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1. 发明申请

WO2018136664A1 NEOANTIGENS AND USES THEREOF FOR TREATING CANCER 审中-公开
公开(公告)号：WO2018136664A1
公开(公告)日：2018-07-26
申请号：PCT/US2018/014282
申请日：2018-01-18
申请人： ICHAN SCHOOL OF MEDICINE AT MOUNT SINAI , THE SIMONS CENTER FOR SYSTEMS BIOLOGY AT THE INSTITUTE FOR ADVANCED STUDY , MEMORIAL SLOAN KETTERING CANCER CENTER , UNIVERSITÄT ZU KÖLN | UNIVERSITY OF COLOGNE , LUKSZA, Marta , BALACHANDRAN, Vinod, P. , LEVINE, Arnold, J. , WOLCHOK, Jedd, D. , MERGHOUB, Taha , LEACH, Steven, D. , CHAN, Timothy, A. , GREENBAUM, Benjamin, D. , LAESSIG, Michael
发明人： LUKSZA, Marta , BALACHANDRAN, Vinod, P. , LEVINE, Arnold, J. , WOLCHOK, Jedd, D. , MERGHOUB, Taha , LEACH, Steven, D. , CHAN, Timothy, A. , GREENBAUM, Benjamin, D. , LAESSIG, Michael
IPC分类号： A61K39/00 , G01N33/574 , C12Q1/68 , G06F19/22 , A61P35/00 , A61K35/15 , A61K35/17 , G01N33/68 , A61K39/395
摘要： Systems and methods for determining the likely responsiveness of a human cancer subject to a checkpoint blockade immunotherapy regimen are provided. Sequencing reads are obtained from samples from the subject representative of the cancer. A human leukocyte antigen type and a plurality of clones is determined from the sequencing reads. For each clone, an initial frequency Xα in the one or more samples is determined and a corresponding clone fitness score of the clone is computed, thereby computing clone fitness scores. Each such fitness score is computed by identifying neoantigens in the respective clone, computing a recognition potential for each neoantigen, and determining the corresponding clone fitness score of the respective clone as an aggregate of these recognition potentials. A total fitness, quantifying the likely responsiveness of the subject to the regimen, is computed by summing the clone fitness scores across the plurality of clones.

2. 发明申请

WO2011044157A1 HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS 审中-公开
标题翻译：杂环化合物可用作PDK1抑制剂
公开(公告)号：WO2011044157A1
公开(公告)日：2011-04-14
申请号：PCT/US2010/051517
申请日：2010-10-05
申请人： BIOGEN IDEC MA INC. , SUNESIS PHARMACEUTICALS, INC. , ARNDT, Joseph , CHAN, Timothy , GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , LEE, Wen-Cherng , LIN, Edward, Yin-shiang , SCOTT, Daniel , SUN, Lihong , THOMAS, Jermaine , VAN VLOTEN, Kurt , WANG, Deping , ZHANG, Lei , ERLANSON, Daniel
发明人： ARNDT, Joseph , CHAN, Timothy , GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , LEE, Wen-Cherng , LIN, Edward, Yin-shiang , SCOTT, Daniel , SUN, Lihong , THOMAS, Jermaine , VAN VLOTEN, Kurt , WANG, Deping , ZHANG, Lei , ERLANSON, Daniel
IPC分类号： A61K31/50
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/452 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/5383 , C07D213/82 , C07D213/85 , C07D241/26 , C07D241/28 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D473/34 , C07D487/04 , C07D491/052 , C07D498/04 , C07D519/00
摘要： The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
摘要翻译：本发明提供可用作PDK1抑制剂的化合物。本发明还提供了其组合物，以及治疗PDK1介导的疾病的方法。

3. 发明申请

WO2012088298A3 EPIGENOMIC MARKERS OF CANCER METASTASIS 审中-公开
标题翻译：癌症METASTASIS的原始标记
公开(公告)号：WO2012088298A3
公开(公告)日：2014-04-10
申请号：PCT/US2011066549
申请日：2011-12-21
申请人： SLOAN KETTERING INST CANCER , CHAN TIMOTHY , FANG FANG , TURCAN SEVIN
发明人： CHAN TIMOTHY , FANG FANG , TURCAN SEVIN
IPC分类号： G01N33/48
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/154
摘要： Methods and kits for assessing risk of metastasis in a cancer patient identified as having breast cancer, colon cancer or glioma use analysis of a classifier for CpG island methylator phenotype.
摘要翻译：鉴定为具有乳腺癌，结肠癌或神经胶质瘤的癌症患者的转移风险的方法和试剂盒，用于分析CpG岛甲基化表型的分析。

4. 发明申请

WO2008030584A3 INDAZOLE DERIVATIVES AS MODULATORS OF INTERLEUKIN- 1 RECEPTOR-ASSOCIATED KINASE 审中-公开
标题翻译：作为INTERLEUKIN-1受体相关激酶调节剂的吲哚衍生物
公开(公告)号：WO2008030584A3
公开(公告)日：2008-07-17
申请号：PCT/US2007019588
申请日：2007-09-07
申请人： BIOGEN IDEC INC , GUCKIAN KEVIN , JEWELL CHARLES , CONLAN PATRICK , LIN EDWARD YIN-SHIANG , CHAN TIMOTHY
发明人： GUCKIAN KEVIN , JEWELL CHARLES , CONLAN PATRICK , LIN EDWARD YIN-SHIANG , CHAN TIMOTHY
IPC分类号： C07D401/14 , A61K31/4164 , A61K31/44 , A61P3/00 , A61P29/00 , A61P35/00 , C07D403/12 , C07D403/14
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14
摘要： The present invention relates to modulators of IRAK kinases of formula (I) and provides compositions comprising such modulators, as well as methods therewith for treating IRAK- mediated or IRAK -associated conditions or diseases.
摘要翻译：本发明涉及式（I）的IRAK激酶的调节剂，并提供包含这种调节剂的组合物，以及其用于治疗IRAK介导的或与IRAK相关的病症或疾病的方法。

5. 发明申请

WO2012088298A2 EPIGENOMIC MARKERS OF CANCER METASTASIS 审中-公开
标题翻译：癌症METASTASIS的原始标记
公开(公告)号：WO2012088298A2
公开(公告)日：2012-06-28
申请号：PCT/US2011/066549
申请日：2011-12-21
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , CHAN, Timothy , FANG, Fang , TURCAN, Sevin
发明人： CHAN, Timothy , FANG, Fang , TURCAN, Sevin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/154
摘要： Methods and kits for assessing risk of metastasis in a cancer patient identified as having breast cancer, colon cancer or glioma use analysis of a classifier for CpG island methylator phenotype.
摘要翻译：用于评估患有乳腺癌，结肠癌或神经胶质瘤的癌症患者的转移风险的方法和试剂盒使用CpG岛甲基化表型分类器的分析。

6. 发明申请

WO2009078856A1 COGNITIVE FUNCTION INDEX 审中-公开
标题翻译：认知功能指标
公开(公告)号：WO2009078856A1
公开(公告)日：2009-06-25
申请号：PCT/US2007/087656
申请日：2007-12-14
申请人： MEDICAL CARE CORPORATION , SHANKLE, William, Rodman , CHAN, Timothy , FORTIER, Dennis, Earle , HARA, Junko , MANGROLA, Tushar
发明人： SHANKLE, William, Rodman , CHAN, Timothy , FORTIER, Dennis, Earle , HARA, Junko , MANGROLA, Tushar
IPC分类号： A61B5/16
CPC分类号： A61B5/16 , A61B5/4088 , G06F19/00 , G16H15/00 , G16H50/20 , G16H80/00
摘要： Methods, systems, and apparatus, including medium-encoded computer program products, for creating a cognitive function index. In one aspect, a method includes receiving first information concerning a person, the first information specifying the person's responses, and lack thereof, for components of a cognitive test administered to the person; generating a cognitive function score for the person by comparing the first information with second information concerning a group of people to whom the cognitive test has been administered; converting the cognitive function score to a value in an index comprising a range of values, wherein a first portion of the range corresponds to a cognitively impaired zone, a second portion of the range corresponds to a cognitively normal zone, and a third portion of the range corresponds to a zone of uncertainty defined by a confidence interval centered on a mid-point of the index; and providing the indexed value for the person.
摘要翻译：用于创建认知功能指数的方法，系统和装置，包括中等编码的计算机程序产品。在一个方面，一种方法包括接收关于人的第一信息，指定人的反应的第一信息，以及对该人的认知测试的组件的缺乏; 通过将第一信息与关于已经进行认知测试的一组人的第二信息进行比较来产生该人的认知功能评分; 将所述认知功能评分转换为包括值范围的索引中的值，其中所述范围的第一部分对应于认知受损区域，所述范围的第二部分对应于认知正常区域，并且所述第三部分范围对应于以指数中点为中心的置信区间定义的不确定区域; 并为该人员提供索引值。

7. 发明申请

WO2008030584A2 MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 审中-公开
标题翻译：白细胞介素-1受体相关激酶的调节剂
公开(公告)号：WO2008030584A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/019588
申请日：2007-09-07
申请人： BIOGEN IDEC MA INC. , GUCKIAN, Kevin , JEWELL, Charles , CONLAN, Patrick , LIN, Edward, Yin-Shiang , CHAN, Timothy
发明人： GUCKIAN, Kevin , JEWELL, Charles , CONLAN, Patrick , LIN, Edward, Yin-Shiang , CHAN, Timothy
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14
摘要： The present invention relates to modulators of IRAK kinases and provides compositions comprising such modulators, as well as methods therewith for treating IRAK- mediated or IRAK-associated conditions or diseases.
摘要翻译：本发明涉及IRAK激酶的调节剂并提供包含这种调节剂的组合物，以及其用于治疗IRAK介导的或与IRAK相关的病症或疾病的方法。

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