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1. 发明申请

WO2009006421A1 SERS NANOTAG ASSAYS WITH ENHANCED ASSAY KINETICS 审中-公开
标题翻译： SERS NANOTAG测试与增强测定动力学
公开(公告)号：WO2009006421A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068813
申请日：2008-06-30
申请人： OXONICA, INC. , DOERING, William E. , STOERMER, Rebecca Louise
发明人： DOERING, William E. , STOERMER, Rebecca Louise
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , G01N33/54326 , G01N33/54346 , G01N33/54393 , G01N33/553
摘要： Methods and systems for the use of surface-enhanced Raman scattering nanotags (SERS nanotags) in various assay platforms which feature accelerated reaction kinetics. One embodiment includes a method detecting a substance of interest by associating a SERS nanotag with the substance of interest while accelerating the reaction kinetics of the association steps. This method also includes detecting a Raman spectrum of a reporter molecule associated with the SERS nanotag. The reaction kinetics of the assay may be accelerated by applying microwave radiation to the sample, heating the sample, agitating the sample, mixing the sample, vibrating the sample or other methods.
摘要翻译：在具有加速反应动力学的各种测定平台中使用表面增强拉曼散射纳米颗粒（SERS纳米标签）的方法和系统。一个实施方案包括通过在加速缔合步骤的反应动力学的同时使SERS纳米标记与目标物质相关联来检测感兴趣的物质的方法。该方法还包括检测与SERS纳米颗粒相关的报告分子的拉曼光谱。可以通过对样品施加微波辐射，加热样品，搅拌样品，混合样品，振动样品或其他方法来加速测定的反应动力学。

2. 发明申请

WO2007092941A3 SERS NANOTAG ASSAYS 审中-公开
标题翻译： SERS NANOTAG测试
公开(公告)号：WO2007092941A3
公开(公告)日：2008-10-16
申请号：PCT/US2007061878
申请日：2007-02-08
申请人： OXONICA INC , NATAN MICHAEL , PENN SHARRON GAYNOR , CROMER REMY , SHA MICHAEL , XU HONGXIA , DOERING WILLIAM E
发明人： NATAN MICHAEL , PENN SHARRON GAYNOR , CROMER REMY , SHA MICHAEL , XU HONGXIA , DOERING WILLIAM E
IPC分类号： C07H21/04 , G01N33/53
CPC分类号： G01N21/658 , B82Y5/00 , C12Q1/6816 , G01N33/54373 , Y10T436/143333 , C12Q2537/125 , C12Q2563/131 , C12Q2563/143 , C12Q2565/632
摘要： Methods and systems for the use of Surface Enhanced Raman Scattering nanotags (SERS nanotags) to create homogeneous (no-wash), heterogeneous or sequence detection assay platforms. In certain embodiments the SERS nanotags are used in combination with magnetic particles. Multiplexed assay platforms are also disclosed. In certain embodiments, the assay is useful for clinical proteomics. Assay platforms suitable for use within a biological matrix, for example within whole blood or serum are also disclosed. The assay formats described herein may be used to detect any analyte of interest including but not limited to the detection of cells, viruses, bacteria, proteins, DNA, RNA, or small molecules in any type of biological (animal or plant kingdom) or environmental samples including but not limited to whole blood or serum, occult samples, urine, feces, air, drinking water, phage, any organism, multicellular clumps of cells, for example, cancer tissue homogenate.
摘要翻译：使用表面增强拉曼散射纳米标签（SERS纳米标签）的方法和系统，以创建均质（非洗涤），异质或序列检测测定平台。在某些实施方案中，SERS纳米颗粒与磁性颗粒结合使用。还公开了多重测定平台。在某些实施方案中，该测定可用于临床蛋白质组学。还公开了适用于生物基质，例如全血或血清中的测定平台。本文描述的测定形式可用于检测感兴趣的任何分析物，包括但不限于检测任何类型的生物（动物或植物界）或环境中的细胞，病毒，细菌，蛋白质，DNA，RNA或小分子样品包括但不限于全血或血清，隐匿样品，尿液，粪便，空气，饮用水，噬菌体，任何生物，细胞多细胞团，例如癌组织匀浆。

3. 发明申请

WO2007059514A2 SERS-BASED METHODS FOR DETECTION OF BIOAGENTS 审中-公开
标题翻译：基于SERS的生物学检测方法
公开(公告)号：WO2007059514A2
公开(公告)日：2007-05-24
申请号：PCT/US2006060930
申请日：2006-11-15
申请人： OXONICA INC , NATAN MICHAEL J , SHA MICHAEL , DOERING WILLIAM E
发明人： NATAN MICHAEL J , SHA MICHAEL , DOERING WILLIAM E
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q2565/632 , C12Q2565/549 , C12Q2565/1015
摘要： An assay and method of assay for optical detection of bioagents, a target nucleic acid or a target protein using a surface enhanced Raman scattering (SERS) active biomolecule molecular beacon. The present invention also provides the assay and method in a multiplexed format.
摘要翻译：使用表面增强拉曼散射（SERS）活性生物分子分子信标的生物标志物，靶核酸或靶蛋白的光学检测的测定和方法。本发明还提供了多种格式的测定方法。

4. 发明申请

WO2005096749A3 POLYCHROMIC LASER SCANNING SYSTEM AND METHOD OF USE 审中-公开
公开(公告)号：WO2005096749A3
公开(公告)日：2005-10-20
申请号：PCT/US2005/010986
申请日：2005-03-30
申请人： PPD BIOMARKER DISCOVERY SCIENCES, LLC , HORCHNER, Uwe , KANTOR, Aaron, B. , NATAN, Michael, J. , DOERING, William, E.
发明人： HORCHNER, Uwe , KANTOR, Aaron, B. , NATAN, Michael, J. , DOERING, William, E.
IPC分类号： G01J3/30
摘要： A system for laser scanning provides spectral flexibility needed for the spectroscopic monitoring of highly multiplexed samples, such as cellular and particle assays in whole blood or other suspensions. In accordance with embodiments of the present invention, the system comprises a scanner to direct an excitation laser through a sample, an objective to collect light emitted by the sample in response to the excitation laser, a spectrograph to disperse the emitted light over a plurality of wavelengths as a spectrum, and a charge coupled device for detecting the spectrum. The system can be used with samples having a variety of reporter tags, including one or more SERS tags, fluorescent organic and protein tags, and quantum dot tags. A laser scanning apparatus and method of using the same is also provided.

5. 发明申请

WO2005096749A2 POLYCHROMIC LASER SCANNING SYSTEM AND METHOD OF USE 审中-公开
标题翻译：多色激光扫描系统及其使用方法
公开(公告)号：WO2005096749A2
公开(公告)日：2005-10-20
申请号：PCT/US2005010986
申请日：2005-03-30
申请人： PPD BIOMARKER DISCOVERY SCIENC , HORCHNER UWE , KANTOR AARON B , NATAN MICHAEL J , DOERING WILLIAM E
发明人： HORCHNER UWE , KANTOR AARON B , NATAN MICHAEL J , DOERING WILLIAM E
IPC分类号： G01J3/28 , G01J3/30 , G01J3/44 , G01N15/14 , G01N21/65
CPC分类号： G01J3/2803 , G01J3/44 , G01N15/1434 , G01N21/6428 , G01N21/658 , G01N2015/008 , G01N2015/144 , G01N2021/6482
摘要： A system for laser scanning provides spectral flexibility needed for the spectroscopic monitoring of highly multiplexed samples, such as cellular and particle assays in whole blood or other suspensions. In accordance with embodiments of the present invention, the system comprises a scanner to direct an excitation laser through a sample, an objective to collect light emitted by the sample in response to the excitation laser, a spectrograph to disperse the emitted light over a plurality of wavelengths as a spectrum, and a charge coupled device for detecting the spectrum. The system can be used with samples having a variety of reporter tags, including one or more SERS tags, fluorescent organic and protein tags, and quantum dot tags. A laser scanning apparatus and method of using the same is also provided.
摘要翻译：用于激光扫描的系统提供了高分辨率样品的光谱监测所需的光谱灵活性，例如全血或其它悬浮液中的细胞和颗粒测定。根据本发明的实施例，该系统包括扫描器，用于将激发激光引导通过样本，用于响应于激发激光收集由样品发射的光的目标，将发射的光分散在多个波长作为光谱，以及用于检测光谱的电荷耦合器件。该系统可以与具有各种报告标签的样品一起使用，包括一个或多个SERS标签，荧光有机和蛋白质标签以及量子点标签。还提供了一种激光扫描装置及其使用方法。

6. 发明申请

WO2011119589A1 WAVELENGTH SELECTIVE SERS NANOTAGS 审中-公开
标题翻译：波长选择性纳豆糖
公开(公告)号：WO2011119589A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029395
申请日：2011-03-22
申请人： CABOT SECURITY MATERIALS INC. , NATAN, Michael J. , FREEMAN, Richard Griffith , DOERING, William E. , PIOTTI, Marcelo Eduardo
发明人： NATAN, Michael J. , FREEMAN, Richard Griffith , DOERING, William E. , PIOTTI, Marcelo Eduardo
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B82Y20/00 , B82Y30/00 , G01N2201/06113 , H01S3/30 , Y10S977/81 , Y10S977/834
摘要： Wavelength selective particles such as SERS nanotags modified for wavelength selectivity. As used herein, a wavelength selective particle is one which cannot be effectively excited or interrogated at one or more wavelengths where a reporter molecule associated with the particle would normally produce a spectrum. Also disclosed are methods of manufacturing wavelength selective particles and methods of tagging materials or objects with wavelength selective particles.
摘要翻译：波长选择性颗粒，如SERS纳米复合材料修饰波长选择性。如本文所用，波长选择性颗粒是在与颗粒相关的报告分子通常产生光谱的一个或多个波长处不能有效激发或询问的粒子。还公开了制造波长选择性颗粒的方法和用波长选择性颗粒标记材料或物体的方法。

7. 发明申请

WO2010135354A1 PARTICLES AND METHODS FOR LONG WAVELENGTH SERS 审中-公开
标题翻译：长波长的颗粒和方法
公开(公告)号：WO2010135354A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035300
申请日：2010-05-18
申请人： OXONICA MATERIALS INC. , NATAN, Michael J. , FREEMAN, Richard Griffith , PIOTTI, Marcelo Eduardo , DOERING, William E. , TAM, Felicia
发明人： NATAN, Michael J. , FREEMAN, Richard Griffith , PIOTTI, Marcelo Eduardo , DOERING, William E. , TAM, Felicia
IPC分类号： G01N33/566 , C12Q1/68
CPC分类号： G01N33/532 , G01N21/658 , G01N33/28
摘要： Embodiments include a particle comprising a surface enhanced spectroscopy (SES) - active core and a SES-active reporter molecule associated with the SES- active core wherein said particle has a measurable SES spectrum when excited by incident light having a wavelength of at least 1400 nm. Alternative embodiments include methods of manufacturing said particle and methods of tagging a material with said particle. The particle may include an SES-active core which supports plasmon resonance at a wavelength of at least 1400 nm. The particle may comprise an anisotropic core. The particle may include an SES-active reporter molecule which is resonant at one or more wavelengths greater than or equal to 1400 nm.
摘要翻译：实施方案包括包含表面增强光谱（SES） - 活性核和与SES活性核相关联的SES活性报告分子的颗粒，其中当波长为至少1400nm的入射光激发时，所述颗粒具有可测量的SES光谱。替代实施例包括制造所述颗粒的方法和用所述颗粒标记材料的方法。颗粒可以包括在至少1400nm的波长下支持等离子体共振的SES活性核心。颗粒可以包括各向异性核。颗粒可以包括在大于或等于1400nm的一个或多个波长处共振的SES活性报道分子。

8. 发明申请

WO2010081018A1 ENERGETIC NANOPOROUS DEVICES FOR SAMPLE PREPARATION 审中-公开
标题翻译：用于样品制备的能量纳米装置
公开(公告)号：WO2010081018A1
公开(公告)日：2010-07-15
申请号：PCT/US2010/020521
申请日：2010-01-08
申请人： OXONICA MATERIALS, INC. , NATAN, Michael, J. , DOERING, William, E. , CURRANO, Luke , BECKER, Collin , MORRIS, Christopher
发明人： NATAN, Michael, J. , DOERING, William, E. , CURRANO, Luke , BECKER, Collin , MORRIS, Christopher
IPC分类号： C12M1/42
CPC分类号： C12M35/04 , G01N1/286 , G01N2001/2866
摘要： A sample preparation device and method of preparing a sample is disclosed. The device includes a sample holder configured to receive a sample. In addition, the sample preparation device includes an explosive element associated with a sample holder and positioned to mechanically disrupt the sample upon actuation of the explosive element. In one embodiment the explosive element is a select quantity of nanoporous silicon having an oxidant within the pores of the nanoporous silicon. The sample preparation device may also include one or more disrupter elements associated with the explosive element positioned to mechanically disrupt the sample upon actuation of the explosive element.
摘要翻译：公开了一种样品制备装置及其制备方法。该装置包括构造成接收样品的样品架。此外，样品制备装置包括与样品保持器相关联的爆炸元件，并且定位成在致动爆炸元件时机械地破坏样品。在一个实施方案中，爆炸元件是在纳米多孔硅的孔内具有氧化剂的选择量的纳米多孔硅。样品制备装置还可以包括与爆炸元件相关联的一个或多个破坏器元件，定位成在爆炸元件致动时机械地破坏样品。

9. 发明申请

WO2007059514A8 SERS-BASED METHODS FOR DETECTION OF BIOAGENTS 审中-公开
标题翻译：基于SERS的检测生物制剂的方法
公开(公告)号：WO2007059514A8
公开(公告)日：2007-12-06
申请号：PCT/US2006060930
申请日：2006-11-15
申请人： OXONICA INC , NATAN MICHAEL J , SHA MICHAEL , DOERING WILLIAM E
发明人： NATAN MICHAEL J , SHA MICHAEL , DOERING WILLIAM E
IPC分类号： C12Q1/68 , C12M1/34 , C12M3/00
CPC分类号： C12Q1/6818 , C12Q2565/632 , C12Q2565/549 , C12Q2565/1015
摘要： An assay and method of assay for optical detection of bioagents, a target nucleic acid or a target protein using a surface enhanced Raman scattering (SERS) active biomolecule molecular beacon. The present invention also provides the assay and method in a multiplexed format.
摘要翻译：使用表面增强拉曼散射（SERS）活性生物分子分子信标对生物试剂，靶核酸或靶蛋白进行光学检测的测定法和方法。本发明还提供了多路复用格式的化验和方法。

10. 发明申请

WO2012030988A1 INLINE SPECTROSCOPIC READER AND METHODS 审中-公开
标题翻译：在线光谱读取器和方法
公开(公告)号：WO2012030988A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/050008
申请日：2011-08-31
申请人： CABOT SECURITY MATERIALS INC. , WALTON, Ian D. , DOERING, William E. , NATAN, Michael J.
发明人： WALTON, Ian D. , DOERING, William E. , NATAN, Michael J.
IPC分类号： G01J3/44
CPC分类号： G01J3/28 , G01J3/0208 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/0294 , G01J3/2803 , G01J3/44 , G01N21/85 , G01N21/8901 , G07D7/1205
摘要： An inline spectroscopic reader having a light source, one or more optics heads, a spectrometer and a data processing system in digital communication with the spectrometer detector. The optics heads include transmission optics providing for the illumination of a target with light from the light source and detection optics providing for the collection of light from the target. Typically, the target is moving with respect to the optics head during spectroscopic interrogation. The spectroscopic reader is thus an inline reader well suited to provide spectrum based production or analytical decision making in real time as the target moves along a production or analysis line. Also disclosed are methods including the steps of illuminating a target with light from a light source; collecting light from the target; obtaining a digitized spectrum with a spectrometer; extracting information content from the digitized spectrum; and basing a contemporaneous process decision upon the information content.
摘要翻译：具有光源，一个或多个光学头，光谱仪和与光谱仪检测器进行数字通信的数据处理系统的在线分光学阅读器。光学头包括传输光学器件，用于提供来自光源的光的目标照明和用于从目标物体收集光的检测光学器件。通常，目标在光谱询问期间相对于光学头移动。因此，光谱阅读器是一个在线阅读器，非常适合随着目标沿着生产线或分析线移动，实时提供基于频谱的生产或分析决策。还公开了包括用来自光源的光照射目标的步骤的方法; 从目标收集光; 用光谱仪获得数字化光谱; 从数字化频谱中提取信息内容; 并对信息内容进行同时代的过程决策。

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