发明申请
WO2005040428A2 DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, OAS1
审中-公开
基本信息:
- 专利标题： DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, OAS1
- 专利标题（中）：检测与抗病毒感染相关的基因中的突变
- 申请号：PCT/US2004/035284 申请日：2004-10-22
- 公开(公告)号：WO2005040428A2 公开(公告)日：2005-05-06
- 发明人： IADONATO, Shawn, P. , MAGNESS, Charles, L. , ROSENBERG, Gary , SCHERER, Christina, A.
- 申请人： ILLUMIGEN BIOSCIENCES, INC. , IADONATO, Shawn, P. , MAGNESS, Charles, L. , ROSENBERG, Gary , SCHERER, Christina, A.
- 申请人地址： 2203 Airport Way South, Suite 450, Seattle, WA 98134 US
- 专利权人： ILLUMIGEN BIOSCIENCES, INC.,IADONATO, Shawn, P.,MAGNESS, Charles, L.,ROSENBERG, Gary,SCHERER, Christina, A.
- 当前专利权人： ILLUMIGEN BIOSCIENCES, INC.,IADONATO, Shawn, P.,MAGNESS, Charles, L.,ROSENBERG, Gary,SCHERER, Christina, A.
- 当前专利权人地址： 2203 Airport Way South, Suite 450, Seattle, WA 98134 US
- 代理机构： POTTER, Jane, E., R.
- 优先权： US60/513,888 2003010023; US60/542,373 20040206; US60/554,758 200403019; US60/560,524 20040408; US60/578,323 20040609; US60/583,503 20040628; US60/605,243 20040826
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
A method for detecting a mutation related to the gene encoding OAS 1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS 1, including antisense oligonucleotides, methods, and compositions specific for human OASI, are also provided.
摘要（中）：
用于检测与编码OAS1的基因相关的突变的方法。本发明和其它公开的突变与人类对包括丙型肝炎的病毒感染的抗性相关。还提供了由突变基因编码的蛋白质或多肽组成的治疗剂，或 编码蛋白质或多肽的多核苷酸。 还提供了人OAS1的抑制剂，包括反义寡核苷酸，方法和人类OASI特异性的组合物。