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1. 发明申请

WO2013013687A1 APPARATUS AND METHOD FOR A LYSIS OF A SAMPLE, IN PARTICULAR FOR AN AUTOMATED AND/OR CONTROLLED LYSIS OF A SAMPLE 审中-公开
标题翻译：用于样品裂解的装置和方法，特别是用于样品的自动和/或受控裂解
公开(公告)号：WO2013013687A1
公开(公告)日：2013-01-31
申请号：PCT/EP2011003770
申请日：2011-07-27
申请人： CURETIS AG , BOOS ANDREAS , LUEDKE GERD , BACHER JOHANNES
发明人： BOOS ANDREAS , LUEDKE GERD , BACHER JOHANNES
IPC分类号： G01N1/28 , G01N1/38 , G01N1/44
CPC分类号： C12M47/06 , C12N1/066 , G01N1/286 , G01N1/38 , G01N1/44 , G01N35/025 , G01N2035/00504 , G01N2035/00524 , G01N2035/0441
摘要： The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample. The apparatus comprises at least one rotation disc (31), at least one vial holder (90) which is configured to receive a vial (100), wherein the vial holder (90) is arranged on the disc (31), at least one driving device (20) which is configured to rotate the disc (31) and the vial holder (90), at least one heating device (60) which is configured to heat the sample to a determined incubation temperature, and - at least one control device (70) which is configured to control the driving device (20) and/or the heating device (60) by means of a timing and/or step control, and/or - at least one transmitting device (80) for inductive coupling for energy and signal transmission, which is configured to transmit the energy for heating to the heating device (60), and/or - wherein the driving device (20) is configured to rotate the disc (31) in a first direction (A1) and/or with a first speed, and to rotate the vial holder (90) in a second direction (A3) and/or with a second speed. The apparatus and the method are adapted for an (automated) lysis procedure, wherein the lysis can be carried out in a safe, efficient and effective manner.
摘要翻译：本发明提供用于裂解过程的设备和方法，特别是用于样品尤其是生物样品的自动化和/或受控裂解过程。该装置包括至少一个旋转盘（31），至少一个配置成接收药瓶（100）的药瓶保持器（90），其中药瓶保持器（90）布置在盘（31）上，至少一个（31）和药瓶支架（90）旋转的驱动装置（20），至少一个加热装置（60），该加热装置构造成将样品加热到确定的温育温度，以及 - 至少一个控制器（70），其被配置为借助定时和/或阶梯控制来控制所述驱动装置（20）和/或所述加热装置（60），和/或 - 至少一个发射装置（80），其用于感应耦合用于能量和信号传输，其被配置为将用于加热的能量传输到所述加热装置（60），和/或 - 其中所述驱动装置（20）被配置为沿第一方向（A1）旋转所述盘（31）和/或以第一速度旋转，并且使药瓶保持器（90）沿第二方向（A3）和/或以第二速度旋转。该装置和方法适用于（自动）裂解程序，其中裂解可以安全，有效且有效的方式进行。

2. 发明申请

WO2007072373A3 A SENSOR FOR BIOMOLECULES AND A METHOD OF ANALYSIS USING SAID SENSOR 审中-公开
标题翻译：生物分子传感器及其应用分析方法
公开(公告)号：WO2007072373A3
公开(公告)日：2007-10-18
申请号：PCT/IB2006054883
申请日：2006-12-15
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
发明人： BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
IPC分类号： B01L3/00 , G01N33/53
CPC分类号： B01L3/502 , B01L2300/0636 , B01L2300/0681
摘要： Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the step of introducing said sample fluid into a chamber equipped with a porous substrate, one or more probe molecules being applied to said porous substrate and said probes being able to specifically bind to said one or more target molecules. The method further comprises the step of moving said substrate and said chamber relatively to each other in order to force said sample fluid through the pores of said porous substrate and to capture the one or more target molecules with the one or more probe molecules. Also disclosed is a sensor for the analysis of a sample fluid.
摘要翻译：公开了一种制备用于分析样品流体的传感器的方法，所述样品流体包含一种或多种目标分子。该方法包括将所述样品流体引入配备有多孔基底的室中的步骤，将一种或多种探针分子施加到所述多孔基底上，并且所述探针能够特异性结合所述一种或多种目标分子。该方法还包括将所述基底和所述腔室相对于彼此移动的步骤，以迫使所述样品流体通过所述多孔基底的孔并用一个或多个探针分子捕获一个或多个目标分子。还公开了一种用于分析样品流体的传感器。

3. 发明申请

WO2007072311A2 A SENSOR FOR BIOMOLECULES AND A METHOD FOR PREPARING AND USING THE SAME 审中-公开
标题翻译：生物分子传感器及其制备和使用方法
公开(公告)号：WO2007072311A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006054792
申请日：2006-12-13
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
发明人： BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/54366
摘要： Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the steps of applying a non-activated porous organic polymer membrane with probes in the form of an array of probe locations, said probes being able to specifically bind to said one or more target molecules. Furthermore, the method comprises the steps of blocking areas remaining free of probes of said porous organic polymer membrane with one or more blocking substances and forcing the sample fluid repeatedly in one or two directions through the pores of said porous organic polymer membrane. Also disclosed is a sensor for the analysis of a sample fluid.
摘要翻译：公开了一种制备用于分析样品流体的传感器的方法，所述样品流体包含一种或多种靶分子。该方法包括以探针位置阵列的形式施加非活化多孔有机聚合物膜的步骤，所述探针能够特异性地结合所述一个或多个靶分子。此外，该方法包括以下步骤：用一种或多种封闭物质阻挡剩余的不含所述多孔有机聚合物膜的探针的区域，并通过所述多孔有机聚合物膜的孔在一个或两个方向上反复强制样品流体。还公开了用于分析样品流体的传感器。

4. 发明申请

WO2007072290A3 METHOD OF PERFORMING A MICROARRAY ASSAY 审中-公开
公开(公告)号：WO2007072290A3
公开(公告)日：2007-06-28
申请号：PCT/IB2006/054737
申请日：2006-12-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd
发明人： BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd
IPC分类号： C12Q1/68
摘要： Disclosed is a method for performing a microarray assay on one or more sample fluid(s), sais fluids comprising target biological compounds. The method comprises the step of tagging said target biological compounds with labels. The following step comprises contacting said sample fluid(s) with a substrate and detecting the presence of said labels at the surface of said substrate. The method is suitable for the simultaneous analysis, in one microarray, of one or more types of target biological compounds, in one or more sample fluid(s). To this end each of said types of biological compounds is tagged with a different label so that target biological compounds belonging to different sample fluids have different labels. Said different labels are discriminable upon detection at the surface of said substrate. Also disclosed is the use of a polymer substrate in a method for performing a microarray assay.

5. 发明申请

WO2003005905A1 SYSTEM FOR POINT OF CARE DIAGNOSIS AND/OR ANALYSIS 审中-公开
标题翻译：护理点诊断和/或分析系统
公开(公告)号：WO2003005905A1
公开(公告)日：2003-01-23
申请号：PCT/IB2002/003004
申请日：2002-07-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOOS, Andreas , BACHER, Johannes , PROSS, Gerhard , SEHER, Jens-Peter
发明人： BOOS, Andreas , BACHER, Johannes , PROSS, Gerhard , SEHER, Jens-Peter
IPC分类号： A61B5/15
CPC分类号： A61B5/157 , A61B5/0002 , A61B5/150022 , A61B5/150786 , A61B5/15087
摘要： The present invention relates to a system for point of care diagnosis and/or analysis of body fluids of a patient, comprising:- a cartridge (2),- a diagnosis and/or analysis apparatus (3),- means (6) for measurement of the concentration of at least one specific component of a sample of the body fluids,- connecting means (8, 13) providing communication for electrical and/or optical values between the cartridge (2) and the diagnosis and/or analysis apparatus (3), wherein said values correlate with at least one of the respective concentrations,- diagnosing and/or analyzing means (14) measuring the respective concentration value via the connecting means (8, 13),- storage means (10) for storing cartridge specific data and/or information,- reading means (15) for reading the data and/or information out of the storage means (10),- wherein the diagnosing and/or analyzing means (14) evaluate the respective concentration values in accordance to the cartridge specific data and/or information.
摘要翻译：本发明涉及一种用于患者体液诊断和/或分析的系统，包括： - 盒（2）， - 诊断和/或分析装置（3）， - 用于测量体液样品的至少一个特定组分的浓度; - 连接装置（8,13），用于提供盒（2）和诊断和/或分析装置之间的电和/或光学值的通信（ 3），其中所述值与各自浓度中的至少一个相关联， - 经由连接装置（8,13）测量相应浓度值的诊断和/或分析装置（14）， - 存储装置（10）特定数据和/或信息， - 用于从存储装置（10）读出数据和/或信息的读取装置（15），其中诊断和/或分析装置（14）根据墨盒特定数据和/或信息。

6. 发明申请

WO2013013687A8 APPARATUS AND METHOD FOR A LYSIS OF A SAMPLE, IN PARTICULAR FOR AN AUTOMATED AND/OR CONTROLLED LYSIS OF A SAMPLE 审中-公开
公开(公告)号：WO2013013687A8
公开(公告)日：2013-01-31
申请号：PCT/EP2011/003770
申请日：2011-07-27
申请人： CURETIS AG , BOOS, Andreas , LÜDKE, Gerd , BACHER, Johannes
发明人： BOOS, Andreas , LÜDKE, Gerd , BACHER, Johannes
IPC分类号： G01N1/28 , G01N1/38 , G01N1/44
摘要： The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample. The apparatus comprises at least one rotation disc (31), at least one vial holder (90) which is configured to receive a vial (100), wherein the vial holder (90) is arranged on the disc (31), at least one driving device (20) which is configured to rotate the disc (31) and the vial holder (90), at least one heating device (60) which is configured to heat the sample to a determined incubation temperature, and - at least one control device (70) which is configured to control the driving device (20) and/or the heating device (60) by means of a timing and/or step control, and/or - at least one transmitting device (80) for inductive coupling for energy and signal transmission, which is configured to transmit the energy for heating to the heating device (60), and/or - wherein the driving device (20) is configured to rotate the disc (31) in a first direction (A1) and/or with a first speed, and to rotate the vial holder (90) in a second direction (A3) and/or with a second speed. The apparatus and the method are adapted for an (automated) lysis procedure, wherein the lysis can be carried out in a safe, efficient and effective manner.

7. 发明申请

WO2007072290A2 METHOD OF PERFORMING A MICROARRAY ASSAY 审中-公开
标题翻译：执行微观测定的方法
公开(公告)号：WO2007072290A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006054737
申请日：2006-12-11
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
发明人： BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
IPC分类号： C12Q1/68
CPC分类号： G01N33/54386 , C12Q1/6837 , G01N33/544 , C12Q2565/102 , C12Q2537/143
摘要： Disclosed is a method for performing a microarray assay on one or more sample fluid(s), sais fluids comprising target biological compounds. The method comprises the step of tagging said target biological compounds with labels. The following step comprises contacting said sample fluid(s) with a substrate and detecting the presence of said labels at the surface of said substrate. The method is suitable for the simultaneous analysis, in one microarray, of one or more types of target biological compounds, in one or more sample fluid(s). To this end each of said types of biological compounds is tagged with a different label so that target biological compounds belonging to different sample fluids have different labels. Said different labels are discriminable upon detection at the surface of said substrate. Also disclosed is the use of a polymer substrate in a method for performing a microarray assay.
摘要翻译：公开了一种对一种或多种样品流体进行微阵列测定的方法，其包含靶生物化合物。该方法包括用标记标记所述靶生物化合物的步骤。接下来的步骤包括使所述样品流体与基底接触，并在所述基底的表面检测所述标记物的存在。该方法适用于在一个或多个样品流体中在一个微阵列中同时分析一种或多种类型的靶生物化合物。为此，每种所述类型的生物化合物被标记有不同的标记，使得属于不同样品流体的目标生物化合物具有不同的标记。所述不同标签在所述基板的表面检测时是可辨别的。还公开了在进行微阵列测定的方法中使用聚合物底物。

8. 发明申请

WO2006030367A1 AN IMAGING METHOD AND APPARATUS FOR ANALYSING OBJECTS 审中-公开
标题翻译：用于分析对象的成像方法和装置
公开(公告)号：WO2006030367A1
公开(公告)日：2006-03-23
申请号：PCT/IB2005/052971
申请日：2005-09-12
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , SEHER, Jens-Peter , BACHER, Johannes
发明人： SEHER, Jens-Peter , BACHER, Johannes
IPC分类号： G01N35/00 , G01N21/00
CPC分类号： G01N35/00732 , G01N35/00584 , G01N2035/00752 , G01N2035/00772
摘要： The invention relates to an imaging system and a method for analysing an object. A first image of the object is created with an image recording unit and used to determine the further processing required and/or the characteristics of the analysed object. Further image processing in order to obtain information from the analysed object is carried out based on the initial information obtained from the image. The system and method are used for example in analysis of medical test strips.
摘要翻译：本发明涉及一种用于分析物体的成像系统和方法。使用图像记录单元创建对象的第一图像，并用于确定所分析对象所需的进一步处理和/或特征。基于从图像获得的初始信息，进行从分析对象获取信息的进一步图像处理。该系统和方法用于例如分析医用测试条。

9. 发明申请

WO2011144345A1 REACTION VESSEL FOR PCR DEVICE AND METHOD OF PERFORMING PCR 审中-公开
标题翻译：用于PCR装置的反应容器和执行PCR的方法
公开(公告)号：WO2011144345A1
公开(公告)日：2011-11-24
申请号：PCT/EP2011/002507
申请日：2011-05-19
申请人： CURETIS AG , LÜDKE, Gerd , BOOS, Andreas , MOTEJADDED, Hassan , BACHER, Johannes
发明人： LÜDKE, Gerd , BOOS, Andreas , MOTEJADDED, Hassan , BACHER, Johannes
IPC分类号： B01L3/00 , B01L7/00 , C12Q1/68 , G01N33/543
CPC分类号： B01L7/52 , B01L3/502 , B01L2200/0631 , B01L2200/10 , B01L2300/047 , B01L2300/0636 , B01L2300/0681 , B01L2300/087 , B01L2400/0487 , B01L2400/049
摘要： The present invention provides a reaction vessel (20) for a PCR device. The reaction vessel (20) comprises a sample vial (32) defining a reaction chamber (33) for performing PCR and a storage vessel (62) defining a storage chamber (63) for optical detection. The reaction chamber (33) is in fluid communication with a liquid supply port (34) for supplying a liquid sample containing at least one target DNA to the reaction chamber (33). The reaction chamber (33) and the storage chamber (63) are in fluid communication via a spacer element (42) and a porous membrane (51) for hybridization of the at least one target DNA within the liquid sample onto specific immobilised hybridization probes. The lower end of the spacer element (42) extends into the reaction chamber (33), but does not reach the bottom thereof. The upper end of the spacer element (42) is located in proximity of the porous membrane (51), which is made from a material having different physical properties in a dry state and a wet state. In the dry state the porous membrane (51) allows air as well as liquid to pass therethrough. In the wet state the porous membrane (51) still allows the passage of liquid therethrough, but not of air, such that during a PCR the liquid sample remains in the reaction chamber (33) and after the PCR the reaction vessel (20) is configured to force the liquid sample via the spacer element (42) to the porous membrane (51 ) for hybridization and detection of the at least one target DNA in the liquid sample. Moreover, a PCR device comprising such a reaction vessel (20) as well as a method for performing PCR are described.
摘要翻译：本发明提供一种用于PCR装置的反应容器（20）。反应容器（20）包括限定用于进行PCR的反应室（33）的样品瓶（32）和限定用于光学检测的储存室（63）的储存容器（62）。反应室（33）与用于将含有至少一种目标DNA的液体样品供应到反应室（33）的液体供应口（34）流体连通。反应室（33）和储存室（63）经由间隔元件（42）和多孔膜（51）流体连通，用于将液体样品中的至少一个目标DNA杂交到特定的固定化杂交探针上。间隔元件（42）的下端延伸到反应室（33）中，但不到达其底部。间隔元件（42）的上端位于多孔膜（51）附近，该多孔膜由在干燥状态和湿态下具有不同物理性质的材料制成。在干燥状态下，多孔膜（51）允许空气以及液体通过。在湿状态下，多孔膜（51）仍然允许液体通过而不是空气通过，使得在PCR期间液体样品保留在反应室（33）中，并且在PCR之后，反应容器（20）是被配置为将液体样品经由间隔元件（42）强制到多孔膜（51），用于杂交和检测液体样品中的至少一种靶DNA。此外，描述了包含这种反应容器（20）的PCR装置以及用于进行PCR的方法。

10. 发明申请

WO2006136990A3 CARTRIDGE, SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS 审中-公开
标题翻译： CARTRIDGE，系统和自动化诊断方法
公开(公告)号：WO2006136990A3
公开(公告)日：2007-03-08
申请号：PCT/IB2006051941
申请日：2006-06-16
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN HAAG CHRIS , JONGERIUS MICHIEL J , SCHAEFER DANNY G A , VAN DEN BIJGAART ADRIANUS W D , DE GIER RONALD C , DE JONG MICHIEL , PROSS GERHARD , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD , SEHER JENS-PETER
发明人： VAN HAAG CHRIS , JONGERIUS MICHIEL J , SCHAEFER DANNY G A , VAN DEN BIJGAART ADRIANUS W D , DE GIER RONALD C , DE JONG MICHIEL , PROSS GERHARD , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD , SEHER JENS-PETER
IPC分类号： B01L3/00 , G01N1/28 , G01N21/76 , G01N33/487 , G01N35/00
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502738 , B01L3/545 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/02 , B01L2300/087 , B01L2300/1805 , G01N21/6428 , G01N35/00069 , G01N2035/00158
摘要： Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.
摘要翻译：公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或量的盒。墨盒包括通用部件和可以连接到通用部件的一个或多个单独的应用特定部件。还公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或数量的系统。该系统包括可重复使用的装置，其中所述装置被配置为接收盒并且控制用于检测存在于所述盒中的样品中目标核苷酸序列的存在，不存在和/或量的过程。

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