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1. 发明申请

WO2012051206A1 SYSTEM AND METHOD FOR CELL ANALYSIS 审中-公开
标题翻译：细胞分析的系统和方法
公开(公告)号：WO2012051206A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/055817
申请日：2011-10-11
申请人： MBIO DIAGNOSTICS, INC. , GIVENS, Monique , IVES, Jeffrey , LOCHHEAD, Michael, J. , DELANEY, Marie, J. , MOLL, Kevin, D. , ROWLEY, Keagan, B. , VOGEL, Kurt, R. , MYATT, Christopher, J.
发明人： GIVENS, Monique , IVES, Jeffrey , LOCHHEAD, Michael, J. , DELANEY, Marie, J. , MOLL, Kevin, D. , ROWLEY, Keagan, B. , VOGEL, Kurt, R. , MYATT, Christopher, J.
IPC分类号： G01N21/00 , G01N33/543
CPC分类号： G01N21/648 , G01N21/0303 , G01N21/7703 , G01N33/54373 , G01N2015/008 , G01N2015/1486
摘要： Although each of the aforedescribed embodiments have been illustrated with various components having particular respective orientations, it should be understood that the system as described in the present disclosure may take on a variety of specific configurations with the various components being located in a variety of positions and mutual orientations and still remain within the spirit and scope of the present disclosure. For example, it should be noted that the present configuration may be applicable for systems in which the core refractive index is greater than the refractive indices of the substrates, such as if a solid core material is used, as long as the surrounding medium refractive index is less than those of the substrates. Additionally, in the various figures described above, the gasket may be eliminated and replaced with direct laser welding of first and second substrates. Furthermore, suitable equivalents may be used in place of or in addition to the various components, the function and use of such substitute or additional components being held to be familiar to those skilled in the art and are therefore regarded as falling within the scope of the present disclosure. Therefore, the present examples are to be considered as illustrative and not restrictive, and the present disclosure is not to be limited to the details given herein but may be modified within the scope of the appended claims.
摘要翻译：尽管已经用具有特定相应取向的各种部件示出了上述实施例中的每一个，但是应当理解，本公开中描述的系统可以采用各种特定配置，其中各种部件位于各种位置，并且相互取向，仍然在本公开的精神和范围内。例如，应当注意，本构造可以适用于芯折射率大于基板的折射率的系统，例如使用固体芯材料时，只要周围介质折射率小于底物。此外，在上述各种图中，垫圈可以被消除，并由第一和第二基板的直接激光焊接代替。此外，可以使用合适的等同物来替代或除了各种组分，这些替代或附加组分的功能和用途被认为是本领域技术人员熟悉的，因此被认为属于本公开。因此，本实施例被认为是说明性的而不是限制性的，并且本公开不限于本文给出的细节，而是可以在所附权利要求的范围内进行修改。

2. 发明申请

WO2012037369A1 SYSTEM AND METHOD FOR DETECTING MULTIPLE MOLECULES IN ONE ASSAY 审中-公开
标题翻译：用于在一个测定中检测多个分子的系统和方法
公开(公告)号：WO2012037369A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/051791
申请日：2011-09-15
申请人： MBIO DIAGNOSTICS, INC. , LOCHHEAD, Michael, J. , IVES, Jeffrey , TODOROF, Kathryn , GREEF, Charles , DELANEY, Marie, J. , MOLL, Kevin, D. , VOGEL, Kurt, R. , ROWLEY, Keagan, B. , WOODRUFF, Evelyn, S. , DUNN, John, S. , MYATT, Christopher, J. , NIEUWLANDT, Daniel, T.
发明人： LOCHHEAD, Michael, J. , IVES, Jeffrey , TODOROF, Kathryn , GREEF, Charles , DELANEY, Marie, J. , MOLL, Kevin, D. , VOGEL, Kurt, R. , ROWLEY, Keagan, B. , WOODRUFF, Evelyn, S. , DUNN, John, S. , MYATT, Christopher, J. , NIEUWLANDT, Daniel, T.
IPC分类号： G01N21/00 , G01N33/543
CPC分类号： G01N33/54373 , B01L3/502715 , B01L9/52 , B01L2300/0636 , B01L2300/0654 , B01L2300/0825 , B01L2400/0406 , G01N21/6452 , G01N21/648 , G01N21/7703
摘要： A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.
摘要翻译：描述了使用少量血液，血清或血浆提供一组血清学测定结果的快速诊断系统。该系统包括基于平面波导成像技术的一次性盒和读取器。该盒在流体通道中结合重组抗原和抗体对照的微阵列，为单个样品提供多个平行的荧光测定结果。

3. 发明申请

WO2011026030A1 INTEGRATED SAMPLE PREPARATION AND ANALYTE DETECTION 审中-公开
标题翻译：综合样品制备和分析检测
公开(公告)号：WO2011026030A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/047145
申请日：2010-08-30
申请人： MBIO DIAGNOSTICS CORPORATION , MOLL, Kevin D. , LOCHHEAD, Michael J. , MYATT, Christopher J. , HEIL, James R.
发明人： MOLL, Kevin D. , LOCHHEAD, Michael J. , MYATT, Christopher J. , HEIL, James R.
IPC分类号： C12M1/42
CPC分类号： G01N33/54326 , G01N33/54373 , G01N33/585 , Y10S435/808 , Y10S436/805 , Y10S436/806
摘要： A system for sample preparation and analyte detection includes a cartridge, with a fluidic channel, a waveguide, and a capture spot. The system further includes a force field generator, an imaging system, and a fluid, which includes a sample potentially containing a target analyte, first type particles, which include binding moieties specific for the target analyte and are responsive to a force field, and second type particles, which include binding moieties specific for the target analyte and capable of generating a signal. When the sample contains the target analyte, specific binding interactions between the target analyte and binding moieties link first and second type particles via the target analyte to form multiple-particle complex capturable at a capture spot. The force field allows manipulation of the particles and multiple-particle complex such that the detected signal from the second type particles is indicative of the target analyte within the sample.
摘要翻译：用于样品制备和分析物检测的系统包括具有流体通道，波导和捕获点的盒。该系统还包括力场发生器，成像系统和流体，其包括潜在地包含目标分析物的样品，第一类型颗粒，其包括对于目标分析物特异的并且对力场有反应的结合部分，并且第二型颗粒，其包括对目标分析物特异的结合部分并且能够产生信号。当样品含有目标分析物时，目标分析物和结合部分之间的特异性结合相互作用通过目标分析物连接第一和第二类型颗粒，以在捕捉点处形成可以捕获的多重颗粒复合物。力场允许操作颗粒和多颗粒复合物，使得来自第二类型颗粒的检测信号指示样品内的目标分析物。

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