.
摘要翻译：用于生物应用的功能化传感器的复用浸渍笔纳米光刻技术，其中多个捕获分子应用于诸如悬臂的传感器元件。传感器元件可以是微型悬臂梁。

2. 发明申请

WO2011008781A1 METHODS FOR FORMING HYDROGELS ON SURFACES AND ARTICLES FORMED THEREBY 审中-公开
标题翻译：表面形成水凝胶的方法及其形成方法
公开(公告)号：WO2011008781A1
公开(公告)日：2011-01-20
申请号：PCT/US2010/041864
申请日：2010-07-13
申请人： NANOINK, INC. , STILES, Paul Leon , NETTIKADAN, Saju , LAM, Ruby , JANG, Jae-Won
发明人： STILES, Paul Leon , NETTIKADAN, Saju , LAM, Ruby , JANG, Jae-Won
IPC分类号： G03F7/00
CPC分类号： G03F7/0002 , Y10T428/24802
摘要： Methods for forming hydrogels on substrates, including patterned hydrogels. One method comprises providing at least one nanoscopic tip, coating the tip with at least one ink composition, and depositing the ink composition onto at least one substrate, wherein the ink composition comprises at least one hydrogel precursor, the hydrogel precursor adapted to form a hydrogel. The precursor can be converted to the hydrogel after patterning. The ink composition can comprise at least two polymers and can be functionalized. The amount of the polymers and the amount of functionalization can be tuned. Also provided are articles formed from the methods, methods for using the articles, ink compositions and related kits.
摘要翻译：在基材上形成水凝胶的方法，包括图案化水凝胶。一种方法包括提供至少一个纳米级尖端，用至少一种油墨组合物涂覆所述尖端，以及将所述油墨组合物沉积在至少一个底物上，其中所述油墨组合物包含至少一种水凝胶前体，所述水凝胶前体适于形成水凝胶。图案化后，可以将前体转化为水凝胶。油墨组合物可以包含至少两种聚合物并且可以被官能化。可以调节聚合物的量和官能化的量。还提供了由方法，使用制品的方法，油墨组合物和相关试剂盒形成的制品。

3. 发明申请

WO2007011405A2 DEVICE AND METHOD OF USE FOR DETECTION AND CHARACTERIZATION OF MICROORGANISMS AND MICROPARTICLES 审中-公开
标题翻译：用于检测和表征微生物和微生物的装置和方法
公开(公告)号：WO2007011405A2
公开(公告)日：2007-01-25
申请号：PCT/US2005038988
申请日：2005-10-26
申请人： BIOFORCE NANOSCIENCES INC , HENDERSON ERIC R , NETTIKADAN SAJU R , MOSHER CURTIS L , JOHNSON JAMES C
发明人： HENDERSON ERIC R , NETTIKADAN SAJU R , MOSHER CURTIS L , JOHNSON JAMES C
IPC分类号： C12Q1/70 , C12M1/26 , C12M1/34 , C12Q1/04 , C12Q1/18 , G01N33/48 , G01N33/50 , G01N33/68 , G01Q30/04 , G01Q60/00 , G06F19/00
CPC分类号： G01N33/56983 , C12M41/36 , C12Q1/04 , C12Q1/18 , C12Q1/686 , G01N33/552 , G01N33/6854 , G01Q70/18 , C12Q2565/518 , C12Q2527/127 , C12Q2521/107
摘要： The present invention includes a method and apparatus for the detection of a microorganism or microparticle.
摘要翻译：本发明包括用于检测微生物或微粒的方法和装置。

4. 发明申请

WO2005115630A3 METHOD AND APPARATUS FOR DEPOSITING MATERIAL ONTO A SURFACE 审中-公开
标题翻译：将材料沉积在表面上的方法和装置
公开(公告)号：WO2005115630A3
公开(公告)日：2006-01-26
申请号：PCT/US2005014899
申请日：2005-04-29
申请人： BIOFORCE NANOSCIENCES INC , HENDERSON ERIC R , XU JUNTAO , LYNCH MICHAEL P , MOSHER CURTIS L , HUFF JANICE LILLIAN , NETTIKADAN SAJU RAPPAI
发明人： HENDERSON ERIC R , XU JUNTAO , LYNCH MICHAEL P , MOSHER CURTIS L , HUFF JANICE LILLIAN , NETTIKADAN SAJU RAPPAI
IPC分类号： A61L2/00 , B01L3/02 , B05B7/06 , B05C1/00 , B05D3/00 , B05C5/00 , G01N1/10
CPC分类号： B01L3/0244 , B01J2219/00387 , B01J2219/00659 , B01L3/0248 , B01L2200/12 , B01L2200/143 , B01L2300/0816 , B01L2300/0838 , B01L2300/10 , B01L2400/02 , B01L2400/0406
摘要： Some embodiments of the present invention provide an apparatus and method in which material is deposited upon a surface from an elongated beam (102) having an aperture (104) defined therein through which the material is moved by passive adsorption. The elongated beam can be substantially planar along substantially its entire length, can be oriented at an acute angle with respect to the surface during deposition processes, and can have a length no greater than about 2mm. In some embodiments, the aperture can be elongated, can extend from a material reservoir (106) to a location short of the terminal end of the elongated beam or through the terminal end of the elongated beam, and can have a portion extending through the thickness of the elongated beam.
摘要翻译：本发明的一些实施例提供了一种装置和方法，其中材料从具有限定在其中的孔（104）的细长梁（102）沉积在表面上，通过该孔径，材料通过被动吸附而移动。细长梁基本上可以在其整个长度上基本上是平面的，在沉积过程中可以相对于表面以锐角定向，并且可以具有不大于约2mm的长度。在一些实施例中，孔可以是细长的，可以从材料储存器（106）延伸到短于细长梁的终端的位置或者通过细长梁的终端，并且可以具有延伸穿过厚度的部分的细长梁。

5. 发明申请

WO2012166794A1 PATTERNING AND CELLULAR CO-CULTURE 审中-公开
标题翻译：文化与细胞文化
公开(公告)号：WO2012166794A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/039991
申请日：2012-05-30
申请人： NANOINK, INC. , COLLINS, John, M. , NETTIKADAN, Saju, R.
发明人： COLLINS, John, M. , NETTIKADAN, Saju, R.
IPC分类号： C12N5/00 , G01N33/50
CPC分类号： C12N5/0068 , C12N2502/00 , C12N2533/12 , C12N2533/52 , C12N2535/10 , G01N2500/10
摘要： Cell co-culturing methods and arrays providing versatility and high resolution. A method comprising: providing at least one substrate; providing at least one first tip with at least one first cell-adhesion material disposed thereon, and at least one second tip with at least one second cell-adhesion material disposed thereon, wherein the first cell-adhesion material is different from the second cell-adhesion material; depositing the first cell-adhesion material from the first tip to the substrate to form at least one first deposit, and depositing the second cell-adhesion material from the second tip to the substrate to form at least one second deposit; and wherein the first and second deposits are capable of providing selective binding to at least one first cell so that the first cell selectively binds to the first deposit, and wherein the second deposit is capable of binding to at least one second cell. Single cell binding and cell interaction studies can be carried out.
摘要翻译：细胞共培养方法和阵列提供多功能性和高分辨率。一种方法，包括：提供至少一个基底; 提供至少一个第一尖端，其上设置有至少一个第一细胞粘附材料，以及至少一个第二尖端，其上设置有至少一个第二细胞粘附材料，其中所述第一细胞粘附材料与所述第二细胞粘附材料不同，粘合材料; 将第一细胞粘附材料从第一末端沉积到基底以形成至少一个第一沉积物，以及将第二细胞粘附材料从第二末端沉积到基底以形成至少一个第二沉积物; 并且其中所述第一和第二沉积物能够提供与至少一个第一细胞的选择性结合，使得所述第一细胞选择性地结合所述第一沉积物，并且其中所述第二沉积物能够结合至少一个第二细胞。可以进行单细胞结合和细胞相互作用研究。

6. 发明申请

WO2004098384A3 PARALLEL ANALYSIS OF MOLECULAR INTERACTIONS 审中-公开
标题翻译：分子相互作用的并行分析
公开(公告)号：WO2004098384A3
公开(公告)日：2006-05-11
申请号：PCT/US2004013358
申请日：2004-04-30
申请人： BIOFORCE NANOSCIENCES INC , HENDERSON ERIC R , JOHNSON JAMES , NETTIKADAN SAJU
发明人： HENDERSON ERIC R , JOHNSON JAMES , NETTIKADAN SAJU
IPC分类号： G01Q80/00 , A61B20060101 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/68 , G01Q10/00 , G01Q60/00 , G01Q60/18 , G01Q60/20 , G01Q70/18 , G01N1/30 , G02B21/00
CPC分类号： C12Q1/6816 , G01N33/54366 , G01N33/5438 , G01N33/6854 , G01Q60/20 , C12Q2565/501 , C12Q2565/601
摘要： Provided are methods of detecting molecular interactions using arrays and near field scanning probe techniques. Also provided are methods of characterizing binding interactions under defined reaction parameters, methods of determining antibody binding specificity, methods of selecting a substrate for an array of immobilized molecules and methods of determining molecular occupancy time with respect to binding interactions.
摘要翻译：提供了使用阵列和近场扫描探针技术检测分子相互作用的方法。还提供了在限定的反应参数下表征结合相互作用的方法，确定抗体结合特异性的方法，选择固定化分子阵列的底物的方法和确定关于结合相互作用的分子占据时间的方法。

7. 发明申请

WO2004098384A2 PARALLEL ANALYSIS OF MOLECULAR INTERACTIONS 审中-公开
标题翻译：分子相互作用的并行分析
公开(公告)号：WO2004098384A2
公开(公告)日：2004-11-18
申请号：PCT/US2004/013358
申请日：2004-04-30
申请人： BIOFORCE NANOSCIENCES, INC. , HENDERSON, Eric, J. , JOHNSON, James , NETTIKADAN, Saju
发明人： HENDERSON, Eric, J. , JOHNSON, James , NETTIKADAN, Saju
IPC分类号： A61B
CPC分类号： C12Q1/6816 , G01N33/54366 , G01N33/5438 , G01N33/6854 , G01Q60/20 , C12Q2565/501 , C12Q2565/601
摘要： Provided are methods of detecting molecular interactions using arrays and near field scanning probe techniques. Also provided are methods of characterizing binding interactions under defined reaction parameters, methods of determining antibody binding specificity, methods of selecting a substrate for an array of immobilized molecules and methods of determining molecular occupancy time with respect to binding interactions.
摘要翻译：提供了使用阵列和近场扫描探针技术检测分子相互作用的方法。还提供了在限定的反应参数下表征结合相互作用的方法，确定抗体结合特异性的方法，选择固定化分子阵列的底物的方法和确定关于结合相互作用的分子占据时间的方法。

8. 发明申请

WO2012047808A1 CELL ASSAY METHODS AND ARTICLES 审中-公开
标题翻译：细胞测定方法和文章
公开(公告)号：WO2012047808A1
公开(公告)日：2012-04-12
申请号：PCT/US2011/054627
申请日：2011-10-03
申请人： NANOINK, INC. , NETTIKADAN, Saju , COLLINS, John M. , SMETANA, Alexander B. , STILES, Paul Leon
发明人： NETTIKADAN, Saju , COLLINS, John M. , SMETANA, Alexander B. , STILES, Paul Leon
IPC分类号： G01N33/50
CPC分类号： G01N33/5008
摘要： Versatile, efficient cell assays which can be prepared with use of nanolithography and can be used to test nanomaterials, pharmaceuticals, toxins, and the like. For example, a method comprising: depositing at least one first composition comprising at least one cell adhesion material on at least one substrate to form a pattern which forms an interior space on the substrate within the pattern, depositing in the interior space on the substrate at least one second composition, different from the first, comprising at least one material adapted to affect or potentially affect cell function. Tip-based deposition and direct-write methods can be used for deposition at nanoscale and sub-cellular resolutions. Nanoscopic and atomic force microscope tips can be used. Multiplexing can be carried out.
摘要翻译：可以使用纳米光刻技术制备的多功能，高效的细胞测定法，可用于测试纳米材料，药物，毒素等。例如，一种方法包括：将至少一种包含至少一种细胞粘附材料的第一组合物沉积在至少一个基底上以形成在图案内的衬底上形成内部空间的图案，在衬底上的内部空间中沉积不同于第一组合物的至少一个第二组合物包含适于影响或潜在地影响细胞功能的至少一种材料。基于尖端的沉积和直写方法可用于以纳米尺度和亚细胞分辨率进行沉积。可以使用纳米镜和原子力显微镜尖端。可以进行多路复用。

9. 发明申请

WO2007011405A3 DEVICE AND METHOD OF USE FOR DETECTION AND CHARACTERIZATION OF MICROORGANISMS AND MICROPARTICLES 审中-公开
公开(公告)号：WO2007011405A3
公开(公告)日：2007-01-25
申请号：PCT/US2005/038988
申请日：2005-10-26
申请人： BIOFORCE NANOSCIENCES, INC. , HENDERSON, Eric, R. , NETTIKADAN, Saju, R. , MOSHER, Curtis, L. , JOHNSON, James, C.
发明人： HENDERSON, Eric, R. , NETTIKADAN, Saju, R. , MOSHER, Curtis, L. , JOHNSON, James, C.
IPC分类号： C12Q1/68
摘要： The present invention includes a method and apparatus for the detection of a microorganism or microparticle.

10. 发明申请

WO2005115630A2 METHOD AND APPARATUS FOR DEPOSITING MATERIAL ONTO A SURFACE 审中-公开
标题翻译：将材料沉积在表面上的方法和装置
公开(公告)号：WO2005115630A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/014899
申请日：2005-04-29
申请人： BIOFORCE NANOSCIENCES, INC. , HENDERSON, Eric, R. , XU, Juntao , LYNCH, Michael, P. , MOSHER, Curtis, L. , HUFF, Janice, Lillian , NETTIKADAN, Saju, Rappai
发明人： HENDERSON, Eric, R. , XU, Juntao , LYNCH, Michael, P. , MOSHER, Curtis, L. , HUFF, Janice, Lillian , NETTIKADAN, Saju, Rappai
IPC分类号： B05B7/06
CPC分类号： B01L3/0244 , B01J2219/00387 , B01J2219/00659 , B01L3/0248 , B01L2200/12 , B01L2200/143 , B01L2300/0816 , B01L2300/0838 , B01L2300/10 , B01L2400/02 , B01L2400/0406
摘要： Some embodiments of the present invention provide an apparatus and method in which material is deposited upon a surface from an elongated beam having an aperture defined therein through which the material is moved by passive adsorption. The elongated beam can be substantially planar along substantially its entire length, can be oriented at an acute angle with respect to the surface during deposition processes, and can have a length no greater than about 2mm. In some embodiments, the aperture can be elongated, can extend from a material reservoir to a location short of the terminal end of the elongated beam or through the terminal end of the elongated beam, and can have a portion extending through the thickness of the elongated beam.
摘要翻译：本发明的一些实施例提供了一种装置和方法，其中材料从具有限定在其中的孔的细长梁沉积在表面上，通过该孔通过被动吸附来移动材料。细长梁基本上可以在其整个长度上基本上是平面的，在沉积过程中可以相对于表面以锐角定向，并且可以具有不大于约2mm的长度。在一些实施例中，孔可以是细长的，可以从材料储存器延伸到短于细长梁的终端的位置或者通过细长梁的终端，并且可以具有延伸穿过细长梁的厚度的部分光束。

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