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1. 发明申请

WO2011026030A1 INTEGRATED SAMPLE PREPARATION AND ANALYTE DETECTION 审中-公开
标题翻译：综合样品制备和分析检测
公开(公告)号：WO2011026030A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/047145
申请日：2010-08-30
申请人： MBIO DIAGNOSTICS CORPORATION , MOLL, Kevin D. , LOCHHEAD, Michael J. , MYATT, Christopher J. , HEIL, James R.
发明人： MOLL, Kevin D. , LOCHHEAD, Michael J. , MYATT, Christopher J. , HEIL, James R.
IPC分类号： C12M1/42
CPC分类号： G01N33/54326 , G01N33/54373 , G01N33/585 , Y10S435/808 , Y10S436/805 , Y10S436/806
摘要： A system for sample preparation and analyte detection includes a cartridge, with a fluidic channel, a waveguide, and a capture spot. The system further includes a force field generator, an imaging system, and a fluid, which includes a sample potentially containing a target analyte, first type particles, which include binding moieties specific for the target analyte and are responsive to a force field, and second type particles, which include binding moieties specific for the target analyte and capable of generating a signal. When the sample contains the target analyte, specific binding interactions between the target analyte and binding moieties link first and second type particles via the target analyte to form multiple-particle complex capturable at a capture spot. The force field allows manipulation of the particles and multiple-particle complex such that the detected signal from the second type particles is indicative of the target analyte within the sample.
摘要翻译：用于样品制备和分析物检测的系统包括具有流体通道，波导和捕获点的盒。该系统还包括力场发生器，成像系统和流体，其包括潜在地包含目标分析物的样品，第一类型颗粒，其包括对于目标分析物特异的并且对力场有反应的结合部分，并且第二型颗粒，其包括对目标分析物特异的结合部分并且能够产生信号。当样品含有目标分析物时，目标分析物和结合部分之间的特异性结合相互作用通过目标分析物连接第一和第二类型颗粒，以在捕捉点处形成可以捕获的多重颗粒复合物。力场允许操作颗粒和多颗粒复合物，使得来自第二类型颗粒的检测信号指示样品内的目标分析物。

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