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1. 发明申请

WO2015134634A1 COMPOSITIONS AND METHODS FOR TREATING CANCER, INHIBITING CELL PROLIFERATION, AND INDUCING CELL DEATH 审中-公开
标题翻译：用于治疗癌症，抑制细胞增殖和诱导细胞死亡的组合物和方法
公开(公告)号：WO2015134634A1
公开(公告)日：2015-09-11
申请号：PCT/US2015/018776
申请日：2015-03-04
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , MILLER, Donald M. , THOMAS, Shelia D. , SOKOLOVA, Alexandra , REZZOUG, Francine
发明人： MILLER, Donald M. , THOMAS, Shelia D. , SOKOLOVA, Alexandra , REZZOUG, Francine
IPC分类号： C12Q1/68
CPC分类号： C12N15/1137 , A61K31/7088 , A61K45/06 , C12N2310/13 , C12N2310/151 , C12N2310/18 , C12N2320/31
摘要： Quadruplex-forming guanine-rich nucleic acid sequences are useful in compositions and methods for inhibiting cellular growth and proliferation and inducing cell death. Compositions for treating a patient are provided, including (i) a safe and effective amount of a sequence having at least 80% nucleic acid identity with a sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12 and combinations thereof, and (ii) a carrier, wherein the isolated oligonucleotide forms at least one quadruplex.
摘要翻译：富含四肽的富含鸟嘌呤的核酸序列可用于抑制细胞生长和增殖并诱导细胞死亡的组合物和方法。提供用于治疗患者的组合物，包括（i）安全有效量的与选自SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：2的序列具有至少80％的核酸同一性的序列 SEQ ID NO：3，SEQ ID NO：4，SEQ ID NO：5，SEQ ID NO：6，SEQ ID NO：7，SEQ ID NO：8，SEQ ID NO：9，SEQ ID NO：10，：11，SEQ ID NO：12及其组合，和（ii）载体，其中所述分离的寡核苷酸形成至少一个四联体。

2. 发明申请

WO2012127436A9 ADAPTABLE LARYNGEAL MASK 审中-公开
标题翻译：适应性喉罩
公开(公告)号：WO2012127436A9
公开(公告)日：2013-03-07
申请号：PCT/IB2012051366
申请日：2012-03-22
申请人： MILLER DONALD MUNRO
发明人： MILLER DONALD MUNRO
IPC分类号： A61M16/04
CPC分类号： A61M16/0434 , A61M16/04 , A61M16/0409 , A61M16/0461 , A61M16/0488
摘要： An airway device (10) is provided which includes a distal part (12) and a proximal part (20) in sealed communication. The distal part (12) has a distal opening (14) for attachment to a breathing apparatus, in sealed communication with a hollow stem (16). The proximal part comprises a hollow sealing chamber (20) with a proximal opening (22), said sealing chamber (20) having means for sealing within and against the mucosal walls of a body cavity with a corresponding proximal opening, for communicating with the lungs. The sealing means of the sealing chamber (20) includes: a longitudinal fold (32) that allows for adaptation to varying cross-sectional dimensions of said body cavity; and said sealing chamber (20) being made of an elastomeric substance and having walls (26,30) that are thicker and relatively less flexible, and walls (24,25) that are thinner and relatively more flexible, said thicker walls (26,30) forming a framework that supports said thinner walls (24,25).
摘要翻译：提供一种气道装置（10），其包括密封连通的远端部分（12）和近端部分（20）。远端部分（12）具有远端开口（14），用于附接到与中空杆（16）密封连通的呼吸装置。近端部分包括具有近端开口（22）的中空密封室（20），所述密封腔（20）具有用于在体腔内和与其相对的近端开口处的粘膜壁密封的装置，用于与肺连通。密封室（20）的密封装置包括：纵向折叠（32），其允许适应所述体腔的变化的横截面尺寸; 并且所述密封室（20）由弹性材料制成并且具有较厚且相对较不柔性的壁（26,30）以及更薄且相对更柔性的壁（24,25），所述较厚壁（26， 30）形成支撑所述较薄壁（24,25）的框架。

3. 发明申请

WO2012127436A3 ADAPTABLE LARYNGEAL MASK 审中-公开
标题翻译：适应性喉舌
公开(公告)号：WO2012127436A3
公开(公告)日：2013-01-17
申请号：PCT/IB2012051366
申请日：2012-03-22
申请人： MILLER DONALD MUNRO
发明人： MILLER DONALD MUNRO
IPC分类号： A61M16/04
CPC分类号： A61M16/0434 , A61M16/04 , A61M16/0409 , A61M16/0461 , A61M16/0488
摘要： An airway device (10) is provided which includes a distal part (12) and a proximal part (20) in sealed communication. The distal part (12) has a distal opening (14) for attachment to a breathing apparatus, in sealed communication with a hollow stem (16). The proximal part comprises a hollow sealing chamber (20) with a proximal opening (22), said sealing chamber (20) having means for sealing within and against the mucosal walls of a body cavity with a corresponding proximal opening, for communicating with the lungs. The sealing means of the sealing chamber (20) includes: a longitudinal fold (32) that allows for adaptation to varying cross-sectional dimensions of said body cavity; and said sealing chamber (20) being made of an elastomeric substance and having walls (26,30) that are thicker and relatively less flexible, and walls (24,25) that are thinner and relatively more flexible, said thicker walls (26,30) forming a framework that supports said thinner walls (24,25).
摘要翻译：提供了一种气道装置（10），其包括密封连通的远侧部分（12）和近侧部分（20）。远侧部分（12）具有用于连接到呼吸装置的远侧开口（14），与中空杆（16）密封连通。近端部分包括具有近端开口（22）的中空密封腔室（20），所述密封腔室（20）具有用于密封在具有相应近端开口的体腔的粘膜壁内并抵靠其的装置，用于与肺部。密封室（20）的密封装置包括：纵向折叠部（32），其允许适应所述体腔的变化的横截面尺寸; 和所述密封室（20）由弹性体材料制成，并且具有较厚和相对较小柔性的壁（26,30）以及较薄且相对较柔性的壁（24,25），所述较厚壁（26,28） 30）形成支撑所述较薄壁（24,25）的框架。

4. 发明申请

WO2010085618A1 DEVICES AND METHODS FOR POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY WITH ADAPTIVE OPTICS 审中-公开
标题翻译：用于具有自适应光学的偏振光敏相关图像的装置和方法
公开(公告)号：WO2010085618A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021759
申请日：2010-01-22
申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION , CENSE, Abraham, J. , MILLER, Donald, T.
发明人： CENSE, Abraham, J. , MILLER, Donald, T.
IPC分类号： A61B6/00
CPC分类号： A61B3/102 , A61B3/1225 , G01B11/168
摘要： The present disclosure includes disclosure of devices, and methods to resolve microscopic structures. In at least one exemplary embodiment, a visualization apparatus comprises a source arm having a light source operable to emit a light beam, wherein the light beam defines a beam pathway, a reference arm comprising a reflecting surface positioned within the beam pathway, a sample arm comprising a wavefront sensor, an adaptive optics wavefront corrector, and a target, each of which are positioned within the beam pathway, wherein the adaptive optics wavefront sensor is operable to compensate for at least one aberration in the light beam, a detector arm comprising a beam detector positioned within the beam pathway, wherein the beam detector is operable to detect the reflected light beam from the reference arm and the target, and wherein the visualization apparatus is operable to minimize at least one aberration of the target.
摘要翻译：本公开包括设备的公开和解决微观结构的方法。在至少一个示例性实施例中，可视化装置包括具有可操作以发射光束的光源的源臂，其中光束限定光束通路，参考臂包括位于光束通路内的反射表面，其包括波前传感器，自适应光学波前校正器和目标，每个都位于所述光束通路内，其中所述自适应光学波前传感器可操作以补偿所述光束中的至少一个像差;检测器臂，包括：光束检测器定位在光束通路内，其中光束检测器可操作以检测来自参考臂和靶的反射光束，并且其中可视化设备可操作以使目标的至少一个像差最小化。

5. 发明申请

WO2009065057A2 CONTINUOUSLY VARIABLE DRIVETRAIN 审中-公开
标题翻译：连续可变驱动器
公开(公告)号：WO2009065057A2
公开(公告)日：2009-05-22
申请号：PCT/US2008/083664
申请日：2008-11-14
申请人： FALLBROOK TECHNOLOGIES INC. , MILLER, Donald, C. , ROSS, Michael, C.
发明人： MILLER, Donald, C. , ROSS, Michael, C.
IPC分类号： B62M1/04
CPC分类号： B62M1/28
摘要： Drivetrains and frames for vehicles, equipment, machines, etc. Some embodiments of the drivetrains and frames are particularly suited for human powered machines, such as bicycles and exercise equipment. In some embodiments, a drivetrain includes a reciprocating crank coupled to a crank pivot. A lever couples to the crank via a lever pivot positioned on the crank. A lever stop cooperates with a lever guide surface to guide a motion of the lever as the lever pivots about the lever pivot. The lever and/or the crank are operably coupled to a drive pulley, idler pulley, and/or compound pulley. In some embodiments, a drive cable operably couples the lever and/or the crank to the drive pulley, idler pulley, and/or the compound pulley. In one embodiment, one or more pulleys couple to the lever's distal ends. In some embodiments, the drivetrain includes a wheel hub adapted to receive torque from the crank via a drive pulley.
摘要翻译：用于车辆，设备，机器等的传动系统和框架。传动系和框架的一些实施例特别适用于人力机器，例如自行车和运动设备。在一些实施例中，传动系包括联接到曲轴枢轴的往复式曲柄。杠杆通过位于曲柄上的杠杆枢轴连接到曲柄上。当杠杆围绕杠杆枢轴枢转时，杠杆止动件与杠杆引导表面配合以引导杠杆的运动。杠杆和/或曲柄可操作地联接到驱动滑轮，惰轮和/或复合滑轮。在一些实施例中，驱动缆线将杠杆和/或曲柄可操作地连接到驱动滑轮，惰轮和/或复合滑轮。在一个实施例中，一个或多个滑轮联接到杠杆的远端。在一些实施例中，传动系包括适于经由驱动皮带轮从曲柄接受扭矩的轮毂。

6. 发明申请

WO2007106490A3 COMMUNICATING WITH AN IMPLANTED WIRELESS SENSOR 审中-公开
公开(公告)号：WO2007106490A3
公开(公告)日：2007-09-20
申请号：PCT/US2007/006319
申请日：2007-03-14
申请人： CardioMEMS, Inc. , MILLER, Donald J. , ELLIS, Michael G. , ALLEN, Mark G.
发明人： MILLER, Donald J. , ELLIS, Michael G. , ALLEN, Mark G.
IPC分类号： A61B5/00
摘要： Aspects of the present invention determine the resonant frequency of a sensor by obtain sensor signals in response to three energizing signals, measure the phase of each sensor signal, and using a group phase delay to determine the resonant frequency. The phase difference between the first and second signal is determined as a first group phase delay. The phase difference between the second and third signal is determined as a second group phase delay. The first group phase delay and second group phase delay are compared. Based on the comparison, the system may lock on the resonant frequency of the sensor or adjust a subsequent set of three energizing signals.

7. 发明申请

WO2006041718A3 CONTINUOUSLY VARIABLE TRANSMISSION 审中-公开
标题翻译：连续可变传输
公开(公告)号：WO2006041718A3
公开(公告)日：2007-08-23
申请号：PCT/US2005035164
申请日：2005-10-03
申请人： FALLBROOK TECHNOLOGIES INC , SMITHSON ROBERT A , POHL BRAD P , ARMSTRONG ORONDE J , MILLER DONALD C , DAWE DANIEL J , THOMASSY FERNAND A , SIMISTER MATTHEW P , POTH WESLEY R , LOHR CHARLES B , NICHOLS JON M
发明人： SMITHSON ROBERT A , POHL BRAD P , ARMSTRONG ORONDE J , MILLER DONALD C , DAWE DANIEL J , THOMASSY FERNAND A , SIMISTER MATTHEW P , POTH WESLEY R , LOHR CHARLES B , NICHOLS JON M
IPC分类号： F16H15/26
CPC分类号： F16H15/503 , B62M9/00 , B62M23/00 , F16H15/28 , F16H15/50 , Y10T29/49462 , Y10T29/49464 , Y10T29/49467 , Y10T29/4984
摘要： A continuously variable transmission (CVT) having a main shaft configured to support and position various components of the CVT. Shift cam discs cooperate with ball-leg assemblies to shift the transmission ration of the CVT. Load cam discs, a torsion disc, rolling elements, and a hub cap shell are configured to generate axial force, transmit torque, and manage reaction forces. In one embodiment, a splined input shaft and a torsion disc having a splined bore cooperate to input torque into the variator of the CVT. Among other things, various ball axles, axle-ball combinations, and reaction force grounding configurations are disclosed. In one embodiment, a CVT having axial force generation means at both the input and output elements is disclosed
摘要翻译：一种无级变速器（CVT），其具有构造成支撑和定位CVT的各种部件的主轴。换档凸轮盘与球腿组件配合以移动CVT的传动比。负载凸轮盘，扭转盘，滚动元件和轮毂盖壳体被配置成产生轴向力，传递扭矩和管理反作用力。在一个实施例中，具有花键孔的花键输入轴和扭转盘配合以将扭矩输入到CVT的变速器中。其中，公开了各种球轴，轴球组合和反作用力接地构造。在一个实施例中，公开了在输入和输出元件两者都具有轴向力产生装置的CVT

8. 发明申请

WO2007030489A1 PREVENTING FALSE LOCKS IN A SYSTEM THAT COMMUNICATES WITH AN IMPLANTED WIRELESS SENSOR 审中-公开
标题翻译：防止在带有无线传感器的通信系统中使用虚假锁
公开(公告)号：WO2007030489A1
公开(公告)日：2007-03-15
申请号：PCT/US2006/034641
申请日：2006-09-06
申请人： CARDIOMENS, INC. , POWERS, Richard , ELLIS, Michael, G. , KROH, Jason , MILLER, Donald, J.
发明人： POWERS, Richard , ELLIS, Michael, G. , KROH, Jason , MILLER, Donald, J.
IPC分类号： A61B5/00 , G08C17/04 , G01L9/12 , G01D5/241
CPC分类号： A61B5/02014 , A61B5/0031 , A61B5/0215 , A61B5/076 , A61B5/726 , A61B2560/0223 , G01D21/00
摘要： The present invention determines the resonant frequency of a wireless sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency. The system receives the ring down response of the sensor and determines the resonant frequency of the sensor, which is used to calculate a physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal. The system identifies false locks by detecting an unwanted beat frequency in the coupled signal, as well as determining whether the coupled signal exhibits pulsatile characteristics that correspond to blood pressure.
摘要翻译：本发明通过调节通电信号的相位和频率直到通电信号的频率与传感器的谐振频率相匹配来确定无线传感器的谐振频率。该系统以低占空比激励传感器，具有预定频率的RF能量门控突发。系统接收传感器的响铃响应，并确定用于计算物理参数的传感器的谐振频率。该系统使用一对锁相环来调节激励信号的相位和频率。该系统通过检测耦合信号中的不期望的拍频来识别假锁，以及确定耦合信号是否表现出对应于血压的脉动特性。

9. 发明申请

WO2007025056A1 CONTINUOUSLY VARIABLE TRANSMISSION 审中-公开
标题翻译：连续可变传输
公开(公告)号：WO2007025056A1
公开(公告)日：2007-03-01
申请号：PCT/US2006/033104
申请日：2006-08-23
申请人： FALLBROOK TECHNOLOGIES INC. , MILLER, Donald, C.
发明人： MILLER, Donald, C.
IPC分类号： F16H61/664 , F16H15/50
CPC分类号： F16H63/067 , F03D15/00 , F03D15/10 , F03D80/70 , F05B2260/40 , F05B2260/402 , F05B2260/403 , F16H15/50 , F16H55/32 , F16H61/664 , Y02E10/722
摘要： Embodiments disclosed include a continuously variable transmission (CVT) where power is transmitted from a group of balls (1) to a shaft (602) via an idler (18). In one -application, the CVT couples to a gearbox and to a generator of a wind turbine (688) . Traction elements of a CVT can be coated and/or textured, using various coating materials and textures, via disclosed coating and/or texturing methods. Methods and systems for shifting a CVT are disclosed. Certain components for a CVT are disclosed. For example, in one embodiment, a CVT includes a shaft (624) having a spline (628) and a shift flange (609) . In another embodiment, a CVT includes a stator (658) adapted to cooperate with shifter components. Disclosed is a CVT configured to produce a variable output speed that is always greater than an input speed. In one embodiment, a CVT produces a variable output speed that is always lower than an input speed.
摘要翻译：所公开的实施例包括其中功率通过惰轮（18）从一组球（1）传递到轴（602）的无级变速器（CVT）。在一个应用中，CVT耦合到齿轮箱和风力发电机的发电机（688）。通过公开的涂层和/或纹理方法，CVT的牵引元件可以使用各种涂层材料和纹理进行涂布和/或纹理化。公开了用于移动CVT的方法和系统。公开了CVT的某些组件。例如，在一个实施例中，CVT包括具有花键（628）和换档凸缘（609）的轴（624）。在另一个实施例中，CVT包括适于与换档器部件配合的定子（658）。公开了一种CVT，其被配置为产生总是大于输入速度的可变输出速度。在一个实施例中，CVT产生始终低于输入速度的可变输出速度。

10. 发明申请

WO2007008493A1 COUPLING LOOP, CABLE ASSEMBLY AND METHOD FOR POSITIONING COUPLING LOOP 审中-公开
标题翻译：耦合环，电缆组件和定位耦合环路的方法
公开(公告)号：WO2007008493A1
公开(公告)日：2007-01-18
申请号：PCT/US2006/026015
申请日：2006-06-30
申请人： CARDIOMEMS, INC. , KROH, Jason , ELLIS, Michael , MILLER, Donald , REFERMAT, Robert
发明人： KROH, Jason , ELLIS, Michael , MILLER, Donald , REFERMAT, Robert
IPC分类号： H04B5/00 , A61B5/00 , G01R33/00
CPC分类号： A61B5/02014 , A61B5/0031 , A61B5/064 , A61B5/07 , A61B2560/0219 , H01B11/20 , H04B5/0043 , Y10S128/903
摘要： A coupling loop or antenna is provided that can be used with a system that determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The coupling loop includes multiple loops. Preferably two tuned loops are used for transmitting the energizing signal to the sensor and an un-tuned loop is used for receiving the sensor signal from the sensor. A cable attached to the coupling loop provides maximum isolation between the energizing signal and the sensor signal by maximizing the distance between the coaxial cables that carry the signals and maintaining the relative positions of the coaxial cables throughout the cable assembly. Orientation features on the housing for the coupling loop and the sensor are provided to assist in positioning the coupling loop relative to the sensor to maximize the coupling between the sensor signal and the coupling loop.
摘要翻译：提供耦合环路或天线，其可以与通过调节激励信号的相位和频率来确定传感器的谐振频率的系统一起使用，直到通电信号的频率与传感器的谐振频率匹配。耦合回路包括多个回路。优选地，两个调谐回路用于将激励信号传输到传感器，并且未调谐回路用于从传感器接收传感器信号。连接到耦合回路的电缆通过使承载信号的同轴电缆之间的距离最大化并且保持同轴电缆在整个电缆组件中的相对位置来提供激励信号和传感器信号之间的最大隔离。提供用于耦合回路和传感器的壳体上的定向特征以帮助相对于传感器定位耦合回路，以使传感器信号和耦合回路之间的耦合最大化。

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