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1. 发明申请

WO2019141828A1 ARTIFICIAL CONTROL TISSUE AND METHOD FOR ITS PRODUCTION 审中-公开
公开(公告)号：WO2019141828A1
公开(公告)日：2019-07-25
申请号：PCT/EP2019/051300
申请日：2019-01-18
申请人： NIENDORF, Axel
发明人： NIENDORF, Axel
IPC分类号： G01N33/50 , C12N5/07 , G01N1/28 , G01N1/31 , C12N5/071 , C12N5/09
CPC分类号： G01N33/5091 , C12N5/0631 , C12N5/0693 , G01N1/286 , G01N1/312 , G01N33/5088 , G01N2001/2866 , G01N2001/2893
摘要： The invention relates to a method for the manufacture of an artificial control tissue comprising the steps of (a) providing ten or more tissue samples; (b) shredding the tissue samples into tissue fragments; (c) mixing the tissue fragments; and (d) forming an artificial control tissue. Further, the invention also pertains inter alia to artificial control tissue manufactured according to the method and/or comprising fragments of 25 or more tissue samples.

2. 发明申请

WO2018182632A1 METHODS OF RECONSTITUTING CORES, FORMATION CORES WITH ACTUAL FORMATION MATERIALS FOR LAB TESTING 审中-公开
公开(公告)号：WO2018182632A1
公开(公告)日：2018-10-04
申请号：PCT/US2017/025092
申请日：2017-03-30
申请人： HALLIBURTON ENERGY SERVICES, INC.
发明人： NGUYEN, Philip D. , MARTYSEVICH, Vladimir Nikolayevich , KHAMATNUROVA, Tatyana V. , PARTON, Christopher R.
IPC分类号： E21B49/02 , E21B49/00 , G01N1/28
CPC分类号： G01N1/286 , E21B21/066 , E21B49/00 , E21B49/02 , G01N2001/2866
摘要： A method to produce reconstituted structures that recreate the chemical, geological, and structural characteristics of a portion of a target reservoir formation by using drill cuttings material from the target reservoir formation. The method includes providing drill cuttings material from a known reservoir formation and grinding the drill cuttings material to particulates of one or more known particle sizes. In particular, an actual core sample may be replicated via a three-dimensional printer using the ground drill cuttings material from the target reservoir formation. A representative reconstituted structure may also be formed by applying a load to the ground drill cuttings material from the target reservoir formation. A slot flow device may also be formed via either three-dimensional printing with drill cutting particulates or the application of a load to the drill cutting particulates.

3. 发明申请

WO2018136465A1 SYSTEM AND METHOD OF INFERRING THE QUALITY LEVEL OF MEDICINES 审中-公开
公开(公告)号：WO2018136465A1
公开(公告)日：2018-07-26
申请号：PCT/US2018/013969
申请日：2018-01-17
申请人： WESTERN NEW ENGLAND UNIVERSITY
发明人： SALMON, Christian , PRIEFER, Ronny
IPC分类号： A61K31/277 , A61K31/337 , A61K31/437
CPC分类号： G01N21/314 , G01N1/286 , G01N1/38 , G01N21/33 , G01N21/9508 , G01N33/15 , G01N2001/2866 , G01N2021/3133 , G01N2021/3137 , G01N2021/3148
摘要： A method and system of inferring a medicine quality level is provided. The method includes diluting the medicine with a solvent. Levels of absorption of UV light are measured at a plurality of predetermined wavelengths. The quality of the medicine is categorized based at least in part on an ELECTRE TRI process using the measured absorption levels. The category is displayed to an operator.

4. 发明申请

WO2017160066A1 바이오 샘플 전처리 장치 审中-公开
标题翻译：生物样品预处理装置
公开(公告)号：WO2017160066A1
公开(公告)日：2017-09-21
申请号：PCT/KR2017/002760
申请日：2017-03-14
申请人： 에스케이텔레콤 주식회사
发明人： 박진성 , 김상호 , 강진석 , 김종선
IPC分类号： G01N1/06 , G01N33/50 , G01N1/22 , G01N1/40
CPC分类号： G01N1/06 , B01L3/5021 , B01L9/06 , B01L9/50 , B01L2300/0681 , B01L2300/18 , B01L2400/043 , G01N1/22 , G01N1/286 , G01N1/38 , G01N1/40 , G01N1/44 , G01N33/50 , G01N2001/2866 , G01N2001/386 , G01N2001/4088
摘要： 본 발명의 일 실시예에 의한 바이오 샘플 전처리 장치는 준비된 용기의 외측에 위치할 수 있도록 배치되고 용기에 자력을 가하는 적어도 둘 이상의 자력인가부를 포함하고, 둘 이상의 자력인가부의 자극 (磁極)이 바뀌는 장치이다.
摘要翻译：
根据本发明被配置为被定位在完成的容器的外侧的一个实施方式的生物试样调制装置包括：将至少两个磁力施加磁力到所述容器部，一个以上的自它是负极性磁极发生变化的装置。

5. 发明申请

WO2017156036A1 METHODS AND DEVICES FOR PRODUCING CELLULAR SUSPENSIONS FROM TISSUE SAMPLES 审中-公开
标题翻译：用于从组织样品产生细胞悬液的方法和装置
公开(公告)号：WO2017156036A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/021207
申请日：2017-03-07
申请人： BECTON, DICKINSON AND COMPANY
发明人： PETTIS, Ronald, J. , FERGUSON, Mitchell
IPC分类号： B01L3/00 , C12M3/02 , B07C5/02 , B01F11/02 , B01D29/70 , B01D29/72 , A61L27/36
CPC分类号： G01N1/38 , B01F11/02 , B01F2215/0037 , B01F2215/0073 , C12M45/02 , G01N1/286 , G01N15/1459 , G01N2001/2866 , G01N2001/386 , G01N2015/1006
摘要： Aspects of the present disclosure include methods of producing a cellular suspension from a tissue sample by applying resonant acoustic energy to a container comprising the tissue sample in a manner sufficient to produce a cellular suspension from the tissue sample. Resonant acoustic mixers and kits for use in producing a cellular suspension from a tissue sample are also provided.
摘要翻译：本公开的方面包括通过以足以从组织样本产生细胞悬液的方式向包含组织样本的容器施加共振声能从组织样本产生细胞悬液的方法。还提供了用于从组织样本产生细胞悬液的共振声学混合器和试剂盒。

6. 发明申请

WO2017015574A1 RAPID CONCENTRATION, RECOVERY AND DETECTION OF PATHOGENS IN FOOD SAMPLES 审中-公开
标题翻译：食物样品中快速浓度，恢复和检测病原体
公开(公告)号：WO2017015574A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/043596
申请日：2016-07-22
申请人： PURDUE RESEARCH FOUNDATION
发明人： LADISCH, Michael, Ralph , XIMINES, Eduardo De Aquino , KU, Seockmo , FOSTER, Kirk, Solon , KREKE, Thomas, Richard , LIU, Xingya (linda) , JONES, James, Thomas , DEERING, Amanda , HARDENSTEIN, Jaycey , TUNGARE, Alisha
IPC分类号： G01N1/40 , G01N33/569 , C12Q1/10
CPC分类号： G01N33/56916 , C12Q1/04 , C12Q1/10 , G01N1/4005 , G01N1/4044 , G01N2001/2866 , G01N2001/4088 , G01N2333/245 , G01N2333/255
摘要： Methods for rapidly concentrating a food sample for efficient detection of bacteria are disclosed. A microfiltration approach followed by centrifugation was used to concentrate the cells with an enzyme (e.g., a protease) added at the beginning of the process to facilitate more efficient micro-filtering. The enzyme was found to have no significant effect on cell viability.
摘要翻译：公开了用于快速浓缩食物样品以有效检测细菌的方法。然后使用微滤方法进行离心，以在该过程开始时加入的酶（例如蛋白酶）来浓缩细胞，以促进更有效的微过滤。发现该酶对细胞活力没有显着影响。

7. 发明申请

WO2016097960A2 DISGREGATING DEVICE OF BIOLOGICAL MATERIAL AND CORRESPONDING MANUFACTURING METHOD AND METHOD FOR THE PREPARATION OF CELL SUSPENSIONS AND TISSUE MICROGRAFTS 审中-公开
标题翻译：生物材料的分解装置和相应的制造方法和制备细胞悬浮液和组织微量元素的方法
公开(公告)号：WO2016097960A2
公开(公告)日：2016-06-23
申请号：PCT/IB2015/059571
申请日：2015-12-14
申请人： HUMAN BRAIN WAVE S.R.L.
发明人： GRAZIANO, Antonio , D'AQUINO, Riccardo
IPC分类号： B02C18/36 , B02C19/20 , B02C18/10
CPC分类号： B02C18/365 , B02C18/10 , B02C18/362 , B02C19/20 , C12M45/02 , G01N2001/2866
摘要： A disgregating device (10) of biological material, comprising: - a hollow outer body (11), defining an inner chamber (12); - a fixed disgregating grid (13), having a plurality of microholes (13a) provided with sharp edges, and housed transversely in the inner chamber (12) so as to define an upper loading chamber (12a) apt to be loaded with the biological material (MB) to be disgregated and a lower collecting chamber (12b) apt to collect the biological material (MB'), after it has been disgregated; and - a bladed rotor (14), rotating in the inner chamber (12), apt to co-operate, rotating, with the fixed disgregating grid (13), so as to feed and bring the biological material (MB), contained in the upper loading chamber (12a), into contact with the microholes (13a) of the disgregating grid (13) and therefore cause the disgregation of the biological material (MB') making it pass through these microholes. The microholes (13a) of the disgregating grid have dimensions or a diameter comprised between 70 and 80 μm, and are obtained by means of a moulding process of the die-punch type, using a conical or polygonal punch (P) to draw and tear a metal sheet (N) of stainless steel, so as to have each one a jagged sharp edge with several tips, for example six, or also using, again within the sphere of a process of moulding of the die- punch type, a source of laser light. As ascertained by thorough experimental tests, thanks to the special features and configuration of the microholes (13a), it is possible to prepare by means of the disgregating device (10), without the aid of chemical reagents, cell suspensions and tissue micrografts which maintain intact and unaltered the features, the functions and the viability of the original biological material, non-disgregated, and which can therefore be advantageously be used in numerous medical, veterinary and cosmetic applications.
摘要翻译：一种生物材料的分散装置（10），包括： - 限定内腔（12）的中空外体（11）; - 固定的隔离栅格（13），其具有设置有锐利边缘的多个微孔（13a），并且横向地容纳在所述内室（12）中，以便限定易于装载所述生物体的上装载室（12a）待分离的材料（MB）和在其分散之后容易收集生物材料（MB'）的下收集室（12b）; 以及 - 在所述内室（12）中旋转的叶片转子（14），其与所述固定的分离格栅（13）易于配合，旋转，以便将所述生物材料（MB）上部装载室（12a）与分散栅格（13）的微孔（13a）接触，因此导致生物材料（MB'）的分散使其通过这些微孔。分散网格的微孔（13a）具有70-80μm的尺寸或直径，并且通过使用锥形或多边形冲头（P）进行拉伸和撕裂的冲模类型的模制方法获得一个不锈钢的金属板（N），以便使每一个具有几个尖端的锯齿形锋利边缘，例如六个，或者也是在模冲模型的成型过程的球体内使用源的激光。通过彻底的实验测试确定，由于微孔（13a）的特殊特征和配置，可以借助于化学试剂，细胞悬浮液和组织微量移植物，借助于分散装置（10）来制备完整且未改变原始生物材料的特征，功能和活力，不分散，因此可有利地用于许多医学，兽医和化妆品应用。

8. 发明申请

WO2016046966A1 検体抽出キット、および、検体抽出方法审中-公开
标题翻译：样品提取试剂盒和样品提取方法
公开(公告)号：WO2016046966A1
公开(公告)日：2016-03-31
申请号：PCT/JP2014/075672
申请日：2014-09-26
申请人：デンカ生研株式会社
发明人：須崎　正士 , 深澤　眞 , 平山　吉朗 , 秋石　和宏
IPC分类号： G01N1/10 , G01N33/48
CPC分类号： G01N1/286 , B01L3/5029 , B01L3/505 , B01L2300/0609 , B01L2400/0481 , B02C19/0006 , G01N1/10 , G01N1/28 , G01N33/48 , G01N2001/028 , G01N2001/2866
摘要：検体抽出キットは、抽出液を収容するように構成される可撓性を有した筒状容器（１０）と、前記筒状容器（１０）を挟んで相互に対向する２つの挟持部（２１）と、相互に対向する２つの挟持部（２１）を連結する連結部（２５）と、相互に対向する挟持部（２１）に設けられて筒状容器（１０）および抽出対象部材（ＥＭ）を折り曲げる折り曲げリブ（２３）とを備える。
摘要翻译：样品提取试剂盒设有：柔性圆柱形容器（10），其被构造成在其中容纳提取液体; 两个夹持部件（21），其夹着圆柱形容器（10）彼此相对; 将彼此相对的两个把持部（21）连接的连接部（25）以及折叠肋（23），它们分别布置在彼此相对的把持部分（21）中，并且能够折叠圆筒形容器（10）和要提取的构件（EM）。

9. 发明申请

WO2016005766A1 IMPROVED EXTRACTION APPARATUS 审中-公开
标题翻译：改进的提取装置
公开(公告)号：WO2016005766A1
公开(公告)日：2016-01-14
申请号：PCT/GB2015/052004
申请日：2015-07-10
申请人： CAMBTEK LIMITED
发明人： MALKIN, Hugh , HASTINGS, Nicholas James , GEORGE, Ian Morgan , PEARL, Martin
IPC分类号： G01N1/28 , B01F11/00 , B02C19/08 , B02C1/14 , C12M1/26 , C12M1/33
CPC分类号： A23F5/265 , B01D11/0215 , B02C19/08 , C09H3/00 , C11B1/10 , G01N1/286 , G01N2001/2866 , G01N2001/4061 , G01N2013/006
摘要： Apparatus for distributing a solid, gel, powder, granular, liquid or viscous liquid test substance in an extraction fluid comprises: a)a flow cell for holding the test substance comprising an extraction chamber of uniform cross-sectional area,a grinding surface, an extraction fluid inlet and an extract outlet; b)a grinding head disposed within the extraction chamber and adapted to reciprocate therein; and c)a recirculating pump for driving extraction fluid: (i) into the flow cell via the extraction fluid inlet; (ii) through the extraction chamber; and (iii) back to the flow cell via the extract outlet.
摘要翻译：用于在提取流体中分配固体，凝胶，粉末，颗粒，液体或粘稠液体测试物质的装置包括：a）用于保持测试物质的流动池，包括具有均匀横截面积的提取室，研磨表面，萃取液入口和提取物出口; b）设置在所述提取室内并适于在其中往复运动的研磨头; 和c）用于驱动提取流体的循环泵：（i）经由提取流体入口进入流动池; （ii）通过提取室; 和（iii）通过提取物出口返回流动池。

10. 发明申请

WO2015172250A1 DEVICE FOR COLLECTING, TRANSPORTING AND STORING BIOMOLECULES FROM A BIOLOGICAL SAMPLE 审中-公开
标题翻译：从生物样品中收集，运输和储存生物分子的装置
公开(公告)号：WO2015172250A1
公开(公告)日：2015-11-19
申请号：PCT/CA2015/050434
申请日：2015-05-13
申请人： DNA GENOTEK INC.
发明人： JACKSON, Adele , ACERO, Maria Mercedes , DOUKHANINE, Evgueni Vladimirovitch , IWASIOW, Rafal Michal , MERINO HERNANDEZ, Carlos Alberto , BIRNBOIM, H. Chaim , LIBERTY, Jonathan D.
IPC分类号： G01N1/38 , B01L3/00 , C12M1/24 , C12M1/28 , C12N15/10 , C12Q1/00 , C12Q1/68 , G01N33/50
CPC分类号： B01L3/502 , A61B10/0096 , B01F13/0052 , B01F2215/0037 , B01L3/50825 , B01L2200/026 , B01L2300/042 , B01L2300/046 , B01L2300/06 , B01L2400/0478 , B01L2400/0481 , C12M45/02 , C12Q1/6806 , G01N1/286 , G01N1/38 , G01N2001/2866
摘要： The present application provides a sample receiving device comprising a vial, a receptacle in communication with the vial for receiving the sample, and a cap comprising a pusher, the pusher for engaging with the sample in the receptacle. The receptacle comprises a disrupting means for disrupting the sample when the pusher engages with the sample in the receptacle and expels the disrupted sample into the vial. Typically, the device can be used for collecting fecal samples. A method of preserving a biomolecule in the device using a biomolecule preserving composition is also provided.
摘要翻译：本申请提供了一种样品接收装置，其包括小瓶，与小瓶连通以用于接收样品的容器，以及包括推动器的盖，该推动器用于与样品接合在容器中。容器包括当推动器与容器中的样品接合并且将破碎的样品排出到小瓶中时破坏样品的破坏装置。通常，该装置可用于收集粪便样品。还提供了使用生物分子保存组合物在装置中保存生物分子的方法。

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