专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009002423A2 POLYCYCLIC GUANINE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
标题翻译：多环类衍生物及其使用方法
公开(公告)号：WO2009002423A2
公开(公告)日：2008-12-31
申请号：PCT/US2008/007592
申请日：2008-06-18
申请人： SCHERING CORPORATION , ALBANY MOLECULAR RESEARCH, INC , TULSHIAN, Deen , GEISS, William, B. , MARTIN, Gregory, S. , LE, Van-duc , HABER, James, C., Jr. , MATASI, Julius, J. , CZARNIECKI, Michael, F. , COOKE, Stephanie, Nicole
发明人： TULSHIAN, Deen , GEISS, William, B. , MARTIN, Gregory, S. , LE, Van-duc , HABER, James, C., Jr. , MATASI, Julius, J. , CZARNIECKI, Michael, F. , COOKE, Stephanie, Nicole
IPC分类号： A61K31/519 , A61P25/00
CPC分类号： C07D487/14
摘要： The present invention relates to Polycyclic Guanine Derivatives, compositions comprising the Polycyclic Guanine Derivatives and methods of using the Polycyclic Guanine Derivatives to treat pain or an inflammatory disease.
摘要翻译：本发明涉及多环鸟嘌呤衍生物，包含多环鸟嘌呤衍生物的组合物和使用多环鸟嘌呤衍生物治疗疼痛或炎性疾病的方法。

2. 发明申请

WO2011079000A1 DERIVATIVES OF 7,8-DIHYDRO-1H-IMIDAZO[2,1-b]PURIN-4(5H)-ONE AND METHODS OF USE THEREOF 审中-公开
标题翻译： 7,8-二氢-1H-咪唑并[2,1-b]嘌呤-4（5H）酮的衍生物及其使用方法
公开(公告)号：WO2011079000A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/060632
申请日：2010-12-16
申请人： SCHERING CORPORATION , TULSHIAN, Deen , MATASI, Julius, J. , CZARNIECKI, Michael, F. , BRUMFIELD, Stephanie Nicole
发明人： TULSHIAN, Deen , MATASI, Julius, J. , CZARNIECKI, Michael, F. , BRUMFIELD, Stephanie Nicole
IPC分类号： A01N43/90 , A61K31/52
CPC分类号： C07D487/12
摘要： The present invention relates to derivatives of 7,8-dihydro-1 H -imidazo[2,1- b ]purin-4(5 H )-one, compositions thereof and methods of use thereof for treating or preventing pain or an inflammatory disease.
摘要翻译：本发明涉及7,8-二氢-1H-咪唑并[2,1-b]嘌呤-4（5H） - 酮的衍生物及其用于治疗或预防疼痛或炎性疾病的组合物及其用途。

3. 发明申请

WO2008005570A1 3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS 审中-公开
标题翻译：作为CXC-CHEMOKINE受体配体的3,4-二取代的环己基-1,2-二酮
公开(公告)号：WO2008005570A1
公开(公告)日：2008-01-10
申请号：PCT/US2007/015671
申请日：2007-07-05
申请人： SCHERING CORPORATION , PHARMACOPEIA, INC. , CHAO, Jianhua , CZARNIECKI, Michael, F. , HE, Zhenmin , LAI, Gaifa , MERRITT, James, Robert
发明人： CHAO, Jianhua , CZARNIECKI, Michael, F. , HE, Zhenmin , LAI, Gaifa , MERRITT, James, Robert
IPC分类号： C07D307/52 , A61K31/341 , A61K31/40 , A61P29/00 , A61P35/00
CPC分类号： C07D405/12 , C07D307/52 , C07D307/56
摘要： Disclosed are novel cyclobutenedione Compounds comprising a cycloclobutenedione ring, a substituted phenyl ring, and a -CH(C 2 H 5 )-furan moiety. The phenyl ring and the -CH(C 2 H 5 )-furan moiety are each bound to the cyclobutenedione ring through a -NH- moiety. Also disclosed are uses o Compounds for the manufacture of a medicament for treating chemokine mediated diseases (e.g., cancer, COPD, acute and chronic inflammatory disorders, psoriasis, cystic fibrosis, and asthma).
摘要翻译：公开了新的环丁烯二酮包含环多烯二酮环，取代的苯环和-CH（C 2 H 5 H 5） - 呋喃部分的化合物。苯环和-CH（C 2 H 5 H 5） - 呋喃部分各自通过-NH-部分与环丁烯二酮环结合。还公开了用于制备用于治疗趋化因子介导的疾病（例如癌症，COPD，急性和慢性炎性疾病，牛皮癣，囊性纤维化和哮喘）的药物的化合物。

4. 发明申请

WO2012040048A2 TRIAZOLOPYRAZINONES AS P2X7 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：三氮唑啉酮作为P2X7受体拮抗剂
公开(公告)号：WO2012040048A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/051923
申请日：2011-09-16
申请人： SCHERING CORPORATION , LABROLI, Marc , CZARNIECKI, Michael, F. , POKER, Cory Seth
发明人： LABROLI, Marc , CZARNIECKI, Michael, F. , POKER, Cory Seth
IPC分类号： A61K31/4985
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06
摘要： The invention provides certain 3,7-disubstituted-[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-ones of the Formula (I), and their pharmaceutically acceptabl salts, wherein R 1 , R 2 , R 3 , R 8 , and X are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating pain or an inflammatory disease.
摘要翻译：本发明提供了式（I）的某些3,7-二取代的 - [1,2,4]三唑并[4,3-a]吡嗪-8（7H） - 酮及其它药学上可接受的盐，其中R 1，R 2，R 3，R 8和X如所定义的于此。本发明还提供了包含这些化合物的药物组合物，以及使用该化合物治疗疼痛或炎性疾病的方法。

5. 发明申请

WO1987002669A1 PHOSPHINYLALKANOYL IMINO ACIDS 审中-公开
标题翻译：磷酰基亚氨基酸
公开(公告)号：WO1987002669A1
公开(公告)日：1987-05-07
申请号：PCT/US1986002215
申请日：1986-10-30
申请人： SCHERING CORPORATION
发明人： SCHERING CORPORATION , WITKOWSKI, Joseph, T. , CZARNIECKI, Michael, F.
IPC分类号： C07F09/65
CPC分类号： C07F9/6547
摘要： Phosphinylalkanoyl imino acids containing a 1,2,4-benzothiadiazine-1,1-dioxide moiety and useful in the treatment of hypertension.
摘要翻译：含有1,2,4-苯并噻二嗪-1,1-二氧化物部分的膦酰基烷酰基亚氨基酸，可用于治疗高血压。

6. 发明申请

WO1996000732A1 PHOSPHINIC ACID DERIVATIVES 审中-公开
标题翻译：磷酸衍生物
公开(公告)号：WO1996000732A1
公开(公告)日：1996-01-11
申请号：PCT/US1995007128
申请日：1995-06-19
申请人： SCHERING CORPORATION
发明人： SCHERING CORPORATION , MCKITTRICK, Brian, A. , CZARNIECKI, Michael, F. , CHACKALAMANNIL, Samuel , CHUNG, Shin , DEFREES, Shawn , STAMFORD, Andrew, W.
IPC分类号： C07F09/30
CPC分类号： C07F9/65583 , C07F9/303 , C07F9/5728
摘要： Phosphinic acid derivatives of structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R is H, alkyl or alkanoyloxymethylene; R1, R2, R3 and R4 are H, alkyl, alkenyl, alkenylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, hydroxyalkyl, carboxyalkyl, thioalkyl, alkoxythioalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl-substituted alkyl or heterocycloalkyl; or R1 and R2 form a cycloalkyl ring of 3-8 members and R3 and R4 are as defined; or R3 and R4 form a cycloalkyl ring of 3-7 members and R1 and R2 are as defined; or R1 and R2 together, and R3 and R4 together, each form a cycloalkyl ring; R5 is -OR9 or -NHR9, wherein R9 is hydrogen or alkyl; n is 0 or 1; A1 is p-aminobenzoyl or p-aminobenzenesulfonyl, or A1 and R5 together form a radical of an alpha -aminoacyl derivative; and R6 is phenylmethoxycarbonyl, arylcarbonyl, heteroarylcarbonyl or -A2-R7, wherein A2 is a divalent alpha -iminoacyl radical, and R7 is a substituent on the alpha -imino atom selected from H, R8OCO-, R8SO2- and R8NHCO-, wherein R8 is aryl, arylmethyl or (C1-C8)alkyl; are disclosed for use as endothelin converting enzyme inhibitors; also disclosed are a genus of novel compounds wherein R and R form a cycloalkyl ring, and pharmaceutical compositions comprising said novel compounds.
摘要翻译：结构式（I）的亚磷酸衍生物或其药学上可接受的盐，其中R是H，烷基或烷酰氧基亚甲基; R 1，R 2，R 3和R 4是H，烷基，烯基，烯基烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，羟基烷基，羧基烷基，硫代烷基，烷氧基硫代烷基，氨基烷基，烷基氨基烷基，环烷基取代的烷基或杂环烷基。或R 1和R 2形成3-8成员的环烷基环，并且R 3和R 4如所定义; 或R 3和R 4形成3-7成员的环烷基环，并且R 1和R 2如所定义; 或R 1和R 2一起，并且R 3和R 4一起形成环烷基环; R5是-OR9或-NHR9，其中R9是氢或烷基; n为0或1; A1是对氨基苯甲酰基或对氨基苯磺酰基，或者A1和R5一起形成α-氨基酰基衍生物的基团; R6为苯基甲氧基羰基，芳基羰基，杂芳基羰基或-A2-R7，其中A2为二价α-亚氨酰基，R7为选自H，R8OCO-，R8SO2-和R8NHCO-的α-亚氨基原子上的取代基，其中R8 是芳基，芳甲基或（C1-C8）烷基; 被公开用作内皮素转化酶抑制剂; 还公开了其中R 3和R 4形成环烷基环的新化合物的属，以及包含所述新化合物的药物组合物。

7. 发明申请

WO2003043980A1 AZETIDINYL DIAMINES USEFUL AS LIGANDS OF THE NOCICEPTIN RECEPTOR ORL-1 审中-公开
标题翻译： AZETIDINYL DIAMINES有效地用作NOCICEPTIN受体ORL-1的配体
公开(公告)号：WO2003043980A1
公开(公告)日：2003-05-30
申请号：PCT/US2002/036402
申请日：2002-11-14
申请人： SCHERING CORPORATION
发明人： BURNETT, Duane, A. , CAPLEN, Mary, Ann , CZARNIECKI, Michael, F. , DOMALSKI, Martin, S. , HO, Ginny, D. , TULSHIAN, Deen , WU, Wen-Lian
IPC分类号： C07D205/04
CPC分类号： C07D231/12 , C07D205/04 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/06
摘要： Disclosed are nociceptin ORL-1 receptor agonists of formula (I) wherein; (a) R 1 is optionally substituted alkyl, fluorenyl, pyrimidinyl or optionally substituted piperidinyl; R 2 is H; and R 3 is -C(H)(R)-NR 7 R 8 ; R is H, optionally substituted aryl or arylalkyl, or heteroaryl; R 7 is -(CH 2 ) x R 9 , optionally substituted tetrahydronaphthyl, or cycloalkyl; and R 8 is H; or R 7 and R 8 together form a substituted piperidinyl or piperazinyl ring; x is 0- 10; and R 9 is H, alkoxy, optionally substituted phenyl, naphthyl, heteroaryl, pyrrolidinyl, pyrrolidonyl, optionally substituted piperidinyl or diphenylmethyl; or (b) R 2 is -NHR 7 or formula (II) and R 3 is H; pharmaceutical compositions; and methods of using the compounds to treat cough and pain.
摘要翻译：公开了式（I）的伤害感受肽ORL-1受体激动剂，其中：（a）R 1是任选取代的烷基，芴基，嘧啶基或任选取代的哌啶基; R2为H; 并且R 3是-C（H）（R）-NR 7 R 8; R是H，任选取代的芳基或芳烷基或杂芳基; R 7为 - （CH 2）x R 9，任选取代的四氢萘基或环烷基; R 8为H; 或R 7和R 8一起形成取代的哌啶基或哌嗪基环; x为0-10; R 9为H，烷氧基，任选取代的苯基，萘基，杂芳基，吡咯烷基，吡咯烷酮基，任选取代的哌啶基或二苯基甲基; 或（b）R2为-NHR7或式（Ⅱ），R3为H; 药物组合物; 以及使用该化合物治疗咳嗽和疼痛的方法。

8. 发明申请

WO1990002117A1 MERCAPTO-ACYLAMINO ACID ANTIHYPERTENSIVES 审中-公开
标题翻译：丙烯酰胺酰胺酸抗坏血酸
公开(公告)号：WO1990002117A1
公开(公告)日：1990-03-08
申请号：PCT/US1989003546
申请日：1989-08-22
申请人： SCHERING CORPORATION
发明人： SCHERING CORPORATION , CZARNIECKI, Michael, F. , LEHMAN DE GAETA, Laura, S.
IPC分类号： C07C323/60
CPC分类号： C07C323/60
摘要： Mercapto-acylamino acids of formula (I), wherein n is 0-4; R is (a), (b), (c); R1 is 1-3 substituents selected from the group consisting of hydrogen, halogeno, lower alkyl, cyclolower alkyl, lower alkoxy, hydroxy, aryl, aryloxy, cyano, aminomethyl, carboxy, lower alkoxy carbonyl and carbamyl; R2 is hydrogen, (d) or (e), wherein R11 is lower alkyl, aryl or arylmethyl; R3 is -OR12, (f) or (g); R4, R5, R6, R7, R8, R9 and R10 are independently lower alkyl, aryl lower alkyl, (cyclolower alkyl) lower alkyl, substituted aryl lower alkyl or substituted (cyclolower alkyl) lower alkyl, wherein in the substituents on the aryl and cyclolower alkyl portions are 1-3 substituents selected from the group consisting of lower alkyl, hydroxy, halogeno, lower alkoxy and amino, or R4 and R5 are alkyl and together with the sulfur and carbon atoms to which they are attached form a 5-7 membered ring; R12 and R13 are independently hydrogen, lower alkyl or substituted lower alkyl wherein the substituents are selected from the group consisting of 1 or 2 hydroxy groups, 1 or 2 lower alkoxy groups, lower alkoxy lower alkoxy, halogeno, halogeno lower alkoxy, amino, mono- or di-lower alkylamino, aryl, substituted aryl wherein the substituents on aryl are 1-3 substituents selected from the group consisting of lower alkyl, hydroxy, halogeno, lower alkoxy and amino, and a 5-6 membered saturated ring comprising 1-2 oxygen atoms as ring members wherein the ring carbon atoms can be substituted with 0-2 lower alkyl substituents; or R12 and R13 together with the nitrogen to which they are attached complete a 5-7 membered ring, wherein one of the 4-6 ring members comprising R12 and R13 may be a nitrogen atom, an alkyl-substituted nitrogen atom or an oxygen atom, and wherein the ring may be substituted on the ring carbon atoms with substituents chosen from alkyl and hydroxy groups; R14 is hydrogen, alkyl, carboxyalkyl, mercaptoalkyl, alkylthioalkyl, aminoalkyl, hydroxyalkyl, phenylalkyl, hydroxyphenylalkyl, guanidinoalkyl, imidazolylalkyl, indolylalkyl or carbamoylalkyl; the pharmaceutically acceptable salts thereof and their combinations with atrial natriuretic factors or angiotensin converting enzyme inhibitors are disclosed. Such preparations are useful for treating hypertension and congestive heart failure.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式