专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010135354A1 PARTICLES AND METHODS FOR LONG WAVELENGTH SERS 审中-公开
标题翻译：长波长的颗粒和方法
公开(公告)号：WO2010135354A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035300
申请日：2010-05-18
申请人： OXONICA MATERIALS INC. , NATAN, Michael J. , FREEMAN, Richard Griffith , PIOTTI, Marcelo Eduardo , DOERING, William E. , TAM, Felicia
发明人： NATAN, Michael J. , FREEMAN, Richard Griffith , PIOTTI, Marcelo Eduardo , DOERING, William E. , TAM, Felicia
IPC分类号： G01N33/566 , C12Q1/68
CPC分类号： G01N33/532 , G01N21/658 , G01N33/28
摘要： Embodiments include a particle comprising a surface enhanced spectroscopy (SES) - active core and a SES-active reporter molecule associated with the SES- active core wherein said particle has a measurable SES spectrum when excited by incident light having a wavelength of at least 1400 nm. Alternative embodiments include methods of manufacturing said particle and methods of tagging a material with said particle. The particle may include an SES-active core which supports plasmon resonance at a wavelength of at least 1400 nm. The particle may comprise an anisotropic core. The particle may include an SES-active reporter molecule which is resonant at one or more wavelengths greater than or equal to 1400 nm.
摘要翻译：实施方案包括包含表面增强光谱（SES） - 活性核和与SES活性核相关联的SES活性报告分子的颗粒，其中当波长为至少1400nm的入射光激发时，所述颗粒具有可测量的SES光谱。替代实施例包括制造所述颗粒的方法和用所述颗粒标记材料的方法。颗粒可以包括在至少1400nm的波长下支持等离子体共振的SES活性核心。颗粒可以包括各向异性核。颗粒可以包括在大于或等于1400nm的一个或多个波长处共振的SES活性报道分子。

2. 发明申请

WO2011119589A1 WAVELENGTH SELECTIVE SERS NANOTAGS 审中-公开
标题翻译：波长选择性纳豆糖
公开(公告)号：WO2011119589A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029395
申请日：2011-03-22
申请人： CABOT SECURITY MATERIALS INC. , NATAN, Michael J. , FREEMAN, Richard Griffith , DOERING, William E. , PIOTTI, Marcelo Eduardo
发明人： NATAN, Michael J. , FREEMAN, Richard Griffith , DOERING, William E. , PIOTTI, Marcelo Eduardo
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B82Y20/00 , B82Y30/00 , G01N2201/06113 , H01S3/30 , Y10S977/81 , Y10S977/834
摘要： Wavelength selective particles such as SERS nanotags modified for wavelength selectivity. As used herein, a wavelength selective particle is one which cannot be effectively excited or interrogated at one or more wavelengths where a reporter molecule associated with the particle would normally produce a spectrum. Also disclosed are methods of manufacturing wavelength selective particles and methods of tagging materials or objects with wavelength selective particles.
摘要翻译：波长选择性颗粒，如SERS纳米复合材料修饰波长选择性。如本文所用，波长选择性颗粒是在与颗粒相关的报告分子通常产生光谱的一个或多个波长处不能有效激发或询问的粒子。还公开了制造波长选择性颗粒的方法和用波长选择性颗粒标记材料或物体的方法。

3. 发明申请

WO2010057212A1 MELAMINE ASSAY METHODS AND SYSTEMS 审中-公开
标题翻译：甲酚测定方法和系统
公开(公告)号：WO2010057212A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/064852
申请日：2009-11-17
申请人： OXONICA MATERIALS, INC. , NATAN, Michael J. , FREEMAN, Richard Griffith , DOERING, William E. , GOLIGHTLY, Rebecca Stoermer
发明人： NATAN, Michael J. , FREEMAN, Richard Griffith , DOERING, William E. , GOLIGHTLY, Rebecca Stoermer
IPC分类号： C12N1/00 , C12P21/06
CPC分类号： G01N21/658 , Y10T436/14 , Y10T436/145555 , Y10T436/147777
摘要： A method of detecting melamine which includes providing a quantity of SERS-active particles and mixing the SERS-active particles with a solution containing melamine. The method further includes detecting a surface enhanced Raman spectrum of the melamine. The foregoing method may optionally include aggregating the SERS-active particles. Aggregation may occur before or after the SERS-active particles are mixed with a solution containing melamine. The method of detecting melamine may optionally include concentration of the SERS-active particles. The method may further include mixing a chaotropic agent having a higher affinity for a selected binding site than melamine into the solution containing melamine. The method may further include mixing a quantity of a SERS-active standard having a known SERS spectrum with the solution containing melamine and SERS-active particles. Assay apparatus and systems are also disclosed.
摘要翻译：一种检测三聚氰胺的方法，其包括提供一定量的SERS-活性颗粒并将SERS-活性颗粒与含有三聚氰胺的溶液混合。该方法还包括检测三聚氰胺的表面增强拉曼光谱。上述方法可以任选地包括聚集SERS活性颗粒。在SERS-活性颗粒与含有三聚氰胺的溶液混合之前或之后，聚集可能发生。检测三聚氰胺的方法可以任选地包括SERS活性颗粒的浓度。该方法还可以包括将具有比三聚氰胺选择的结合位点更高亲和力的离液剂混合到含有三聚氰胺的溶液中。该方法还可以包括将一定数量的具有已知SERS光谱的SERS-活性标准物与含有三聚氰胺和SERS-活性颗粒的溶液混合。测定装置和系统也被公开。

4. 发明申请

WO2012030988A1 INLINE SPECTROSCOPIC READER AND METHODS 审中-公开
标题翻译：在线光谱读取器和方法
公开(公告)号：WO2012030988A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/050008
申请日：2011-08-31
申请人： CABOT SECURITY MATERIALS INC. , WALTON, Ian D. , DOERING, William E. , NATAN, Michael J.
发明人： WALTON, Ian D. , DOERING, William E. , NATAN, Michael J.
IPC分类号： G01J3/44
CPC分类号： G01J3/28 , G01J3/0208 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/0294 , G01J3/2803 , G01J3/44 , G01N21/85 , G01N21/8901 , G07D7/1205
摘要： An inline spectroscopic reader having a light source, one or more optics heads, a spectrometer and a data processing system in digital communication with the spectrometer detector. The optics heads include transmission optics providing for the illumination of a target with light from the light source and detection optics providing for the collection of light from the target. Typically, the target is moving with respect to the optics head during spectroscopic interrogation. The spectroscopic reader is thus an inline reader well suited to provide spectrum based production or analytical decision making in real time as the target moves along a production or analysis line. Also disclosed are methods including the steps of illuminating a target with light from a light source; collecting light from the target; obtaining a digitized spectrum with a spectrometer; extracting information content from the digitized spectrum; and basing a contemporaneous process decision upon the information content.
摘要翻译：具有光源，一个或多个光学头，光谱仪和与光谱仪检测器进行数字通信的数据处理系统的在线分光学阅读器。光学头包括传输光学器件，用于提供来自光源的光的目标照明和用于从目标物体收集光的检测光学器件。通常，目标在光谱询问期间相对于光学头移动。因此，光谱阅读器是一个在线阅读器，非常适合随着目标沿着生产线或分析线移动，实时提供基于频谱的生产或分析决策。还公开了包括用来自光源的光照射目标的步骤的方法; 从目标收集光; 用光谱仪获得数字化光谱; 从数字化频谱中提取信息内容; 并对信息内容进行同时代的过程决策。

5. 发明申请

WO2007059514A3 SERS-BASED METHODS FOR DETECTION OF BIOAGENTS 审中-公开
公开(公告)号：WO2007059514A3
公开(公告)日：2007-05-24
申请号：PCT/US2006/060930
申请日：2006-11-15
申请人： OXONICA, INC. , NATAN, Michael J. , SHA, Michael , DOERING, William E.
发明人： NATAN, Michael J. , SHA, Michael , DOERING, William E.
IPC分类号： C12Q1/68 , C12M1/34 , C12M3/00
摘要： An assay and method of assay for optical detection of bioagents, a target nucleic acid or a target protein using a surface enhanced Raman scattering (SERS) active biomolecule molecular beacon. The present invention also provides the assay and method in a multiplexed format.

6. 发明申请

WO2009006421A1 SERS NANOTAG ASSAYS WITH ENHANCED ASSAY KINETICS 审中-公开
标题翻译： SERS NANOTAG测试与增强测定动力学
公开(公告)号：WO2009006421A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068813
申请日：2008-06-30
申请人： OXONICA, INC. , DOERING, William E. , STOERMER, Rebecca Louise
发明人： DOERING, William E. , STOERMER, Rebecca Louise
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , G01N33/54326 , G01N33/54346 , G01N33/54393 , G01N33/553
摘要： Methods and systems for the use of surface-enhanced Raman scattering nanotags (SERS nanotags) in various assay platforms which feature accelerated reaction kinetics. One embodiment includes a method detecting a substance of interest by associating a SERS nanotag with the substance of interest while accelerating the reaction kinetics of the association steps. This method also includes detecting a Raman spectrum of a reporter molecule associated with the SERS nanotag. The reaction kinetics of the assay may be accelerated by applying microwave radiation to the sample, heating the sample, agitating the sample, mixing the sample, vibrating the sample or other methods.
摘要翻译：在具有加速反应动力学的各种测定平台中使用表面增强拉曼散射纳米颗粒（SERS纳米标签）的方法和系统。一个实施方案包括通过在加速缔合步骤的反应动力学的同时使SERS纳米标记与目标物质相关联来检测感兴趣的物质的方法。该方法还包括检测与SERS纳米颗粒相关的报告分子的拉曼光谱。可以通过对样品施加微波辐射，加热样品，搅拌样品，混合样品，振动样品或其他方法来加速测定的反应动力学。

7. 发明申请

WO2007092941A2 SERS NANOTAG ASSAYS 审中-公开
标题翻译： SERS NANOTAG测试
公开(公告)号：WO2007092941A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/061878
申请日：2007-02-08
申请人： OXONICA, INC. , NATAN, Michael , PENN, Sharron Gaynor , CROMER, Remy , SHA, Michael , XU, Hongxia , DOERING, William E.
发明人： NATAN, Michael , PENN, Sharron Gaynor , CROMER, Remy , SHA, Michael , XU, Hongxia , DOERING, William E.
CPC分类号： G01N21/658 , B82Y5/00 , C12Q1/6816 , G01N33/54373 , Y10T436/143333 , C12Q2537/125 , C12Q2563/131 , C12Q2563/143 , C12Q2565/632
摘要： Methods and systems for the use of Surface Enhanced Raman Scattering nanotags (SERS nanotags) to create homogeneous (no-wash), heterogeneous or sequence detection assay platforms. In certain embodiments the SERS nanotags are used in combination with magnetic particles. Multiplexed assay platforms are also disclosed. In certain embodiments, the assay is useful for clinical proteomics. Assay platforms suitable for use within a biological matrix, for example within whole blood or serum are also disclosed. The assay formats described herein may be used to detect any analyte of interest including but not limited to the detection of cells, viruses, bacteria, proteins, DNA, RNA, or small molecules in any type of biological (animal or plant kingdom) or environmental samples including but not limited to whole blood or serum, occult samples, urine, feces, air, drinking water, phage, any organism, multicellular clumps of cells, for example, cancer tissue homogenate.
摘要翻译：使用表面增强拉曼散射纳米标签（SERS纳米标签）的方法和系统，以创建均质（非洗涤），异质或序列检测测定平台。在某些实施方案中，SERS纳米颗粒与磁性颗粒结合使用。还公开了多重测定平台。在某些实施方案中，该测定可用于临床蛋白质组学。还公开了适用于生物基质，例如全血或血清中的测定平台。本文描述的测定形式可用于检测感兴趣的任何分析物，包括但不限于检测任何类型的生物（动物或植物界）或环境中的细胞，病毒，细菌，蛋白质，DNA，RNA或小分子样品包括但不限于全血或血清，隐匿样品，尿液，粪便，空气，饮用水，噬菌体，任何生物，细胞多细胞团，例如癌组织匀浆。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式