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1. 发明申请

WO2010135462A1 DEVICES FOR REDUCING THE SIZE OF AN INTERNAL TISSUE OPENING 审中-公开
标题翻译：用于减少内部组织开放尺寸的装置
公开(公告)号：WO2010135462A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035464
申请日：2010-05-19
申请人： COHEREX MEDICAL, INC. , LINDER, Richard, J. , DAVIS, Clark, C. , MILES, Scott, D. , FOX, DeWayne, C. , EDMISTON, Daryl, R. , EWELL, David, A.
发明人： LINDER, Richard, J. , DAVIS, Clark, C. , MILES, Scott, D. , FOX, DeWayne, C. , EDMISTON, Daryl, R. , EWELL, David, A.
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00623
摘要： A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The closure device can include a body portion operatively associated with a first anchor and a second anchor. The body portion can include a plurality of segments defining a multi-cellular structure. The closure device can be configured to apply lateral force to tissue of the internal tissue opening to bring tissue together. The closure device can have a substantially flat aspect, and have a depth thickness that is substantially greater than the thickness or width of a majority of the members forming the closure device to reduce out of plane bending. The closure device can also include a member adapted to induce tissue growth.
摘要翻译：用于治疗内部组织开口的医疗系统可以包括闭合装置和相关联的递送装置。闭合装置可以包括与第一锚固件和第二锚固件可操作地相关联的主体部分。身体部分可以包括限定多细胞结构的多个片段。闭合装置可以构造成向内部组织开口的组织施加横向力以将组织带到一起。闭合装置可以具有基本平坦的方面，并且具有基本上大于形成闭合装置的构件的大部分的厚度或宽度的深度厚度，以减少平面外的弯曲。闭合装置还可以包括适于诱导组织生长的构件。

2. 发明申请

WO2009132141A1 DEVICE, SYSTEM AND METHOD FOR ANEURYSM EMBOLIZATION 审中-公开
标题翻译：装置，系统和方法进行神经阻塞
公开(公告)号：WO2009132141A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/041454
申请日：2009-04-22
申请人： COHEREX MEDICAL, INC. , LINDER, Richard, J. , MILES, Scott, D. , EDMISTON, Daryl, R. , DAVIS, Clark, C.
发明人： LINDER, Richard, J. , MILES, Scott, D. , EDMISTON, Daryl, R. , DAVIS, Clark, C.
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12118 , A61B17/12181 , A61B17/1219 , A61B2017/00898 , A61B2017/1205
摘要： An apparatus, method and system (30) directed to treatment of aneurysms are disclosed. In one embodiment a medical device delivery system may include a handle, a controller coupled to the handle and a catheter (40) coupled to the handle. The delivery system may also include multiple embolic elements (50). Each of the embolic elements are positioned in a distal portion (42) of the catheter in a compressed configuration and lined in a row within the distal portion of the catheter. The embolic elements are configured to be separately and discretely released from the catheter to be freely and randomly positioned within an aneurysm cavity and are each configured to self expand to an configuration larger in size than the compressed configuration. The catheter might be inserted in the aneurysm through the cells (24) of a tubular stent (20) which acts as a retainer member.
摘要翻译：公开了一种针对动脉瘤治疗的装置，方法和系统（30）。在一个实施例中，医疗装置递送系统可以包括手柄，耦合到手柄的控制器和联接到手柄的导管（40）。递送系统还可以包括多个栓塞元件（50）。每个栓塞元件以压缩构型定位在导管的远端部分（42）中，并且在导管的远端部分内排列成一列。栓塞元件被构造成从导管分离和离散地释放，以自由和随机地定位在动脉瘤腔内，并且每个构造成自膨胀至比压缩构型更大尺寸的构型。导管可以通过用作保持构件的管状支架（20）的细胞（24）插入动脉瘤中。

3. 发明申请

WO2009094588A3 SYSTEMS AND METHODS FOR REDUCTION OF ATRIAL FIBRILLATION 审中-公开
公开(公告)号：WO2009094588A3
公开(公告)日：2009-07-30
申请号：PCT/US2009/031903
申请日：2009-01-23
申请人： COHEREX MEDICAL, INC. , DAVIS, Clark, C. , LINDER, Richard, J. , MILES, Scott, D. , EDMISTON, Daryl, R.
发明人： DAVIS, Clark, C. , LINDER, Richard, J. , MILES, Scott, D. , EDMISTON, Daryl, R.
IPC分类号： A61B5/027 , A61M25/00
摘要： Embodiments of the present invention are directed to ablation catheter systems configured, for example, to ablate tissue adjacent an ostium of the pulmonary vein in a left atria of a heart, hi one embodiment, an ablation catheter system includes a handle including an actuator and a catheter coupled to the handle defining a lumen extending through a length of the catheter, the catheter including a tip portion at a distal end thereof. The ablation catheter system may also include an electrode coupled to the handle with lines extending through the lumen of the catheter, the electrode being configured to be constrained within the tip portion of the catheter and configured to be deployed from the tip portion and self expand to an expanded configuration. With this arrangement, the electrode is configured to self expand to a conical configuration with a tip portion configured to be disposed within the pulmonary vein.

4. 发明申请

WO2009094585A2 METHODS AND APPARATUS FOR REDUCING VALVE PROLASPE 审中-公开
标题翻译：用于减少阀门凸起的方法和设备
公开(公告)号：WO2009094585A2
公开(公告)日：2009-07-30
申请号：PCT/US2009/031900
申请日：2009-01-23
申请人： COHEREX MEDICAL, INC. , LINDER, Richard, J. , MILES, Scott, D. , EDMISTON, Daryl, R. , DAVIS, Clark, C.
发明人： LINDER, Richard, J. , MILES, Scott, D. , EDMISTON, Daryl, R. , DAVIS, Clark, C.
IPC分类号： A61M25/00 , A61M39/22
CPC分类号： A61F2/2454 , A61B2017/00243 , A61F2/2457
摘要： Medical devices, systems and methods for treating valve prolapse in, for example, the mitral valve. The medical device is employed by delivering the device percutaneously and lodging the device adjacently above the valve. With this arrangement, the device provides a back-stop to prevent valve prolapse and, thus, prevent valve regurgitation.
摘要翻译：用于治疗例如二尖瓣中的瓣膜脱垂的医疗装置，系统和方法医疗装置通过将装置经皮递送并将装置相邻地放置在瓣膜上方来使用。通过这种安排，该装置提供了一个止回阀来防止瓣膜脱垂，从而防止瓣膜返流。

5. 发明申请

WO2009052432A2 MEDICAL DEVICE FOR MODIFICATION OF LEFT ATRIAL APPENDANGE AND RELATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于修改左心室附件的医疗装置及相关系统及方法
公开(公告)号：WO2009052432A2
公开(公告)日：2009-04-23
申请号：PCT/US2008/080374
申请日：2008-10-17
申请人： COHEREX MEDICAL, INC. , MILES, Scott, D. , LINDER, Richard, J. , DAVIS, Clark, C. , WHISENANT, Brian, K. , EDMISTON, Daryl, R. , FOX, Dewayne, C.
发明人： MILES, Scott, D. , LINDER, Richard, J. , DAVIS, Clark, C. , WHISENANT, Brian, K. , EDMISTON, Daryl, R. , FOX, Dewayne, C.
IPC分类号： A61B17/12
CPC分类号： A61B17/12122 , A61B17/00491 , A61B17/12022 , A61B17/1214 , A61B17/1215 , A61B17/12159 , A61B17/12172 , A61B17/12186 , A61B17/1219 , A61B2017/00243 , A61B2017/00898 , A61B2017/0412 , A61B2017/0427 , A61B2017/0649 , A61B2017/1205
摘要： Several embodiments are set forth of devices, systems and methods for modifying an atrial appendage such as a left atrial appendage (LAA). In one embodiment, a device includes a body that is collapsible and self-expanding. The body includes a textured surface with protruding portions and recessed portions. The body may be formed of a reticulated foam material and may exhibit a substantially spherical geometry or a truncated spherical geometry. The body may be substantially hollow. In one embodiment, portions of the textured surface may be metalized or have a coating placed thereon to enhance frictional engagement of the body with the atrial appendage wall. In another embodiment, a mesh bag is disposed within an LAA and one or more self- expanding bodies are disposed within the mesh bag. The mesh bag is then secured to retain the self-expanding bodies within the bag and the LAA.
摘要翻译：阐述用于修改诸如左心耳（LAA）的心房附件的装置，系统和方法的几个实施例。在一个实施例中，装置包括可折叠和自展开的主体。主体包括具有突出部分和凹陷部分的纹理表面。主体可以由网状泡沫材料形成，并且可以呈现基本上球形的几何形状或截顶的球形几何形状。身体可以是基本上中空的。在一个实施例中，纹理表面的部分可以被金属化或者具有放置在其上的涂层，以增强身体与心耳壁的摩擦接合。在另一个实施例中，网袋设置在LAA内，并且一个或多个自扩张体设置在网袋内。然后固定网袋以将自膨胀体保持在袋和LAA内。

6. 发明申请

WO2007140420A3 METHODS, SYSTEMS, AND DEVICES FOR CLOSING A PATENT FORAMEN OVALE USING MECHANICAL STRUCTURES 审中-公开
标题翻译：使用机械结构封闭专利的瓦楞纸的方法，系统和装置
公开(公告)号：WO2007140420A3
公开(公告)日：2008-09-25
申请号：PCT/US2007069995
申请日：2007-05-30
申请人： COHEREX MEDICAL INC , DAVIS CLARK C , MILES SCOTT D , EDMISTON DARYL R , WHISENANT BRIAN K , LINDER RICHARD J , FOX DEWAYNE C
发明人： DAVIS CLARK C , MILES SCOTT D , EDMISTON DARYL R , WHISENANT BRIAN K , LINDER RICHARD J , FOX DEWAYNE C
IPC分类号： A61B18/18
CPC分类号： A61B17/0057 , A61B18/1492 , A61B2017/00557 , A61B2017/00575 , A61B2017/00623 , A61B2018/1435
摘要： A medical device is disclosed that can include a first atrial anchor, a first delivery shaft linked to the first atrial anchor, wherein the first delivery shaft is adapted to move the first atrial anchor, a second atrial anchor, a second delivery shaft linked to the second atrial anchor, wherein the second delivery shaft is adapted to move the second atrial anchor, and a biasing member linking either (i) the first atrial anchor to the first delivery shaft or (ii) the second atrial anchor to the second delivery shaft. The medical device can include an insulation material coupled to one or more of the first or second atrial anchors, or the first or second delivery shaft. A method for treating an internal tissue opening is also disclosed wherein a first and second electrode can be operated between unipolar and bipolar modes to initiate tissue damage, thereby inducing tissue regrowth.
摘要翻译：公开了一种医疗装置，其可以包括第一心房锚，连接到第一心房锚的第一输送轴，其中第一输送轴适于移动第一心房锚，第二心房锚，第二输送轴第二心房锚，其中第二输送轴适于移动第二心房锚，以及将（i）第一心房锚与第一输送轴连接的偏压构件，或（ii）第二心房锚固件连接到第二输送轴。医疗装置可以包括耦合到第一或第二心房锚或第一或第二输送轴中的一个或多个的绝缘材料。还公开了一种用于治疗内部组织开口的方法，其中第一和第二电极可以在单极和双极模式之间操作以引发组织损伤，从而诱导组织再生长。

7. 发明申请

WO2007103678A3 STENT DELIVERY CATHETER 审中-公开
标题翻译： STENT输送管
公开(公告)号：WO2007103678A3
公开(公告)日：2008-02-21
申请号：PCT/US2007062944
申请日：2007-02-28
申请人： BOSTON SCIENT SCIMED INC , GOODIN RICHARD L , GUNDERSON RICHARD C , DAVIS CLARK C , TURNLUND TODD H , LIPPERT JOHN A
发明人： GOODIN RICHARD L , GUNDERSON RICHARD C , DAVIS CLARK C , TURNLUND TODD H , LIPPERT JOHN A
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2/958 , A61F2002/9665
摘要： Stent delivery catheters (10) adapted to provide both flexibility and strength are disclosed. Such stent delivery catheters may have outer shafts (20) adapted for tensile strength and inner shafts (24) adapted for compressive strength. In some instances, at least one of the outer shaft and/or the inner shaft may include a micromachined portion.
摘要翻译：公开了适于提供柔性和强度的支架输送导管（10）。这种支架输送导管可以具有适于抗拉强度的外轴（20）和适于抗压强度的内轴（24）。在一些情况下，外轴和/或内轴中的至少一个可以包括微加工部分。

8. 发明申请

WO2007140420A2 METHODS, SYSTEMS, AND DEVICES FOR CLOSING A PATENT FORAMEN OVALE USING MECHANICAL STRUCTURES 审中-公开
标题翻译：使用机械结构封闭专利废弃物的方法，系统和装置
公开(公告)号：WO2007140420A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/069995
申请日：2007-05-30
申请人： COHEREX MEDICAL, INC. , DAVIS, Clark, C. , MILES, Scott, D. , EDMISTON, Daryl, R. , WHISENANT, Brian, K. , LINDER, Richard, J. , FOX, Dewayne, C.
发明人： DAVIS, Clark, C. , MILES, Scott, D. , EDMISTON, Daryl, R. , WHISENANT, Brian, K. , LINDER, Richard, J. , FOX, Dewayne, C.
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B18/1492 , A61B2017/00557 , A61B2017/00575 , A61B2017/00623 , A61B2018/1435
摘要： A medical device is disclosed that can include a first atrial anchor, a first delivery shaft linked to the first atrial anchor, wherein the first delivery shaft is adapted to move the first atrial anchor, a second atrial anchor, a second delivery shaft linked to the second atrial anchor, wherein the second delivery shaft is adapted to move the second atrial anchor, and a biasing member linking either (i) the first atrial anchor to the first delivery shaft or (ii) the second atrial anchor to the second delivery shaft. The medical device can include an insulation material coupled to one or more of the first or second atrial anchors, or the first or second delivery shaft. A method for treating an internal tissue opening is also disclosed wherein a first and second electrode can be operated between unipolar and bipolar modes to initiate tissue damage, thereby inducing tissue regrowth.
摘要翻译：公开了一种医疗装置，其可以包括第一心房锚，连接到第一心房锚的第一输送轴，其中第一输送轴适于移动第一心房锚，第二心房锚，第二输送轴第二心房锚，其中所述第二输送轴适于移动所述第二心房锚，以及偏压构件，所述偏压构件将（i）所述第一心房锚固件连接到所述第一输送轴，或（ii）所述第二心房锚固件连接到所述第二输送轴。医疗装置可以包括耦合到第一或第二心房锚或第一或第二输送轴中的一个或多个的绝缘材料。还公开了一种用于治疗内部组织开口的方法，其中第一和第二电极可以在单极和双极模式之间操作以引发组织损伤，从而诱导组织再生长。

9. 发明申请

WO2007103678A2 STENT DELIVERY CATHETER 审中-公开
标题翻译： STENT输送管
公开(公告)号：WO2007103678A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/062944
申请日：2007-02-28
申请人： BOSTON SCIENTIFIC SCIMED, INC. , GOODIN, Richard L. , GUNDERSON, Richard C. , DAVIS, Clark C. , TURNLUND, Todd H. , LIPPERT, John A.
发明人： GOODIN, Richard L. , GUNDERSON, Richard C. , DAVIS, Clark C. , TURNLUND, Todd H. , LIPPERT, John A.
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2/958 , A61F2002/9665
摘要： Stent delivery catheters adapted to provide both flexibility and strength are disclosed. Such stent delivery catheters may have outer shafts adapted for tensile strength and inner shafts adapted for compressive strength. In some instances, at least one of the outer shaft and/or the inner shaft may include a micromachined portion.
摘要翻译：公开了适于提供灵活性和强度的支架输送导管。这种支架输送导管可以具有适于抗拉强度的外轴和适于抗压强度的内轴。在一些情况下，外轴和/或内轴中的至少一个可以包括微加工部分。

10. 发明申请

WO2007038608A2 DELIVERY SYSTEM FOR PATENT FORAMEN OVALE CLOSURE DEVICE 审中-公开
标题翻译：专利废物封闭装置的输送系统
公开(公告)号：WO2007038608A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/037690
申请日：2006-09-26
申请人： COHEREX MEDICAL, INC. , WHISENANT, Brian, K. , DAVIS, Clark, C. , EDMISTON, Daryl, R.
发明人： WHISENANT, Brian, K. , DAVIS, Clark, C. , EDMISTON, Daryl, R.
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623
摘要： A medical system for use in reducing the size of an internal tissue opening is disclosed. The medical system can include a patent foramen ovale or PFO closure device and a delivery device therefore. The PFO closure device can include left and right anchors connected by a stem. The delivery device is configured to selectively deploy at least one of the right or left anchors of PFO closure device so as to enable a practitioner to adjust PFO closure device during the positioning procedure. In one embodiment, the delivery device includes a filament operating shaft linked to the right anchor by one or more filaments. A practitioner can move the filament operating shaft to selectively deploy and retract the right anchor during positioning of the PFO closure device. Furthermore, the delivery device comprises a tether shaft for coupling delivery device to PFO closure device. In one embodiment, the tether shaft comprises a first portion and a flexible second portion, wherein the flexible second portion is at a distal end of the tether shaft.
摘要翻译：公开了一种用于减小内部组织开口尺寸的医疗系统。因此，医疗系统可以包括卵孔或PFO封闭装置和输送装置。 PFO闭合装置可以包括由杆连接的左和右锚定器。输送装置被配置为选择性地展开PFO闭合装置的右侧或左侧锚固件中的至少一个，以使得从业者能够在定位过程期间调节PFO闭合装置。在一个实施例中，输送装置包括通过一个或多个细丝连接到右锚的细丝操作轴。在定位PFO闭合装置期间，从业者可以移动细丝操作轴以选择性地展开和缩回右锚。此外，输送装置包括用于将输送装置耦合到PFO闭合装置的系绳轴。在一个实施例中，系绳轴包括第一部分和柔性第二部分，其中柔性第二部分位于系绳轴的远端。

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