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1. 发明申请

WO2010045173A1 OPTICAL TRANSMISSION COUPLING 审中-公开
标题翻译：光传输耦合
公开(公告)号：WO2010045173A1
公开(公告)日：2010-04-22
申请号：PCT/US2009/060418
申请日：2009-10-13
申请人： SONOSITE, INC. , DAVIDSON, Daniel , SKIDMORE, Joseph, E. , FINE, Richard, A.
发明人： DAVIDSON, Daniel , SKIDMORE, Joseph, E. , FINE, Richard, A.
IPC分类号： G02B6/38
CPC分类号： G02B6/3813 , G02B6/3825 , G02B6/3849 , G02B6/3894
摘要： The present invention relates generally to an optical transmission coupling and more particularly to an optical transmission coupling that substantially prevents harmful light from the optical source from prematurely escaping the coupling before the target optical transmission connector is inserted into the coupling.
摘要翻译：本发明一般涉及一种光传输耦合器，更具体地说，涉及一种光传输耦合器，其在将目标光传输连接器插入耦合器之前基本上防止来自光源的有害光过早地逸出耦合器。

2. 发明申请

WO2008154286A2 MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH 审中-公开
标题翻译：化学感受器的调节和与之相关的配体
公开(公告)号：WO2008154286A2
公开(公告)日：2008-12-18
申请号：PCT/US2008/065907
申请日：2008-06-05
申请人： SENOMYX, INC. , LI, Xiaodong , ZHANG, Feng , XU, Hong , TACHDJIAN, Catherine , ADAMSKI-WERNER, Sara , PATRON, Andrew , ZLOTNIK, Albert , ZOLLER, Mark , KLEBANSKY, Boris , FINE, Richard , KANG, Xinshan
发明人： LI, Xiaodong , ZHANG, Feng , XU, Hong , TACHDJIAN, Catherine , ADAMSKI-WERNER, Sara , PATRON, Andrew , ZLOTNIK, Albert , ZOLLER, Mark , KLEBANSKY, Boris , FINE, Richard , KANG, Xinshan
IPC分类号： A61K31/495 , A61P27/00 , C07D487/00 , C12N5/06 , G01N33/53 , G06G7/48
CPC分类号： A61K31/495 , C07F9/65586 , C07F9/65616 , G01N33/566 , G01N2333/726 , G01N2500/04 , G06F19/16 , G06F19/18
摘要： The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.
摘要翻译：本发明提供了用于鉴定化学感受器及其配体的调节剂的筛选方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获结构域内的一个或多个相互作用位点相互作用，以及能够调节化学感受器及其配体。

3. 发明申请

WO2005008372A2 METHOD AND APPARATUS FOR LINKING BUSINESS INTERESTS 审中-公开
标题翻译：连接商业利益的方法和设备
公开(公告)号：WO2005008372A2
公开(公告)日：2005-01-27
申请号：PCT/US2004/021350
申请日：2004-07-02
申请人： FINE, Richard, J.
发明人： FINE, Richard, J.
IPC分类号： G06F
CPC分类号： G06Q30/02 , G06Q10/101 , G06Q30/0631 , G06Q50/188
摘要： Methods and apparatus for linking business interests, which are particularly suited for linking business interests, such as equipment, real estate, technical expertise, product purchasers, material inventories, purchase agreements, intellectual property and investment capital via the vehicle of the Internet for the purpose of forming or growing a business.
摘要翻译：连接商业利益的方法和装置，特别适用于通过设备，房地产，技术专长，产品购买者，材料库存，购买协议，知识产权和投资资本将商业利益连接起来互联网的载体，以形成或发展企业。

4. 发明申请

WO2006014168A1 NICOTINAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS 审中-公开
标题翻译： NICOTINAMIDE衍生物及其作为治疗药物使用
公开(公告)号：WO2006014168A1
公开(公告)日：2006-02-09
申请号：PCT/US2004/021792
申请日：2004-07-06
申请人： XENON PHARMACEUTICALS INC. , FU, Jian-Min , KODUMURU, Vishnumurthy , SUN, Shaoyi , WINTHER, Michael, D. , FINE, Richard, M. , HARVEY, Daniel, F. , KLEBANSKY, Boris , GRAY-KELLER, Mark , GSCHWEND, Heinz, W.
发明人： FU, Jian-Min , KODUMURU, Vishnumurthy , SUN, Shaoyi , WINTHER, Michael, D. , FINE, Richard, M. , HARVEY, Daniel, F. , KLEBANSKY, Boris , GRAY-KELLER, Mark , GSCHWEND, Heinz, W.
IPC分类号： A61K31/496
CPC分类号： A61K31/496
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where m, n, p, V, R1, R2, R3, R4, R5 and R6 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译：公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中m，n，p，V，R ，R2，R3，R4，R5和R6如本文所定义。还公开了包含式（I）化合物的药物组合物。

5. 发明申请

WO2005008372A3 METHOD AND APPARATUS FOR LINKING BUSINESS INTERESTS 审中-公开
标题翻译：连接业务利益的方法和设备
公开(公告)号：WO2005008372A3
公开(公告)日：2005-05-12
申请号：PCT/US2004021350
申请日：2004-07-02
申请人： FINE RICHARD J
发明人： FINE RICHARD J
IPC分类号： G06Q30/00 , G06F17/60
CPC分类号： G06Q30/02 , G06Q10/101 , G06Q30/0631 , G06Q50/188
摘要： Methods and apparatus for linking business interests, which are particularly suited for linking business interests, such as equipment, real estate, technical expertise, product purchasers, material inventories, purchase agreements, intellectual property and investment capital via the vehicle of the Internet for the purpose of forming or growing a business.
摘要翻译：通过互联网的车辆连接商业利益的方法和装置，特别适合于通过互联网的车辆连接商业利益，如设备，房地产，技术专长，产品购买者，物料清单，采购协议，知识产权和投资资本形成或成长业务。

6. 发明申请

WO2017181008A1 METHODS FOR IDENTIFYING MODULATORS OF GPR92 审中-公开
标题翻译：鉴定GPR92调节因子的方法
公开(公告)号：WO2017181008A1
公开(公告)日：2017-10-19
申请号：PCT/US2017/027626
申请日：2017-04-14
申请人： MARS, INCORPORATED , MCGRANE, Scott, Joseph , GIBBS, Matthew, Ronald , FINE, Richard, Masten , KLEBANSKY, Boris
发明人： MCGRANE, Scott, Joseph , GIBBS, Matthew, Ronald , FINE, Richard, Masten , KLEBANSKY, Boris
IPC分类号： C07K14/00 , C07K14/705 , C12Q1/00
摘要： The present disclosure provides methods for identifying compounds that modulate the activity and/or expression of GPR92, wherein said compounds can be incorporated into flavor compositions that can be used to modify the taste and/or palatability of pet food products. In certain non-limiting embodiments, the present disclosure provides a method for identifying a composition that modulates the activity of a GPR92 receptor comprising (a) contacting a test agent with a GPR92 receptor, (b) determining the activity of the GPR92 receptor, and (c) selecting as the composition, a test agent that increases the activity of the GPR92 receptor.
摘要翻译：本公开内容提供了用于鉴定调节GPR92的活性和/或表达的化合物的方法，其中所述化合物可以掺入可用于改变宠物的味道和/或可口性的风味组合物中食物产品。在某些非限制性实施方案中，本公开内容提供了用于鉴定调节GPR92受体活性的组合物的方法，其包括（a）使测试药剂与GPR92受体接触，（b）确定GPR92受体的活性，以及（c）选择增加GPR92受体活性的试剂作为组合物。

7. 发明申请

WO2008019497A1 FLUID DISPENSING SYSTEM SUITABLE FOR DISPENSING LIQUID FLAVORINGS 审中-公开
标题翻译：适用于分配液体挥发油的流体分配系统
公开(公告)号：WO2008019497A1
公开(公告)日：2008-02-21
申请号：PCT/CA2007/001425
申请日：2007-08-15
申请人： ZAVIDA COFFEE COMPANY INC. , LITTERST, Charles , FINE, Richard
发明人： LITTERST, Charles , FINE, Richard
IPC分类号： B67D1/12 , B67D1/10 , F04B49/06
CPC分类号： B67D1/102 , B67D1/1231 , B67D1/1236 , B67D1/1247 , B67D2001/0812
摘要： An apparatus and method for dispensing a discrete volume of fluid. The apparatus includes a pump operable in discrete cycles, a power source connected to the pump, and a controller connected to at least one of the pump and the power source. The controller is configured to vary the power provided from the power source to the pump during at least a portion of each discrete cycle based on characteristics of the pump and the fluid. For example, the controller may vary power by controlling the duration of the provision of power, or by controlling the amplitude of the power. Varying the power is intended to improve the accuracy of the discrete volume of fluid dispensed. Correspondingly, the method of dispensing a discrete volume of fluid includes receiving information pertaining to the fluid to be dispensed, and adjusting a provision of power to a pump based on the information. The method may include adjusting the duration of the provision of power, or adjusting the amplitude of the provision of power.
摘要翻译：用于分配离散体积的流体的装置和方法。该装置包括以离散循环操作的泵，连接到泵的电源以及连接到泵和电源中的至少一个的控制器。控制器被配置为基于泵和流体的特性，在每个离散循环的至少一部分期间改变从电源向泵提供的功率。例如，控制器可以通过控制提供功率的持续时间，或通过控制功率的幅度来改变功率。改变功率旨在提高分配的分散体积的精度。相应地，分配离散体积的流体的方法包括接收与要分配的流体有关的信息，以及基于该信息调节向泵提供功率。该方法可以包括调整提供功率的持续时间，或者调整提供功率的幅度。

8. 发明申请

WO0237104A3 METHOD OF PURIFICATION OF NEUROPEPTIDE CONTAINING VESICLES FROM THE BRAIN 审中-公开
标题翻译：从脑中提纯含有神经肽的方法
公开(公告)号：WO0237104A3
公开(公告)日：2002-08-22
申请号：PCT/US0145485
申请日：2001-10-31
申请人： UNIV BOSTON , FINE RICHARD E , BERG ERIC A
发明人： FINE RICHARD E , BERG ERIC A
IPC分类号： C07K7/22 , G01N33/50 , A61K35/30
CPC分类号： C07K7/22
摘要： The invention is directed to a new method of isolating and purifying a large quantity of neuropeptide containing secretory vesicles (dense core vesicles) from a specific brain region and subsequently isolating and identifying novel neuropeptides contained therein. The method of the invention has significant practical value. The availability of large quantities of such vesicles will enable the identification of novel peptides using highly sensitive techniques, e.g., mass spectroscopy. Such neuropeptides are highly likely to have novel biological effects.
摘要翻译：本发明涉及从特定脑区域分离和纯化大量含有神经肽的分泌囊泡（致密核心囊泡）并随后分离和鉴定其中所含新型神经肽的新方法。本发明的方法具有重要的实用价值。大量此类囊泡的可用性将使得能够使用高度灵敏的技术（例如质谱）鉴定新型肽。这种神经肽极有可能具有新的生物效应。

9. 发明申请

WO2008154221A3 MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH 审中-公开
标题翻译：化学感受器的调节和与之相关的配体
公开(公告)号：WO2008154221A3
公开(公告)日：2009-02-19
申请号：PCT/US2008065650
申请日：2008-06-03
申请人： SENOMYX INC , TACHDJIAN CATHERINE , KARANEWSKY DONALD S , TANG XIAO-QING , LI XIAODONG , ZHANG FENG , SERVANT GUY , CHEN QING , DARMOHUSODO VINCENT , FINE RICHARD , FOTSING JOSEPH R , HAMMAKER JEFFREY ROBERT , KANG XINSHAN , KIMMICH RACHEL D A , KLEBANSKY BORIS , LIU HAITIAN , PETROVIC GORAN , RINNOVA MARKETA , ADAMSKI-WERNER SARA , YAMAMOTO JEFFREY , ZHANG HONG , ZLOTNIK ALBERT , ZOLLER MARK
发明人： TACHDJIAN CATHERINE , KARANEWSKY DONALD S , TANG XIAO-QING , LI XIAODONG , ZHANG FENG , SERVANT GUY , CHEN QING , DARMOHUSODO VINCENT , FINE RICHARD , FOTSING JOSEPH R , HAMMAKER JEFFREY ROBERT , KANG XINSHAN , KIMMICH RACHEL D A , KLEBANSKY BORIS , LIU HAITIAN , PETROVIC GORAN , RINNOVA MARKETA , ADAMSKI-WERNER SARA , YAMAMOTO JEFFREY , ZHANG HONG , ZLOTNIK ALBERT , ZOLLER MARK
IPC分类号： G01N33/53
CPC分类号： C07D513/04 , A23L2/39 , A23L2/60 , A23L27/30 , A23L27/31 , A23L27/33 , A23L27/34 , A23L27/88 , C07D215/42 , C07D215/54 , C07D215/56 , C07D239/70 , C07D239/84 , C07D239/94 , C07D239/95 , C07D285/16 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/056 , C07D493/04 , C07D495/04 , C07D495/14 , C07D513/20 , G01N33/566
摘要： The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.
摘要翻译：本发明包括用于鉴定化学感受器及其配体的调节剂的方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获区域内的一个或多个相互作用位点相互作用，以及能够调节化学感应受体的调节剂及其配体。本发明还包括具有式（I），其亚属和特定化合物的化学感应受体及其配体的改性剂。此外，本发明包括含有化学感应受体调节剂及其配体的可摄入组合物，以及使用化学感应受体及其配体改性剂增强可摄入组合物的甜味或治疗与化学感觉受体相关的病症的方法。此外，本发明包括制备化学感受器及其配体的改性剂的方法。

10. 发明申请

WO2005060560A3 SUCTION SLEEVE AND INTERVENTIONAL DEVICES HAVING SUCH A SUCTION SLEEVE 审中-公开
标题翻译：抽吸套管和具有这样一个吸取套筒的传统装置
公开(公告)号：WO2005060560A3
公开(公告)日：2006-07-20
申请号：PCT/US2004040436
申请日：2004-12-03
申请人： RUBICOR MEDICAL INC , BROUNSTEIN DANIEL M , DANIEL SEAN C , MOSHE MEIR H , ANDERSON SCOTT C , FINE RICHARD E , VETTER JAMES W
发明人： BROUNSTEIN DANIEL M , DANIEL SEAN C , MOSHE MEIR H , ANDERSON SCOTT C , FINE RICHARD E , VETTER JAMES W
IPC分类号： A61M5/178 , A61B18/00 , A61B18/14
CPC分类号： A61B18/00 , A61B18/148 , A61B2218/007 , A61B2218/008
摘要： A suction sleeve is configured to couple to the shaft of an RF device to evacuate hot gasses, fluids and/or other aspirates. The suction sleeve may be configured to be disposed coaxially around the shaft between the first end of the shaft and the work element (e.g., an RF cutting element) thereof. The suction sleeve defines a suction port and a plurality of openings near the work element, and is configured to enable suction in through the plurality of openings and out through the suction port.
摘要翻译：抽吸套筒被配置成耦合到RF装置的轴以排出热气体，流体和/或其它抽吸物。抽吸套筒可以构造成在轴的第一端和工件（例如，其RF切割元件）之间围绕轴同轴设置。吸入套筒限定了工作元件附近的吸入口和多个开口，并且构造成能够通过多个开口吸入并通过吸入口排出。

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