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1. 发明申请

WO2012003030A9 METHODS OF IDENTIFYING & USING ANTI-VIRAL COMPOUNDS 审中-公开
公开(公告)号：WO2012003030A9
公开(公告)日：2012-01-05
申请号：PCT/US2011/033257
申请日：2011-04-20
申请人： KINETA, INC. , IADONATO, Shawn, P. , BEDARD, Kristin
发明人： IADONATO, Shawn, P. , BEDARD, Kristin
IPC分类号： G01N33/569 , G01N33/52 , G01N33/15
摘要： Disclosed herein are methods for identifying compounds for the treatment of viral infection, including RNA viral infection and uses of the compounds as pharmaceutical compositions. The identified compounds modulate the RIG-I pathway in vertebrate cells.

2. 发明申请

WO2011133722A2 ANTI-VIRAL COMPOUNDS 审中-公开
标题翻译：反虚构化合物
公开(公告)号：WO2011133722A2
公开(公告)日：2011-10-27
申请号：PCT/US2011/033326
申请日：2011-04-20
申请人： KINETA, INC. , IADONATO, Shawn, P. , BEDARD, Kristin
发明人： IADONATO, Shawn, P. , BEDARD, Kristin
IPC分类号： A61K31/519 , A61K31/495 , C07D487/04 , A61P31/12
CPC分类号： A61K31/519 , A61K31/495
摘要： Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG- I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.
摘要翻译：本文公开了用于治疗病毒感染的化合物和相关组合物，包括RNA病毒感染，以及可以在脊椎动物细胞中调节RIG-1途径的化合物，包括可以激活RIG-1途径的化合物。

3. 发明申请

WO2011133719A2 ANTI-VIRAL COMPOUNDS 审中-公开
公开(公告)号：WO2011133719A2
公开(公告)日：2011-10-27
申请号：PCT/US2011/033322
申请日：2011-04-20
申请人： KINETA, INC. , IADONATO, Shawn, P. , BEDARD, Kristin
发明人： IADONATO, Shawn, P. , BEDARD, Kristin
IPC分类号： A61K31/426 , A61K31/34 , C07D277/36 , C07D417/14 , A61P31/12
CPC分类号： A61K31/427 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/4439 , C07D401/06 , C07D413/06 , C07D417/06 , C07D421/06
摘要： Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.

4. 发明申请

WO2006004660A2 DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION 审中-公开
标题翻译：检测与病毒感染相关的基因中的突变
公开(公告)号：WO2006004660A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/022729
申请日：2005-06-27
申请人： ILLUMIGEN BIOSCIENCES, INC. , IADONATO, Shawn, P. , MAGNESS, Charles, L. , SCHERER, Christina, A.
发明人： IADONATO, Shawn, P. , MAGNESS, Charles, L. , SCHERER, Christina, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C07K14/705 , C12Q1/707 , C12Q2600/156 , C12Q2600/172
摘要： A method for detecting a mutation related to the gene encoding LDLR. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the wild-type and mutated genes, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human LDLR, including antisense oligonucleotides, methods, and compositions specific for human LDLR, are also provided.
摘要翻译：检测与编码LDLR的基因有关的突变的方法。这个和其他公开的突变与人类对包括丙型肝炎的病毒感染的抗性相关。还提供了由野生型和突变基因编码的蛋白质或多肽或编码蛋白质或多肽的多核苷酸组成的治疗剂。还提供了人LDLR的抑制剂，包括反义寡核苷酸，方法和人LDLR特异性的组合物。

5. 发明申请

WO2012170392A3 SHK-BASED PHARMACEUTICAL COMPOSITIONS AND METHODS OF MANUFACTURING AND USING THE SAME 审中-公开
公开(公告)号：WO2012170392A3
公开(公告)日：2012-12-13
申请号：PCT/US2012/040857
申请日：2012-06-05
申请人： KINETA ONE, LLC , IADONATO, Shawn, P. , TARCHA, Eric, J.
发明人： IADONATO, Shawn, P. , TARCHA, Eric, J.
IPC分类号： A61K38/16 , A61K38/17 , A61P17/00
摘要： Disclosed herein are pharmaceutical compositions having the sequence Arg-Ser-Cys-lle-Asp-Thr-lle-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Xaa-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys (SEQ ID NO:1 ). The disclosed compositions can include an acid or amide at the C-terminus of SEQ ID NO: 1 and the polypeptide can be attached to an organic or inorganic chemical entity that has an anionic charge. The polypeptide can be detectably labeled for diagnostic purposes. Methods of manufacturing and using the pharmaceutical compounds are also disclosed.

6. 发明申请

WO2012170392A2 SHK-BASED PHARMACEUTICAL COMPOSITIONS AND METHODS OF MANUFACTURING AND USING THE SAME 审中-公开
标题翻译：基于SHK的药物组合物及其制造方法和使用方法
公开(公告)号：WO2012170392A2
公开(公告)日：2012-12-13
申请号：PCT/US2012040857
申请日：2012-06-05
申请人： KINETA ONE LLC , IADONATO SHAWN P , TARCHA ERIC J
发明人： IADONATO SHAWN P , TARCHA ERIC J
IPC分类号： A61K38/16 , A61K38/17 , A61P17/00
CPC分类号： A61K49/0004 , A61K38/00 , A61K38/16 , A61K38/1767 , A61K49/0002 , A61K51/0482 , A61K51/088 , B01L3/12 , B01L9/00 , B01L99/00 , C07K14/00 , C07K14/43504
摘要： Disclosed herein are pharmaceutical compositions having the sequence Arg-Ser-Cys-lle-Asp-Thr-lle-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Xaa-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys (SEQ ID NO:1 ). The disclosed compositions can include an acid or amide at the C-terminus of SEQ ID NO: 1 and the polypeptide can be attached to an organic or inorganic chemical entity that has an anionic charge. The polypeptide can be detectably labeled for diagnostic purposes. Methods of manufacturing and using the pharmaceutical compounds are also disclosed.
摘要翻译：本文公开了具有序列Arg-Ser-Cys-Lle-Asp-Thr-Lle-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Xaa- Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys（SEQ ID NO：1）。所公开的组合物可以在SEQ ID NO：1的C末端包括酸或酰胺，并且多肽可以连接到具有阴离子电荷的有机或无机化学实体。为了诊断目的，多肽可以被可检测地标记。还公开了制备和使用药物化合物的方法。

7. 发明申请

WO2012003030A3 METHODS OF IDENTIFYING & USING ANTI-VIRAL COMPOUNDS 审中-公开
标题翻译：鉴定和使用抗病毒化合物的方法
公开(公告)号：WO2012003030A3
公开(公告)日：2012-05-10
申请号：PCT/US2011033257
申请日：2011-04-20
申请人： KINETA INC , IADONATO SHAWN P , BEDARD KRISTIN
发明人： IADONATO SHAWN P , BEDARD KRISTIN
IPC分类号： G01N33/569 , G01N33/15 , G01N33/52
CPC分类号： G01N33/573
摘要： Disclosed herein are methods for identifying compounds for the treatment of viral infection, including RNA viral infection and uses of the compounds as pharmaceutical compositions. The identified compounds modulate the RIG-I pathway in vertebrate cells.
摘要翻译：本文公开了用于鉴定用于治疗病毒感染（包括RNA病毒感染）的化合物的方法以及所述化合物作为药物组合物的用途。鉴定的化合物调节脊椎动物细胞中的RIG-I途径。

8. 发明申请

WO2011133727A2 ANTI-VIRAL COMPOUNDS 审中-公开
公开(公告)号：WO2011133727A2
公开(公告)日：2011-10-27
申请号：PCT/US2011/033334
申请日：2011-04-20
申请人： KINETA, INC. , IADONATO, Shawn, P. , BEDARD, Kristin
发明人： IADONATO, Shawn, P. , BEDARD, Kristin
IPC分类号： A61K31/5375 , A61K31/4418 , A61K31/433 , A61K31/421 , A61P31/12
CPC分类号： A61K31/4439 , A61K31/44 , A61K45/06 , C07D213/85 , Y02A50/393
摘要： Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.

9. 发明申请

WO2005040428A2 DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, OAS1 审中-公开
标题翻译：检测与抗病毒感染相关的基因中的突变
公开(公告)号：WO2005040428A2
公开(公告)日：2005-05-06
申请号：PCT/US2004/035284
申请日：2004-10-22
申请人： ILLUMIGEN BIOSCIENCES, INC. , IADONATO, Shawn, P. , MAGNESS, Charles, L. , ROSENBERG, Gary , SCHERER, Christina, A.
发明人： IADONATO, Shawn, P. , MAGNESS, Charles, L. , ROSENBERG, Gary , SCHERER, Christina, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/707 , A61K38/45 , C07K16/40 , C12N9/1241 , C12N15/1137 , C12Q1/6876 , C12Q1/6883 , C12Q1/6888 , C12Q1/70 , C12Q2600/156 , C12Q2600/172 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/463 , Y02A50/465 , Y02A50/53 , Y02A50/54
摘要： A method for detecting a mutation related to the gene encoding OAS 1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS 1, including antisense oligonucleotides, methods, and compositions specific for human OASI, are also provided.
摘要翻译：用于检测与编码OAS1的基因相关的突变的方法。本发明和其它公开的突变与人类对包括丙型肝炎的病毒感染的抗性相关。还提供了由突变基因编码的蛋白质或多肽组成的治疗剂，或编码蛋白质或多肽的多核苷酸。还提供了人OAS1的抑制剂，包括反义寡核苷酸，方法和人类OASI特异性的组合物。

10. 发明申请

WO0241234A3 SYSTEM AND METHOD FOR SELECTIVELY CLASSIFYING A POPULATION 审中-公开
标题翻译：选择人口分类的系统和方法
公开(公告)号：WO0241234A3
公开(公告)日：2003-06-05
申请号：PCT/US0150759
申请日：2001-10-25
申请人： ILLUMIGEN BIOSCIENCES INC , MAGNESS CHARLES L , IADONATO SHAWN P
发明人： MAGNESS CHARLES L , IADONATO SHAWN P
IPC分类号： A61B5/00 , G06F19/00 , G06Q50/00
CPC分类号： G16H10/60 , G16H10/20
摘要： A technique is disclosed for classifying a population of subjects into various sub-populations for a selected biological condition. Patients are categorized in accordance with numeric scores for a affected status for the selected biological condition and a risk status for the selected biological condition. The numeric scores for an overall population are determined in advance for the selected biological condition. Medical test results, including genetic tests, and risk factors are numerically scored and may further be weighted in accordance with their relevance in determining affected status and risk. Medical test results and medical histories for individual subjects within the population may then automatically be scored in accordance with the predefined characteristics. The numerical scores for affected status and risk status may be stored in a data structure, such as a database. The numeric scores are extracted from the data structure and used to classify individuals in the population into one of a group of selected sub-populations comprising at-risk affected (ARA) and at-risk unaffected (ARU). Additional sub-populations, such as unknown risk, unaffected (URU) may also be used.
摘要翻译：公开了一种用于将受试者群体分类为用于所选生物学条件的各种亚群体的技术。患者根据所选生物学条件的受影响状态的数值分数和所选生物学条件的风险状态进行分类。对于选定的生物学条件，预先确定总体群体的数值分数。医学检验结果包括遗传检测和危险因素在数值上得分，并可根据其在确定受影响状态和风险中的相关性进一步加权。然后可以根据预定义的特征自动计算人群内个体受试者的医学检查结果和病史。受影响状态和风险状态的数值分数可存储在数据结构中，如数据库。从数据结构中提取数字分数，并用于将群体中的个体分类为一组选定的亚群，其中包括风险受影响（ARA）和风险未受影响（ARU）。还可以使用其他子种群，例如未知风险，未受影响（URU）。

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