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1. 发明申请

WO2010085618A1 DEVICES AND METHODS FOR POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY WITH ADAPTIVE OPTICS 审中-公开
标题翻译：用于具有自适应光学的偏振光敏相关图像的装置和方法
公开(公告)号：WO2010085618A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021759
申请日：2010-01-22
申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION , CENSE, Abraham, J. , MILLER, Donald, T.
发明人： CENSE, Abraham, J. , MILLER, Donald, T.
IPC分类号： A61B6/00
CPC分类号： A61B3/102 , A61B3/1225 , G01B11/168
摘要： The present disclosure includes disclosure of devices, and methods to resolve microscopic structures. In at least one exemplary embodiment, a visualization apparatus comprises a source arm having a light source operable to emit a light beam, wherein the light beam defines a beam pathway, a reference arm comprising a reflecting surface positioned within the beam pathway, a sample arm comprising a wavefront sensor, an adaptive optics wavefront corrector, and a target, each of which are positioned within the beam pathway, wherein the adaptive optics wavefront sensor is operable to compensate for at least one aberration in the light beam, a detector arm comprising a beam detector positioned within the beam pathway, wherein the beam detector is operable to detect the reflected light beam from the reference arm and the target, and wherein the visualization apparatus is operable to minimize at least one aberration of the target.
摘要翻译：本公开包括设备的公开和解决微观结构的方法。在至少一个示例性实施例中，可视化装置包括具有可操作以发射光束的光源的源臂，其中光束限定光束通路，参考臂包括位于光束通路内的反射表面，其包括波前传感器，自适应光学波前校正器和目标，每个都位于所述光束通路内，其中所述自适应光学波前传感器可操作以补偿所述光束中的至少一个像差;检测器臂，包括：光束检测器定位在光束通路内，其中光束检测器可操作以检测来自参考臂和靶的反射光束，并且其中可视化设备可操作以使目标的至少一个像差最小化。

2. 发明申请

WO2003105678A3 METHOD AND APPARATUS FOR IMPROVING BOTH LATERAL AND AXIAL RESOLUTION IN OPHTHALMOSCOPY 审中-公开
公开(公告)号：WO2003105678A3
公开(公告)日：2003-12-24
申请号：PCT/US2003/018511
申请日：2003-06-11
申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. , MILLER, Donald, T. , JONNAL, Ravi, S. , QU, Junle , THORNE, Karen, E.
发明人： MILLER, Donald, T. , JONNAL, Ravi, S. , QU, Junle , THORNE, Karen, E.
IPC分类号： A61B3/12
摘要： The invention provides a method of optical imaging comprising providing a sample to be imaged, measuring and correcting aberrations associated with the sample using adaptive optics, and imaging the sample by optical coherence tomography. The method can be used to image the fundus of a human eye to provide diagnostic information about retinal pathologies such as macular degeneration, retinitis pigmentosa, glaucoma, or diabetic retinopathy. The invention further provides an apparatus comprising an adaptive optics subsystem and a two-dimensional optical coherence tomography subsystem.

3. 发明申请

WO2003105678A2 METHOD AND APPARATUS FOR IMPROVING BOTH LATERAL AND AXIAL RESOLUTION IN OPHTHALMOSCOPY 审中-公开
标题翻译：改善眼底两侧和双侧分辨率的方法和装置
公开(公告)号：WO2003105678A2
公开(公告)日：2003-12-24
申请号：PCT/US2003/018511
申请日：2003-06-11
申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. , MILLER, Donald, T. , JONNAL, Ravi, S. , QU, Junle , THORNE, Karen, E.
发明人： MILLER, Donald, T. , JONNAL, Ravi, S. , QU, Junle , THORNE, Karen, E.
IPC分类号： A61B3/00
CPC分类号： G01B9/02007 , A61B3/102 , G01B9/02003 , G01B9/02038 , G01B9/02068 , G01B9/02091 , G01B2290/45
摘要： The invention provides a method of optical imaging comprising providing a sample to be imaged, measuring and correcting aberrations associated with the sample using adaptive optics, and imaging the sample by optical coherence tomography. The method can be used to image the fundus of a human eye to provide diagnostic information about retinal pathologies such as macular degeneration, retinitis pigmentosa, glaucoma, or diabetic retinopathy. The invention further provides an apparatus comprising an adaptive optics subsystem and a two-dimensional optical coherence tomography subsystem.
摘要翻译：本发明提供了一种光学成像方法，包括提供待成像样本，使用自适应光学器件测量和校正与样本相关联的像差，以及通过光学相干断层摄影对样本进行成像。该方法可用于对人眼的眼底进行成像，以提供关于视网膜病变如黄斑变性，色素性视网膜炎，青光眼或糖尿病性视网膜病变的诊断信息。本发明还提供一种包括自适应光学子系统和二维光学相干断层扫描子系统的装置。

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