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1. 发明申请

WO2011091283A1 SYSTEMS, DEVICES AND METHODS FOR IMAGING AND SURGERY 审中-公开
标题翻译：用于成像和手术的系统，装置和方法
公开(公告)号：WO2011091283A1
公开(公告)日：2011-07-28
申请号：PCT/US2011/022099
申请日：2011-01-21
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , THE GENERAL HOSPITAL CORPORATION , BEN-YAKAR, Adela , HOY, Christopher L. , EVERETT, William Neil , KOBLER, James B. , ANDERSON, Richard Rox , FARINELLI, William A. , ZEITELS, Steven M.
发明人： BEN-YAKAR, Adela , HOY, Christopher L. , EVERETT, William Neil , KOBLER, James B. , ANDERSON, Richard Rox , FARINELLI, William A. , ZEITELS, Steven M.
IPC分类号： A61B18/20
CPC分类号： A61B18/20 , A61B2017/00057 , A61B2018/20351
摘要： Provided herein are devices, systems and methods for treating a vocal fold pathology by forming a substantially planar void below the epithelium of the vocal fold using optical energy. Also provided are devices, systems, and methods for combined imaging and treating of a vocal fold pathology.
摘要翻译：本文提供了通过使用光能在声带的上皮下方形成基本平坦的空隙来治疗声带折叠病理学的装置，系统和方法。还提供了用于组合成像和治疗声带折叠病理学的装置，系统和方法。

2. 发明申请

WO2011140497A2 METHOD AND APPARATUS FOR TISSUE GRAFTING AND COPYING 审中-公开
标题翻译：组织培养和复制的方法和装置
公开(公告)号：WO2011140497A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/035613
申请日：2011-05-06
申请人： THE GENERAL HOSPITAL CORPORATION , ANDERSON, Richard, R. , FARINELLI, William, A. , FRANCO, Walfre , TAM, Joshua , SAKAMOTO, Fernanda, H. , DOUKAS, Apostolos, G. , PURSCHKE, Martin , YAO, Min
发明人： ANDERSON, Richard, R. , FARINELLI, William, A. , FRANCO, Walfre , TAM, Joshua , SAKAMOTO, Fernanda, H. , DOUKAS, Apostolos, G. , PURSCHKE, Martin , YAO, Min
IPC分类号： A61B17/322 , A61B17/34 , A61F2/10
CPC分类号： A61B17/322 , A61B10/0233 , A61B17/3205 , A61B17/32053 , A61B2017/00747 , A61B2017/00752 , A61B2017/00969 , A61B2017/3225
摘要： Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue ("micrografts") to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.
摘要翻译：提供了用于获得生物组织（“微移植物”）的一个或多个部分以形成移植物的装置和方法的示例性实施方案。例如，中空管可以在供体部位的组织中插入，并且设置在管内的销可以有助于从管中控制移除微小移植物。可以通过管和引脚的协调运动来收获微生物并将其直接植入上覆的生物相容性基质中。可以围绕管设置针，以便于将微移植物直接植入远程受体部位或基质。示例性装置可以包括多个这样的管和销，用于同时收集和/或植入多个微移植物。收获的微量移植物可以具有小尺寸，例如小于约1mm，这可以促进供体部位的愈合和/或收获组织的活力。

3. 发明申请

WO2010036788A3 METHOD AND APPARATUS FOR GRAFTING OF SKIN TISSUE 审中-公开
公开(公告)号：WO2010036788A3
公开(公告)日：2010-04-01
申请号：PCT/US2009/058194
申请日：2009-09-24
申请人： THE GENERAL HOSPITAL CORPORATION , ASRANI, Falguni , FARINELLI, William, A. , SHAH, Ajay , LIU, Vincent , ANDERSON, R., Rox
发明人： ASRANI, Falguni , FARINELLI, William, A. , SHAH, Ajay , LIU, Vincent , ANDERSON, R., Rox
IPC分类号： A61B17/322 , A61F2/10 , A61B17/00
摘要： Methods and apparatus are provided for affecting an appearance of skin by harvesting small portions of tissue from a donor (first) site and applying them at a recipient (second) site. A plurality of micrografts can be formed from a piece of graft tissue and attached to a dressing material. The dressing material can then be expanded to increase a separation distance between the micrografts, and the dressing material having spaced-apart micrografts attached thereto can be applied to a prepared recipient site. An apparatus can be provided that expands the dressing material using a pressurized fluid. A further method can include providing a suspension of small portions of graft tissue in a solution. The solution can be injected into blisters formed at a recipient (second) site and the tissue portions allowed to attach and proliferate. A method and apparatus can also be provided for forming corresponding blisters at a donor site and at a recipient site. The raised (removed) portions of the blisters can be removed and attached to a dressing material, and the portions from the donor (first) site can be placed onto the exposed blister areas at the recipient site.

4. 发明申请

WO2009146077A1 METHOD AND APPARATUS FOR SELECTIVE PHOTOTHERMOLYSIS OF VEINS 审中-公开
标题翻译：用于选择性光合热解的方法和装置
公开(公告)号：WO2009146077A1
公开(公告)日：2009-12-03
申请号：PCT/US2009/039153
申请日：2009-04-01
申请人： THE GENERAL HOSPITAL CORPORATION , ANDERSON, Richard, Rox , RUBIN, Iris , FARINELLI, William, A.
发明人： ANDERSON, Richard, Rox , RUBIN, Iris , FARINELLI, William, A.
IPC分类号： A61N5/06 , A61N5/067
CPC分类号： A61N5/06 , A61N5/0616 , A61N2005/0602 , A61N2005/0659
摘要： Exemplary embodiments of the present disclosure provide method and apparatus for providing electromagnetic radiation to a biological tissue that may be selectively absorbed by venous structures as compared to arteries. For example, a wavelength of the electromagnetic radiation can be selected based on absorptivity of the radiation by oxygenated hemoglobin, deoxygenated hemoglobin, and/or met-hemoglobin. The wavelength can be, e.g., between about 685 nm and about 705 nm, or between about 690 nm and about 700 nm, or about 694 nm. The exemplary methods and apparatus can be used, e.g., for photothermolysis treatment of venous structures such as port wine stains or varicose veins, while reducing or avoiding undesirable damage to nearby arteries in the irradiated tissue.
摘要翻译：本公开的示例性实施例提供了用于向生物组织提供电磁辐射的方法和装置，其可以与静脉相比可以被静脉结构选择性吸收。例如，电磁辐射的波长可以基于氧合血红蛋白，脱氧血红蛋白和/或血红蛋白的辐射吸收率来选择。波长可以是例如约685nm至约705nm，或约690nm至约700nm，或约694nm。可以使用示例性的方法和装置，例如用于光聚合处理静脉结构如端口葡萄酒渍或静脉曲张，同时减少或避免对经照射的组织中的附近动脉的不期望的损伤。

5. 发明申请

WO2011140497A3 METHOD AND APPARATUS FOR TISSUE GRAFTING AND COPYING 审中-公开
标题翻译：组织培养和复制的方法和装置
公开(公告)号：WO2011140497A3
公开(公告)日：2012-03-01
申请号：PCT/US2011035613
申请日：2011-05-06
申请人： GEN HOSPITAL CORP , ANDERSON RICHARD R , FARINELLI WILLIAM A , FRANCO WALFRE , TAM JOSHUA , SAKAMOTO FERNANDA H , DOUKAS APOSTOLOS G , PURSCHKE MARTIN , YAO MIN
发明人： ANDERSON RICHARD R , FARINELLI WILLIAM A , FRANCO WALFRE , TAM JOSHUA , SAKAMOTO FERNANDA H , DOUKAS APOSTOLOS G , PURSCHKE MARTIN , YAO MIN
IPC分类号： A61B17/322 , A61B17/34 , A61F2/10
CPC分类号： A61B17/322 , A61B10/0233 , A61B17/3205 , A61B17/32053 , A61B2017/00747 , A61B2017/00752 , A61B2017/00969 , A61B2017/3225
摘要： Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue ("micrografts") to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.
摘要翻译：提供了用于获得生物组织（“微移植物”）的一个或多个部分以形成移植物的装置和方法的示例性实施方案。例如，中空管可以在供体部位的组织中插入，并且设置在管内的销可以促进微管从管中的控制移除。可以通过管和针的协调运动来收获微生物并将其直接植入上覆的生物相容性基质中。可以围绕管设置针，以便于将微移植物直接植入远程受体部位或基质。示例性装置可以包括多个这样的管和销，用于同时收集和/或植入多个微移植物。收获的微量移植物可以具有小尺寸，例如小于约1mm，这可以促进供体部位的愈合和/或收获组织的活力。

6. 发明申请

WO2010144257A1 METHOD AND APPARATUS FOR DERMAL DELIVERY OF A SUBSTANCE 审中-公开
标题翻译：用于物质传送的方法和装置
公开(公告)号：WO2010144257A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/036156
申请日：2010-05-26
申请人： THE GENERAL HOSPITAL CORPORATION , ANDERSON, Richard, Rox , FARINELLI, William, A.
发明人： ANDERSON, Richard, Rox , FARINELLI, William, A.
IPC分类号： A61M35/00 , A61M1/00
CPC分类号： A61K33/24 , A61B18/04 , A61K8/19 , A61K9/0014 , A61K9/16 , A61K41/0052 , A61K41/0057 , A61K2800/81 , A61M1/0084 , A61M1/08 , A61M35/003 , A61M37/0092 , A61M2205/3653 , A61M2205/368 , A61M2210/04 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61Q19/00 , A61Q19/10
摘要： The present invention is directed to a method and apparatus for delivering substances, e.g. , therapeutic substances, into openings on or near a skin surface, such as hair follicles, pores and/or into sebaceous glands. This can be achieved by using an apparatus to direct a substance into the openings under pressure via one or more nozzles or slits. A portion of the sebum present in the hair follicle is optionally heated and/or removed, e.g. using low-pressure conduit located on the lower surface of the apparatus, before introducing the therapeutic substance.
摘要翻译：本发明涉及用于将诸如治疗物质的物质输送到诸如毛囊，孔和/或皮脂腺的皮肤表面上或附近的开口中的方法和装置。这可以通过使用装置通过一个或多个喷嘴或狭缝将物质引导到压力下的开口中来实现。存在于毛囊中的皮脂的一部分任选地被加热和/或去除，例如，在引入治疗物质之前，使用位于装置下表面上的低压导管。

7. 发明申请

WO2010036788A2 METHOD AND APPARATUS FOR GRAFTING OF SKIN TISSUE 审中-公开
标题翻译：摄取皮肤组织的方法和装置
公开(公告)号：WO2010036788A2
公开(公告)日：2010-04-01
申请号：PCT/US2009058194
申请日：2009-09-24
申请人： GEN HOSPITAL CORP , ASRANI FALGUNI , FARINELLI WILLIAM A , SHAH AJAY , LIU VINCENT , ANDERSON R ROX
发明人： ASRANI FALGUNI , FARINELLI WILLIAM A , SHAH AJAY , LIU VINCENT , ANDERSON R ROX
IPC分类号： A61B17/322 , A61B17/00 , A61F2/10
CPC分类号： A61B17/322 , A61B2017/00969 , A61B2017/3225 , A61F2/105
摘要： Methods and apparatus are provided for affecting an appearance of skin by harvesting small portions of tissue from a donor (first) site and applying them at a recipient (second) site. A plurality of micrografts can be formed from a piece of graft tissue and attached to a dressing material. The dressing material can then be expanded to increase a separation distance between the micrografts, and the dressing material having spaced-apart micrografts attached thereto can be applied to a prepared recipient site. An apparatus can be provided that expands the dressing material using a pressurized fluid. A further method can include providing a suspension of small portions of graft tissue in a solution. The solution can be injected into blisters formed at a recipient (second) site and the tissue portions allowed to attach and proliferate. A method and apparatus can also be provided for forming corresponding blisters at a donor site and at a recipient site. The raised (removed) portions of the blisters can be removed and attached to a dressing material, and the portions from the donor (first) site can be placed onto the exposed blister areas at the recipient site.
摘要翻译：提供了通过从供体（第一）部位收集少部分组织并将其施用于受体（第二）部位来提供影响皮肤外观的方法和装置。多个微移植物可由一块移植组织形成，并附着于敷料。然后可以将敷料材料膨胀以增加微移植物之间的间隔距离，并且具有连接到其上的间隔开的微移植物的敷料材料可以应用于制备的受体部位。可以提供一种使用加压流体来膨胀敷料材料的装置。另外的方法可以包括提供移植组织的小部分在溶液中的悬浮液。溶液可以注射到在受体（第二）部位形成的水疱中，并且组织部分允许附着和增殖。还可以提供一种方法和装置，用于在施主部位和受体部位处形成相应的水泡。泡罩的隆起（去除）部分可以被去除并附着到敷料材料上，并且来自供体（第一）部位的部分可以被放置在受体部位的暴露的吸塑区域上。

8. 发明申请

WO2009146072A1 METHOD AND APPARATUS FOR TISSUE EXPANSION 审中-公开
标题翻译：组织扩张的方法和装置
公开(公告)号：WO2009146072A1
公开(公告)日：2009-12-03
申请号：PCT/US2009/039125
申请日：2009-04-01
申请人： THE GENERAL HOSPITAL CORPORATION , ANDERSON, Richard, Rox , WILLEY, Andrea , FARINELLI, William, A.
发明人： ANDERSON, Richard, Rox , WILLEY, Andrea , FARINELLI, William, A.
IPC分类号： A61B10/02 , A61B17/3209 , A61B18/20
CPC分类号： A61B18/20 , A61B17/32093 , A61B17/322 , A61B90/02
摘要： Exemplary embodiments of the present disclosure provide method and apparatus for facilitating stretching of a biological tissue by forming a plurality of micro-slits in the tissue. Each micro-slit can be less than about 2 mm or less than about 1.5 mm long, or even less than about 1 mm, such that small gaps that can heal quickly can be formed when the tissue is stretched. The micro-slits can be formed using a plurality of cutting arrangements or an ablative laser. The micro-slits can be formed in various patterns, including staggered rows, circular or spiral patterns, or random patterns.
摘要翻译：本公开的示例性实施例提供了通过在组织中形成多个微缝隙来促进生物组织的拉伸的方法和装置。每个微缝可以小于约2mm或小于约1.5mm长，或甚至小于约1mm，使得当组织被拉伸时可以形成能够快速愈合的小间隙。可以使用多个切割装置或烧蚀激光器来形成微缝隙。微缝可以以各种图案形成，包括交错行，圆形或螺旋图案或随机图案。

9. 发明申请

WO2009146068A1 METHOD AND APPARATUS FOR TISSUE GRAFTING 审中-公开
标题翻译：用于组织接种的方法和装置
公开(公告)号：WO2009146068A1
公开(公告)日：2009-12-03
申请号：PCT/US2009/039114
申请日：2009-04-01
申请人： THE GENERAL HOSPITAL CORPORATION , ANDERSON, Richard, Rox , HAMBLIN, Michael, R. , MANSTEIN, Dieter , FARINELLI, William, A.
发明人： ANDERSON, Richard, Rox , HAMBLIN, Michael, R. , MANSTEIN, Dieter , FARINELLI, William, A.
IPC分类号： A61B17/50 , A61B17/22 , A61B10/02 , A61B19/00 , A61F2/02
CPC分类号： A61B17/32053 , A61B10/0233 , A61B17/32093 , A61B17/322 , A61B2017/00752 , A61B2017/00969 , A61B2017/306 , A61B2017/3225
摘要： Exemplary embodiments of apparatus and method for harvesting small portions of tissue ("micrografts") to form grafts can be provided. For example, a hollow tube can be inserted into tissue at a donor site, where a distal end of the hollow tube can have two or more points or extensions to facilitate separation of the micrografts from the surrounding tissue. The exemplary apparatus can be provided that includes a plurality of such tubes for simultaneous harvesting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, or less than about 0.3 mm, which can promote healing of the donor site and/or viability of the harvested tissue. The micrografts can be approximately cylindrical or strip-shaped, and can be placed in a biocompatible matrix to form a graft or directly into tissue at the recipient site. Such exemplary micrografts can be obtained from skin or other types of tissue, e.g., various internal organs.
摘要翻译：可以提供用于收集小部分组织（“微移植物”）以形成移植物的装置和方法的示例性实施方案。例如，中空管可以在供体部位的组织中插入，其中中空管的远端可以具有两个或更多个点或延伸部，以促进微移植物与周围组织的分离。可以提供示例性装置，其包括多个这样的管，用于同时收集多个微移植物。收获的微移植物可以具有小尺寸，例如小于约1mm，或小于约0.3mm，这可以促进供体部位的愈合和/或收获的组织的活力。微移植物可以是大致圆柱形或带状，并且可以放置在生物相容性基质中以在受体部位形成移植物或直接进入组织。这样的示例性微移植物可以从皮肤或其他类型的组织例如各种内部器官获得。

10. 发明申请

WO2009003173A1 METHOD AND APPARATUS FOR OPTICAL INHIBITION OF PHOTODYMANIC THERAPY 审中-公开
标题翻译：光学治疗光学抑制的方法和装置
公开(公告)号：WO2009003173A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/068593
申请日：2008-06-27
申请人： THE GENERAL HOSPITAL CORPORATION , SAKAMOTO, Fernanda, Hidemi , ANDERSON, Richard, Rox , FARINELLI, William, A. , DOUKAS, Apostolos, G.
发明人： SAKAMOTO, Fernanda, Hidemi , ANDERSON, Richard, Rox , FARINELLI, William, A. , DOUKAS, Apostolos, G.
IPC分类号： A61B18/18
CPC分类号： A61N5/062 , A61K41/0057 , A61K41/0061 , A61K41/0071 , A61N2005/0658
摘要： A system and method are provided for preventing damage to the epidermis or other epithelial or non-target tissue during photodynamic therapy treatment. For example, an inhibiting radiation can be used to control formation of a photosensitizer from a precursor photosensitizer in the epidermis or epithelial tissue. Subsequent application of a treatment radiation can activate the photosensitizer to damage or destroy target sites while the non-target tissue remains substantially unaffected.
摘要翻译：提供了一种系统和方法，用于在光动力疗法治疗期间防止对表皮或其它上皮或非靶组织的损伤。例如，可以使用抑制辐射来控制来自表皮或上皮组织中的前体光敏剂的光敏剂的形成。随后施加治疗辐射可以激活光敏剂以在非目标组织基本上不受影响的同时损伤或破坏靶位点。

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