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1. 发明申请

WO2011096676A3 INDIRUBIN-3'-OXIME DERIVATIVES AS POTENT CYCLIN DEPENDENT KINASE INHIBITORS 审中-公开
标题翻译： INDIRUBIN-3'-OXIME衍生物作为游离CYPIN依赖性激酶抑制剂
公开(公告)号：WO2011096676A3
公开(公告)日：2011-12-15
申请号：PCT/KR2011000611
申请日：2011-01-28
申请人： ANYGEN CO LTD , KIM YONG-CHUL , KIM JAE-IL , BAN SOO-HO , JEONG SOON-YOUNG , CHOI SOO-JEONG , LEE JUNG-EUN
发明人： KIM YONG-CHUL , KIM JAE-IL , BAN SOO-HO , JEONG SOON-YOUNG , CHOI SOO-JEONG , LEE JUNG-EUN
IPC分类号： C07D209/38 , A61K31/404 , A61K31/4155 , A61P35/00
CPC分类号： A61K31/404 , C07D403/04
摘要： The present invention relates to an indirubin-3'-oxime derivative as potent cyclin dependent kinase inhibitor with anti-cancer activity. More particularly, this invention relates to an indirubin-3'-oxime derivative as potent cyclin dependent kinase inhibitor having excellent anti-cancer activity against human lung cancer cell, human fibro sarcoma cell, human colon cancer cell, human leukemia cell, human stomach cancer cell, human nasopharyngeal cancer cell and/or human breast cancer cell.
摘要翻译：本发明涉及靛玉红-3'-肟衍生物作为具有抗癌活性的有效的细胞周期蛋白依赖性激酶抑制剂。更具体地说，本发明涉及靛玉红-3'-肟衍生物作为有效的细胞周期蛋白依赖性激酶抑制剂，对人肺癌细胞，人纤维肉瘤细胞，人结肠癌细胞，人白血病细胞，人胃癌具有优异的抗癌活性细胞，人鼻咽癌细胞和/或人乳腺癌细胞。

2. 发明申请

WO2008114976A8 SPINORPHIN DERIVATIVES AS POTENT AND SELECTIVE HUMAN P2X3 RECEPTOR ANTAGONIST 审中-公开
标题翻译：磷脂衍生物作为POTENT和选择性人P2X3受体拮抗剂
公开(公告)号：WO2008114976A8
公开(公告)日：2009-11-05
申请号：PCT/KR2008001476
申请日：2008-03-17
申请人： ANYGEN CO LTD , KIM YONG-CHUL , JEONG KWAN-YOUNG
发明人： KIM YONG-CHUL , JEONG KWAN-YOUNG
IPC分类号： C07K7/06
CPC分类号： C07K7/06
摘要： The present invention relates to a spinorphin derivative useful as a potent and selective human P2X3 receptor antagonist. More particularly, the present invention provides a spinorphin derivative useful as a potent and selective human P2X3 receptor antagonist selected from peptide AVVYPWT, peptide LAVYPWT, peptide LVAYPWT, peptide LVVAPWT and/ or cyclic peptide LWYPWT. Human P2X3 receptor antagonist has been developed on the electrophysiological evaluation of spinorphin peptide derivatives, truncated peptide analogues, cyclic peptides and a retroinverso peptide at human P2X3 receptors to determine the channel blocking activity.
摘要翻译：本发明涉及可用作有效和选择性的人P2X3受体拮抗剂的鸢尾甙衍生物。更具体地，本发明提供了一种可用作选自肽AVVYPWT，肽LAVYPWT，肽LVAYPWT，肽LVVAPWT和/或环肽LWYPWT的有效和选择性人P2X3受体拮抗剂的鸢尾甙衍生物。人类P2X3受体拮抗剂已经在人类P2X3受体的电生理学评估中被开发出来，以确定通道阻断活性，这些电刺激肽衍生物，截短肽类似物，环肽和反转肽在人P2X3受体上进行电生理学评估。

3. 发明申请

WO0073307A8 SUBSTITUTED 8-PHENYLXANTHINES USEFUL AS ANTAGONISTS OF A2B ADENOSINE RECEPTORS 审中-公开
标题翻译：作为A2B腺苷受体拮抗剂有用的替代8-苯丙氨酸
公开(公告)号：WO0073307A8
公开(公告)日：2002-02-28
申请号：PCT/US0015233
申请日：2000-06-01
申请人： UNIV VIRGINIA , NAT INST HEALTH , LINDEN JOEL M , JACOBSON KENNETH A , KIM YONG CHUL
发明人： LINDEN JOEL M , JACOBSON KENNETH A , KIM YONG-CHUL
IPC分类号： A61K31/522 , A61P1/12 , A61P3/10 , A61P9/10 , A61P9/14 , A61P11/06 , A61P27/02 , A61P35/00 , A61P43/00 , C07D473/06 , A61K31/505
CPC分类号： C07D473/06
摘要： The present invention provides compounds and pharmaceutical compositions that are selective antagonists of A2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
摘要翻译：本发明提供了作为A2B腺苷受体（AR）的选择性拮抗剂的化合物和药物组合物。这些化合物和组合物可用作药剂。

4. 发明申请

WO2012177020A3 COMPOSITION AND FORMULATION COMPRISING RECOMBINANT HUMAN IDURONATE-2-SULFATASE AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：包含重组人尿酸-2-磺酸酯酶的组合物和制剂及其制备方法
公开(公告)号：WO2012177020A3
公开(公告)日：2013-04-04
申请号：PCT/KR2012004734
申请日：2012-06-15
申请人： GREEN CROSS CORP , MEDIGENEBIO CORP , JIN THONG-GYU , CHUNG YO KYUNG , PAIK SANG HOON , PARK YOO CHANG , SEO JINWOOK , CHOI YONG WOON , SON JONG MUN , KIM YONG-CHUL
发明人： JIN THONG-GYU , CHUNG YO KYUNG , PAIK SANG HOON , PARK YOO CHANG , SEO JINWOOK , CHOI YONG WOON , SON JONG MUN , KIM YONG-CHUL
IPC分类号： A61K38/46 , A61K38/17 , A61P31/12
CPC分类号： C12N9/16 , A61K38/465 , C12Y301/06013
摘要： Disclosed is a composition comprising recombinant iduronate-2-sulfatase (IDS). The glycosylation pattern and formylglycine content of the IDS composition are different from those of Elaprase and have superior pharmaceutical efficacy and are safer than the conventional agent and thus can be effectively used for the therapy of Hunter syndrome.
摘要翻译：公开了包含重组艾杜糖醛酸-2-硫酸酯酶（IDS）的组合物。 IDS组合物的糖基化模式和甲酰甘氨酸含量与Elaprase不同，具有优良的药效，并且比传统药物更安全，因此可以有效地用于治疗亨特综合征。

5. 发明申请

WO2011034328A3 COMPOSITION INCLUDING CHLOROPHYLL A AS AN ACTIVE INGREDIENT FOR PREVENTING AND TREATING TH2-MEDIATED IMMUNOLOGICAL DISEASES 审中-公开
标题翻译：包含叶绿素A作为预防和治疗TH2介导的免疫疾病的活性成分的组合物
公开(公告)号：WO2011034328A3
公开(公告)日：2011-08-11
申请号：PCT/KR2010006268
申请日：2010-09-14
申请人： KWANGJU INST SCI & TECH , KIM YONG-CHUL , PARK ZEE YONG
发明人： KIM YONG-CHUL , PARK ZEE YONG
IPC分类号： A61K31/409 , A23L1/30 , A61P17/00 , A61P37/08
CPC分类号： A61K31/409 , A23L33/105 , A23V2002/00 , A61K8/494 , A61Q19/00 , A23V2250/21
摘要： The present invention relates to a composition including chlorophyll a as an active ingredient for preventing and treating Th2-mediated immunological diseases. The composition of the present invention is very effective for preventing and treating atopic dermatitis which is one of the Th2-mediated immunological diseases. Chlorophyll a is a natural ingredient used to treat atopic dermatitis and is advantageous in that it causes absolutely no side effects in humans. Further, the composition of the present invention may be applied as a medical composition including chlorophyll a, which has preventive and therapeutic effects for atopic dermatitis, as a food composition, as a cosmetic composition, and for various other products using chlorophyll a, and has excellent marketability.
摘要翻译：本发明涉及包含叶绿素a作为用于预防和治疗Th2介导的免疫疾病的活性成分的组合物。本发明的组合物对预防和治疗作为Th2介导的免疫疾病之一的特应性皮炎非常有效。叶绿素a是用于治疗特应性皮炎的天然成分，其优点在于它对人类完全没有副作用。此外，本发明的组合物可以作为医药组合物使用，所述医药组合物包含具有对特应性皮炎的预防和治疗效果的叶绿素a，作为食品组合物，作为化妆品组合物以及使用叶绿素a的各种其他产品，出色的适销性。

6. 发明申请

WO9727177A3 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS 审中-公开
标题翻译：二氢吡啶，吡啶，苯并噻唑和三唑并噻唑衍生物，其制备及其用作腺苷受体拮抗剂
公开(公告)号：WO9727177A3
公开(公告)日：1997-11-13
申请号：PCT/US9701252
申请日：1997-01-29
申请人： US HEALTH , JACOBSON KENNETH A , JIANG JI LONG , KIM YONG CHUL , KARTON YISHAI , RHEE ALBERT M VAN
发明人： JACOBSON KENNETH A , JIANG JI-LONG , KIM YONG-CHUL , KARTON YISHAI , VAN RHEE ALBERT M
IPC分类号： A61K31/4422 , A61K31/4545 , A61P7/02 , A61P9/10 , A61P25/22 , A61P43/00 , C07D211/90 , C07D311/22 , C07D311/30 , C07D311/32 , C07D317/70 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D487/04 , C07D493/04 , C07F7/08 , A61K31/44 , C07D407/04
CPC分类号： C07D401/04 , C07D211/90 , C07D311/22 , C07D311/30 , C07D311/32 , C07D317/70 , C07D405/04 , C07D409/04 , C07D487/04 , C07D493/04 , C07F7/0812
摘要： The present invention provides certain novel compounds, compositions, and a method of treating a mammal by blocking its adenosine receptors comprising administering at least one compound of the present invention. Examples of the present inventive compounds include certain flavonoids of formulae (I) and (II), wherein R1 to R4 are as defined in the description, and M is -CH(OH)-CH(R2)- or -C(OH)= C(R2)- and R1, R2 are as defined in the description; or dihydropyridines of formula (III), wherein R2 to R6 are as defined in the description; or pyridines of formula (IV), wherein R2 to R6 are as defined in the description, or triazoloquinazolines of formula (V), wherein R1 and R2 are as defined in the description; and their derivatives, or pharmaceutically acceptable salts thereof.
摘要翻译：本发明提供某些新的化合物，组合物和通过阻断其腺苷受体来治疗哺乳动物的方法，包括施用至少一种本发明的化合物。本发明化合物的实例包括式（I）和（II）的某些类黄酮，其中R 1至R 4如说明书中所定义，M为-CH（OH）-CH（R 2） - 或-C （OH）= C（R 2） - 和R 1，R 2如说明书中所定义; 或式（III）的二氢吡啶类，其中R 2至R 6如说明书中所定义; 或式（Ⅳ）的吡啶，其中R 2至R 6如说明书中所定义，或式（Ⅴ）的三唑并喹唑啉，其中R 1和R 2如说明书中所定义; 及其衍生物或其药学上可接受的盐。

7. 发明申请

WO2012157984A3 NOVEL HETEROAROMATIC COMPOUNDS AND USE THEREOF 审中-公开
标题翻译：新型异构化合物及其用途
公开(公告)号：WO2012157984A3
公开(公告)日：2013-03-21
申请号：PCT/KR2012003912
申请日：2012-05-17
申请人： KWANGJU INST SCI & TECH , KIM YONG-CHUL , KIM BO-KYOUNG , CHO JOONG-HEUI
发明人： KIM YONG-CHUL , KIM BO-KYOUNG , CHO JOONG-HEUI
IPC分类号： C07D413/12 , A61K31/42 , A61P31/12
CPC分类号： C07D413/12 , C07D261/18 , C07D413/14
摘要： The present invention relates to novel heteroaromatic derivative compounds, and to a composition using same for preventing or treating diseases caused by Coxsackievirus infection. The composition of the present invention binds with high affinity to enzymes related to the replication of Coxsackievirus, and thus may efficiently inhibit viral replication and activity. Therefore, the composition of the present invention may be valuably used in the prevention or treatment of diseases caused by Coxsackievirus infection.
摘要翻译：本发明涉及新颖的杂芳族衍生物化合物，以及涉及用于预防或治疗由柯萨奇病毒感染引起的疾病的组合物。本发明的组合物以高亲和力结合与柯萨奇病毒复制相关的酶，因此可有效抑制病毒复制和活性。因此，本发明的组合物可以有价值地用于预防或治疗由柯萨奇病毒感染引起的疾病。

8. 发明申请

WO2012177020A2 COMPOSITION AND FORMULATION COMPRISING RECOMBINANT HUMAN IDURONATE-2-SULFATASE AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：包含重组人IDURONATE-2-SULFATASE的组合物和制剂及其制备方法
公开(公告)号：WO2012177020A2
公开(公告)日：2012-12-27
申请号：PCT/KR2012004734
申请日：2012-06-15
申请人： GREEN CROSS CORP , MEDIGENEBIO CORP , JIN THONG-GYU , CHUNG YO KYUNG , PAIK SANG HOON , PARK YOO CHANG , SEO JINWOOK , CHOI YONG WOON , SON JONG MUN , KIM YONG-CHUL
发明人： JIN THONG-GYU , CHUNG YO KYUNG , PAIK SANG HOON , PARK YOO CHANG , SEO JINWOOK , CHOI YONG WOON , SON JONG MUN , KIM YONG-CHUL
IPC分类号： A61K38/46 , A61K38/17 , A61P31/12
CPC分类号： C12N9/16 , A61K38/465 , C12Y301/06013
摘要： Disclosed is a composition comprising recombinant iduronate-2-sulfatase (IDS). The glycosylation pattern and formylglycine content of the IDS composition are different from those of Elaprase and have superior pharmaceutical efficacy and are safer than the conventional agent and thus can be effectively used for the therapy of Hunter syndrome.
摘要翻译：公开了包含重组异丙肾上腺素-2-硫酸酯酶（IDS）的组合物。 IDS组合物的糖基化模式和甲酰甘氨酸含量与Elaprase不同，具有优异的药物功效，比常规药物更安全，因此可有效用于Hunter综合征的治疗。

9. 发明申请

WO2010008166A3 WIND POWER GENERATION SYSTEM 审中-公开
标题翻译：风力发电系统
公开(公告)号：WO2010008166A3
公开(公告)日：2010-04-22
申请号：PCT/KR2009003833
申请日：2009-07-14
申请人： MP TECH CORP , KIM YONG-SUNG , KIM YONG-CHUL
发明人： KIM YONG-SUNG , KIM YONG-CHUL
IPC分类号： F03D3/06
CPC分类号： F03D3/0436 , F03D3/005 , F05B2240/2212 , F05B2240/40 , F05B2240/94 , F05B2250/313 , Y02E10/74
摘要： The present invention relates to a wind power generation system having a generator for converting the rotating force generated from wind into electrical energy. The wind power generation system of the present invention includes: a first shaft and a second shaft which are arranged with a mutual angle and which rotate; a first blade and a second blade coupled to the first shaft and the second shaft to rotate the first shaft and the second shaft, and which are rotated by the wind; a first clutch and a second clutch arranged on the respective first and second shafts to control the rotating force; and a rotation transfer unit arranged in the intersection area of the first shaft and the second shaft to transfer the rotating force of either the first shaft or the second shaft to the generator. Whereby, at least one of the first and second shafts is selectively used in accordance with a given condition.
摘要翻译：本发明涉及具有发电机的风力发电系统，该发电机将从风产生的旋转力转换为电能。本发明的风力发电系统包括：第一轴和第二轴，其相互配合并且旋转; 第一叶片和第二叶片，其联接到第一轴和第二轴，以旋转第一轴和第二轴，并且其被风旋转; 第一离合器和第二离合器，布置在相应的第一和第二轴上以控制旋转力; 以及旋转传递单元，其布置在第一轴和第二轴的交叉区域中，以将第一轴或第二轴的旋转力传递到发生器。由此，根据给定的条件选择性地使用第一和第二轴中的至少一个。

10. 发明申请

WO0073307A3 SUBSTITUTED 8-PHENYLXANTHINES USEFUL AS ANTAGONISTS OF A2B ADENOSINE RECEPTORS 审中-公开
标题翻译：作为A2B腺苷受体拮抗剂有用的替代8-苯丙氨酸
公开(公告)号：WO0073307A3
公开(公告)日：2001-05-31
申请号：PCT/US0015233
申请日：2000-06-01
申请人： UNIV VIRGINIA , LINDEN JOEL M , JACOBSON KENNETH A , KIM YONG CHUL
发明人： LINDEN JOEL M , JACOBSON KENNETH A , KIM YONG-CHUL
IPC分类号： A61K31/522 , A61P1/12 , A61P3/10 , A61P9/10 , A61P9/14 , A61P11/06 , A61P27/02 , A61P35/00 , A61P43/00 , C07D473/06 , A61K31/505
CPC分类号： C07D473/06
摘要： The present invention provides compounds and pharmaceutical compositions that are selective antagonists of A2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
摘要翻译：本发明提供了作为A2B腺苷受体（AR）的选择性拮抗剂的化合物和药物组合物。这些化合物和组合物可用作药剂。

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