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1. 发明申请

WO2011096676A2 INDIRUBIN-3'-OXIME DERIVATIVES AS POTENT CYCLIN DEPENDENT KINASE INHIBITORS 审中-公开
标题翻译：靛玉红-3'-氧肟衍生物作为有效的周期蛋白依赖性激酶抑制剂
公开(公告)号：WO2011096676A2
公开(公告)日：2011-08-11
申请号：PCT/KR2011/000611
申请日：2011-01-28
申请人： ANYGEN CO., LTD. , KIM, Yong-Chul , KIM, Jae-Il , BAN, Soo-Ho , JEONG, Soon-Young , CHOI, Soo-Jeong , LEE, Jung-Eun
发明人： KIM, Yong-Chul , KIM, Jae-Il , BAN, Soo-Ho , JEONG, Soon-Young , CHOI, Soo-Jeong , LEE, Jung-Eun
IPC分类号： C07D209/38 , A61K31/4155 , A61K31/404 , A61P35/00
CPC分类号： A61K31/404 , C07D403/04
摘要： The present invention relates to an indirubin-3'-oxime derivative as potent cyclin dependent kinase inhibitor with anti-cancer activity. More particularly, this invention relates to an indirubin-3'-oxime derivative as potent cyclin dependent kinase inhibitor having excellent anti-cancer activity against human lung cancer cell, human fibro sarcoma cell, human colon cancer cell, human leukemia cell, human stomach cancer cell, human nasopharyngeal cancer cell and/or human breast cancer cell.
摘要翻译：本发明涉及作为具有抗癌活性的强效细胞周期蛋白依赖性激酶抑制剂的靛玉红-3'-肟衍生物。更具体地说，本发明涉及对人肺癌细胞，人纤维肉瘤细胞，人结肠癌细胞，人白血病细胞，人胃癌具有优异的抗癌活性的靛玉红-3'-肟衍生物作为有效的细胞周期蛋白依赖性激酶抑制剂细胞，人类鼻咽癌细胞和/或人乳腺癌细胞。

2. 发明申请

WO2005070416A1 INDIRUBIN DERIVATIVES HAVING ANTICANCER PROPERTY AGAINST HUMAN CANCER CELL ME 审中-公开
标题翻译：具有抗癌药物的人类癌症细胞的INDIRUBIN衍生物
公开(公告)号：WO2005070416A1
公开(公告)日：2005-08-04
申请号：PCT/KR2005/000209
申请日：2005-01-26
申请人： ANYGEN CO., LTD. , KIM, Yong-Chul , KIM, Si Wouk , KIM, Tae Sung , LEE, Sang Kook , KIM, Jae II , YOON, Jung-Hoon , AHN, Sang-Gun , MOON, Myoung Ju
发明人： KIM, Yong-Chul , KIM, Si Wouk , KIM, Tae Sung , LEE, Sang Kook , KIM, Jae II , YOON, Jung-Hoon , AHN, Sang-Gun , MOON, Myoung Ju
IPC分类号： A61K31/403
CPC分类号： A61K31/403 , C07D209/36 , C07D209/40
摘要： The present invention relates to an indirubin derivative having anticancer property by inhibiting cell proliferation as to human cancer cell line. More particularly, this invention provides the synthesis of indirubin derivative known as CDK(Cyclin-dependent kinase) inhibitor. Further, inhibition activity of proliferation as to human cancer cell line and apoptosis against induced-differentiation of said indirubin derivative are researched to develop a novel indirubin derivative having efficacious anticancer properties as to various human cell lines.
摘要翻译：本发明涉及通过抑制人癌细胞系的细胞增殖而具有抗癌性的靛玉红衍生物。更具体地，本发明提供称为CDK（细胞周期蛋白依赖性激酶）抑制剂的靛玉红衍生物的合成。此外，研究了对人癌细胞系增殖的抑制活性和对所述靛玉红衍生物的诱导分化的凋亡，以开发出对各种人细胞系具有有效抗癌特性的新的靛玉红衍生物。

3. 发明申请

WO2008114976A1 SPINORPHIN DERIVATIVES AS POTENT AND SELECTIVE HUMAN P2X3 RECEPTOR ANTAGONIST 审中-公开
标题翻译：磷脂衍生物作为POTENT和选择性人P2X3受体拮抗剂
公开(公告)号：WO2008114976A1
公开(公告)日：2008-09-25
申请号：PCT/KR2008/001476
申请日：2008-03-17
申请人： ANYGEN CO., LTD. , KIM, Yong-Chul , JEONG, Kwan-Young
发明人： KIM, Yong-Chul , JEONG, Kwan-Young
IPC分类号： C07K7/06
CPC分类号： C07K7/06
摘要： The present invention relates to a spinorphin derivative useful as a potent and selective human P2X 3 receptor antagonist. More particularly, the present invention provides a spinorphin derivative useful as a potent and selective human P2X 3 receptor antagonist selected from peptide AVVYPWT, peptide LAVYPWT, peptide LVAYPWT, peptide LVVAPWT and/ or cyclic peptide LWYPWT. Human P2X 3 receptor antagonist has been developed on the electrophysiological evaluation of spinorphin peptide derivatives, truncated peptide analogues, cyclic peptides and a retroinverso peptide at human P2X 3 receptors to determine the channel blocking activity.
摘要翻译：本发明涉及可用作有效和选择性的人P2X 3受体拮抗剂的鸢尾甙衍生物。更具体地说，本发明提供了一种可用作选自肽AVVYPWT，肽LAVYPWT，肽LVAYPWT，肽LVVAPWT和/或环肽LWYPWT的有效和选择性人P2X 3受体拮抗剂的spinorphin衍生物。人P2X 3受体拮抗剂已经在人P2X 3受体的电生理学评价上被开发出来，以确定通道的旋转肽肽衍生物，截短的肽类似物，环肽和逆转肽阻止活动。

4. 发明申请

WO2006096030A1 POTASSIUM CHANNEL OPENER HAVING BENZOFUROINDOLE SKELETON 审中-公开
标题翻译：具有BENZOFUROINDOLE SKELETON的钾通道开口
公开(公告)号：WO2006096030A1
公开(公告)日：2006-09-14
申请号：PCT/KR2006/000855
申请日：2006-03-10
申请人： ANYGEN CO., LTD. , KIM, Yong-Chul , PARK, Chul-Seung , HA, Tal-Soo
发明人： KIM, Yong-Chul , PARK, Chul-Seung , HA, Tal-Soo
IPC分类号： A61K31/404 , C07D491/04 , A61P9/12 , A61P11/06
CPC分类号： A61K31/404 , A61K31/407 , C07D491/04
摘要： The object of the present invention is to provide a potassium channel opener having benzofuroindole skeleton representing the following formula (I) wherein, R 1 is hydrogen, R 2 is CF 3 , R 3 is COOH, R 4 is hydrogen, R 5 is hydrogen or chloride and R 6 is hydrogen or chloride.
摘要翻译：本发明的目的是提供具有代表下式（I）的苯并呋喃吲哚骨架的钾通道开放剂，其中R 1是氢，R 2是CF _{3，R 3是COOH，R 4是氢，R 5是氢或氯，R 6 是氢或氯化物。}

5. 发明申请

WO2006006771A1 AQUEOUS CONDUCTIVE POLYMER COMPOSITION WITH PTC OF RESISTIVITY AND PREPARATION THEREOF 审中-公开
标题翻译：具有电阻率和制备性的PTC的水性导电聚合物组合物
公开(公告)号：WO2006006771A1
公开(公告)日：2006-01-19
申请号：PCT/KR2005/002003
申请日：2005-06-27
申请人： PARK, Chul-Yong , KIM, Yong-Chul
发明人： PARK, Chul-Yong , KIM, Yong-Chul
IPC分类号： H01B1/04
CPC分类号： H01B1/18
摘要： The present invention relates to an aqueous conductive polymer composition with positive temperature coefficients (PTC) of resistivity, and more particularly, to an aqueous conductive polymer composition used for preparation of a plane heater and having PTC characteristics (self-temperature control characteristics) where it is heated only to an initial heating temperature of 60-70 0C and no longer heated, as well as a preparation method thereof.
摘要翻译：本发明涉及具有电阻率的正温度系数（PTC）的水性导电聚合物组合物，更具体地，涉及用于制备平面加热器并具有PTC特性（自温度控制特性）的水性导电聚合物组合物，其中它仅加热到初始加热温度为60-70℃并且不再加热，以及其制备方法。

6. 发明申请

WO2012177020A9 COMPOSITION AND FORMULATION COMPRISING RECOMBINANT HUMAN IDURONATE-2-SULFATASE AND PREPARATION METHOD THEREOF 审中-公开
公开(公告)号：WO2012177020A9
公开(公告)日：2012-12-27
申请号：PCT/KR2012/004734
申请日：2012-06-15
申请人： GREEN CROSS CORPORATION , MEDIGENEBIO CORPORATION , JIN, Thong-Gyu , CHUNG, Yo Kyung , PAIK, Sang Hoon , PARK, Yoo Chang , SEO, Jinwook , CHOI, Yong Woon , SON, Jong Mun , KIM, Yong-Chul
发明人： JIN, Thong-Gyu , CHUNG, Yo Kyung , PAIK, Sang Hoon , PARK, Yoo Chang , SEO, Jinwook , CHOI, Yong Woon , SON, Jong Mun , KIM, Yong-Chul
IPC分类号： A61K38/46 , A61K38/17 , A61P31/12
摘要： Disclosed is a composition comprising recombinant iduronate-2-sulfatase (IDS). The glycosylation pattern and formylglycine content of the IDS composition are different from those of Elaprase and have superior pharmaceutical efficacy and are safer than the conventional agent and thus can be effectively used for the therapy of Hunter syndrome.

7. 发明申请

WO2003006628A3 NAD SYNTHETASE INHIBITORS AND USES THEREOF 审中-公开
公开(公告)号：WO2003006628A3
公开(公告)日：2003-01-23
申请号：PCT/US2002/005172
申请日：2002-02-22
申请人： VIRTUAL DRUG DEVELOPMENT, INC. , THE UAB RESEARCH FOUNDATION , BROUILLETTE, Wayne, J. , DELUCAS, Lawrence, J. , BROUILLETTE, Christie, G. , VELU, Sadanandan, E. , KIM, Yong-Chul , MOU, Liyuan , PORTER, R., Stephen
发明人： BROUILLETTE, Wayne, J. , DELUCAS, Lawrence, J. , BROUILLETTE, Christie, G. , VELU, Sadanandan, E. , KIM, Yong-Chul , MOU, Liyuan , PORTER, R., Stephen
IPC分类号： A01N25/34 , A61K31/44 , C07D213/02 , C07D213/20 , C07D209/04
摘要： Disclosed are compounds that inhibit the microbial NAD synthetase enzyme. For example, disclosed are compounds of the formula Ar 1 -X-Ar 2 -Y-L-Z-Q, wherein Q is Q 1 Ar 3 or Ar 3 Q 1 ; Ar 1 , Ar 2 , and Ar 3 are independently aryl or heteroaryl, optionally substituted with one or more substituents; X, Y, and Z are independently selected from the group consisting of a covalent bond or groups containing one or more of C, H, N, O, S atoms; L is a linker and Q 1 is an alkylenyl, alkylenyl carbonyloxy alkyl, or alkylenyl carbonylamino alkyl group, optionally having a substituent; a covalent bond; a group containing amidine or guanidine function wherein the amidine or guanidine may be optionally N-substituted with an alkyl; or a zwitterion; or a pharmaceutically acceptable salt thereof. Also disclosed are methods which involve the use of the compounds of the present invention, for example, in treating or preventing a microbial infection in a mammal or plant, killing a prokaryote or decreasing prokaryotic growth, disinfecting a material or environment contaminated by a microbe, increasing food animal production, controlling harm to plants by a pest or insect and combating agroterrorism. Examples of microbes affected by the compounds of the present invention are bacteria and fungi.

8. 发明申请

WO2008082200A1 ANTITUMORIC COMPOSITIONS FOR ORAL ADMINISTRATION COMPRISING CHLORIN COMPOUNDS 审中-公开
标题翻译：用于包含氯林化合物的口服药物的抗肿瘤药物组合物
公开(公告)号：WO2008082200A1
公开(公告)日：2008-07-10
申请号：PCT/KR2007/006964
申请日：2007-12-28
申请人： GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY , KIM, Yong-Chul , PARK, Zee-Yong , KIM, Hyo-Jun
发明人： KIM, Yong-Chul , PARK, Zee-Yong , KIM, Hyo-Jun
IPC分类号： A61K31/409
CPC分类号： A61K31/409 , A61K45/06 , A61K2300/00
摘要： The present invention relates to an antitumoric composition for oral administration comprising a chlorin compound, or its pharmaceutically acceptable salt as an active ingredient, wherein the chlorin compound or its pharmaceutically acceptable salt exhibits the antitumoric activity without light irradiation. This invention suggests a novel use and application of the chlorin compound, which is conventionally used in a photodynamic therapy for cancer as photosensitive substances. Thus, according to this invention, the chlorin compound is orally administrated, and may have antitumoric effects without light irradiation. The composition of this invention is orally administrated, well absorbed in human through gastro-intestinal tract, and showed an excellent antitumoric effect. The composition of this invention does not have a cytotoxicity and an immunetoxicity, so that the composition has a higher safety to human.
摘要翻译：本发明涉及用于口服给药的抗肿瘤组合物，其包含二氢卟酚化合物或其药学上可接受的盐作为活性成分，其中二氢卟酚化合物或其药学上可接受的盐在没有光照射的情况下表现出抗肿瘤活性。本发明提出了二氢卟酚化合物的新用途和应用，其通常用于光动力学治疗癌症作为光敏物质。因此，根据本发明，口服给予二氢卟酚化合物，并且可以在没有光照射的情况下具有抗肿瘤效果。口服本发明组合物，通过胃肠道良好地吸收人体，显示出优异的抗肿瘤作用。本发明的组合物不具有细胞毒性和免疫毒性，使得组合物对人的安全性更高。

9. 发明申请

WO2008054050A1 METHODS FOR PREPARING CHLOROPHYLL a AND CHLORIN e 6 审中-公开
标题翻译：制备氯代乙酰氯和氯林的方法e 6
公开(公告)号：WO2008054050A1
公开(公告)日：2008-05-08
申请号：PCT/KR2007/002177
申请日：2007-05-03
申请人： GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY , LS PHARM CO., LTD. , KIM, Yong-Chul , PARK, Zee Yong , KIM, Hyo Jun
发明人： KIM, Yong-Chul , PARK, Zee Yong , KIM, Hyo Jun
IPC分类号： C12N1/12
CPC分类号： C12P17/182
摘要： The present invention relates to a method for preparing chlorophyll-a and chlorin e6. This invention extracts chlorophyll-a by use of undisrupted chlorella cells themselves, thereby preparing chlorin e6 from the chlorophyll-a extract. The high contents of chlorophyll-a may be obtained by the pretreatment procedure of chlorella cells themselves selected in this invention. The present method is performed according to relatively simple procedures, and is suitable in the mass production of chlorin e6.
摘要翻译：本发明涉及一种叶绿素a和二氢卟酚e6的制备方法。本发明通过使用未破坏的小球藻细胞本身提取叶绿素a，从而从叶绿素a提取物中制备二氢卟酚e6。通过本发明中选择的小球藻细胞的预处理程序可以获得高含量的叶绿素-α。本方法按照相对简单的程序进行，适用于大量生产二氢卟酚e6。

10. 发明申请

WO2008039006A1 MULTI POSITION DETECTING METHOD AND AREA DETECTING METHOD IN INFRARED RAYS TYPE TOUCH SCREEN 审中-公开
标题翻译：红外线类型触摸屏中的多位置检测方法和区域检测方法
公开(公告)号：WO2008039006A1
公开(公告)日：2008-04-03
申请号：PCT/KR2007/004721
申请日：2007-09-27
申请人： NEXIO CO., LTD. , KIM, Kil-Sun , KIM, Yong-Chul
发明人： KIM, Kil-Sun , KIM, Yong-Chul
IPC分类号： G06F3/041
CPC分类号： G06F3/0421
摘要： A method for detecting the coordinates of multiple touching objects on an infrared touch screen without errors and a method for detecting the area of the touched spot are provided. The coordinate detection method includes measuring and storing the maximum received level of a pair of infrared emitting and receiving elements, emission and receptionof which is not impeded by any object, and initializing an index variable for identification of multiple touched spots, de¬ termining that the screen has been touched when a received level of a pair of infrared emitting and receiving elements, emission and reception of which is impeded by an object, is less than the maximum level, measuring the minimum level to detect center coordinates of the object, and reading an index variable for the center coordinates and determining that the center coordinates are new and setting an index variable for the center coordinates if no index variable is read for the center coordinates and storing the center coordinates and the index variable for the center co¬ ordinates. The area detection method also includes measuring received levels of three pairs of infrared emitting and receiving elements corresponding to the center and two ends of the object and measuring and storing X and Y-axis diameters of a spot touched by the object based on the measured levels, and measuring thearea of the touched spot based on the diameters under the assumption that the spot is an oval.
摘要翻译：提供一种用于检测红外触摸屏上的多个触摸对象的坐标而没有错误的方法以及用于检测触摸点的区域的方法。坐标检测方法包括测量和存储一对红外线发射和接收元件的最大接收电平，其发射和接收不被任何物体阻碍，并且初始化用于识别多个接触点的索引变量，从而确定当发射和接收被对象阻碍的一对红外发射和接收元件的接收电平小于最大电平时，屏幕被触摸，测量检测对象的中心坐标的最小电平和读取中心坐标的索引变量，并确定中心坐标是新的，并且如果没有为中心坐标读取索引变量并存储中心坐标和中心坐标的索引变量，则为中心坐标设置索引变量。区域检测方法还包括测量对象于物体的中心和两端的三对红外发射和接收元件的接收电平，并且基于测量的电平来测量和存储由对象触摸的点的X和Y轴直径并且在假设斑点为椭圆形的情况下基于直径来测量接触点的面积。

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