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1. 发明申请

WO2014174052A1 SYSTEM AND METHOD FOR TRACKING A NON-VISIBLE STRUCTURE OF A BODY 审中-公开
标题翻译：跟踪身体不可见结构的系统和方法
公开(公告)号：WO2014174052A1
公开(公告)日：2014-10-30
申请号：PCT/EP2014/058406
申请日：2014-04-24
申请人： NAVIGATE SURGICAL TECHNOLOGIES, INC. , DAON, Ehud (Udi) , BECKETT, Martin, Gregory
发明人： DAON, Ehud (Udi) , BECKETT, Martin, Gregory
IPC分类号： A61B19/00
CPC分类号： A61B34/20 , A61B90/39 , A61B2034/2055 , A61B2034/2065 , A61B2090/363 , A61B2090/364 , A61B2090/3937 , A61B2090/3966 , A61B2090/3983 , A61B2090/3991 , A61C1/082 , G06T7/0014 , G06T7/74 , G06T2207/30036 , G06T2207/30204 , H04N13/20
摘要： A monitoring system tracks the non-visible structure of a body in three dimensions. A tracker (508) obtains image information of the object and instruments (506) in its vicinity, all bearing 3D tracking markers (504). A controller spatially relates the image information with previously obtained scan data of the object revealing a non- visible structure (612') of the object. For the scan a fiducial reference detectable in the scan is removably attached to a location on the object. The scan data and image information is used by the controller to provide the user with real time information on the relative 3D locations and orientations of the instruments and the non-visible structure of the body. In a further embodiment the monitoring system may be used to model and track the changes in the body itself. In other embodiments, a model of the body and instruments is used to track contemplated actions and warn about possibly inappropriate instrument procedures.
摘要翻译：监控系统在三个维度上跟踪身体的不可见结构。跟踪器（508）获取其附近的物体和仪器（506）的图像信息，全部具有3D跟踪标记（504）。控制器在空间上将图像信息与先前获得的物体的扫描数据相关联，从而显示对象的不可见结构（612'）。对于扫描，扫描中可检测的基准参考可移除地附接到物体上的位置。控制器使用扫描数据和图像信息来向用户提供关于仪器的相对3D位置和取向以及身体的不可见结构的实时信息。在另一实施例中，监视系统可用于对身体本身的变化进行建模和跟踪。在其他实施例中，使用身体和器械的模型来跟踪预期的动作并警告可能不适当的仪器过程。

2. 发明申请

WO2014134090A1 ULTRASONIC APPARATUS AND METHOD FOR CELL RELEASE 审中-公开
标题翻译：超声波装置和细胞释放方法
公开(公告)号：WO2014134090A1
公开(公告)日：2014-09-04
申请号：PCT/US2014/018481
申请日：2014-02-26
申请人： CORNING INCORPORATED , MARTIN, Gregory Roger , TANNER, Allison Jean
发明人： MARTIN, Gregory Roger , TANNER, Allison Jean
IPC分类号： C12M1/26
CPC分类号： C12M33/00 , C12M23/08 , C12M23/10 , C12M23/12 , C12M33/08 , C12N13/00
摘要： An apparatus (100) for cell release from a cell culture article (101), including: an ultrasonic source (105); a stage comprising a base (112) and a raised portion (114) that defines a cell culture article confinement area; and a mechanism for relative scan motion between the ultrasonic source and the cell culture article confined to the stage. Also disclosed is a method for cell release and harvesting from a cell culture article (101), including: securing a cell culture article in the disclosed cell release apparatus; and accomplishing relative motion scanning between the energized ultrasonic source and the cell culture article for a time, as defined herein.
摘要翻译：一种用于从细胞培养物品（101）释放细胞的装置（100），包括：超声波源（105）; 包括限定细胞培养物品限制区域的基部（112）和凸起部分（114）的台阶; 以及超声波源和限于该阶段的细胞培养物之间的相对扫描运动的机制。还公开了从细胞培养物（101）进行细胞释放和收获的方法，包括：确保细胞培养物品在所公开的细胞释放装置中; 并且如本文所定义的那样，在通电的超声波源和细胞培养物品之间完成一段时间的相对运动扫描。

3. 发明申请

WO2013116421A1 CELL CULTURE SYSTEMS 审中-公开
标题翻译：细胞培养系统
公开(公告)号：WO2013116421A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/023981
申请日：2013-01-31
申请人： CORNING INCORPORATED , BENNETT, Scott, Matthew , KENNEY, David, Alan , MARTIN, Gregory, Roger , TANNER, Allison, Jean
发明人： BENNETT, Scott, Matthew , KENNEY, David, Alan , MARTIN, Gregory, Roger , TANNER, Allison, Jean
IPC分类号： C12M1/36 , C12M3/06 , C12M1/00
CPC分类号： C12M27/16 , C12M23/50 , C12M23/52 , C12M29/00 , C12M29/14 , C12M33/08 , C12M41/40 , C12M41/44 , C12M41/48
摘要： An integrated cell culture system may include one or more cell culture vessels, manipulation apparatus, pumping apparatus, cell release apparatus, monitoring apparatus, and a control apparatus. The control apparatus may be used to monitor and control the system to facilitate effective cell culturing. The cell release apparatus may be used to release a plurality of cells adhered to the cell culture surfaces of the cell culture vessels.
摘要翻译：综合细胞培养系统可以包括一个或多个细胞培养容器，操作装置，泵送装置，细胞释放装置，监测装置和控制装置。控制装置可用于监测和控制系统以促进有效的细胞培养。细胞释放装置可以用于释放粘附于细胞培养容器的细胞培养表面的多个细胞。

4. 发明申请

WO2010099264A2 CELL CULTURE SYSTEM WITH MANIFOLD 审中-公开
标题翻译：细胞培养系统
公开(公告)号：WO2010099264A2
公开(公告)日：2010-09-02
申请号：PCT/US2010/025321
申请日：2010-02-25
申请人： CORNING INCORPORATED , KENNEY, David, A. , MARTIN, Gregory, R. , WALL, Joseph, C.
发明人： KENNEY, David, A. , MARTIN, Gregory, R. , WALL, Joseph, C.
IPC分类号： C12M1/24
CPC分类号： C12M23/08 , C12M23/34 , C12M23/40 , C12M23/44 , Y10T29/49826
摘要： A cell culture apparatus includes cell culture units having cell culture chambers, each with at least one manifold. The manifold connects the cell culture unit to a fluid flow channel. The manifold has a dam which allows liquid to pool in the manifold and allows for the creation of an airspace in the manifold, which reduces hydrostatic pressure inside the apparatus and enables the stacking of multiple cell culture units. Embodiments include cascading manifolds, manifolds having reservoirs, and manifolds having valves.
摘要翻译：细胞培养装置包括具有细胞培养室的细胞培养单元，每个细胞培养室具有至少一个歧管。歧管将细胞培养单元连接到流体流动通道。歧管具有允许液体在歧管中汇集并且允许在歧管中创建空气空间的坝，这降低了设备内部的静水压力，并且能够堆叠多个细胞培养单元。实施例包括级联歧管，具有储存器的歧管和具有阀的歧管。

5. 发明申请

WO2009148512A3 ASSEMBLY OF CELL CULTURE VESSELS 审中-公开
公开(公告)号：WO2009148512A3
公开(公告)日：2009-12-10
申请号：PCT/US2009/003127
申请日：2009-05-20
申请人： CORNING INCORPORATED , CATTADORIS, Henry, J. , MARTIN, Gregory, R. , TANNER, Allison, J.
发明人： CATTADORIS, Henry, J. , MARTIN, Gregory, R. , TANNER, Allison, J.
IPC分类号： B29C65/14 , C12M1/14
摘要： A cell culture apparatus includes a cell culture chamber formed by a first major surface, an opposing second major surface spaced apart from the first major surface, and a first side wall around the first chamber and extending between the first and second major surfaces. A portion of the first sidewall proximate the first major surface comprises an infrared absorbent material, and a portion the first sidewall proximate the second major surface is formed from substantially non-infrared absorbent material. The first major surface is formed by a gas permeable polymeric film that is impermeable to cell culture liquid.

6. 发明申请

WO2009145875A1 METHOD FOR ULTRASONIC CELL REMOVAL 审中-公开
标题翻译：超声波清除方法
公开(公告)号：WO2009145875A1
公开(公告)日：2009-12-03
申请号：PCT/US2009/003092
申请日：2009-05-19
申请人： CORNING INCORPORATED , MARTIN, Gregory, R. , TANNER, Allison, J.
发明人： MARTIN, Gregory, R. , TANNER, Allison, J.
IPC分类号： C12M1/42 , C12M3/00
CPC分类号： C12M33/12 , C12M23/04 , C12M23/08 , C12M23/24 , C12M23/34 , C12M23/44
摘要： The present invention provides a method for treating cell culture vessels including multi-layer cell culture vessels with ultrasonic energy to dissociate cells growing on surfaces of cell culture vessels.
摘要翻译：本发明提供一种处理细胞培养容器的方法，其包括具有超声能量的多层细胞培养容器，以解离细胞培养容器表面生长的细胞。

7. 发明申请

WO2004016745A3 BACKTERIAL EFFECTOR PROTEINS WHICH INHIBIT PROGRAMMED CELL DEATH 审中-公开
标题翻译：禁止编程细胞死亡的后备效应蛋白
公开(公告)号：WO2004016745A3
公开(公告)日：2009-06-18
申请号：PCT/US0325247
申请日：2003-08-13
申请人： THOMPSON BOYCE PLANT RES , MARTIN GREGORY B , ABRAMOVITCH ROBERT B , LIN NAI WEN , KIM YOUNG-JIN
发明人： MARTIN GREGORY B , ABRAMOVITCH ROBERT B , LIN NAI WEN , KIM YOUNG-JIN
IPC分类号： C07K1/00 , C07K14/21 , C12N15/82
CPC分类号： A61K38/164 , C07K14/21 , C12N15/8249 , C12N15/8257 , C12N15/8263 , C12N15/8279 , C12N15/8281
摘要： The present invention relates to a bacterial effector protein which inhibits programmed cell death in eukaryotes and a nucleic acid molecule encoding such a protein. The present invention also relates to methods of suppressing programmed cell death in eukaryotes, delaying senescence in plants, and increasing protein expression in plants. The present invention further relates to a nucleic acid construct having a nucleic acid molecule encoding a first protein, which suppresses immunity by inhibition of programmed cell death in eukaryotes, coupled to a nucleic acid molecule encoding a second protein which is toxic when expressed in eukaryotes. Additionally, the present invention provides a method of stabilizing a transgenic plant transformed with such a nucleic acid construct. Finally, the present invention provides a method of treating subjects for a condition mediated by programmed cell death involving administering to the subject a bacterial effector protein which inhibits programmed cell death.
摘要翻译：本发明涉及抑制真核生物中程序性细胞死亡的细菌效应蛋白和编码这种蛋白质的核酸分子。本发明还涉及抑制真核生物中程序性细胞死亡的方法，延缓植物中的衰老和增加植物中的蛋白质表达。本发明还涉及具有编码第一种蛋白质的核酸分子的核酸构建体，其通过抑制真核生物中的程序性细胞死亡而抑制免疫，其与编码当在真核生物中表达时具有毒性的第二种蛋白质的核酸分子偶联。另外，本发明提供了一种稳定用这种核酸构建体转化的转基因植物的方法。最后，本发明提供了一种治疗受试者由程序性细胞死亡介导的病症的方法，其涉及对受试者施用抑制程序性细胞死亡的细菌效应蛋白。

8. 发明申请

WO2009006225A2 SPINAL STABILIZATION DEVICE 审中-公开
标题翻译：脊柱稳定装置
公开(公告)号：WO2009006225A2
公开(公告)日：2009-01-08
申请号：PCT/US2008/068393
申请日：2008-06-26
申请人： SPINAL ELEMENTS, INC. , BLAIN, Jason , MARTIN, Gregory , LAKE, Matthew
发明人： BLAIN, Jason , MARTIN, Gregory , LAKE, Matthew
IPC分类号： A61B17/58
CPC分类号： A61B17/7002 , A61B17/7032 , A61B17/7037
摘要： A bone attachment device comprises an attachment collar having a hinged lid is disclosed. The bone attachment device may also comprise a bone fastener (such as a bone screw). A bone attachment device including an attachment collar and a spinal rod locking device is disclosed. A bone attachment device as described herein may be used together with a spinal stabilization rod and one or more additional bone attachment devices. Such devices are adapted to clamp and hold a spinal stabilization rod. Methods for implanting a spinal stabilizer having a bone attachment device including a hinged Ud are disclosed.
摘要翻译：骨附着装置包括具有铰接盖的附接环。骨附着装置还可以包括骨紧固件（例如骨螺钉）。公开了一种包括附接环和脊柱杆锁定装置的骨附着装置。本文所述的骨附着装置可与脊椎稳定杆和一个或多个另外的骨附着装置一起使用。这种装置适于夹紧和保持脊柱稳定杆。公开了用于植入具有包括铰链Ud的骨附着装置的脊柱稳定器的方法。

9. 发明申请

WO2009002423A2 POLYCYCLIC GUANINE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
标题翻译：多环类衍生物及其使用方法
公开(公告)号：WO2009002423A2
公开(公告)日：2008-12-31
申请号：PCT/US2008/007592
申请日：2008-06-18
申请人： SCHERING CORPORATION , ALBANY MOLECULAR RESEARCH, INC , TULSHIAN, Deen , GEISS, William, B. , MARTIN, Gregory, S. , LE, Van-duc , HABER, James, C., Jr. , MATASI, Julius, J. , CZARNIECKI, Michael, F. , COOKE, Stephanie, Nicole
发明人： TULSHIAN, Deen , GEISS, William, B. , MARTIN, Gregory, S. , LE, Van-duc , HABER, James, C., Jr. , MATASI, Julius, J. , CZARNIECKI, Michael, F. , COOKE, Stephanie, Nicole
IPC分类号： A61K31/519 , A61P25/00
CPC分类号： C07D487/14
摘要： The present invention relates to Polycyclic Guanine Derivatives, compositions comprising the Polycyclic Guanine Derivatives and methods of using the Polycyclic Guanine Derivatives to treat pain or an inflammatory disease.
摘要翻译：本发明涉及多环鸟嘌呤衍生物，包含多环鸟嘌呤衍生物的组合物和使用多环鸟嘌呤衍生物治疗疼痛或炎性疾病的方法。

10. 发明申请

WO2008005244A3 HIGH DENSITY PERMEABLE SUPPORTS FOR HIGH THROUGHPUT SCREENING 审中-公开
标题翻译：高密度渗透性支持用于高通量筛选
公开(公告)号：WO2008005244A3
公开(公告)日：2008-04-03
申请号：PCT/US2007014852
申请日：2007-06-27
申请人： CORNING INC , MARTIN GREGORY R , TANNER ALLISON J
发明人： MARTIN GREGORY R , TANNER ALLISON J
IPC分类号： B01L3/00 , C12M3/06
CPC分类号： C12M25/04 , B01L3/50255 , B01L3/50857 , B01L2300/0681 , B01L2300/0829 , C12M23/24 , C12M23/38
摘要： A class of designs is provided for a permeable support where the design principle includes a permeable support layer (250), such as a membrane, bonded midway between two arrays of wells (110, 130) or multiwell plates, attached at their bottom portions, forming a double-sided multiwell plate. Thus, opposite facing wells on either side of the permeable support layer are accessible by inversion of the double-sided multiwell plate. Well fluid is held in place in the novel multiwell plate by capillary forces in the case of aligned upper and lower well arrays or by surface tension on patterned well regions on a permeable membrane layer. No additional components are necessary to form compartments for fluid retention. These new plate designs allow the surface area of the permeable support layer to be maximized, eliminate potential wicking and. cross contamination issues that may arise from multiple component sidewalls, and take advantage of the small well diameters to retain fluid by utilizing the effects of surface tension or capillary forces.
摘要翻译：提供了一类用于可渗透支撑件的设计，其中设计原理包括在其底部附接的两个井组（110,130）或多孔板之间的中间的粘合剂（例如膜）的可渗透支撑层（250）形成双面多孔板。因此，可渗透支撑层的任一侧上的相对面对的孔可通过双面多孔板的倒置进入。在新颖的多孔板中，在对准的上下阵列的情况下通过毛细作用力将液体保持在适当的位置，或者通过可渗透膜层上的图案化阱区域上的表面张力来保持良好的流体。不需要额外的部件来形成用于流体保持的隔室。这些新的板设计允许可渗透支撑层的表面积最大化，消除潜在的芯吸。可能由多个部件侧壁产生的交叉污染问题，并且通过利用表面张力或毛细管力的作用，利用小孔直径来保留流体。

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