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1. 发明申请

WO2013078612A1 DIAMOND-LIKE CARBON 审中-公开
标题翻译：类似钻石的碳
公开(公告)号：WO2013078612A1
公开(公告)日：2013-06-06
申请号：PCT/CN2011/083138
申请日：2011-11-29
申请人： XI'AN JIAOTONG UNIVERSITY , WANG, Yun-hai , CHEN, Qing-yun , LI, Xiang-lin , ZHAO, Jing-lian
发明人： WANG, Yun-hai , CHEN, Qing-yun , LI, Xiang-lin , ZHAO, Jing-lian
IPC分类号： C23C16/26
CPC分类号： C01B31/06 , C01B32/00 , C01B32/25 , H01J37/32522 , Y10T428/30
摘要： Embodiments presented herein relate generally to the formation of diamond-like carbon, forms of diamond-like carbon and/or carbon dioxide fixation.
摘要翻译：本文提供的实施方案一般涉及类金刚石碳的形成，类金刚石碳和/或二氧化碳固定的形式。

2. 发明申请

WO2009149272A1 DETERGENT COMPOSITION 审中-公开
标题翻译：洗涤剂组合物
公开(公告)号：WO2009149272A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046280
申请日：2009-06-04
申请人： THE PROCTER & GAMBLE COMPANY , PRICE, Kenneth, Nathan , OH, Hiroshi , CHEN, Qing , TANG, Ming , GONG, Suxuan , MENDEZ-MATA, Lucia
发明人： PRICE, Kenneth, Nathan , OH, Hiroshi , CHEN, Qing , TANG, Ming , GONG, Suxuan , MENDEZ-MATA, Lucia
IPC分类号： C11D1/14 , C11D1/22
CPC分类号： C11D1/143 , C11D1/146 , C11D1/22
摘要： A detergent composition comprising: - a non-sulphated anionic surfactant, - alkyl sulphate surfactant(s) of formula R 2 -O-SO 3 - M + , with R 2 being a linear or branched, substituted or unsubsiiluted, optionally alkoxylaled, C 6 -C 18 alkyl and with M + being a proton or a cation which provides charge neutrality, and wherein the alkyl sulphate surfactant(s) of formula R 2 -O-SO 3 - M + , comprises from 85% to 100% by weight of alkyl sulphate surfactant(s) of formula R 1 -O-SO 3 - M + , with R 1 being a linear or branched, substituted or unsubstituted, optionally alkoxylated, C 6 -C 14 alkyl and with M + being a proton or a cation which provides charge neutrality, wherein the composition comprises from O to 20% of zeolite, and wherein the composition does not comprise from 41,10% to 41,20% by weight of sodium chloride or from 52,25% to 52,35% or from 59,20% to 59,30% by weight of sodium sulphat.
摘要翻译：一种洗涤剂组合物，其包含： - 非硫酸化阴离子表面活性剂， - 式R 2 -O-SO 3 - M +的烷基硫酸盐表面活性剂，其中R 2是直链或支链，取代或未取代的，任选烷氧基的C 6 -C 18烷基和其中M +是提供电荷中性的质子或阳离子，并且其中式R2-O-SO3-M +的烷基硫酸盐表面活性剂包含85重量％至100重量％的式 R1-O-SO3-M +，其中R1是直链或支链的取代或未取代的任选烷氧基化的C 6 -C 14烷基，M +是提供电荷中性的质子或阳离子，其中组合物包含0-20％的沸石，并且其中所述组合物不包含41,10重量％至41,20重量％的氯化钠或52重量％至52.35重量％或59重量％至59重量％的59重量％硫酸钠

3. 发明申请

WO2008031061A3 ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF 审中-公开
公开(公告)号：WO2008031061A3
公开(公告)日：2008-03-13
申请号：PCT/US2007/077923
申请日：2007-09-07
申请人： AMGEN INC. , HAN, Hq , CHEN, Qing , KWAK, Keith, Soo-Nyung , ZHOU, Xiaolan
发明人： HAN, Hq , CHEN, Qing , KWAK, Keith, Soo-Nyung , ZHOU, Xiaolan
IPC分类号： C07K16/00 , A61K39/395 , C12N15/13 , A61P5/06 , A61P9/10 , A61P35/00 , A61P37/00 , A61P43/00
摘要： The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

4. 发明申请

WO2007124152A2 COMESTIBLE COMPOSITIONS COMPRISING HIGH POTENCY SAVORY FLAVORANTS, AND PROCESSES FOR PRODUCING THEM 审中-公开
标题翻译：包含高度保存性鲜花的不可思议的组合物及其制造方法
公开(公告)号：WO2007124152A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/009828
申请日：2007-04-19
申请人： SENOMYX, INC. , SHIGEMURA, Rhondi , CHEN, Qing , DARMOHUSODO, Vincent , DEAN, Aaron, R.
发明人： SHIGEMURA, Rhondi , CHEN, Qing , DARMOHUSODO, Vincent , DEAN, Aaron, R.
IPC分类号： A23L1/22
CPC分类号： A23L27/204 , A23L2/56 , A23L13/428 , A23L19/18 , A23L23/00 , A23L27/205 , A23L27/2052 , A23L27/2054 , A23L27/26 , A23L27/70 , A23L29/219 , A23L29/238
摘要： The present invention relates to the use of certain high potency savory ("umami") taste modifiers, as savory flavoring agents and/or enhancers of monosodium glutamate, for the preparation of foods, beverages, and other comestible compositions, and to processes for preparing food flavorant compositions for use in the preparation of comestible food and drink.
摘要翻译：本发明涉及某些高效度（“鲜味”）味觉调节剂，作为味精调味剂和/或谷氨酸钠的增强剂用于制备食品，饮料和其他可食用组合物的用途，以及制备方法用于制备可食用食物和饮料的食用香料组合物。

5. 发明申请

WO2007047985A2 TRPM5 BASED ASSAYS AND THE USE THEREOF FOR THE IDENTIFICATION OF MODULATORS OF SWEET, BITTER OR UMAMI (SAVORY) TASTE 审中-公开
标题翻译：基于TRPM5的测定及其用于鉴定甜味剂，铋或麝香（调味品）调味剂的调味品的用途
公开(公告)号：WO2007047985A2
公开(公告)日：2007-04-26
申请号：PCT/US2006041152
申请日：2006-10-19
申请人： SENOMYX INC , SERVANT GUY , WILLIAMS MARK , PATRON ANDREW , KAMDAR POONIT , CHEN QING , MOYER BRYAN , DAHAN DAVID , DITSCHUN TANYA , RAY SUMITA , LIGANI AMY
发明人： SERVANT GUY , WILLIAMS MARK , PATRON ANDREW , KAMDAR POONIT , CHEN QING , MOYER BRYAN , DAHAN DAVID , DITSCHUN TANYA , RAY SUMITA , LIGANI AMY
IPC分类号： E01C3/06
CPC分类号： E01C3/06
摘要： Robust cell based assays are provided that use cells that express wild-type or modified TRPM5 nucleic acid sequences in order to identify putative taste modulators, preferably sweet, bitter and umami taste modulators. The preferred assays use HEK-293 cells that express TRPM5, optionally at least one GPCR, preferably a taste specific GPCR, and a G protein that couples therewith. These assays detect TRPM5 modulators by use of membrane potential dyes that emit fluorescence on changes in TRPM5 activity based on changes in membrane potential and these changes in fluorescence are detectable using Fluorimetric Imaging Plate Readers (FLIPR).
摘要翻译：提供了基于稳健细胞的测定法，其使用表达野生型或修饰型TRPM5核酸序列的细胞，以鉴定推定的味觉调节剂，优选甜味，苦味和鲜味调味剂。优选的测定法使用表达TRPM5，任选地至少一种GPCR，优选味道特异性GPCR的HEK-293细胞和与其偶联的G蛋白。这些测定法通过使用膜电位染料检测TRPM5调节剂，其基于膜电位的变化发射荧光的TRPM5活性的变化，并且使用荧光成像板读数器（FLIPR）检测这些荧光变化。

6. 发明申请

WO2004093809A2 SUBSTITUTED ISOCHROMAN COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS, CANCER AND OTHER DISEASES 审中-公开
标题翻译：用于治疗代谢性疾病，癌症和其他疾病的替代化合物
公开(公告)号：WO2004093809A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/012284
申请日：2004-04-19
申请人： INCYTE CORPORATION , TACHDJIAN, Catherine , GUO, Jianhua , BOUDJELAL, Mohamed , AL-SHAMMA, Hussien, A. , GIACHINO, Andrea, Fanjul , JAKUBOWICZ-JAILLARDON, Karine , CHEN, Qing , ZAPF, James, W. , PFAHL, Magnus
发明人： TACHDJIAN, Catherine , GUO, Jianhua , BOUDJELAL, Mohamed , AL-SHAMMA, Hussien, A. , GIACHINO, Andrea, Fanjul , JAKUBOWICZ-JAILLARDON, Karine , CHEN, Qing , ZAPF, James, W. , PFAHL, Magnus
IPC分类号： A61K
CPC分类号： C07D417/10 , C07D277/34
摘要： The invention relates to novel heterocyclic compounds having the structure illustrated by Formula (1) wherein the Ar 1 radicals are substituted isochroman radicals, the Ar 2 radicals are aryl or heteroaryl radicals; and HAr is a 2,4-thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidinedione or 2-thioxo-imidazolidine-4-one radical. The compounds of Formula (1) can have biological activity for advantageously regulating carbohydrate metabolism, including serum glucose level, and lipid metabolism, and can be useful for the treatment of hyperlipidernia and/or hypercholesterolemia, and Type 11 diabetes. The compounds of Formula (1) can also have utility in the treatment of diseases of uncontrolled proliferation, including cancer.
摘要翻译：本发明涉及具有式（1）所示结构的新型杂环化合物，其中Ar 1基团是取代的异苯并二氢吡喃基，Ar 2基团是芳基或杂芳基; 并且HAr是2,4-噻唑烷二酮，2-硫代 - 噻唑烷-4-酮，2,4-咪唑烷二酮或2-硫代 - 咪唑烷-4-酮基。式（1）的化合物可以具有有利地调节碳水化合物代谢的生物活性，包括血清葡萄糖水平和脂质代谢，并且可用于治疗高脂血症和/或高胆固醇血症和11型糖尿病。式（1）的化合物还可用于治疗不受控制的增殖疾病，包括癌症。

7. 发明申请

WO2013025560A1 SWEET FLAVOR MODIFIER 审中-公开
标题翻译：甜味调味剂
公开(公告)号：WO2013025560A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/050461
申请日：2012-08-10
申请人： SENOMYX, INC. , TACHDJIAN, Catherine , TANG, Xiao Qing , KARANEWSKY, Donald S. , SERVANT, Guy , LI, Xiaodong , ZHANG, Feng , CHEN, Qing , ZHANG, Hong , DAVIS, Timothy , DARMOHUSODO, Vincent , WONG, Melissa , SELCHAU, Victor
发明人： TACHDJIAN, Catherine , TANG, Xiao Qing , KARANEWSKY, Donald S. , SERVANT, Guy , LI, Xiaodong , ZHANG, Feng , CHEN, Qing , ZHANG, Hong , DAVIS, Timothy , DARMOHUSODO, Vincent , WONG, Melissa , SELCHAU, Victor
IPC分类号： C07D215/42 , C07D403/12 , C07D405/12 , C07D413/12 , A61K31/4725 , A61P1/00
CPC分类号： C07D405/12 , A23L2/60 , A23L27/88 , A23V2002/00 , A61K47/22 , C07D215/42 , C07D215/54 , C07D401/12 , C07D451/06
摘要： The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.
摘要翻译：本发明包括具有结构式（I）的化合物或其盐或溶剂化物。这些化合物可用作甜味调味剂。本发明还包括包含本发明化合物的组合物和增强组合物甜味的方法。

8. 发明申请

WO2012116471A1 DISHWASHING METHOD 审中-公开
标题翻译：洗衣方法
公开(公告)号：WO2012116471A1
公开(公告)日：2012-09-07
申请号：PCT/CN2011/000342
申请日：2011-03-03
申请人： THE PROCTER & GAMBLE COMPANY , PEREZ-PRAT VINUESA, Eva Maria , WHITELY, Nathan Ray , ASMANIDOU, Anna , CHEN, Qing , KEULEERS, Robby Renilde Francois , VAN Laere, An
发明人： PEREZ-PRAT VINUESA, Eva Maria , WHITELY, Nathan Ray , ASMANIDOU, Anna , CHEN, Qing , KEULEERS, Robby Renilde Francois , VAN Laere, An
IPC分类号： C11D1/65 , C11D3/20 , C11D3/37
CPC分类号： C11D1/65 , C11D1/835 , C11D3/227 , C11D3/3723 , C11D11/0023
摘要： A method for manually cleaning dishware using a liquid hand dishwashing detergent composition is provided, wherein the detergent composition comprises an anionic surfactant and a cationic polymer having a MW below or equal to 2,100,000, and a charge density above or equal to 0.45 meq/g. Said compositon has a coacervation index upon dilution of at least 2.5%, to provide skin care.
摘要翻译：提供了一种使用液体手洗餐具洗涤剂组合物手动清洗餐具的方法，其中洗涤剂组合物包含阴离子表面活性剂和MW低于或等于210万的阳离子聚合物，电荷密度高于或等于0.45meq / g。所述组合物在稀释至少2.5％时具有凝聚指数，以提供皮肤护理。

9. 发明申请

WO2012024242A1 ANTIBODIES THAT BIND MYOSTATIN, COMPOSITIONS AND METHODS 审中-公开
标题翻译：包括肌营养肽，组合物和方法的抗体
公开(公告)号：WO2012024242A1
公开(公告)日：2012-02-23
申请号：PCT/US2011/047806
申请日：2011-08-15
申请人： AMGEN INC. , HAN, Hq , ARORA, Taruna , CHEN, Qing , LU, Hsieng Sen , ZHOU, Xiaolan
发明人： HAN, Hq , ARORA, Taruna , CHEN, Qing , LU, Hsieng Sen , ZHOU, Xiaolan
IPC分类号： C07K16/22 , A61P19/08 , A61P21/00
CPC分类号： C07K16/26 , A61K2039/505 , C07K16/22 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： There are disclosed selective myostatin antagonists (including antibodies), nucleic acids encoding them, and methods of making and using them. Neutralizing antibodies recognizing the conformational epitope near position 21 to 31 and position 50 to 60.
摘要翻译：公开了选择性肌生成抑制素拮抗剂（包括抗体），编码它们的核酸，以及制备和使用它们的方法。识别位置21至31位置50至60附近的构象表位的中和抗体。

10. 发明申请

WO2010014666A2 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS 审中-公开
标题翻译：制作甜味剂增强剂的方法和中间体
公开(公告)号：WO2010014666A2
公开(公告)日：2010-02-04
申请号：PCT/US2009/052048
申请日：2009-07-29
申请人： SENOMYX, INC. , TACHDJIAN, Catherine , KARANEWSKY, Donald, S. , TANG, Xiao, Qing , CHEN, Qing , LEEMING, Peter , RASHID, Tayyab , LEVIN, Daniel
发明人： TACHDJIAN, Catherine , KARANEWSKY, Donald, S. , TANG, Xiao, Qing , CHEN, Qing , RASHID, Tayyab , LEVIN, Daniel
IPC分类号： C07D285/24 , C07D285/20 , C07D285/15
CPC分类号： C07D285/16 , C01B21/096 , C07C231/02 , C07C231/14 , C07C235/20 , C07C237/44 , C07C253/30 , C07C255/54 , C07C255/57 , C07C255/59 , C07C303/40 , C07C307/10
摘要： The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): (I), wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.
摘要翻译：本发明包括用于制备具有结构式（I）的化合物的方法/方法和中间体：（I），其中X是烷基，取代的烷基，烯基，取代的烯基，杂烷基，取代的杂烷基，杂烯基或取代的杂烯基。

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