专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005021085A2 FUZZY LOGIC GUIDED INVERSE TREATMENT PLANNING 审中-公开
标题翻译： FUZZY逻辑指导反向治疗计划
公开(公告)号：WO2005021085A2
公开(公告)日：2005-03-10
申请号：PCT/US2004/027893
申请日：2004-08-27
申请人： HENRY FORD HEALTH SYSTEM , YIN, Fang-Fang , KIM, Jae, Ho , YAN,Hui
发明人： YIN, Fang-Fang , KIM, Jae, Ho , YAN,Hui
IPC分类号： A61N
CPC分类号： A61N5/1031
摘要： A fuzzy inference system for use in modulating radiation treatment including a fuzzifier for inputting imaging data, an inference device operatively connected to the fuzzifier, the inference device being used for analyzing the imaging data and determining radiation treatment target from non-treatment target, and a defuzzifier for modulating radiation treatment pursuant to the analysis from the inference device. A method of modulating radiation treatment by inputting patient data into the fuzzy inference system disclosed above and modulating radiation treatment pursuant to data obtained from the fuzzy inference system. An apparatus for producing modulating radiation therapy in patients including an imaging device for creating and storing image data of relevant tissue and organ parts and a fuzzy inference system operatively connected to the imaging device for modulating radiation treatment. A fuzzy inference system for use in modulating radiation treatment including a fuzzifier for inputting imaging data, an inference device operatively connected to the fuzzifier, the inference device being used for analyzing the imaging data and determining the strength of radiation treatment, and a defuzzifier for modulating radiation treatment pursuant to the analysis from the inference device.
摘要翻译：一种用于调制辐射处理的模糊推理系统，包括用于输入成像数据的模糊器，可操作地连接到模糊器的推理装置，用于分析成像数据的推理装置和从非处理目标确定放射线治疗目标，根据推理装置的分析调制放射治疗的解模糊器。通过将患者数据输入到上述公开的模糊推理系统中来调节放射治疗的方法，并根据从模糊推理系统获得的数据调节辐射治疗。一种用于在患者中产生调节放射治疗的装置，包括用于创建和存储相关组织和器官部分的图像数据的成像装置和可操作地连接到成像装置用于调节放射治疗的模糊推理系统。一种用于调制放射治疗的模糊推理系统，包括用于输入成像数据的模糊器，可操作地连接到模糊器的推理装置，用于分析成像数据和确定辐射治疗强度的推理装置，以及用于调制根据推理装置的分析进行放射治疗。

2. 发明申请

WO2004047735A3 BROAD SPECTRUM ANTI-VIRAL THERAPEUTICS AND PROPHYLAXIS 审中-公开
标题翻译：广播光谱抗病毒治疗和预防
公开(公告)号：WO2004047735A3
公开(公告)日：2004-09-23
申请号：PCT/US0337158
申请日：2003-11-21
申请人： YU MANG , FANG FANG
发明人： YU MANG , FANG FANG
IPC分类号： A61K20060101 , A61K38/16 , A61K38/17 , A61K38/47 , A61K38/48 , A61K38/55 , A61K38/56 , A61K38/57 , A61K39/00 , A61K47/48
CPC分类号： B82Y5/00 , A61K38/47 , A61K38/57
摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of the target cell by a pathogen, such as a virus. Preferred target cells are epithelial cells. The invention provides compositions and methods for preventing viral diseases, such as influenza, using compounds having anchoring domains that can bind target cells linked to enzymatic activities that can act extracellularly to interfere with viral infection of target cells. The invention also provides compositions and methods for preventing viral diseases such as influenza using compounds having anchoring domains that can bind target cells linked to protease inhibitors that can act extracellularly to interfere with viral infection of target cells.
摘要翻译：本发明提供了用于预防和治疗病原体感染的新的组合物和方法。特别地，本发明提供具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。优选的靶细胞是上皮细胞。本发明提供了用于预防病毒性疾病（例如流行性感冒）的组合物和方法，使用具有锚定结构域的化合物，所述化合物具有可结合与细胞外作用以干扰靶细胞的病毒感染的酶活性连接的靶细胞。本发明还提供了用于使用具有锚定结构域的化合物来预防病毒性疾病例如流感的组合物和方法，所述化合物具有可以结合与蛋白酶抑制剂连接的靶细胞，其可以在细胞外作用以干扰靶细胞的病毒感染。

3. 发明申请

WO2009015286A3 TECHNOLOGY FOR THE PREPARATION OF MICROPARTICLES 审中-公开
公开(公告)号：WO2009015286A3
公开(公告)日：2009-01-29
申请号：PCT/US2008/071055
申请日：2008-07-24
申请人： NEXBIO, INC. , MALAKHOV, Michael , FANG, Fang
发明人： MALAKHOV, Michael , FANG, Fang
IPC分类号： A61K9/16
摘要： Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

4. 发明申请

WO2007136692A2 CRYSTALLINE FORMS OF 5-CHLORO-6- (2, 6-DIFLUORO-4- [3- (METHYLAMINO) PROPOXY] PHENYL)-N-((1S)-2, 2, 2,-TRIFLUORO-1-METHYLETHYL] [1,2,4] TRIAZOLO [1,5-A] PYRIMIDIN-7-AMINE SALTS 审中-公开
标题翻译： 5-二氯-6-（2,6-二氟-4- [3-（甲基氨基）丙氧基]苯基）-N - （（1S）-2,2,2-三氟-1-甲基乙基] 1,2,4]三唑[1,5-A]嘧啶-7-胺盐
公开(公告)号：WO2007136692A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/011817
申请日：2007-05-17
申请人： WYETH HOLDINGS CORPORATION , QI, Fang, Fang , KU, Mannching, Sherry , WU, Yanzhong , BLUM, David, M.
发明人： QI, Fang, Fang , KU, Mannching, Sherry , WU, Yanzhong , BLUM, David, M.
IPC分类号： C07D487/04 , A61K31/519 , A61P35/04
CPC分类号： C07D487/04
摘要： The present invention relates to crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3- (methylamino)propoxy]phenyl}-N-[(1S)-2,2,2- trifluoro- 1 - methylethyl][l,2,4]triazolo[l,5-a]pyrimidin-7-amine salts; processes for the production thereof; pharmaceutical compositions thereof; and methods for inhibiting tumor growth therewith.
摘要翻译：本发明涉及5-氯-6- {2,6-二氟-4- [3-（甲基氨基）丙氧基]苯基} -N - [（1S）-2,2,2-三氟-1 - 甲基乙基] [1,2,4]三唑并[1,5-a]嘧啶-7-胺盐; 生产过程; 其药物组合物; 以及抑制肿瘤生长的方法。

5. 发明申请

WO2006031291A2 A NOVEL CLASS OF THERAPEUTIC PROTEIN BASED MOLECULES 审中-公开
标题翻译：一类新的基于蛋白质的蛋白质分子
公开(公告)号：WO2006031291A2
公开(公告)日：2006-03-23
申请号：PCT/US2005/025831
申请日：2005-07-21
申请人： FANG, Fang , MALAKHOV, Michael
发明人： FANG, Fang , MALAKHOV, Michael
IPC分类号： C12N9/36 , C07H21/04 , C12N1/21 , C12N15/75
CPC分类号： C12N9/2402 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N2760/16111 , C12Y302/01018
摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.
摘要翻译：本发明提供了用于预防和治疗病原体感染的新的组合物和方法。特别地，本发明提供了具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。本发明还包括具有唾液酸酶活性的治疗组合物，包括具有唾液酸酶催化结构域的蛋白质类化合物。本发明的化合物可用于治疗或预防病原体感染，以及用于治疗和减少变态反应和炎症反应。本发明还提供了通过重组病毒增强靶细胞转导的组合物和方法。这些组合物和方法可用于基因治疗。

6. 发明申请

WO2012088298A3 EPIGENOMIC MARKERS OF CANCER METASTASIS 审中-公开
标题翻译：癌症METASTASIS的原始标记
公开(公告)号：WO2012088298A3
公开(公告)日：2014-04-10
申请号：PCT/US2011066549
申请日：2011-12-21
申请人： SLOAN KETTERING INST CANCER , CHAN TIMOTHY , FANG FANG , TURCAN SEVIN
发明人： CHAN TIMOTHY , FANG FANG , TURCAN SEVIN
IPC分类号： G01N33/48
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/154
摘要： Methods and kits for assessing risk of metastasis in a cancer patient identified as having breast cancer, colon cancer or glioma use analysis of a classifier for CpG island methylator phenotype.
摘要翻译：鉴定为具有乳腺癌，结肠癌或神经胶质瘤的癌症患者的转移风险的方法和试剂盒，用于分析CpG岛甲基化表型的分析。

7. 发明申请

WO2010120196A1 ZINC OXIDE NANOSTRUCTURES AND SENSORS USING ZINC OXIDE NANOSTRUCTURES 审中-公开
标题翻译：使用氧化锌纳米结构的氧化锌纳米结构和传感器
公开(公告)号：WO2010120196A1
公开(公告)日：2010-10-21
申请号：PCT/NZ2010/000068
申请日：2010-04-14
申请人： INSTITUTE OF GEOLOGICAL AND NUCLEAR SCIENCES LIMITED , KENNEDY, John Vedamuthu , FUTTER, Richard John , FANG, Fang , MARKWITZ, Andreas
发明人： KENNEDY, John Vedamuthu , FUTTER, Richard John , FANG, Fang , MARKWITZ, Andreas
IPC分类号： B82B3/00 , C01G9/02 , G01N27/403 , B82B1/00 , C01G9/03 , C01B13/14 , G01N27/02
CPC分类号： C01G9/03 , B82Y30/00 , C01P2002/54 , C01P2002/72 , C01P2002/76 , C01P2004/03 , C01P2004/16 , C01P2004/54 , C01P2006/40 , C01P2006/60 , C04B35/453 , C04B35/62231 , C04B35/6268 , C04B2235/3279 , C04B2235/3284 , C04B2235/526 , C04B2235/5264 , G01N33/0027
摘要： A method for preparing zinc oxide nanostructures using arc discharge is disclosed. The method comprises the provision of an anode and a cathode in an arc discharge chamber. Current is supplied to the anode and the cathode to establish an arc discharge between the cathode and the anode to vaporise the anode and produce zinc oxide nanostructures. Contemplated is the use of the zinc oxide nanostructures to produce components that have applications in, for example, optoelectronics, energy storage devices, field emission devices, and sensors such as UV photosensors, gas sensors and humidity sensors. Disclosed is a gas sensor and method for its production, where said method comprises the provision of a sensor substrate comprising a conducting thin film at least partially covering at least two regions on at least one surface of a sensor substrate material to define a gap in the conducting thin film, the application of a mixture of zinc oxide nanostructures and a non-ionic polymer to at least a portion of the gap in the conducting thin film to thereby bridge the gap. Optionally contemplated is a step of annealing the mixture of zinc oxide nanostructures and non-ionic polymer applied to said sensor substrate to produce the sensor component.
摘要翻译：公开了一种使用电弧放电制备氧化锌纳米结构的方法。该方法包括在电弧放电室中提供阳极和阴极。电流被提供给阳极和阴极，以在阴极和阳极之间建立电弧放电，以蒸发阳极并产生氧化锌纳米结构。考虑使用氧化锌纳米结构来生产在例如光电子学，能量存储器件，场致发射器件以及诸如UV光电传感器，气体传感器和湿度传感器的传感器中应用的部件。公开了一种用于其生产的气体传感器和方法，其中所述方法包括提供传感器基底，其包括导电薄膜，至少部分地覆盖传感器基底材料的至少一个表面上的至少两个区域，以在导电薄膜，将氧化锌纳米结构和非离子聚合物的混合物施加到导电薄膜中的间隙的至少一部分，从而桥接间隙。可以预期的是退火施加到所述传感器基底上的氧化锌纳米结构和非离子聚合物的混合物以产生传感器部件的步骤。

8. 发明申请

WO2009015286A2 TECHNOLOGY FOR THE PREPARATION OF MICROPARTICLES 审中-公开
标题翻译：微粒制备技术
公开(公告)号：WO2009015286A2
公开(公告)日：2009-01-29
申请号：PCT/US2008071055
申请日：2008-07-24
申请人： NEXBIO INC , MALAKHOV MICHAEL , FANG FANG
发明人： MALAKHOV MICHAEL , FANG FANG
CPC分类号： A61K9/1682 , A61K9/0048 , A61K9/0075 , A61K9/1652 , A61K9/1658 , A61K9/19 , A61K9/5089 , A61K31/198 , A61K31/337 , A61K31/343 , A61K31/405 , A61K31/43 , A61K31/555 , A61K31/557 , A61K31/5575 , A61K31/65 , A61K31/7036 , A61K31/721 , A61K31/724 , A61K35/76 , A61K38/08 , A61K38/12 , A61K38/14 , A61K38/168 , A61K38/1709 , A61K38/1808 , A61K38/38 , A61K38/385 , A61K38/42 , A61K38/465 , A61K38/47 , A61K38/4826 , C07D305/14 , C07K9/008 , C07K14/765 , C12N7/00 , C12N9/96 , C12N15/113 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/50 , C12N2330/30 , C12N2770/00021 , C12N2770/00051 , C12Y301/21001 , C12Y301/27005 , C12Y302/00 , C12Y302/01017 , C12Y302/01018 , C12Y304/21004
摘要： Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.
摘要翻译：通过使溶剂中的大分子或小分子溶液与反溶剂和抗衡离子接触并冷却溶液来制备微球。微球可用于制备具有限定尺寸的药物，营养品，化妆品等。

9. 发明申请

WO2007114881A1 TECHNOLOGY FOR PREPARATION OF MACROMOLECULAR MICROSPHERES 审中-公开
标题翻译：制备大分子微球的技术
公开(公告)号：WO2007114881A1
公开(公告)日：2007-10-11
申请号：PCT/US2007/001914
申请日：2007-01-24
申请人： NEXBIO, INC. , MALAKHOV, Michael, P. , FANG, Fang
发明人： MALAKHOV, Michael, P. , FANG, Fang
IPC分类号： A61K9/16 , A61K38/16 , A61K38/48
CPC分类号： A61K9/1682 , A61K9/0073 , A61K9/14 , A61K9/1617 , A61K9/1647 , A61K9/19 , A61K38/18 , A61K38/47 , A61K38/57 , C12Y302/01018 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/401 , Y02A50/402 , Y02A50/411 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/478 , Y02A50/48 , Y02A50/481 , Y02A50/483 , Y02A50/491 , Y10T428/2982
摘要： Microspheres are produced by contacting an aqueous solution of a protein or other macromoiecule with an organic solvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions.
摘要翻译：通过使蛋白质或其他大分子的水溶液与有机溶剂和抗衡离子接触并冷却溶液来制备微球体。微球可用于制备具有限定尺寸的药物。

10. 发明申请

WO2005120201A2 IMAGE-GUIDED INTENSITY-MODULATED X-RAY BRACHYTHERAPY SYSTEM 审中-公开
标题翻译：图像强度调制的X射线穿透系统
公开(公告)号：WO2005120201A2
公开(公告)日：2005-12-22
申请号：PCT/US2005019984
申请日：2005-06-07
申请人： FORD HENRY HEALTH SYSTEM , YIN FANG-FANG , KIM JAE HO
发明人： YIN FANG-FANG , KIM JAE HO
IPC分类号： A61N5/10
CPC分类号： A61N5/1027 , A61N5/1007 , A61N5/1031 , A61N5/1048 , A61N5/1067 , A61N2005/1061
摘要： In some embodiments, without limitation, the invention comprises a modulated image-guided x-ray brachytherapy system including a source providing low-energy photons, the source configured for placement at least partially within a patient, a control system configured to modulate the source, and an imaging systems for locating the source relative to a treatment location in the patient. The system may further comprises a target at least partially within the patient, a generator located outside the patient for providing low-energy photons, the generator configured to direct low-energy photons to the target, and a conduit between the generator and the target providing a path for the low-energy photons to travel inside the patient. The system may further comprise an in situ x-ray generator for insertion within the patient. The system may further comprise a radioactive pellet.
摘要翻译：在一些实施例中，但不限于，本发明包括调制图像引导的x射线近距离放射治疗系统，其包括提供低能量光子的源，所述源被配置为至少部分地放置在患者体内，被配置为调制源，以及用于将源相对于患者中的治疗位置定位的成像系统。所述系统还可以包括至少部分地在患者体内的目标，位于患者外部的用于提供低能量光子的发生器，所述发生器被配置为将低能量光子引导到靶，以及发电机和靶之间的管道，低能量光子在患者体内行进的途径。系统还可以包括用于插入患者体内的原位X射线发生器。该系统还可以包括放射性丸粒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式