基本信息:
- 专利标题： PROCESS FOR THE PREPARATION OF ARYL HYDRAZONE AND ARYL HYDRAZINE
- 专利标题（中）：制备ARYL HYDRAZONE和ARYL HYDRAZINE的方法
- 申请号：PCT/GB2002/004459 申请日：2002-10-02
- 公开(公告)号：WO2003035604A1 公开(公告)日：2003-05-01
- 发明人： ATHERTON, John, Heathcote , BLACKER, Andrew, John , FIELDEN, Jan, Michael , JACKSON, David, Anthony , DODMAN, David
- 申请人： SYNGENTA LIMITED , ATHERTON, John, Heathcote , BLACKER, Andrew, John , FIELDEN, Jan, Michael , JACKSON, David, Anthony , DODMAN, David
- 申请人地址： European Regional Centre, Priestley Road, Surrey Research Park, Guildford, Surrey GU2 7YH GB
- 专利权人： SYNGENTA LIMITED,ATHERTON, John, Heathcote,BLACKER, Andrew, John,FIELDEN, Jan, Michael,JACKSON, David, Anthony,DODMAN, David
- 当前专利权人： SYNGENTA LIMITED,ATHERTON, John, Heathcote,BLACKER, Andrew, John,FIELDEN, Jan, Michael,JACKSON, David, Anthony,DODMAN, David
- 当前专利权人地址： European Regional Centre, Priestley Road, Surrey Research Park, Guildford, Surrey GU2 7YH GB
- 代理机构： WATERMAN, John, Richard
- 优先权： GB0125442.4 20011023
- 主分类号： C07C251/86
- IPC分类号： C07C251/86
摘要：
A process for the preparation of a compound of formula (I): wherein Ar represents an optionally substituted aromatic carbocycle or heterocycle, and R 1 and R 2 independently represent hydrogen, C 1-10 alkyl, C(O)C 1-10 alkyl or optionally substituted aryl provided that R 1 and R 2 are not both hydrogen which process comprises reacting together a compound of formula (II): Ar-X, wherein Ar is as defined in relation to formula (I) and X represents a leaving group with a compound of formula (III): wherein R 1 and R 2 are as defined in relation to formula (I) under aqueous conditions in the presence of a Pd (II) salt, a ligand and a Group I or Group II metal hydroxide base at a pH greater than 7. Compounds of formula (I) may be hydrolysed to the corresponding hydrazine.
摘要（中）：
制备式（I）化合物的方法：其中Ar表示任选取代的芳族碳环或杂环，R 1和R 2独立地表示氢，C 1-10烷基，C（O）C 1-10烷基 或任选取代的芳基，条件是R 1和R 2不是氢，该方法包括使式（II）化合物：Ar-X（其中Ar如关于式（I）所定义）与X 代表具有式（III）化合物的离去基团：其中R 1和R 2如在式（I）中所定义，在水溶液条件下，在Pd（II）盐，配体和 在大于7的pH下的第I族或II族金属氢氧化物碱。式（I）化合物可以被水解成相应的肼。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C251/00 | 氮原子以双键与碳架相连接的含氮化合物 |
| --------C07C251/02 | .含有亚胺基团 |
| ----------C07C251/86 | ..腙基的双键碳原子连接六元芳环的碳原子 |