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1. 发明申请

WO2008154286A2 MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH 审中-公开
标题翻译：化学感受器的调节和与之相关的配体
公开(公告)号：WO2008154286A2
公开(公告)日：2008-12-18
申请号：PCT/US2008/065907
申请日：2008-06-05
申请人： SENOMYX, INC. , LI, Xiaodong , ZHANG, Feng , XU, Hong , TACHDJIAN, Catherine , ADAMSKI-WERNER, Sara , PATRON, Andrew , ZLOTNIK, Albert , ZOLLER, Mark , KLEBANSKY, Boris , FINE, Richard , KANG, Xinshan
发明人： LI, Xiaodong , ZHANG, Feng , XU, Hong , TACHDJIAN, Catherine , ADAMSKI-WERNER, Sara , PATRON, Andrew , ZLOTNIK, Albert , ZOLLER, Mark , KLEBANSKY, Boris , FINE, Richard , KANG, Xinshan
IPC分类号： A61K31/495 , A61P27/00 , C07D487/00 , C12N5/06 , G01N33/53 , G06G7/48
CPC分类号： A61K31/495 , C07F9/65586 , C07F9/65616 , G01N33/566 , G01N2333/726 , G01N2500/04 , G06F19/16 , G06F19/18
摘要： The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.
摘要翻译：本发明提供了用于鉴定化学感受器及其配体的调节剂的筛选方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获结构域内的一个或多个相互作用位点相互作用，以及能够调节化学感受器及其配体。

2. 发明申请

WO2008154221A2 MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH 审中-公开
标题翻译：化学感受器的调节和与之相关的配体
公开(公告)号：WO2008154221A2
公开(公告)日：2008-12-18
申请号：PCT/US2008/065650
申请日：2008-06-03
申请人： SENOMYX, INC. , TACHDJIAN, Catherine , KARANEWSKY, Donald S. , TANG, Xiao-qing , LI, Xiaodong , ZHANG, Feng , SERVANT, Guy , CHEN, Qing , DARMOHUSODO, Vincent , FINE, Richard , FOTSING, Joseph R. , HAMMAKER, Jeffrey Robert , KANG, Xinshan , KIMMICH, Rachel, D.A. , KLEBANSKY, Boris , LIU, Haitian , PETROVIC, Goran , RINNOVA, Marketa , ADAMSKI-WERNER, Sara , YAMAMOTO, Jeffrey , ZHANG, Hong , ZLOTNIK, Albert , ZOLLER, Mark
发明人： TACHDJIAN, Catherine , KARANEWSKY, Donald S. , TANG, Xiao-qing , LI, Xiaodong , ZHANG, Feng , SERVANT, Guy , CHEN, Qing , DARMOHUSODO, Vincent , FINE, Richard , FOTSING, Joseph R. , HAMMAKER, Jeffrey Robert , KANG, Xinshan , KIMMICH, Rachel, D.A. , KLEBANSKY, Boris , LIU, Haitian , PETROVIC, Goran , RINNOVA, Marketa , ADAMSKI-WERNER, Sara , YAMAMOTO, Jeffrey , ZHANG, Hong , ZLOTNIK, Albert , ZOLLER, Mark
IPC分类号： A61K31/495 , A61K31/517 , A61K31/519 , A61P27/00 , C07D487/00 , C12N5/06 , G01N33/53
CPC分类号： C07D513/04 , A23L2/39 , A23L2/60 , A23L27/30 , A23L27/31 , A23L27/33 , A23L27/34 , A23L27/88 , C07D215/42 , C07D215/54 , C07D215/56 , C07D239/70 , C07D239/84 , C07D239/94 , C07D239/95 , C07D285/16 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/056 , C07D493/04 , C07D495/04 , C07D495/14 , C07D513/20 , G01N33/566
摘要： The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.
摘要翻译：本发明包括用于鉴定化学感受器及其配体的调节剂的方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获区域内的一个或多个相互作用位点相互作用，以及能够调节化学感应受体及其配体。本发明还包括具有式（I），其亚属和特定化合物的化学感应受体及其配体的改性剂。此外，本发明包括含有化学感应受体调节剂及其配体的可摄入组合物，以及使用化学感应受体及其配体改性剂增强可摄入组合物的甜味或治疗与化学感觉受体相关的病症的方法。此外，本发明包括制备化学感受器及其配体的改性剂的方法。

3. 发明申请

WO2008019497A1 FLUID DISPENSING SYSTEM SUITABLE FOR DISPENSING LIQUID FLAVORINGS 审中-公开
标题翻译：适用于分配液体挥发油的流体分配系统
公开(公告)号：WO2008019497A1
公开(公告)日：2008-02-21
申请号：PCT/CA2007/001425
申请日：2007-08-15
申请人： ZAVIDA COFFEE COMPANY INC. , LITTERST, Charles , FINE, Richard
发明人： LITTERST, Charles , FINE, Richard
IPC分类号： B67D1/12 , B67D1/10 , F04B49/06
CPC分类号： B67D1/102 , B67D1/1231 , B67D1/1236 , B67D1/1247 , B67D2001/0812
摘要： An apparatus and method for dispensing a discrete volume of fluid. The apparatus includes a pump operable in discrete cycles, a power source connected to the pump, and a controller connected to at least one of the pump and the power source. The controller is configured to vary the power provided from the power source to the pump during at least a portion of each discrete cycle based on characteristics of the pump and the fluid. For example, the controller may vary power by controlling the duration of the provision of power, or by controlling the amplitude of the power. Varying the power is intended to improve the accuracy of the discrete volume of fluid dispensed. Correspondingly, the method of dispensing a discrete volume of fluid includes receiving information pertaining to the fluid to be dispensed, and adjusting a provision of power to a pump based on the information. The method may include adjusting the duration of the provision of power, or adjusting the amplitude of the provision of power.
摘要翻译：用于分配离散体积的流体的装置和方法。该装置包括以离散循环操作的泵，连接到泵的电源以及连接到泵和电源中的至少一个的控制器。控制器被配置为基于泵和流体的特性，在每个离散循环的至少一部分期间改变从电源向泵提供的功率。例如，控制器可以通过控制提供功率的持续时间，或通过控制功率的幅度来改变功率。改变功率旨在提高分配的分散体积的精度。相应地，分配离散体积的流体的方法包括接收与要分配的流体有关的信息，以及基于该信息调节向泵提供功率。该方法可以包括调整提供功率的持续时间，或者调整提供功率的幅度。

4. 发明申请

WO2008011568A2 PADDING FOR PETS WITH INTEGRATED HEATING, COOLING, OR A COMBINATION OF HEATING AND COOLING 审中-公开
标题翻译：采用集成加热，冷却或加热和冷却组合的PET填充
公开(公告)号：WO2008011568A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/073986
申请日：2007-07-20
申请人： HYPERION INNOVATIONS, INC. , AXINTE, Grigore , FINE, Richard , BORGMANN, Russell , MARTIN, Amy
发明人： FINE, Richard , BORGMANN, Russell , MARTIN, Amy
IPC分类号： A01K1/035
CPC分类号： A01K1/0353
摘要： Portable heated or cooled pet beds, and methods and systems for using the same, are disclosed. According to various embodiments, these pads may be easily transportable between different locations (e.g., using a handle or by simply gripping one or more portions thereof), and are provided with cushion material to compensate for harsh (e.g., hard) resting or sleeping conditions that would otherwise be faced by a pet. According to various preferred embodiments, the portable pet pads may include one or more cooling elements. These cooling elements may be based on thermoelectric principles, such as a Peltier device.
摘要翻译：公开了便携式加热或冷却的宠物床以及使用该宠物床的方法和系统。根据各种实施例，这些垫可以容易地在不同位置之间运输（例如，使用手柄或通过简单地抓住其一个或多个部分），并且设置有缓冲材料以补偿恶劣（例如，硬）休息或睡眠条件否则会被宠物所面对。根据各种优选实施例，便携式宠物垫可以包括一个或多个冷却元件。这些冷却元件可以基于热电原理，例如珀尔帖装置。

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