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1. 发明申请

WO2012128580A1 WATER-SOLUBLE POLYPEPTIDES COMPRISED OF REPEAT MODULES, METHOD FOR PREPARING THE SAME AND METHOD FOR A TARGET-SPECIFIC POLYPEPTIDE AND ANALYSIS OF BIOLOGICAL ACTIVITY THEREOF 审中-公开
标题翻译：重复模块包含的水溶性聚合物，其制备方法和目标特异性多肽的方法及其生物活性分析
公开(公告)号：WO2012128580A1
公开(公告)日：2012-09-27
申请号：PCT/KR2012/002094
申请日：2012-03-22
申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY , KIM, Hak Sung , KIM, Dong Sup , LEE, Sang Chul , LEE, Byung Chul , HAN, Ji Eun , LEE, Joong Jae , PARK, Keun Wan , HONG, Seung Pyo
发明人： KIM, Hak Sung , KIM, Dong Sup , LEE, Sang Chul , LEE, Byung Chul , HAN, Ji Eun , LEE, Joong Jae , PARK, Keun Wan , HONG, Seung Pyo
IPC分类号： C07K19/00 , C12N15/62
CPC分类号： C07K14/195 , C07K14/46 , C07K14/461 , C07K14/705 , C07K2319/35 , C07K2319/70 , C12N15/70 , C12Q1/6897 , G01N33/5023 , G06F19/16
摘要： The present invention relates to a soluble polypeptide comprised of repeat modules. More particularly, the present invention relates to a soluble fusion polypeptide of the N-terminal domain of internalin and LRR (Leucine rich repeat) family protein, a method for preparing the polypeptide, a vector comprising a nucleic acid sequence encoding the polypeptide, a host cell comprising the vector, a method for producing a solubility and folding-improved fusion polypeptide by expressing the vector in the host cell, and a method for improving the solubility and folding of the fusion polypeptide. Further, the present invention relates to a method for preparing the polypeptide bound with a specific target and analyzing the efficacy of the soluble polypeptide.
摘要翻译：本发明涉及由重复模块组成的可溶性多肽。更具体地说，本发明涉及内源蛋白和LRR（富含亮氨酸重复）家族蛋白质的N-末端结构域的可溶性融合多肽，制备该多肽的方法，包含编码该多肽的核酸序列的载体，宿主包含载体的细胞，通过在宿主细胞中表达载体产生溶解性和折叠改良的融合多肽的方法，以及改善融合多肽的溶解性和折叠的方法。此外，本发明涉及制备与特异性靶标结合的多肽的方法，并分析可溶性多肽的功效。

2. 发明申请

WO2011136613A3 GLYCOPROTEIN ANALYSIS KIT AND USE THEREOF 审中-公开
标题翻译：糖蛋白分析试剂盒及其用途
公开(公告)号：WO2011136613A3
公开(公告)日：2012-04-12
申请号：PCT/KR2011003214
申请日：2011-04-29
申请人： KOREA ADVANCED INST SCI & TECH , KIM HAK SUNG , PARK SUN YOUNG , KIM WAN JUNG , KIM YONG TAE , SON YOUNG DOK , LEE SANG CHUL , KIM EUN KYOUNG , KIM SUNG HO , KIM JUNG HOE
发明人： KIM HAK SUNG , PARK SUN YOUNG , KIM WAN JUNG , KIM YONG TAE , SON YOUNG DOK , LEE SANG CHUL , KIM EUN KYOUNG , KIM SUNG HO , KIM JUNG HOE
IPC分类号： G01N33/533 , G01N33/68
CPC分类号： G01N33/746 , C12N15/85 , G01N33/6803 , G01N33/6842 , G01N2400/02
摘要： The present invention relates to a glycoprotein analysis kit and to the use thereof, and more particularly, to a glycoprotein analysis kit comprising a fluorescein-labelled antibody, a fluorescein-labelled biomaterial, and a support, to a double-probe method that enables, using the kit, a quantitative analysis of the content and glycosylation characteristics of a glycoprotein at the same time, to a method for selecting, using the kit, a single cell which produces a glycoprotein having desired glycosylation characteristics, and to a cell which is selected by means of the method, and which produces a glycoprotein having desired glycosylation characteristics.
摘要翻译：本发明涉及糖蛋白分析试剂盒及其用途，更具体地，涉及包含荧光素标记的抗体，荧光素标记的生物材料和载体的糖蛋白分析试剂盒，其涉及双探针方法，使用试剂盒，同时对糖蛋白的含量和糖基化特征的定量分析，使用试剂盒选择产生具有所需糖基化特征的糖蛋白的单细胞的方法和选择的细胞通过该方法，并产生具有所需糖基化特征的糖蛋白。

3. 发明申请

WO2011055987A3 METHOD FOR SCREENING OF QUORUM SENSING INHIBITORS 审中-公开
标题翻译：检测质量敏感抑制剂的方法
公开(公告)号：WO2011055987A3
公开(公告)日：2011-11-03
申请号：PCT/KR2010007733
申请日：2010-11-04
申请人： KOREA ADVANCED INST SCI & TECH , KIM HAK-SUNG , KIM JIN-HYUN , LEE SANG-CHUL , JEONG YOUNG-SU
发明人： KIM HAK-SUNG , KIM JIN-HYUN , LEE SANG-CHUL , JEONG YOUNG-SU
IPC分类号： C12N15/63 , C12N15/52 , G01N33/15
CPC分类号： C12N15/63
摘要： The present invention relates to a vector comprising an expression cassette for screening quorum sensing inhibitors, which comprises a gene encoding a transcriptional regulator that recognizes and binds to acyl homoserine lactone, a gene encoding an inhibitor of antibiotic-degrading enzyme that is operably linked to a promoter regulated by the transcriptional regulator, and a gene encoding an antibiotic-degrading enzyme that is inhibited by the inhibitor of antibiotic-degrading enzyme, a method for screening a quorum sensing inhibitor and a quorum sensing inhibitor screened by the method.
摘要翻译：本发明涉及一种载体，其包含用于筛选群体感应抑制剂的表达盒，其包含编码识别并结合酰基高丝氨酸内酯的转录调节因子的基因，编码抗生素降解酶抑制剂的基因，所述基因可操作地连接至由编码抗生素降解酶抑制剂的抗生素降解酶基因编码的基因，筛选通过该方法筛选的群体感应抑制剂和群体感应抑制剂的方法。

4. 发明申请

WO2003092292A1 IMAGE STORAGING APPARATUS AND METHOD OF THEREOF 审中-公开
标题翻译：图像储存装置及其方法
公开(公告)号：WO2003092292A1
公开(公告)日：2003-11-06
申请号：PCT/KR2002/001313
申请日：2002-07-11
申请人： ALOGICS CO., LTD. , KIM, Hak-Sung
发明人： KIM, Hak-Sung
IPC分类号： H04N7/18
CPC分类号： H04N7/188 , H04N5/76
摘要： A video monitoring system and an apparatus and method capable of recording the video data of previous and subsequent times before and after an event occurrence are disclosed. The method comprises the steps of: configuring and displaying one or more channel display screens with video signals outputted from one or more video cameras on a video display device; receiving video data being displayed in a feedback form and storing the video data being displayed in a memory; if a predetermined event signal is inputted while the video data being displayed is stored, stopping the storing of the video data being displayed after a predetermined time period T1, and completing recording of the video data of previous and subsequent times shortly before and after an event occurrence; and reproducing and outputting the video data stored in the memory in response to a reproduction request.
摘要翻译：公开了一种视频监视系统以及能够在事件发生之前和之后记录先前和之后的时间的视频数据的装置和方法。该方法包括以下步骤：利用视频显示设备上的一个或多个摄像机输出的视频信号来配置和显示一个或多个频道显示屏; 接收以反馈形式显示的视频数据并将正在显示的视频数据存储在存储器中; 如果在存储正在显示的视频数据的同时输入预定的事件信号，则停止在预定时间段T1之后正在显示的视频数据的存储，并且在事件之前和之后不久完成之前和之后的时间的视频数据的记录发生; 并且响应于再现请求再现和输出存储在存储器中的视频数据。

5. 发明申请

WO2003009599A1 VIDEO MONITORING SYSTEM USING DAISY CHAIN 审中-公开
标题翻译：使用DAISY链的视频监控系统
公开(公告)号：WO2003009599A1
公开(公告)日：2003-01-30
申请号：PCT/KR2002/001314
申请日：2002-07-11
申请人： ALOGICS CO., LTD. , KIM, Hak-Sung
发明人： KIM, Hak-Sung
IPC分类号： H04N7/18
CPC分类号： H04N7/181 , G08B13/19656 , G08B13/19693 , H04N5/2624
摘要： A video minitoring system using daisy chain is disclosed. A video monitoring system uses daisy chain, which can display more than four divided screens on one display screen with a simple configuration of the video monitoring system by passing video signals captured by a plurality of video cameras through many stages.
摘要翻译：公开了一种使用菊花链的视频监控系统。视频监控系统采用菊花链，通过多个视频摄像机拍摄的视频信号经过多个阶段，可以在一个显示屏上显示四个以上的划分屏幕，并具有视频监控系统的简单配置。

6. 发明申请

WO2012128577A3 METHOD FOR PERFORMANCE ANALYSIS AND SCREENING OF SEPTICAEMIA PROTEIN THERAPEUTIC AGENTS 审中-公开
标题翻译：分离蛋白质治疗药物的性能分析和筛选方法
公开(公告)号：WO2012128577A3
公开(公告)日：2013-01-24
申请号：PCT/KR2012002091
申请日：2012-03-22
申请人： KOREA RES INST OF BIOSCIENCE , KOREA ADVANCED INST SCI & TECH , LEE SEUNG GOO , KIM HAK SUNG , KIM YU JUNG , LEE SANG CHUL , HAN JI EUN , KIM SU JIN , SOHN JUNG HOON , HA JAE SEOK
发明人： LEE SEUNG GOO , KIM HAK SUNG , KIM YU JUNG , LEE SANG CHUL , HAN JI EUN , KIM SU JIN , SOHN JUNG HOON , HA JAE SEOK
IPC分类号： C12Q1/02 , C12N15/63 , G01N33/15 , G01N33/53 , G01N33/68
CPC分类号： C07K14/195 , C07K14/46 , C07K14/461 , C07K14/705 , C07K2319/35 , C07K2319/70 , C12N15/70 , C12Q1/6897 , G01N33/5023 , G06F19/16
摘要： The present invention relates to the construction of an assay system for analysing the performance of LRR (leucine rich repeat) proteins, that are constituted by the repeat combination of LRR modules, as septicaemia-inhibiting protein therapeutic agents, and for screening protein therapeutic agents that exhibit an outstanding inhibiting performance from a sequence variation library. More specifically, the present invention relates to: a performance analysis method or screening method for septicaemia protein therapeutic agents, comprising the step of adding purified MD-2 protein to an assay system using a cell line in which an LPS signal transmission receptor is expressed on the surface; a performance analysis method or screening method for septicaemia protein therapeutic agents, comprising the step of adding a purified foreign MD-2 protein to a THP-1 cell line; the cell line for performance analysis or for screening; and a kit for septicaemia therapeutic agent screening or performance analysis, comprising the cell line and purified foreign MD-2.
摘要翻译：本发明涉及用于分析LRR（富含亮氨酸重复）蛋白质的性能的测定系统的构建，其由LRR模块的重复组合构成，作为败血病抑制蛋白质治疗剂，并用于筛选蛋白质治疗剂，从序列变异库显示出优异的抑制性能。更具体地，本发明涉及：败血病蛋白治疗剂的性能分析方法或筛选方法，包括将纯化的MD-2蛋白加入到使用其中表达LPS信号传递受体的细胞系的测定系统的步骤表面用于败血病蛋白治疗剂的性能分析方法或筛选方法，包括将纯化的外源MD-2蛋白加入到THP-1细胞系中的步骤; 用于性能分析或筛选的细胞系; 以及用于败血症治疗剂筛选或性能分析的试剂盒，其包含细胞系和纯化的外源MD-2。

7. 发明申请

WO2011002176A3 METHOD FOR PRIORITIZING OPERATION OF RELAY NODE IN A WIRELESS COMMUNICATION SYSTEM AND APPARATUS FOR THE SAME 审中-公开
公开(公告)号：WO2011002176A3
公开(公告)日：2011-01-06
申请号：PCT/KR2010/004101
申请日：2010-06-24
申请人： LG ELECTRONICS INC. , SEO, Han Byul , KIM, Hak Sung
发明人： SEO, Han Byul , KIM, Hak Sung
IPC分类号： H04B7/14
摘要： Various methods and apparatuses for prioritizing operation of Relay Node are disclosed. A method for prioritizing the transmission and receipt of uplink signals in a relay node of a wireless communication system is presented. The method comprises determining radio resource requirements for receiving one or more access link signals and/or transmitting one or more backhaul link signal, determining the signal type of the one or more access link signals and/or determining the signal type of the one or more backhaul link signals, and selecting one of a transmitting mode operation and a receiving mode operation based on the radio resource requirements for receiving the one or more access link signals and/or transmitting the one or more backhaul link signals, and based on the signal type of the one or more access link signals and/or the signal type of the one or more backhaul link signals.

8. 发明申请

WO2009090493A3 TLR4 DECOY RECEPTOR PROTEIN 审中-公开
标题翻译： TLR4诱饵受体蛋白
公开(公告)号：WO2009090493A3
公开(公告)日：2009-11-26
申请号：PCT/IB2008003936
申请日：2008-12-08
申请人： KOREA ADVANCED INST SCI & TECH , JUNG KEEHOON , KIM HOMIN , KIM HAK-ZOO , LEE JUNG-EUN , LEE GYUN MIN , KIM SUN CHANG , LEE JIE-OH , KIM HAK-SUNG , KOH GOU YOUNG
发明人： JUNG KEEHOON , KIM HOMIN , KIM HAK-ZOO , LEE JUNG-EUN , LEE GYUN MIN , KIM SUN CHANG , LEE JIE-OH , KIM HAK-SUNG , KOH GOU YOUNG
IPC分类号： C12N15/62 , C07K14/705 , C07K16/28 , C07K19/00
CPC分类号： C07K14/705 , C07K2319/32
摘要： The present application discloses a nucleic acid molecule encoding a fusion polypeptide capable of binding myeloid differentiation protein-2 (MD-2) polypeptide, which includes: a nucleotide sequence encoding an MD-2 polypeptide-binding portion of human toll-like receptor 4 (TLR4), a leucine-rich repeats (LRR) module, and a multimerizing component.
摘要翻译：本申请公开了编码能够结合髓样分化蛋白-2（MD-2）多肽的融合多肽的核酸分子，其包括：编码人toll样受体4的MD-2多肽结合部分的核苷酸序列（ TLR4），富含亮氨酸重复序列（LRR）模块和多聚化组分。

9. 发明申请

WO2009090493A2 TLR4 DECOY RECEPTOR PROTEIN 审中-公开
标题翻译： TLR4 DECOY受体蛋白
公开(公告)号：WO2009090493A2
公开(公告)日：2009-07-23
申请号：PCT/IB2008/003936
申请日：2008-12-08
申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY , JUNG, Keehoon , KIM, HoMin , KIM, Hak-Zoo , LEE, Jung-Eun , LEE, Gyun Min , KIM, Sun Chang , LEE, Jie-Oh , KIM, Hak-Sung , KOH, Gou Young
发明人： JUNG, Keehoon , KIM, HoMin , KIM, Hak-Zoo , LEE, Jung-Eun , LEE, Gyun Min , KIM, Sun Chang , LEE, Jie-Oh , KIM, Hak-Sung , KOH, Gou Young
CPC分类号： C07K14/705 , C07K2319/32
摘要： The present application discloses a nucleic acid molecule encoding a fusion polypeptide capable of binding myeloid differentiation protein-2 (MD-2) polypeptide, which includes: a nucleotide sequence encoding an MD-2 polypeptide-binding portion of human toll-like receptor 4 (TLR4), a leucine-rich repeats (LRR) module, and a multimerizing component.
摘要翻译：本申请公开了编码能够结合骨髓分化蛋白-2（MD-2）多肽的融合多肽的核酸分子，其包括：编码人类toll样受体4的MD-2多肽结合部分的核苷酸序列（ TLR4），富含亮氨酸的重复序列（LRR）模块和多聚体组分。

10. 发明申请

WO2011002176A2 METHOD FOR PRIORITIZING OPERATION OF RELAY NODE IN A WIRELESS COMMUNICATION SYSTEM AND APPARATUS FOR THE SAME 审中-公开
标题翻译：在无线通信系统中对继电器节点的操作进行优先化的方法及其装置
公开(公告)号：WO2011002176A2
公开(公告)日：2011-01-06
申请号：PCT/KR2010004101
申请日：2010-06-24
申请人： LG ELECTRONICS INC , SEO HAN BYUL , KIM HAK SUNG
发明人： SEO HAN BYUL , KIM HAK SUNG
IPC分类号： H04B7/14
CPC分类号： H04B7/15542 , H04W72/12 , H04W72/1247 , H04W72/1257 , H04W84/047
摘要： Various methods and apparatuses for prioritizing operation of Relay Node are disclosed. A method for prioritizing the transmission and receipt of uplink signals in a relay node of a wireless communication system is presented. The method comprises determining radio resource requirements for receiving one or more access link signals and/or transmitting one or more backhaul link signal, determining the signal type of the one or more access link signals and/or determining the signal type of the one or more backhaul link signals, and selecting one of a transmitting mode operation and a receiving mode operation based on the radio resource requirements for receiving the one or more access link signals and/or transmitting the one or more backhaul link signals, and based on the signal type of the one or more access link signals and/or the signal type of the one or more backhaul link signals.
摘要翻译：公开了用于优先化中继节点的操作的各种方法和设备。呈现了用于优先化无线通信系统的中继节点中的上行链路信号的发送和接收的方法。该方法包括确定用于接收一个或多个接入链路信号和/或发送一个或多个回程链路信号，确定一个或多个接入链路信号的信号类型和/或确定一个或多个接入链路信号的信号类型的无线电资源要求回程链路信号，并且基于用于接收所述一个或多个接入链路信号和/或发送所述一个或多个回程链路信号的无线电资源需求来选择发射模式操作和接收模式操作中的一个，并且基于所述信号类型一个或多个接入链路信号的信号类型和/或一个或多个回程链路信号的信号类型。

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