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1. 发明申请

WO2008137539A9 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A MEDICAL DEVICE 审中-公开
标题翻译：用于检测医疗设备中的心律失常的方法和设备
公开(公告)号：WO2008137539A9
公开(公告)日：2008-12-31
申请号：PCT/US2008062206
申请日：2008-05-01
申请人： MEDTRONIC INC , GHANEM RAJA N , STADLER ROBERT W , ZHANG XUSHENG , KLECKNER KARIN J , KRAUSE PAUL G
发明人： GHANEM RAJA N , STADLER ROBERT W , ZHANG XUSHENG , KLECKNER KARIN J , KRAUSE PAUL G
IPC分类号： A61B5/046 , A61B5/0464 , A61B5/0472 , A61N1/362 , A61N1/39
CPC分类号： A61B5/0464 , A61B5/7239 , A61N1/3621 , A61N1/3704 , A61N1/3925
摘要： A method and apparatus for determining oversensing in a medical device that includes sensing cardiac signals, determining an oversensing characteristic associated with cardiac signals sensed during a predetermined sensing window, identifying oversensing in response to the oversensing characteristic, determining, in response to oversensing being identified, an adjusting characteristic associated with cardiac signals sensed during the predetermined sensing window, and updating a sensing parameter in response to the determined adjusting characteristic.
摘要翻译： 1.一种用于确定医疗设备中的过度感测的方法和设备，所述过度感测包括感测心脏信号，确定与在预定感测窗口期间感测的心脏信号相关联的过度感测特征，响应于过度感测特征识别过度感测，响应于识别出过度感测，与在预定感测窗口期间感测的心脏信号相关联的调整特性，以及响应于所确定的调整特性来更新感测参数。

2. 发明申请

WO2008137529A2 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A MEDICAL DEVICE 审中-公开
标题翻译：用于检测医疗设备中的心律失常的方法和设备
公开(公告)号：WO2008137529A2
公开(公告)日：2008-11-13
申请号：PCT/US2008/062193
申请日：2008-05-01
申请人： MEDTRONIC, INC. , GHANEM, Raja, N. , STADLER, Robert, W. , ZHANG, Xusheng , KLECKNER, Karin, J. , KRAUSE, Paul, G.
发明人： GHANEM, Raja, N. , STADLER, Robert, W. , ZHANG, Xusheng , KLECKNER, Karin, J. , KRAUSE, Paul, G.
IPC分类号： A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/0472 , A61N1/362
CPC分类号： A61N1/3704 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61N1/05 , A61N1/0563 , A61N1/3925
摘要： A method and apparatus for determining oversensing of cardiac signals that includes a housing containing electronic circuitry, an electrode coupled to the electronic circuitry to sense cardiac signals, and a processor, positioned within the housing, to determine an oversensing characteristic associated with the cardiac signals sensed over a predetermined sensing window, and to identify oversensing in response to the determined oversensing characteristic.
摘要翻译：一种用于确定心脏信号的过度感测的方法和设备，所述方法和设备包括：包含电子电路的外壳，耦合到电子电路以感测心脏信号的电极，以及位于外壳内的处理器，以确定过度感测特征与在预定感测窗口上感测的心脏信号相关联，并且响应于所确定的过度感测特征来识别过度感测。

3. 发明申请

WO2006060705A1 SUBCUTANEOUS IMPLANTABLE CARDIOVERTER/DEFIBRILLATOR 审中-公开
标题翻译：皮下植入式心脏起搏器/除颤器
公开(公告)号：WO2006060705A1
公开(公告)日：2006-06-08
申请号：PCT/US2005/043718
申请日：2005-12-05
申请人： MEDTRONIC, INC. , GHANEM, Raja, N. , OLSON, Walter, H.
发明人： GHANEM, Raja, N. , OLSON, Walter, H.
IPC分类号： A61N1/362 , A61N1/05
CPC分类号： A61N1/05 , A61N1/362
摘要： A cardiac pacemaker and method of its use. The pacemaker is provided with a pacing electrode array configured for location at a left anterior portion of a patient’s thorax between the patients third and sixth ribs, outside the patient’s thoracic cavity. The pacing electrode array includes multiple pacing electrodes and preferably includes one or more steering electrodes for configuring the electrical field produced by delivery of pacing pulses to avoid unwanted nerve and muscle stimulation while allowing cardiac stimulation. The electrode array may be located subcutaneously, submuscularly or on the patient’s skin.
摘要翻译：心脏起搏器及其使用方法
起搏器设置有起搏电极阵列，该起搏电极阵列被配置为位于患者第三和第六肋骨之间患者胸腔外的患者胸腔的左前部。起搏电极阵列包括多个起搏电极，并且优选地包括一个或多个导向电极，用于配置通过递送起搏脉冲产生的电场以避免不期望的神经和肌肉刺激，同时允许心脏刺激。电极阵列可位于皮下，肌下或患者皮肤上。

4. 发明申请

WO2011153428A8 SYSTEM AND METHOD FOR ASSESSING A LIKELIHOOD OF A PATIENT TO EXPERIENCE A FUTURE CARDIAC ARRHYTHMIA USING DYNAMIC CHANGES IN A BIOLOGICAL PARAMETER 审中-公开
标题翻译：用于评估患者身体的体系和方法使用生物参数中的动态变化的未来心脏心律失常
公开(公告)号：WO2011153428A8
公开(公告)日：2012-07-19
申请号：PCT/US2011039057
申请日：2011-06-03
申请人： MEDTRONIC INC , GHANEM RAJA N , DEGROOT PAUL J
发明人： GHANEM RAJA N , DEGROOT PAUL J
IPC分类号： A61B5/0452 , A61B5/04 , A61N1/37 , A61N1/39
CPC分类号： A61B5/04012 , A61B5/0452 , A61N1/3702 , A61N1/3925
摘要： System and method for assessing a likelihood of a patient to experience a cardiac arrhythmia using dynamic changes in a biological parameter. A biological sensor is configured to sense a biological parameter of the patient. A processor is coupled to the biological sensor and is configured to determine a dynamic change of the biological parameter and determine the likelihood of the patient experiencing a cardiac arrhythmia based, at least in part, on the dynamic change of the biological parameter.
摘要翻译：使用生物参数中的动态变化评估患者体验心律失常的可能性的系统和方法。生物传感器被配置为感测患者的生物学参数。处理器耦合到生物传感器并且被配置为确定生物参数的动态变化并且至少部分地基于生物参数的动态变化来确定患者经历心律失常的可能性。

5. 发明申请

WO2010014063A1 PERIODIC BEAT DETECTION TO DETECT ARTIFACTS IN A CARDIAC ELECTROGRAM 审中-公开
标题翻译：在心脏电泳中检测人体的周期性BEAT检测
公开(公告)号：WO2010014063A1
公开(公告)日：2010-02-04
申请号：PCT/US2008/009244
申请日：2008-07-31
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , GHANEM, Raja , STADLER, Robert, W.
发明人： ZHANG, Xusheng , GHANEM, Raja , STADLER, Robert, W.
IPC分类号： A61B5/0464
CPC分类号： A61B5/0464 , A61B5/0006 , A61B5/7203 , A61B5/7239 , A61N1/365
摘要： Techniques for determining whether artifacts are present in a cardiac electrogram are described. According to one example, a medical device senses a cardiac electrogram via electrodes. The medical device determines a derivative, e.g., a second order derivative, the electrogram. The medical device detects beats within the derivative, e.g., by comparing a rectified version of the derivative to one or more thresholds determined based on a maximum of the rectified derivative. The medical device determines whether the beats are periodic, and determines whether artifacts are present in the cardiac electrogram based on the determination of whether the beats are periodic. The medical device may further determine whether tachyarrhythmia is present and/or whether the cardiac rhythm of the patient is treatable based on the determination of whether the beats are periodic. For example, the medical device may determine that an electrogram is not treatable when the beats are periodic.
摘要翻译：描述了用于确定伪像是否存在于心电图中的技术。根据一个示例，医疗装置通过电极感测心电图。医疗设备确定导数，例如二阶导数，电描记图。医疗设备检测导数内的跳动，例如通过将导数的整流版本与基于校正导数的最大值确定的一个或多个阈值进行比较。医疗器械确定节拍是否是周期性的，并且基于确定节拍是否是周期性的确定来确定心脏电图中是否存在人造物。医疗装置可以基于是否是周期性的确定来进一步确定是否存在快速性心律失常和/或患者的心律是否可治疗。例如，当节拍是周期性的时，医疗装置可以确定电描记图是不可治疗的。

6. 发明申请

WO2007117822A1 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A SUBCUTANEOUS MEDICAL DEVICE 审中-公开
标题翻译：用于检测亚急性医疗器械中的ARRHYTHMIAS的方法和装置
公开(公告)号：WO2007117822A1
公开(公告)日：2007-10-18
申请号：PCT/US2007/063784
申请日：2007-03-12
申请人： MEDTRONIC, INC. , STADLER, Robert W. , GHANEM, Raja N. , ZHANG, Xusheng , GREENHUT, Saul E.
发明人： STADLER, Robert W. , GHANEM, Raja N. , ZHANG, Xusheng , GREENHUT, Saul E.
IPC分类号： A61B5/046 , A61B5/0464 , A61N1/39
CPC分类号： A61N1/3956 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61N1/3621
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, advancing from a first state to a second state in response to processing of an interval associated with a cardiac cycle of the sensed cardiac signals, and advancing from the second state in response to processing of a cardiac signal sensed during a predetermined sensing window.
摘要翻译：一种用于检测医疗装置中的心脏事件的方法和装置，包括：感测来自形成第一感测向量的多个电极的心脏信号和响应于间隔的处理从第一状态进入第二状态的第二感测向量与感测的心脏信号的心动周期相关联，并且响应于在预定感测窗口期间感测的心脏信号的处理而从第二状态前进。

7. 发明申请

WO2007115104A3 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A MEDICAL DEVICE 审中-公开
公开(公告)号：WO2007115104A3
公开(公告)日：2007-10-11
申请号：PCT/US2007/065520
申请日：2007-03-29
申请人： MEDTRONIC, INC , ZHANG, Xusheng , STADLER, Robert W. , GHANEM, Raja N. , KLECKNER, Karen J. , KRAUSE, Paul G. , MAHAJAN, Veerdhaval
发明人： ZHANG, Xusheng , STADLER, Robert W. , GHANEM, Raja N. , KLECKNER, Karen J. , KRAUSE, Paul G. , MAHAJAN, Veerdhaval
IPC分类号： A61B5/046 , A61B5/0464 , H04B15/00 , A61N1/39
摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, determining inflections of the sensed cardiac signals, generating a pulse amplitude threshold in response to the determined inflections, determining whether the sensed cardiac signals are corrupted by noise in response to the determined inflections and the generated pulse amplitude threshold, and determining, in response to the sensed cardiac signals being corrupted by noise, whether the sensed cardiac signals are both corrupted by noise and shockable.

8. 发明申请

WO2007115104A2 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A MEDICAL DEVICE 审中-公开
标题翻译：用于检测医疗器械中的ARRHYTHMIAS的方法和装置
公开(公告)号：WO2007115104A2
公开(公告)日：2007-10-11
申请号：PCT/US2007065520
申请日：2007-03-29
申请人： MEDTRONIC INC , ZHANG XUSHENG , STADLER ROBERT W , GHANEM RAJA N , KLECKNER KAREN J , KRAUSE PAUL G , MAHAJAN VEERDHAVAL
发明人： ZHANG XUSHENG , STADLER ROBERT W , GHANEM RAJA N , KLECKNER KAREN J , KRAUSE PAUL G , MAHAJAN VEERDHAVAL
IPC分类号： A61B5/046 , A61B5/0464 , A61N1/39 , H04B15/00
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, determining inflections of the sensed cardiac signals, generating a pulse amplitude threshold in response to the determined inflections, determining whether the sensed cardiac signals are corrupted by noise in response to the determined inflections and the generated pulse amplitude threshold, and determining, in response to the sensed cardiac signals being corrupted by noise, whether the sensed cardiac signals are both corrupted by noise and shockable.
摘要翻译：一种检测医疗装置中的心脏事件的方法，包括：感测来自形成第一感测向量和第二感测向量的多个电极的心脏信号，确定感测的心脏信号的变形，响应于所确定的心脏信号产生脉冲幅度阈值拐点，响应于所确定的变形和所产生的脉冲幅度阈值确定所感测到的心脏信号是否被噪声破坏，以及响应于感测到的心脏信号被噪声破坏，确定所感测的心脏信号是否被噪声破坏并可震撼。

9. 发明申请

WO2006115778A3 LEVEL CROSSING DETECTOR FOR DETECTING NOISE, SINUS RHYTHM AND VENTRICULAR FIBRILLATION IN SUBCUTANEOUS OR BODY SURFACE SIGNALS 审中-公开
标题翻译：用于检测噪声的水平交叉检测器，子午线或身体表面信号中的心脏和心室颤动
公开(公告)号：WO2006115778A3
公开(公告)日：2007-04-12
申请号：PCT/US2006013599
申请日：2006-04-11
申请人： MEDTRONIC INC , GHANEM RAJA N , GILLBERG JEFFREY M
发明人： GHANEM RAJA N , GILLBERG JEFFREY M
IPC分类号： A61N1/39 , A61B5/04 , G06F17/00
CPC分类号： A61N1/0563 , A61N1/3918 , A61N1/3956
摘要： A SubQ ICD that is entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and associated with subcutaneous leads provides distributed cardioversion- defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. A level crossing detection system and process is implemented to detect noise, sinus rhythm and ventricular fibrillation in subcutaneous or body surface signals to deliver therapies as needed.
摘要翻译：完全可植入皮下的SubQ ICD，以最小的外科手术入侵患者身体并与皮下引线相关联，可提供分布式心脏复律除颤感和刺激电极，用于在需要时在整个心脏中传递心脏复律除颤休克和起搏治疗。实施了一个电平交叉检测系统和过程，用于检测皮下或体表信号中的噪声，窦性心律和心室颤动，以根据需要提供治疗。

10. 发明申请

WO2011153428A1 SYSTEM AND METHOD FOR ASSESSING A LIKELIHOOD OF A PATIENT TO EXPERIENCE A FUTURE CARDIAC ARRHYTHMIA USING DYNAMIC CHANGES IN A BIOLOGICAL PARAMETER 审中-公开
标题翻译：用于评估患者身体的体系和方法使用生物参数中的动态变化的未来心脏心律失常
公开(公告)号：WO2011153428A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/039057
申请日：2011-06-03
申请人： MEDTRONIC, INC. , GHANEM, Raja, N. , DEGROOT, Paul, J.
发明人： GHANEM, Raja, N. , DEGROOT, Paul, J.
IPC分类号： A61B5/0452 , A61B5/04 , A61N1/37 , A61N1/39
CPC分类号： A61B5/04012 , A61B5/0452 , A61N1/3702 , A61N1/3925 , G06F19/00
摘要： System and method for assessing a likelihood of a patient to experience a cardiac arrhythmia using dynamic changes in a biological parameter. A biological sensor is configured to sense a biological parameter of the patient. A processor is coupled to the biological sensor and is configured to determine a dynamic change of the biological parameter and determine the likelihood of the patient experiencing a cardiac arrhythmia based, at least in part, on the dynamic change of the biological parameter.
摘要翻译：使用生物参数中的动态变化评估患者体验心律失常的可能性的系统和方法。生物传感器被配置为感测患者的生物学参数。处理器耦合到生物传感器并且被配置为确定生物参数的动态变化并且至少部分地基于生物参数的动态变化来确定患者经历心律失常的可能性。

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