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1. 发明申请

WO2010081039A1 MEDICAL DEVICE FOR MODIFICATION OF LEFT ATRIAL APPENDAGE AND RELATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于修改左心室附件的医疗装置及相关系统及方法
公开(公告)号：WO2010081039A1
公开(公告)日：2010-07-15
申请号：PCT/US2010/020547
申请日：2010-01-08
申请人： COHEREX MEDICAL, INC. , MILES, Scott, D. , EDMISTON, Daryl, R. , DAVIS, Clark, C.
发明人： MILES, Scott, D. , EDMISTON, Daryl, R. , DAVIS, Clark, C.
IPC分类号： A61B17/12 , A61B17/00
CPC分类号： A61B17/1215 , A61B17/00234 , A61B17/0057 , A61B17/0401 , A61B17/0487 , A61B17/06166 , A61B17/12022 , A61B17/12031 , A61B17/1204 , A61B17/12122 , A61B17/12131 , A61B17/12159 , A61B17/12172 , A61B17/122 , A61B2017/00243 , A61B2017/00526 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/0061 , A61B2017/00632 , A61B2017/00867 , A61B2017/00884 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0437 , A61B2017/0446 , A61B2017/0448 , A61B2017/0459 , A61B2017/0464 , A61B2017/1205 , Y10T29/49826
摘要： A medical device and system for modifying a left atrial appendage ("LAA"), as well as related methods, are provided. In accordance with one embodiment, a medical device includes a plurality of discrete frame segments coupled with at least one ring member to form a frame structure. Each discrete frame segment includes an expanding leg, a collapsing leg and a hub extension. A tissue growth member is coupled with the plurality of discrete frame segments to define a substantially convex surface and a substantially concave surface.
摘要翻译：提供了一种用于修改左心耳（“LAA”）的医疗装置和系统以及相关方法。根据一个实施例，医疗设备包括与至少一个环构件联接以形成框架结构的多个离散框架段。每个离散的帧段包括扩展的腿，折叠腿和轮毂延伸。组织生长构件与多个分立的框架段联接以限定基本上凸的表面和基本上凹的表面。

2. 发明申请

WO2010005897A2 APPARATUS AND METHODS FOR OCCLUDING A FALLOPIAN TUBE 审中-公开
标题翻译：装置和方法，用于遮挡倒伏管
公开(公告)号：WO2010005897A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/049689
申请日：2009-07-06
申请人： COHEREX MEDICAL, INC. , CARTER, Phillip, J. , LINDER, Richard, J. , JONES, Randall, K. , MILES, Scott, D. , DAVIS, Clark, C. , EDMISTON, Daryl, R. , FOX, Dewayne, C.
发明人： CARTER, Phillip, J. , LINDER, Richard, J. , JONES, Randall, K. , MILES, Scott, D. , DAVIS, Clark, C. , EDMISTON, Daryl, R. , FOX, Dewayne, C.
IPC分类号： A61F6/22 , A61B17/12
CPC分类号： A61F6/225
摘要： The present invention is directed to various embodiments of medical devices and methods for occluding a fallopian tube for contraception and permanent sterilization. In one embodiment, the medical device includes an outer member, an inner member and a tissue growth member. The outer member includes an outer surface and an inner surface, wherein the inner surface defines a bore in the outer member. The inner member is configured to be positioned within the bore of the outer member. The tissue growth member is attached to the outer surface of the outer member and is configured to induce tissue growth thereto. With this arrangement, the medical device can be implanted within the fallopian tube and serve as a permanent occluding device therein. If desired, the medical device can be partially removed from the fallopian tube to restore the ability for conception.
摘要翻译：本发明涉及用于闭塞输卵管用于避孕和永久灭菌的医疗装置和方法的各种实施例。在一个实施例中，医疗装置包括外部构件，内部构件和组织生长构件。外部构件包括外表面和内表面，其中内表面在外构件中限定孔。内部构件构造成定位在外部构件的孔内。组织生长构件附接到外部构件的外表面并且构造成诱导组织生长。利用这种布置，医疗装置可以植入输卵管内并用作其中的永久性闭塞装置。如果需要，医疗设备可以部分地从输卵管中移除以恢复受孕的能力。

3. 发明申请

WO2009094585A3 METHODS AND APPARATUS FOR REDUCING VALVE PROLASPE 审中-公开
标题翻译：减压阀的方法和装置
公开(公告)号：WO2009094585A3
公开(公告)日：2009-10-15
申请号：PCT/US2009031900
申请日：2009-01-23
申请人： COHEREX MEDICAL INC , LINDER RICHARD J , MILES SCOTT D , EDMISTON DARYL R , DAVIS CLARK C
发明人： LINDER RICHARD J , MILES SCOTT D , EDMISTON DARYL R , DAVIS CLARK C
IPC分类号： A61M25/00 , A61M39/22
CPC分类号： A61F2/2454 , A61B2017/00243 , A61F2/2457
摘要： Medical devices, systems and methods for treating valve prolapse in, for example, the mitral valve. The medical device is employed by delivering the device percutaneously and lodging the device adjacently above the valve. With this arrangement, the device provides a back-stop to prevent valve prolapse and, thus, prevent valve regurgitation.
摘要翻译：用于治疗例如二尖瓣的瓣膜脱垂的医疗装置，系统和方法。通过经皮递送装置并将装置放置在阀上方相邻的位置来使用医疗装置。通过这种布置，该装置提供了一个后挡块，以防止瓣膜脱垂，从而防止瓣膜反流。

4. 发明申请

WO2009052437A1 MEDICAL DEVICE FOR PERCUTANEOUS PARAVALVULAR LEAK AND RELATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于经常性旁路淋巴结的医疗装置及相关系统和方法
公开(公告)号：WO2009052437A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/080380
申请日：2008-10-17
申请人： COHEREX MEDICAL, INC. , MILES, Scott, D. , DAVIS, Clark, C. , LINDER, Richard, J.
发明人： MILES, Scott, D. , DAVIS, Clark, C. , LINDER, Richard, J.
IPC分类号： A61F2/24
CPC分类号： A61F2/24 , A61F2/2409 , A61F2/2445 , A61F2250/0069
摘要： The present invention provides devices, systems and methods for closing a paravalvular leak. In accordance with one embodiment, a medical device includes at least one multicellular frame member (112) configured to be implanted at a paravalvular leak. The medical device further includes at least one tissue in-growth member (116) associated with the frame member, the tissue in-growth member being configured to promote tissue growth and permanently maintain the frame member at the leak. The frame member may be self expanding device formed, for example, of a shape-memory alloy. The tissue in-growth member may be formed from a polymer material. In one particular embodiment, the frame member may be a substantially tubular structure and the tissue in-growth member may be disposed within an interior space defined by the tubular structure. In another embodiment, the frame ember may be a substantially flat or planar structure.
摘要翻译：本发明提供了用于闭合瓣膜泄漏的装置，系统和方法。根据一个实施例，医疗装置包括至少一个多细胞框架构件（112），其构造成以瓣间泄漏植入。医疗装置还包括与框架构件相关联的至少一个组织生长构件（116），所述组织生长构件被构造成促进组织生长并将框架构件永久地保持在泄漏处。框架构件可以是例如由形状记忆合金形成的自扩张装置。组织生长部件可以由聚合物材料形成。在一个具体实施例中，框架构件可以是基本上管状的结构，并且组织生长构件可以设置在由管状结构限定的内部空间内。在另一个实施例中，框架余烬可以是基本平坦或平面的结构。

5. 发明申请

WO2008036478A2 DEVICES FOR REDUCING THE SIZE OF AN INTERNAL TISSUE OPENING 审中-公开
标题翻译：用于减少内部组织开放尺寸的装置
公开(公告)号：WO2008036478A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/075611
申请日：2007-08-09
申请人： COHEREX MEDICAL, INC. , LINDER, Richard, J. , DAVIS, Clark, C. , MILES, Scott, D. , FOX, DeWayne, C. , EDMISTON, Daryl, R.
发明人： LINDER, Richard, J. , DAVIS, Clark, C. , MILES, Scott, D. , FOX, DeWayne, C. , EDMISTON, Daryl, R.
IPC分类号： A61F2/02
CPC分类号： A61B17/0057 , A61B17/0487 , A61B17/083 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/00084 , A61B2017/00407 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00606 , A61B2017/0061 , A61B2017/00619 , A61B2017/00623 , A61B2017/00654 , A61B2017/00858 , A61B2017/00862 , A61B2017/00867 , A61B2017/00884 , A61B2017/0488 , A61B2017/0496 , A61B2017/12054
摘要： A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The closure device can include a body portion operatively associated with a first anchor and a second anchor. The body portion can include a plurality of segments defining a multi-cellular structure. The closure device can be configured to apply lateral force to tissue of the internal tissue opening to bring tissue together. The closure device can have a substantially flat aspect, and have a depth thickness that is substantially greater than the thickness or width of a majority of the members forming the closure device to reduce out of plane bending. The closure device can also include a member adapted to induce tissue growth.
摘要翻译：用于治疗内部组织开口的医疗系统可以包括闭合装置和关联装置

6. 发明申请

WO2008021969A2 METHODS, SYSTEMS AND DEVICES FOR REDUCING THE SIZE OF AN INTERNAL TISSUE OPENING 审中-公开
标题翻译：用于减少内部组织开放尺寸的方法，系统和装置
公开(公告)号：WO2008021969A2
公开(公告)日：2008-02-21
申请号：PCT/US2007/075608
申请日：2007-08-09
申请人： COHEREX MEDICAL, INC. , DAVIS, Clark, C. , MILES, Scott, D. , FOX, Dewayne, C. , EDMISTON, Daryl, R. , LINDER, Richard, J.
发明人： DAVIS, Clark, C. , MILES, Scott, D. , FOX, Dewayne, C. , EDMISTON, Daryl, R. , LINDER, Richard, J.
IPC分类号： A61F2/02
CPC分类号： A61B17/0057 , A61B17/0487 , A61B17/083 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/00084 , A61B2017/00407 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00606 , A61B2017/0061 , A61B2017/00619 , A61B2017/00623 , A61B2017/00654 , A61B2017/00858 , A61B2017/00862 , A61B2017/00867 , A61B2017/00884 , A61B2017/0488 , A61B2017/0496 , A61B2017/12054
摘要： A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The closure device can include a multi-cellular body portion operatively associated with a first anchor and a second anchor. The closure device can be configured to apply lateral force to tissue of the internal tissue opening to bring tissue together. The closure device can have a substantially flat aspect, and have a depth that is substantially greater than the thickness of a majority of the members forming the closure device. The closure device can also include a member for promoting tissue growth. The delivery device can include an actuating assembly configured to partially deploy the closure device by a first movement, and deploy a second portion of the closure device by a second movement. The delivery device can also include a release assembly to selectively release or disconnect the closure device from the delivery device.
摘要翻译：用于治疗内部组织开口的医疗系统可以包括闭合装置和相关联的递送装置。闭合装置可以包括与第一锚固件和第二锚固件可操作地相关联的多细胞主体部分。闭合装置可以构造成向内部组织开口的组织施加横向力以将组织带到一起。闭合装置可以具有基本平坦的方面，并且具有基本上大于形成闭合装置的构件的大部分的厚度的深度。闭合装置还可以包括用于促进组织生长的构件。输送装置可以包括构造成通过第一运动部分展开闭合装置的致动组件，并且通过第二运动来展开闭合装置的第二部分。输送装置还可以包括释放组件，用于选择性地将封闭装置从输送装置释放或断开。

7. 发明申请

WO2003001980A2 CANNULATION APPARATUS AND METHOD 审中-公开
标题翻译：肛门装置和方法
公开(公告)号：WO2003001980A2
公开(公告)日：2003-01-09
申请号：PCT/US2002/020539
申请日：2002-06-28
申请人： MEDQUEST PRODUCTS,INC. , MILES, Scott , NIEMAN, Timothy , BECK, Kent
发明人： MILES, Scott , NIEMAN, Timothy , BECK, Kent
IPC分类号： A61B
CPC分类号： A61M1/3653 , A61B2017/00252 , A61B2017/3425 , A61M1/10 , A61M1/1008 , A61M1/101 , A61M1/1096 , A61M1/12 , A61M1/122 , A61M1/3659 , A61M1/3666 , A61M1/3667
摘要： A remote cannulation assembly is disclosed for rapidly cannulating a body part such as a heart during a medical procedure. Cannulation is often conducted in procedures such as the installation of a ventricular assist device. The cannulation assembly of the invention utilizes an isolation valve to create a sealed fluid environment for the procedure. The invention further includes a coring assembly that may be used with the cannulation apparatus. Methods of cannulating a heart or other body part are also disclosed in which the risk of emboli is reduced. Additionally, methods of connecting and disconnecting two fluid conducting elements are disclosed.
摘要翻译：公开了一种远程插管组件，用于在医疗过程中快速插入诸如心脏的身体部位。插管通常在诸如安装心室辅助装置的过程中进行。本发明的插管组件利用隔离阀为该过程创建一个密封的流体环境。本发明还包括可与插管装置一起使用的取芯组件。还披露了插入心脏或其他身体部位的方法，其中栓塞的风险降低。此外，公开了连接和断开两个流体传导元件的方法。

8. 发明申请

WO1997035203A1 OSCILLATION APPARATUS AND METHODS FOR MULTI-ANALYTE HOMOGENEOUS FLUORO-IMMUNOASSAYS 审中-公开
标题翻译：多分辨荧光免疫荧光法的振荡装置及方法
公开(公告)号：WO1997035203A1
公开(公告)日：1997-09-25
申请号：PCT/US1997004378
申请日：1997-03-19
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , HERRON, James, N. , CHRISTENSEN, Douglas, A. , MILES, Scott, D.
发明人： UNIVERSITY OF UTAH RESEARCH FOUNDATION
IPC分类号： G01N33/552
CPC分类号： G01N33/54386 , G01N33/54373 , Y10S435/808 , Y10S436/807
摘要： An apparatus and method for rapidly analyzing samples for analytes of interest by an homogeneous immunofluorescence assay. The apparatus includes a sample test cartridge having a high control sample section, a low control sample section, and at least one test sample section. Each of these sections contain at least one pre-loaded reagent housed in a well within the the cartridge wherein the low control sample section contains a known low amount of an analyte of interest and the high control sample section contains a known high amount of an analyte of interest. The cartridge includes a biosensor comprising a planar waveguide having first and second parallel plane surfaces and an edge extending between them, the edge having a receiving region for receiving a light beam. Each of the high control sample section, the low control sample section, and the test sample control sections have a well which includes a waveguide surface, wherein the contents of each section contacts capture molecules immobilized on the waveguide surface. The capture molecules are configured to specifically bind a chosen analyte and fluoresce when interacting with light passing through the waveguide surface. The concentration of said analyte of interest in said sample fluid is determined by a comparison of intensities of fluorescence of between said capture molecule areas of said sample capture molecule well, said low control capture molecule well, and said high control capture molecule well.
摘要翻译：用于通过均匀免疫荧光测定快速分析感兴趣的分析物的样品的装置和方法。该装置包括具有高控制样品部分，低对照样品部分和至少一个测试样品部分的样品测试盒。这些部分中的每一个包含至少一个预先装载的试剂，其容纳在筒内的孔中，其中低对照样品部分含有已知的低量感兴趣的分析物，并且高对照样品部分含有已知的大量分析物出于兴趣。所述盒包括生物传感器，所述生物传感器包括具有第一和第二平行平面的平面波导和在它们之间延伸的边缘，所述边缘具有用于接收光束的接收区域。高控制采样部分，低控制样品部分和测试样品控制部分中的每一个具有包括波导表面的阱，其中每个部分的内容物接触固定在波导表面上的捕获分子。捕获分子被配置为特异性地结合所选择的分析物并且当与通过波导表面的光相互作用时发出荧光。通过比较所述样品捕获分子阱的所述捕获分子区域，所述低对照捕获分子阱和所述高对照捕获分子阱之间的荧光强度来确定所述样品流体中所述目标分析物的浓度。

9. 发明申请

WO2010005897A3 APPARATUS FOR OCCLUDING A FALLOPIAN TUBE 审中-公开
标题翻译：装置倒装管的装置
公开(公告)号：WO2010005897A3
公开(公告)日：2010-04-22
申请号：PCT/US2009049689
申请日：2009-07-06
申请人： COHEREX MEDICAL INC , CARTER PHILLIP J , LINDER RICHARD J , JONES RANDALL K , MILES SCOTT D , DAVIS CLARK C , EDMISTON DARYL R , FOX DEWAYNE C
发明人： CARTER PHILLIP J , LINDER RICHARD J , JONES RANDALL K , MILES SCOTT D , DAVIS CLARK C , EDMISTON DARYL R , FOX DEWAYNE C
IPC分类号： A61F6/22 , A61B17/12
CPC分类号： A61F6/225
摘要： The present invention is directed to a medical device for occluding a fallopian tube for contraception and sterilization. The medical device includes an outer member (12), an inner member (14) and a tissue growth member (16). The outer member includes an outer surface (20) and an inner surface (22), wherein the inner surface defines a bore (24) in the outer member. The inner member is configured to be positioned within the bore of the outer member. The tissue growth member is attached to the outer surface of the outer member and is configured to induce tissue growth thereto. With this arrangement, the medical device can be implanted within the fallopian tube and serve as an occluding device therein. If desired, the medical device can be partially removed from the fallopian tube to restore the ability for conception.
摘要翻译：本发明涉及一种用于闭塞输卵管用于避孕和灭菌的医疗装置。医疗装置包括外部构件（12），内部构件（14）和组织生长构件（16）。外部构件包括外表面（20）和内表面（22），其中内表面在外部构件中限定孔（24）。内部构件构造成定位在外部构件的孔内。组织生长构件附接到外部构件的外表面并且构造成诱导组织生长。通过这种布置，医疗装置可以植入输卵管内并用作其中的闭塞装置。如果需要，医疗设备可以部分地从输卵管中移除以恢复受孕的能力。

10. 发明申请

WO2009137530A3 VENTRICULAR ASSIST DEVICE AND RELATED METHODS 审中-公开
标题翻译：静脉辅助装置及相关方法
公开(公告)号：WO2009137530A3
公开(公告)日：2010-04-22
申请号：PCT/US2009042910
申请日：2009-05-05
申请人： COHEREX MEDICAL INC , WHISENANT BRIAN K , MILES SCOTT D
发明人： WHISENANT BRIAN K , MILES SCOTT D
IPC分类号： A61M1/36
CPC分类号： A61F2/06 , A61B2017/00243 , A61B2017/00252 , A61B2017/3425 , A61B2017/3484 , A61B2017/3488 , A61F2/064 , A61M27/002
摘要： A method and system are provided for percutaneously gaining access to oxygenated blood with an anastomosis device and pumping such oxygenated blood to other arterial regions of the vascular system via an LVAD system. In one embodiment, a system may include an anastomosis device extending through an opening of the atrial septum. A filament may be coupled to the anastomosis device. A snare device may access the right atrium through the superior vena cava, grasp the filament, and withdraw the filament through the superior vena cava. The filament may then be used as a guide to direct a catheter, a conduit or some other structure into the right atrium of the heart via the superior vena cava. A flow path may be defined between the anastomosis device and an arterial location, such as in the aorta, such that at least some oxygenated blood may by-pass the left ventricle and be discharged into the aorta.
摘要翻译：提供了一种方法和系统，用于通过吻合装置经皮获得含氧血液，并经由LVAD系统将这种氧合血液泵送到血管系统的其他动脉区域。在一个实施例中，系统可以包括延伸穿过心房隔膜的开口的吻合装置。丝可以连接到吻合装置。圈套装置可以通过上腔静脉进入右心房，抓住细丝，并通过上腔静脉取出细丝。然后可以将细丝用作引导件，以将导管，导管或一些其它结构经由上腔静脉引导到心脏的右心房。可以在吻合装置和动脉位置（例如主动脉）之间限定流动路径，使得至少一些氧合血液可以绕过左心室并排出到主动脉。

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