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1. 发明申请

WO2005040428A2 DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, OAS1 审中-公开
标题翻译：检测与抗病毒感染相关的基因中的突变
公开(公告)号：WO2005040428A2
公开(公告)日：2005-05-06
申请号：PCT/US2004/035284
申请日：2004-10-22
申请人： ILLUMIGEN BIOSCIENCES, INC. , IADONATO, Shawn, P. , MAGNESS, Charles, L. , ROSENBERG, Gary , SCHERER, Christina, A.
发明人： IADONATO, Shawn, P. , MAGNESS, Charles, L. , ROSENBERG, Gary , SCHERER, Christina, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/707 , A61K38/45 , C07K16/40 , C12N9/1241 , C12N15/1137 , C12Q1/6876 , C12Q1/6883 , C12Q1/6888 , C12Q1/70 , C12Q2600/156 , C12Q2600/172 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/463 , Y02A50/465 , Y02A50/53 , Y02A50/54
摘要： A method for detecting a mutation related to the gene encoding OAS 1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS 1, including antisense oligonucleotides, methods, and compositions specific for human OASI, are also provided.
摘要翻译：用于检测与编码OAS1的基因相关的突变的方法。本发明和其它公开的突变与人类对包括丙型肝炎的病毒感染的抗性相关。还提供了由突变基因编码的蛋白质或多肽组成的治疗剂，或编码蛋白质或多肽的多核苷酸。还提供了人OAS1的抑制剂，包括反义寡核苷酸，方法和人类OASI特异性的组合物。

2. 发明申请

WO0241234A3 SYSTEM AND METHOD FOR SELECTIVELY CLASSIFYING A POPULATION 审中-公开
标题翻译：选择人口分类的系统和方法
公开(公告)号：WO0241234A3
公开(公告)日：2003-06-05
申请号：PCT/US0150759
申请日：2001-10-25
申请人： ILLUMIGEN BIOSCIENCES INC , MAGNESS CHARLES L , IADONATO SHAWN P
发明人： MAGNESS CHARLES L , IADONATO SHAWN P
IPC分类号： A61B5/00 , G06F19/00 , G06Q50/00
CPC分类号： G16H10/60 , G16H10/20
摘要： A technique is disclosed for classifying a population of subjects into various sub-populations for a selected biological condition. Patients are categorized in accordance with numeric scores for a affected status for the selected biological condition and a risk status for the selected biological condition. The numeric scores for an overall population are determined in advance for the selected biological condition. Medical test results, including genetic tests, and risk factors are numerically scored and may further be weighted in accordance with their relevance in determining affected status and risk. Medical test results and medical histories for individual subjects within the population may then automatically be scored in accordance with the predefined characteristics. The numerical scores for affected status and risk status may be stored in a data structure, such as a database. The numeric scores are extracted from the data structure and used to classify individuals in the population into one of a group of selected sub-populations comprising at-risk affected (ARA) and at-risk unaffected (ARU). Additional sub-populations, such as unknown risk, unaffected (URU) may also be used.
摘要翻译：公开了一种用于将受试者群体分类为用于所选生物学条件的各种亚群体的技术。患者根据所选生物学条件的受影响状态的数值分数和所选生物学条件的风险状态进行分类。对于选定的生物学条件，预先确定总体群体的数值分数。医学检验结果包括遗传检测和危险因素在数值上得分，并可根据其在确定受影响状态和风险中的相关性进一步加权。然后可以根据预定义的特征自动计算人群内个体受试者的医学检查结果和病史。受影响状态和风险状态的数值分数可存储在数据结构中，如数据库。从数据结构中提取数字分数，并用于将群体中的个体分类为一组选定的亚群，其中包括风险受影响（ARA）和风险未受影响（ARU）。还可以使用其他子种群，例如未知风险，未受影响（URU）。

3. 发明申请

WO2006004660A2 DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION 审中-公开
标题翻译：检测与病毒感染相关的基因中的突变
公开(公告)号：WO2006004660A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/022729
申请日：2005-06-27
申请人： ILLUMIGEN BIOSCIENCES, INC. , IADONATO, Shawn, P. , MAGNESS, Charles, L. , SCHERER, Christina, A.
发明人： IADONATO, Shawn, P. , MAGNESS, Charles, L. , SCHERER, Christina, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C07K14/705 , C12Q1/707 , C12Q2600/156 , C12Q2600/172
摘要： A method for detecting a mutation related to the gene encoding LDLR. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the wild-type and mutated genes, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human LDLR, including antisense oligonucleotides, methods, and compositions specific for human LDLR, are also provided.
摘要翻译：检测与编码LDLR的基因有关的突变的方法。这个和其他公开的突变与人类对包括丙型肝炎的病毒感染的抗性相关。还提供了由野生型和突变基因编码的蛋白质或多肽或编码蛋白质或多肽的多核苷酸组成的治疗剂。还提供了人LDLR的抑制剂，包括反义寡核苷酸，方法和人LDLR特异性的组合物。

4. 发明申请

WO2007061690A2 NOVEL PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRUS INFECTION AND CANCER 审中-公开
标题翻译：用于治疗病毒感染和癌症的新型药物组合物
公开(公告)号：WO2007061690A2
公开(公告)日：2007-05-31
申请号：PCT/US2006044176
申请日：2006-11-13
申请人： ILLUMIGEN BIOSCIENCES INC , IADONATO SHAWN P , MAGNESS CHARLES L , BRANUM MARK , MCVEAN MARALEE , SCHERER CHRISTINA A
发明人： IADONATO SHAWN P , MAGNESS CHARLES L , BRANUM MARK , MCVEAN MARALEE , SCHERER CHRISTINA A
IPC分类号： C07K14/435
CPC分类号： C12N9/1241 , A61K38/45 , C12N15/102 , C12Y207/07
摘要： The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, improved antiviral activity, improved enzymatic activity, or absent enzymatic activity. The pharmaceutical compositions have improved drug properties and retain or have enhanced antiviral activity relative to their native forms. The pharmaceutical compositions further include chemically modified oligoadenylate synthetases, such chemical modifications being designed to increase serum stability and reduce immunogenicity in vivo. Such chemical modifications further increase drug stability and manufacturability in vitro. Compositions composed of more than ninety novel modifications are described. Also described are antibodies to polypeptides of the invention.
摘要翻译：本发明描述了用于治疗病毒感染和癌症的新型药物组合物。药物组合物包括具有增强的细胞渗透性，降低的氧化潜力，改善的抗病毒活性，改善的酶活性或缺乏酶活性的突变型寡腺苷酸合成酶（OAS）。药物组合物具有改善的药物性质并且相对于其天然形式保留或具有增强的抗病毒活性。药物组合物还包括化学修饰的寡聚腺苷酸合成酶，这种化学修饰被设计为增加血清稳定性并降低体内的免疫原性。这种化学修饰进一步提高了药物稳定性和体外制造能力。描述了由超过九十个新颖的修饰组成的组合物。还描述了本发明多肽的抗体。

5. 发明申请

WO2007027557A2 DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, MX1 审中-公开
标题翻译：检测与病毒感染相关的基因中的突变，MX1
公开(公告)号：WO2007027557A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/033413
申请日：2006-08-25
申请人： ILLUMIGEN BIOSCIENCES, INC. , MAGNESS, Charles, L. , IADONATO, Shawn, P. , SCHERER, Christina, A. , FELLIN, Phillip, Campion , STEIGER, Kathryn, V.
发明人： MAGNESS, Charles, L. , IADONATO, Shawn, P. , SCHERER, Christina, A. , FELLIN, Phillip, Campion , STEIGER, Kathryn, V.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/701
摘要： A method for detecting a mutation related to the gene encoding MxA. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the wild-type and mutated genes, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human MxA, including antisense oligonucleotides, methods, and compositions specific for human MxA, are also provided.
摘要翻译：用于检测与编码MxA的基因有关的突变的方法。这个和其他公开的突变与人类对包括丙型肝炎的病毒感染的抗性相关。还提供了由野生型和突变基因编码的蛋白质或多肽或编码蛋白质或多肽的多核苷酸组成的治疗剂。还提供人MxA的抑制剂，包括反义寡核苷酸，方法和人MxA特异性的组合物。

6. 发明申请

WO2006119363A2 MUTATIONS IN OAS1 GENES 审中-公开
标题翻译： OAS1基因突变
公开(公告)号：WO2006119363A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016983
申请日：2006-05-03
申请人： ILLUMIGEN BIOSCIENCES, INC. , IADONATO, Shawn, P. , MAGNESS, Charles, L. , SCHERER, Christina, A. , FELLIN, P., Campion , HAGEN, Tory , OLSON, Amy
发明人： IADONATO, Shawn, P. , MAGNESS, Charles, L. , SCHERER, Christina, A. , FELLIN, P., Campion , HAGEN, Tory , OLSON, Amy
CPC分类号： C12N9/1241 , C12N9/1077 , C12N9/88 , C12Q1/6883 , C12Q2600/156
摘要： Modified amino acid sequences of OAS1 proteins in non-human primates, and genes related thereto, are provided.
摘要翻译：提供非人灵长类动物中OAS1蛋白的修饰氨基酸序列，以及与其相关的基因。

7. 发明申请

WO2007027557A3 DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, MX1 审中-公开
标题翻译：检测与病毒感染相关的基因中的突变，MX1
公开(公告)号：WO2007027557A3
公开(公告)日：2008-01-24
申请号：PCT/US2006033413
申请日：2006-08-25
申请人： ILLUMIGEN BIOSCIENCES INC , MAGNESS CHARLES L , IADONATO SHAWN P , SCHERER CHRISTINA A , FELLIN PHILLIP CAMPION , STEIGER KATHRYN V
发明人： MAGNESS CHARLES L , IADONATO SHAWN P , SCHERER CHRISTINA A , FELLIN PHILLIP CAMPION , STEIGER KATHRYN V
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/701
摘要： A method for detecting a mutation related to the gene encoding MxA. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the wild-type and mutated genes, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human MxA, including antisense oligonucleotides, methods, and compositions specific for human MxA, are also provided.
摘要翻译：用于检测与编码MxA的基因有关的突变的方法。这个和其他公开的突变与人类对包括丙型肝炎的病毒感染的抗性相关。还提供了由野生型和突变基因编码的蛋白质或多肽或编码蛋白质或多肽的多核苷酸组成的治疗剂。还提供人MxA的抑制剂，包括反义寡核苷酸，方法和人MxA特异性的组合物。

8. 发明申请

WO2006004660A3 DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION 审中-公开
标题翻译：一个与抗病毒相关基因突变的检测
公开(公告)号：WO2006004660A3
公开(公告)日：2006-05-26
申请号：PCT/US2005022729
申请日：2005-06-27
申请人： ILLUMIGEN BIOSCIENCES INC , IADONATO SHAWN P , MAGNESS CHARLES L , SCHERER CHRISTINA A
发明人： IADONATO SHAWN P , MAGNESS CHARLES L , SCHERER CHRISTINA A
IPC分类号： C12Q1/68 , A61K31/7088 , A61P31/12 , C07K14/705 , C07K16/40 , C12N15/11
CPC分类号： C12Q1/6883 , C07K14/705 , C12Q1/707 , C12Q2600/156 , C12Q2600/172
摘要： A method for detecting a mutation related to the gene encoding LDLR. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the wild-type and mutated genes, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human LDLR, including antisense oligonucleotides, methods, and compositions specific for human LDLR, are also provided.
摘要翻译：用于检测与编码LDLR的基因相关的突变的方法。该公开的突变与人类对包括丙型肝炎在内的病毒感染的抗性相关。还提供了由野生型和突变基因编码的蛋白质或多肽或编码蛋白质或多肽的多核苷酸组成的治疗剂。还提供了人LDLR的抑制剂，包括对人LDLR特异的反义寡核苷酸，方法和组合物。

9. 发明申请

WO2005040428A3 DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, OAS1 审中-公开
标题翻译：检测与抗病毒相关的基因突变，OAS1
公开(公告)号：WO2005040428A3
公开(公告)日：2005-09-15
申请号：PCT/US2004035284
申请日：2004-10-22
申请人： ILLUMIGEN BIOSCIENCES INC , IADONATO SHAWN P , MAGNESS CHARLES L , ROSENBERG GARY , SCHERER CHRISTINA A , GUILLAUDEUX THIERRY
发明人： IADONATO SHAWN P , MAGNESS CHARLES L , ROSENBERG GARY , SCHERER CHRISTINA A , GUILLAUDEUX THIERRY
IPC分类号： C07H21/04 , C12N1/21 , C12N9/12 , C12N9/22 , C12N15/869 , C12Q1/68 , C12Q1/70 , A61K31/7088 , C07K16/40 , C12N15/11 , C12N15/54
CPC分类号： C12Q1/707 , A61K38/45 , C07K16/40 , C12N9/1241 , C12N15/1137 , C12Q1/6876 , C12Q1/6883 , C12Q1/6888 , C12Q1/70 , C12Q2600/156 , C12Q2600/172
摘要： A method for detecting a mutation related to the gene encoding OAS 1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS 1, including antisense oligonucleotides, methods, and compositions specific for human OASI, are also provided.
摘要翻译：用于检测与编码OAS1的基因相关的突变的方法。这种和其它公开的突变与人类对包括丙型肝炎在内的病毒感染的抗性相关。还提供了由突变基因编码的蛋白质或多肽组成的治疗剂，或编码蛋白质或多肽的多核苷酸。还提供了人OAS1的抑制剂，包括对人OASI特异的反义寡核苷酸，方法和组合物。

10. 发明申请

WO2007025079A3 DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, OAS2 OR OAS3 审中-公开
标题翻译：检测与抗病毒感染相关的基因中的突变，OAS2或OAS3
公开(公告)号：WO2007025079A3
公开(公告)日：2009-04-23
申请号：PCT/US2006033137
申请日：2006-08-23
申请人： ILLUMIGEN BIOSCIENCES INC , MAGNESS CHARLES L , IADONATO SHAWN P , SCHERER CHRISTINA A , FELLIN PHILLIP CAMPION , STEIGER KATHRYN V
发明人： MAGNESS CHARLES L , IADONATO SHAWN P , SCHERER CHRISTINA A , FELLIN PHILLIP CAMPION , STEIGER KATHRYN V
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q1/707 , C12Q2600/136 , C12Q2600/172
摘要： Compositions and methods are provided for detecting a mutation in a human oligoadenylate synthetase gene, particularly OAS2 or OAS3, wherein the mutation confers resistance to flavivirus infection, including infection by hepatitis C virus, and the mutation relates to other disease states including prostate cancer and diabetes, and uses of the encoded proteins and antibodies thereto.
摘要翻译：提供了用于检测人寡聚腺苷酸合成酶基因，特别是OAS2或OAS3中的突变的组合物和方法，其中突变赋予对黄病毒感染的抗性，包括丙型肝炎病毒的感染，并且该突变涉及包括前列腺癌和糖尿病在内的其它疾病状态，以及编码的蛋白质及其抗体的用途。

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