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1. 发明申请

WO2008137529A2 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A MEDICAL DEVICE 审中-公开
标题翻译：用于检测医疗设备中的心律失常的方法和设备
公开(公告)号：WO2008137529A2
公开(公告)日：2008-11-13
申请号：PCT/US2008/062193
申请日：2008-05-01
申请人： MEDTRONIC, INC. , GHANEM, Raja, N. , STADLER, Robert, W. , ZHANG, Xusheng , KLECKNER, Karin, J. , KRAUSE, Paul, G.
发明人： GHANEM, Raja, N. , STADLER, Robert, W. , ZHANG, Xusheng , KLECKNER, Karin, J. , KRAUSE, Paul, G.
IPC分类号： A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/0472 , A61N1/362
CPC分类号： A61N1/3704 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61N1/05 , A61N1/0563 , A61N1/3925
摘要： A method and apparatus for determining oversensing of cardiac signals that includes a housing containing electronic circuitry, an electrode coupled to the electronic circuitry to sense cardiac signals, and a processor, positioned within the housing, to determine an oversensing characteristic associated with the cardiac signals sensed over a predetermined sensing window, and to identify oversensing in response to the determined oversensing characteristic.
摘要翻译：一种用于确定心脏信号的过度感测的方法和设备，所述方法和设备包括：包含电子电路的外壳，耦合到电子电路以感测心脏信号的电极，以及位于外壳内的处理器，以确定过度感测特征与在预定感测窗口上感测的心脏信号相关联，并且响应于所确定的过度感测特征来识别过度感测。

2. 发明申请

WO2006060705A1 SUBCUTANEOUS IMPLANTABLE CARDIOVERTER/DEFIBRILLATOR 审中-公开
标题翻译：皮下植入式心脏起搏器/除颤器
公开(公告)号：WO2006060705A1
公开(公告)日：2006-06-08
申请号：PCT/US2005/043718
申请日：2005-12-05
申请人： MEDTRONIC, INC. , GHANEM, Raja, N. , OLSON, Walter, H.
发明人： GHANEM, Raja, N. , OLSON, Walter, H.
IPC分类号： A61N1/362 , A61N1/05
CPC分类号： A61N1/05 , A61N1/362
摘要： A cardiac pacemaker and method of its use. The pacemaker is provided with a pacing electrode array configured for location at a left anterior portion of a patient’s thorax between the patients third and sixth ribs, outside the patient’s thoracic cavity. The pacing electrode array includes multiple pacing electrodes and preferably includes one or more steering electrodes for configuring the electrical field produced by delivery of pacing pulses to avoid unwanted nerve and muscle stimulation while allowing cardiac stimulation. The electrode array may be located subcutaneously, submuscularly or on the patient’s skin.
摘要翻译：心脏起搏器及其使用方法
起搏器设置有起搏电极阵列，该起搏电极阵列被配置为位于患者第三和第六肋骨之间患者胸腔外的患者胸腔的左前部。起搏电极阵列包括多个起搏电极，并且优选地包括一个或多个导向电极，用于配置通过递送起搏脉冲产生的电场以避免不期望的神经和肌肉刺激，同时允许心脏刺激。电极阵列可位于皮下，肌下或患者皮肤上。

3. 发明申请

WO2010056425A1 CARDIAC RISK STRATIFICATION UTILIZING BAROREFLEX SENSITIVITY MEASURMENT 审中-公开
标题翻译： CARDIAC风险分析利用BAROREFLEX灵敏度测量
公开(公告)号：WO2010056425A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/059150
申请日：2009-10-01
申请人： MEDTRONIC, INC. , GHANEM, Raja, N.
发明人： GHANEM, Raja, N.
IPC分类号： A61B5/0205 , A61B5/0215 , A61B5/042 , A61B5/0456 , A61N1/08
CPC分类号： A61N1/36564 , A61B5/02158 , A61B5/042 , A61B5/0456 , A61N1/36585 , A61N1/36592
摘要： A monitoring or therapy system may obtain a baroreflex sensitivity (BRS) measurement via an implantable medical device (IMD). The monitoring or therapy system then may generate a risk stratification indicator based on the BRS measurement. In some examples, the IMD generates the risk stratification indicator, while in other examples, an external computing device, such as a programmer, generates the risk stratification indicator. The monitoring or therapy system also may obtain at least one of a heart rate variability (HRV) measurement and a non-sustained ventricular tachycardia (NSVT) indicator via the IMD, and may generate the risk stratification indicator based on the BRS measurement and one or both of the HRV measurement and the NSVT indicator. In some examples, the monitoring or therapy system may generate an instruction, indicator, or alert based on the risk stratification indicator. The indicator may indicate that the patient is a candidate for an implantable therapy device.
摘要翻译：监测或治疗系统可以通过可植入医疗装置（IMD）获得压力反射灵敏度（BRS）测量。然后，监测或治疗系统可以基于BRS测量产生风险分层指标。在一些示例中，IMD生成风险分层指标，而在其他示例中，外部计算设备（例如程序员）生成风险分层指标。监测或治疗系统还可以经由IMD获得心率变异性（HRV）测量值和非持续性室性心动过速（NSVT）指标中的至少一项，并且可以基于BRS测量产生风险分层指标， HRV测量和NSVT指标。在一些示例中，监测或治疗系统可以基于风险分层指示符产生指令，指示符或警报。指示符可以指示患者是可植入治疗装置的候选者。

4. 发明申请

WO2007131173A2 METHOD AND APPARATUS FOR DISCRIMINATING CARDIAC SIGNALS IN A MEDICAL DEVICE BASED ON WAVELET DECOMPOSITION ANALYSIS 审中-公开
标题翻译：基于小波分解分析的医疗设备鉴别心脏信号的方法与装置
公开(公告)号：WO2007131173A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/068249
申请日：2007-05-04
申请人： MEDTRONIC, INC. , GHANEM, Raja, N. , JACKSON, Troy, E.
发明人： GHANEM, Raja, N. , JACKSON, Troy, E.
IPC分类号： A61B5/04 , A61B5/0402 , A61N1/362 , G06F17/00
CPC分类号： A61B5/0464 , A61B5/0422 , A61B5/0424 , A61B5/046 , A61B5/726 , A61N1/362 , A61N1/3706 , G06K9/00536 , G06K9/527
摘要： A method of detecting cardiac signals in a medical device that includes decomposing a cardiac signal using a wavelet function at a plurality of scales to form a corresponding wavelet transform, determining approximation coefficients in response to the plurality of scales, reconstructing a first wavelet representation of the wavelet transform using predetermined approximation coefficients of the determined approximation coefficients, and evaluating the detected cardiac signals in response to the reconstructing.
摘要翻译：一种检测医疗装置中的心脏信号的方法，包括使用多个尺度的小波函数分解心脏信号以形成对应的小波变换，响应于所述多个标度确定近似系数，重建所述多个尺度的第一小波表示使用所确定的近似系数的预定近似系数的小波变换，以及响应于重建来评估检测到的心脏信号。

5. 发明申请

WO2011153428A1 SYSTEM AND METHOD FOR ASSESSING A LIKELIHOOD OF A PATIENT TO EXPERIENCE A FUTURE CARDIAC ARRHYTHMIA USING DYNAMIC CHANGES IN A BIOLOGICAL PARAMETER 审中-公开
标题翻译：用于评估患者身体的体系和方法使用生物参数中的动态变化的未来心脏心律失常
公开(公告)号：WO2011153428A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/039057
申请日：2011-06-03
申请人： MEDTRONIC, INC. , GHANEM, Raja, N. , DEGROOT, Paul, J.
发明人： GHANEM, Raja, N. , DEGROOT, Paul, J.
IPC分类号： A61B5/0452 , A61B5/04 , A61N1/37 , A61N1/39
CPC分类号： A61B5/04012 , A61B5/0452 , A61N1/3702 , A61N1/3925 , G06F19/00
摘要： System and method for assessing a likelihood of a patient to experience a cardiac arrhythmia using dynamic changes in a biological parameter. A biological sensor is configured to sense a biological parameter of the patient. A processor is coupled to the biological sensor and is configured to determine a dynamic change of the biological parameter and determine the likelihood of the patient experiencing a cardiac arrhythmia based, at least in part, on the dynamic change of the biological parameter.
摘要翻译：使用生物参数中的动态变化评估患者体验心律失常的可能性的系统和方法。生物传感器被配置为感测患者的生物学参数。处理器耦合到生物传感器并且被配置为确定生物参数的动态变化并且至少部分地基于生物参数的动态变化来确定患者经历心律失常的可能性。

6. 发明申请

WO2011068618A1 CONTINUOUS MONITORING OF RISK BURDEN FOR SUDDEN CARDIAC DEATH RISK STRATIFICATION 审中-公开
标题翻译：持续监测减少心脏死亡风险分析的风险
公开(公告)号：WO2011068618A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/055407
申请日：2010-11-04
申请人： MEDTRONIC, INC. , GHANEM, Raja, N. , DEGROOT, Paul, J.
发明人： GHANEM, Raja, N. , DEGROOT, Paul, J.
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/7275 , G06F19/00
摘要： System and method for assessing a likelihood of a patient to experience a cardiac arrhythmia. A biological sensor is configured to sense biological parameters of the patient. A processor is coupled to the biological sensor and is configured to determine the likelihood of the patient experiencing a cardiac arrhythmia based, at least in part, on a combination of the biological parameters, the combination dynamically weighting each of the plurality of biological parameters based on another one of the plurality of biological parameters. In a particular example, markers utilized include heart rate T-wave alternans, turbulence, premature ventricular contractions per hour and a modified moving average of a maximum daily heart rate. Genetic and/or clinical information may also be incorporated.
摘要翻译：用于评估患者经历心律失常的可能性的系统和方法。生物传感器被配置为感测患者的生物学参数。处理器耦合到所述生物传感器并且被配置为至少部分地基于所述生物参数的组合来确定所述患者体验心律失常的可能性，所述组合基于所述多个生物参数中的每一个基于多个生物参数中的另一个。在一个特定的例子中，使用的标记物包括心率T波交替，湍流，每小时早搏心室收缩和最大日心率的修正移动平均值。也可以并入遗传和/或临床信息。

7. 发明申请

WO2007131176A2 METHOD AND APPARATUS FOR DISCRIMINATING CARDIAC SIGNALS IN A MEDICAL DEVICE BASED ON WAVELET DECOMPOSITION ANALYSIS 审中-公开
标题翻译：基于小波分解分析的医疗设备鉴别心脏信号的方法与装置
公开(公告)号：WO2007131176A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/068255
申请日：2007-05-04
申请人： MEDTRONIC, INC. , GHANEM, Raja, N. , JACKSON, Troy, E.
发明人： GHANEM, Raja, N. , JACKSON, Troy, E.
CPC分类号： A61B5/0464 , A61B5/0422 , A61B5/0424 , A61B5/046 , A61B5/726 , A61N1/362 , A61N1/3706 , G06K9/00536 , G06K9/527
摘要： A method and device for detecting cardiac signals in a medical device that includes decomposing sensed cardiac signals using a wavelet function to form a corresponding wavelet transform, generating a first wavelet representation corresponding to the wavelet transform that is responsive to RR intervals of the sensed cardiac signals, generating a second wavelet representation that is not responsive to RR intervals associated with the sensed cardiac signals, and determining a device failure in response to the first wavelet representation and the second wavelet representation. The method and device may also include decomposing sensed cardiac signals using a wavelet function to form a corresponding wavelet transform, generating a wavelet representation that is not responsive to RR intervals of the sensed cardiac signals, determining RR intervals associated with the sensed cardiac signals, and determining a device failure in response to the first wavelet representation and the determined RR intervals.
摘要翻译：一种用于检测医疗装置中的心脏信号的方法和装置，包括使用小波函数分解感测到的心脏信号以形成相应的小波变换，产生对应于小波变换的第一小波表示，所述小波变换响应于感测的心脏信号的RR间隔产生不响应于与感测到的心脏信号相关联的RR间隔的第二小波表示，以及响应于第一小波表示和第二小波表示来确定设备故障。所述方法和装置还可以包括使用小波函数分解感测到的心脏信号以形成相应的小波变换，产生不响应感测的心脏信号的RR间隔的小波表示，确定与感测到的心脏信号相关联的RR间隔，以及响应于第一小波表示和所确定的RR间隔来确定设备故障。

8. 发明申请

WO2006115778A2 LEVEL CROSSING DETECTOR FOR DETECTING NOISE, SINUS RHYTHM AND VENTRICULAR FIBRILLATION IN SUBCUTANEOUS OR BODY SURFACE SIGNALS 审中-公开
标题翻译：用于检测噪声的水平交叉检测器，子午线或身体表面信号中的心脏和心室颤动
公开(公告)号：WO2006115778A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/013599
申请日：2006-04-11
申请人： MEDTRONIC, INC. , GHANEM, Raja, N. , GILLBERG, Jeffrey, M.
发明人： GHANEM, Raja, N. , GILLBERG, Jeffrey, M.
IPC分类号： A61N1/39 , A61B5/04 , G06F17/00
CPC分类号： A61N1/0563 , A61N1/3918 , A61N1/3956
摘要： A SubQ ICD that is entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and associated with subcutaneous leads provides distributed cardioversion- defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. A level crossing detection system and process is implemented to detect noise, sinus rhythm and ventricular fibrillation in subcutaneous or body surface signals to deliver therapies as needed.
摘要翻译：完全可植入皮下的SubQ ICD，以最小的外科手术入侵患者身体并与皮下引线相关联，可提供分布式心脏复律除颤感和刺激电极，用于在需要时在整个心脏中传递心脏复律除颤休克和起搏治疗。实施了一个电平交叉检测系统和过程，用于检测皮下或体表信号中的噪声，窦性心律和心室颤动，以根据需要提供治疗。

9. 发明申请

WO2006115815A2 REMOTELY ENABLED PACEMAKER AND IMPLANTABLE SUBCUTANEOUS CARDIOVERTER/DEFIBRILLATOR SYSTEM 审中-公开
标题翻译：远程启动的遥控器和可植入的辅助放大器/除颤器系统
公开(公告)号：WO2006115815A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/013956
申请日：2006-04-12
申请人： MEDTRONIC. INC. , MARKOWITZ, H., Toby , HETTRICK, Douglas, A. , COMBS, William, J. , SHELDON, Todd, J. , THOMPSON, David, L. , GHANEM, Raja, N. , WANASEK, Kevin, A.
发明人： MARKOWITZ, H., Toby , HETTRICK, Douglas, A. , COMBS, William, J. , SHELDON, Todd, J. , THOMPSON, David, L. , GHANEM, Raja, N. , WANASEK, Kevin, A.
IPC分类号： A61N1/372
CPC分类号： A61N1/3962 , A61N1/025 , A61N1/37211 , A61N1/37229 , A61N1/37288
摘要： Subcutaneous Implantable cardioverter-defibrillators (SubQ ICDs) are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion-defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. The SubQ ICD is implemented with other implantable and external medical devices and communicates to provide drugs and therapy in a coordinated and synergistic manner.
摘要翻译：皮下植入式心律转复除颤器（SubQ ICD）被公开，其完全可植入皮下，以最小的手术入侵患者体内，并提供分布式心脏复律除颤感和刺激电极，用于在整个心脏中递送心脏复律除颤休克和起搏疗法必要。 SubQ ICD与其他植入式和外部医疗设备一起实施，并以协调和协同的方式进行通信以提供药物和治疗。

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