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1. 发明申请

WO2013039308A3 A WATER-SOLUBLE FLUORESCENCE COMPOUND AND METHOD FOR PREPARING THE SAME 审中-公开
公开(公告)号：WO2013039308A3
公开(公告)日：2013-03-21
申请号：PCT/KR2012/007137
申请日：2012-09-05
申请人： SNU R&DB FOUNDATION , KIM, Seong Keun , YANG, Il Seung , HWANG, Seon Jin , LEE, Jung Eun , LEE, Jong Woo , KANG, Jun Hee , LIM, Eun Hak
发明人： KIM, Seong Keun , YANG, Il Seung , HWANG, Seon Jin , LEE, Jung Eun , LEE, Jong Woo , KANG, Jun Hee , LIM, Eun Hak
IPC分类号： C09K11/06 , A61K51/04
摘要： The present invention provides a water-soluble fluorescent compound of resveratrone 6-O-β-glucoside [( E )-4-(8-hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)naphthalen-2-yl)but-3-en-2-one] and its derivatives of Forumula 1 which have at least one water-soluble substituent, and a method for preparing the same by a photochemical reaction of resveratrol 3-O-β-glucoside and its derivatives of having Formula 3 which are not fluorescent. Said new water-soluble fluorescent compounds has single-photon absorptive characteristics and/or two-photon absorptive characteristics as well as no or little toxicity, and can be usefully utilized in fields that requires water-soluble fluorescent characteristics (diagnosis, fluorescent probe, in vivo imaging, display, etc.).

2. 发明申请

WO2011096676A3 INDIRUBIN-3'-OXIME DERIVATIVES AS POTENT CYCLIN DEPENDENT KINASE INHIBITORS 审中-公开
标题翻译： INDIRUBIN-3'-OXIME衍生物作为游离CYPIN依赖性激酶抑制剂
公开(公告)号：WO2011096676A3
公开(公告)日：2011-12-15
申请号：PCT/KR2011000611
申请日：2011-01-28
申请人： ANYGEN CO LTD , KIM YONG-CHUL , KIM JAE-IL , BAN SOO-HO , JEONG SOON-YOUNG , CHOI SOO-JEONG , LEE JUNG-EUN
发明人： KIM YONG-CHUL , KIM JAE-IL , BAN SOO-HO , JEONG SOON-YOUNG , CHOI SOO-JEONG , LEE JUNG-EUN
IPC分类号： C07D209/38 , A61K31/404 , A61K31/4155 , A61P35/00
CPC分类号： A61K31/404 , C07D403/04
摘要： The present invention relates to an indirubin-3'-oxime derivative as potent cyclin dependent kinase inhibitor with anti-cancer activity. More particularly, this invention relates to an indirubin-3'-oxime derivative as potent cyclin dependent kinase inhibitor having excellent anti-cancer activity against human lung cancer cell, human fibro sarcoma cell, human colon cancer cell, human leukemia cell, human stomach cancer cell, human nasopharyngeal cancer cell and/or human breast cancer cell.
摘要翻译：本发明涉及靛玉红-3'-肟衍生物作为具有抗癌活性的有效的细胞周期蛋白依赖性激酶抑制剂。更具体地说，本发明涉及靛玉红-3'-肟衍生物作为有效的细胞周期蛋白依赖性激酶抑制剂，对人肺癌细胞，人纤维肉瘤细胞，人结肠癌细胞，人白血病细胞，人胃癌具有优异的抗癌活性细胞，人鼻咽癌细胞和/或人乳腺癌细胞。

3. 发明申请

WO2011096676A2 INDIRUBIN-3'-OXIME DERIVATIVES AS POTENT CYCLIN DEPENDENT KINASE INHIBITORS 审中-公开
标题翻译：靛玉红-3'-氧肟衍生物作为有效的周期蛋白依赖性激酶抑制剂
公开(公告)号：WO2011096676A2
公开(公告)日：2011-08-11
申请号：PCT/KR2011/000611
申请日：2011-01-28
申请人： ANYGEN CO., LTD. , KIM, Yong-Chul , KIM, Jae-Il , BAN, Soo-Ho , JEONG, Soon-Young , CHOI, Soo-Jeong , LEE, Jung-Eun
发明人： KIM, Yong-Chul , KIM, Jae-Il , BAN, Soo-Ho , JEONG, Soon-Young , CHOI, Soo-Jeong , LEE, Jung-Eun
IPC分类号： C07D209/38 , A61K31/4155 , A61K31/404 , A61P35/00
CPC分类号： A61K31/404 , C07D403/04
摘要： The present invention relates to an indirubin-3'-oxime derivative as potent cyclin dependent kinase inhibitor with anti-cancer activity. More particularly, this invention relates to an indirubin-3'-oxime derivative as potent cyclin dependent kinase inhibitor having excellent anti-cancer activity against human lung cancer cell, human fibro sarcoma cell, human colon cancer cell, human leukemia cell, human stomach cancer cell, human nasopharyngeal cancer cell and/or human breast cancer cell.
摘要翻译：本发明涉及作为具有抗癌活性的强效细胞周期蛋白依赖性激酶抑制剂的靛玉红-3'-肟衍生物。更具体地说，本发明涉及对人肺癌细胞，人纤维肉瘤细胞，人结肠癌细胞，人白血病细胞，人胃癌具有优异的抗癌活性的靛玉红-3'-肟衍生物作为有效的细胞周期蛋白依赖性激酶抑制剂细胞，人类鼻咽癌细胞和/或人乳腺癌细胞。

4. 发明申请

WO2009090493A3 TLR4 DECOY RECEPTOR PROTEIN 审中-公开
标题翻译： TLR4诱饵受体蛋白
公开(公告)号：WO2009090493A3
公开(公告)日：2009-11-26
申请号：PCT/IB2008003936
申请日：2008-12-08
申请人： KOREA ADVANCED INST SCI & TECH , JUNG KEEHOON , KIM HOMIN , KIM HAK-ZOO , LEE JUNG-EUN , LEE GYUN MIN , KIM SUN CHANG , LEE JIE-OH , KIM HAK-SUNG , KOH GOU YOUNG
发明人： JUNG KEEHOON , KIM HOMIN , KIM HAK-ZOO , LEE JUNG-EUN , LEE GYUN MIN , KIM SUN CHANG , LEE JIE-OH , KIM HAK-SUNG , KOH GOU YOUNG
IPC分类号： C12N15/62 , C07K14/705 , C07K16/28 , C07K19/00
CPC分类号： C07K14/705 , C07K2319/32
摘要： The present application discloses a nucleic acid molecule encoding a fusion polypeptide capable of binding myeloid differentiation protein-2 (MD-2) polypeptide, which includes: a nucleotide sequence encoding an MD-2 polypeptide-binding portion of human toll-like receptor 4 (TLR4), a leucine-rich repeats (LRR) module, and a multimerizing component.
摘要翻译：本申请公开了编码能够结合髓样分化蛋白-2（MD-2）多肽的融合多肽的核酸分子，其包括：编码人toll样受体4的MD-2多肽结合部分的核苷酸序列（ TLR4），富含亮氨酸重复序列（LRR）模块和多聚化组分。

5. 发明申请

WO2009096627A1 INTEGRATED POWER SYSTEM COMBINING TIDAL POWER GENERATION AND OCEAN CURRENT POWER GENERATION 审中-公开
标题翻译：综合电力系统组合发电和海洋电力发电
公开(公告)号：WO2009096627A1
公开(公告)日：2009-08-06
申请号：PCT/KR2008/001388
申请日：2008-03-12
申请人： JANG, Kyung Soo , LEE, Jung Eun , JANG, Jae Won , JANG, Seung Won
发明人： JANG, Kyung Soo , LEE, Jung Eun , JANG, Jae Won , JANG, Seung Won
IPC分类号： F03B13/26
CPC分类号： F03B13/264 , F03B13/08 , F03B13/268 , F03B17/061 , F03B17/062 , Y02E10/28
摘要： An integrated power system combining tidal power generation and ocean current power generation comprises: constructing barrages across the sea to make up a lake; installing turbine structures of a tidal power plant and sluice structures of a tidal power dam for generating electricity by using the potential energy difference between seawaters caused by tides and ebbs; forming an ocean current power park in a lake side by installing a plurality of ocean current generators, for generating electricity by using the flow of the seawater discharged through turbine generators, in a rear lake side of the turbine structures of the tidal power plant; and forming an ocean current power park in a sea side by installing ocean current generators, for generating electricity by using the seawater with the fast speed discharged into the sea through sluice gates, in a rear sea side of the sluice structures of the tidal power dam.
摘要翻译：结合潮汐发电和海洋发电的综合电力系统，包括：在海上建设堰坝组成湖泊; 通过使用潮汐和潮汐引起的海水之间的潜在能量差异来安装潮汐发电厂的涡轮机结构和潮汐发电大坝的水闸结构，以发电; 通过在潮汐发电厂的涡轮机结构的后湖侧安装多个用于通过涡轮发电机排出的海水的流量来发电的多个洋流发电机，在湖侧形成海洋电力公园; 并通过安装海洋电力发电机组成海上电力公园，通过使用海水通过闸门将快速排放到海上的海水发电，在潮汐发电坝的闸门结构的后海侧。

6. 发明申请

WO2009090493A2 TLR4 DECOY RECEPTOR PROTEIN 审中-公开
标题翻译： TLR4 DECOY受体蛋白
公开(公告)号：WO2009090493A2
公开(公告)日：2009-07-23
申请号：PCT/IB2008/003936
申请日：2008-12-08
申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY , JUNG, Keehoon , KIM, HoMin , KIM, Hak-Zoo , LEE, Jung-Eun , LEE, Gyun Min , KIM, Sun Chang , LEE, Jie-Oh , KIM, Hak-Sung , KOH, Gou Young
发明人： JUNG, Keehoon , KIM, HoMin , KIM, Hak-Zoo , LEE, Jung-Eun , LEE, Gyun Min , KIM, Sun Chang , LEE, Jie-Oh , KIM, Hak-Sung , KOH, Gou Young
CPC分类号： C07K14/705 , C07K2319/32
摘要： The present application discloses a nucleic acid molecule encoding a fusion polypeptide capable of binding myeloid differentiation protein-2 (MD-2) polypeptide, which includes: a nucleotide sequence encoding an MD-2 polypeptide-binding portion of human toll-like receptor 4 (TLR4), a leucine-rich repeats (LRR) module, and a multimerizing component.
摘要翻译：本申请公开了编码能够结合骨髓分化蛋白-2（MD-2）多肽的融合多肽的核酸分子，其包括：编码人类toll样受体4的MD-2多肽结合部分的核苷酸序列（ TLR4），富含亮氨酸的重复序列（LRR）模块和多聚体组分。

7. 发明申请

WO2013039308A2 A WATER-SOLUBLE FLUORESCENCE COMPOUND AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：一种水溶性荧光化合物及其制备方法
公开(公告)号：WO2013039308A2
公开(公告)日：2013-03-21
申请号：PCT/KR2012007137
申请日：2012-09-05
申请人： SNU R&DB FOUNDATION , KIM SEONG KEUN , YANG IL SEUNG , HWANG SEON JIN , LEE JUNG EUN , LEE JONG WOO , KANG JUN HEE , LIM EUN HAK
发明人： KIM SEONG KEUN , YANG IL SEUNG , HWANG SEON JIN , LEE JUNG EUN , LEE JONG WOO , KANG JUN HEE , LIM EUN HAK
IPC分类号： C09K11/06 , A61K51/04
CPC分类号： C09K11/06 , C07H15/20 , C09K2211/1011
摘要： The present invention provides a water-soluble fluorescent compound of resveratrone 6-O-beta-glucoside [(E)-4-(8-hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)naphthalen-2-yl)but-3-en-2-one] and its derivatives of Forumula 1 which have at least one water-soluble substituent, and a method for preparing the same by a photochemical reaction of resveratrol 3-O-beta-glucoside and its derivatives of having Formula 3 which are not fluorescent. Said new water-soluble fluorescent compounds has single-photon absorptive characteristics and/or two-photon absorptive characteristics as well as no or little toxicity, and can be usefully utilized in fields that requires water-soluble fluorescent characteristics (diagnosis, fluorescent probe, in vivo imaging, display, etc.).
摘要翻译：本发明提供了白藜芦醇6-O-β-葡糖苷[（E）-4-（8-羟基-6 - （（2S，3R，4S，5S，6R）-3,4 ，5-三羟基-6-（羟甲基）四氢-2H-吡喃-2-基）氧）萘-2-基）丁-3-烯-2-酮]及其具有至少一个水的其衍生物以及通过不发荧光的具有式3的白藜芦醇3-O-β-葡糖苷及其衍生物的光化学反应制备该化合物的方法。所述新的水溶性荧光化合物具有单光子吸收特性和/或双光子吸收特性以及无毒性或很小的毒性，并且可以有用地用于需要水溶性荧光特性的领域（诊断，荧光探针，体内成像，显示等）。

8. 发明申请

WO2010126229A3 SMALL-SCALE, LARGE-CAPACITY, SEAWATER-FLOW POWER GENERATOR FOR HIGH-SPEED SEAWATER FLOWS 审中-公开
标题翻译：用于高速海水流动的小型，大容量海水流动发电机
公开(公告)号：WO2010126229A3
公开(公告)日：2010-12-23
申请号：PCT/KR2010002005
申请日：2010-04-01
申请人： JANG KYUNG SOO , LEE JUNG EUN , JANG SEUNG WON , JANG JAE WON
发明人： JANG KYUNG SOO , LEE JUNG EUN , JANG SEUNG WON , JANG JAE WON
IPC分类号： F03B13/08 , F03B13/26
CPC分类号： F03B13/264 , F03B13/08 , F05B2240/133 , F05B2240/40 , Y02E10/28
摘要： The present invention relates to a seawater-flow power generator for obtaining electrical energy by causing the blades of a water turbine to rotate using seawater flowing at high speed through man-made sea-based structures such as lock gate or sluice gate structures in sea walls or sea-based power generation systems such as a tidal power generation systems, and provides a small-scale, large-capacity, seawater-flow power generator for high-speed seawater flows which is suitable for seawater flowing at very much faster speeds than the speeds of tidal currents created by the natural phenomenon of ebb and flow alone.
摘要翻译：本发明涉及一种海水流动发电机，其通过使水力涡轮机的叶片利用高速流过的海水通过人造海基结构例如锁门或海堤中的闸门结构而旋转以获得电能或潮汐发电系统等海上发电系统，并为高速海水流提供小型，大容量，海水流动发电机，适用于海水以比其速度快得多的速度流动由自然衰退和流动现象产生的潮流速度。

9. 发明申请

WO2009123375A1 SUSPENDED MATTER BLOCKING FENCE FOR AN OCEAN POWER SYSTEM 审中-公开
标题翻译：海洋动力系统阻塞障碍
公开(公告)号：WO2009123375A1
公开(公告)日：2009-10-08
申请号：PCT/KR2008/002415
申请日：2008-04-29
申请人： JANG, Kyung Soo , LEE, Jung Eun , JANG, Jae Won , JANG, Seung Won , LEE, Jun Yeul , LEE, Jae Woon , CHANG, Woong Bin
发明人： JANG, Kyung Soo , LEE, Jung Eun , JANG, Jae Won , JANG, Seung Won , LEE, Jun Yeul , LEE, Jae Woon , CHANG, Woong Bin
IPC分类号： E02B8/02
CPC分类号： E02B8/023 , E02B8/06 , E02B9/04 , E02B15/08 , E02B15/0814 , E02B15/085 , E02B15/0885 , F03B11/08 , F03B13/268 , F05B2260/63 , Y02E10/22 , Y02E10/226
摘要： The present invention is to provide a suspended matter blocking fence for an ocean power system to prevent suspended matters in a sea side and a lake side from flowing into turbine generators and sluice structures so as to protect facilities of the ocean power plant and prevent the lowering of operating capacity of the ocean power plant. The suspended matter blocking fence for the ocean power system, which has turbine structures in a barrage to divide the sea and the lake and sluice structures at one side of the turbine structures, comprises: a lake side suspended matter blocking barrier installed at the lake side to prevent the suspended matters from flowing from the lake into the turbine and sluice structures; and a sea-side suspended matter blocking barrier installed at the sea side to prevent the suspended matters from flowing from the sea into the turbine and sluice structures.
摘要翻译：本发明提供一种用于海洋动力系统的悬浮物拦截栅，以防止海侧和湖侧的悬浮物流入涡轮发电机和闸门结构，以保护海洋发电厂的设施并防止下降的海洋发电厂的运行能力。海洋动力系统的悬挂物拦截栅栏，其具有在涡轮机结构的一侧划分大海和湖泊和闸门结构的水坝的涡轮机结构，包括：安装在湖侧的湖侧悬浮物阻挡屏障防止悬浮物从湖流入涡轮机和闸门结构; 以及安装在海侧的海侧悬浮物阻挡屏障，以防止悬浮物从海洋流入涡轮机和闸门结构。

10. 发明申请

WO2009119934A1 COMPLEX OCEAN POWER SYSTEM COMBINING SLUICE POWER AND OCEAN CURRENT POWER 审中-公开
标题翻译：复合海洋电力系统组合电力和海洋电力
公开(公告)号：WO2009119934A1
公开(公告)日：2009-10-01
申请号：PCT/KR2008/002414
申请日：2008-04-29
申请人： JANG, Kyung Soo , LEE, Jung Eun , JANG, Jae Won , JANG, Seung Won
发明人： JANG, Kyung Soo , LEE, Jung Eun , JANG, Jae Won , JANG, Seung Won
IPC分类号： F03B13/08
CPC分类号： F03B13/264 , E02B9/08 , E02C1/00 , F03B13/268 , Y02A10/386 , Y02A20/12 , Y02E10/28
摘要： There is provided with a complex ocean power system combining ocean current power generation for generating electricity by forming a plurality of ocean current generators in front and rear of sluice structures of tidal power dams and sluice power generation for generating electricity by forming a plurality of ocean current generators in sluice conduits of the sluice structures, comprising: constructing barrages, which cross over the sea, to make up a lake; installing sluice structures of tidal power dams between the barrages 10 to generate electricity by changing a potential energy difference between seawaters caused by tides and ebbs to kinetic energy; installing ocean current generators in front and rear of the sluice structures and in the sluice conduits of the sluice structures to generate electricity by rotating turbine blades using the flow of the incoming seawater from a sea side into a lake side during flood tide and the flow of the seawater discharged from the lake side into the sea side during ebb tide; and installing sluice gates in the sluice structures 102, 210 to close and open the sluice conduits during flood tide and ebb tide.
摘要翻译：提供了一个复杂的海洋电力系统，通过在潮汐发电大坝的闸门结构和水闸发电的前后形成多个海流发电器，通过形成多个洋流来发电，组合了海流发电发电闸闸结构的闸管中的发电机，包括：建造横过海面的拦河坝，组成湖泊; 通过改变由潮汐引起的海水与动能之间的潜在能量差异，在堰坝10之间安装潮汐力坝的闸门结构以发电; 在闸门结构的前后和水闸结构的闸管中安装洋流发电机，以便在洪潮期间使用海水从海侧向湖侧流动的涡轮叶片，从而发电在潮水期间，海水从湖边排入海边; 并在闸门结构102,210中安装闸门，以在洪潮和潮汐潮期间关闭和打开闸门管道。

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