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1. 发明申请

WO2020033934A2 SMART FLOW CYTOMETERS WITH SELF MONITORING AND SELF VALIDATION 审中-公开
公开(公告)号：WO2020033934A2
公开(公告)日：2020-02-13
申请号：PCT/US2019/046071
申请日：2019-08-10
申请人： CYTEK BIOSCIENCES, INC.
发明人： JIANG, Janine , VRANE, David
IPC分类号： G01N15/14
摘要： In some embodiments, a smart flow cytometer includes a monitoring system to monitor differing operational parameters of the smart flow cytometer to detect an advanced failure of components and an advanced need for maintenance. In others, a smart flow cytometer includes a quality control system including a reservoir of quality control beads to periodically run a validation test with the quality control beads in order to determine the ability of the flow cytometer to generate quality data output from a plurality of light detectors. In some embodiments, a plurality of smart flow cytometers are coupled into communication with a computer communication network; a central repair server system is coupled into communication with the computer communication network and the plurality of smart flow cytometers; wherein each of the plurality of smart flow cytometers includes a monitoring system coupled to monitor differing operational parameters of the smart flow cytometer for possible failure.

2. 发明申请

WO2022170354A1 INTEGRATED AIR FILTERING AND CONDITIONING OF DROPLET CHAMBER IN A COMPACT CELL SORTER 审中-公开
公开(公告)号：WO2022170354A1
公开(公告)日：2022-08-11
申请号：PCT/US2022/070543
申请日：2022-02-05
申请人： CYTEK BIOSCIENCES, INC.
发明人： KRUEGER, Glen , VRANE, David , WANG, Kuncheng , GU, Qiuta
IPC分类号： B01L1/00 , G01N15/14 , G01N35/00
摘要： A compact sorting flow cytometer system is disclosed. The system includes a fluidics system having a flow cell and a deflection chamber in communication with the flow cell to receive drops in a stream of a sample biological fluid with one or more biological cells or particles and selectively deflect the drops in the stream of the sample biological fluid with the one or more biological cells or particles; and a droplet deposition unit (DDU) system in communication with the deflection chamber to receive the selectively deflected drops in the stream of the sample biological fluid with the one or more biological cells or particles into one or more containers. The DDU system includes a case or a housing with an open face surround by edges of the case, the case forming a portion of a containment chamber, the case having a top side opening aligned with the deflection chamber to receive the selectively deflected drops in the stream of the sample biological fluid into one or more containers in the containment chamber, a seal mounted around edges of the case, one or more hinges coupled to a bottom portion of the case, and a door coupled to the one or more hinges to pivot the door about the one or more hinges, the door when closed to press against the seal and close off the containment chamber from an external environment. A method for evacuation of air in a containment chamber of a flow cytometer is disclosed. The method includes turning off a return fan in a first tunnel between an air conditioning chamber and a containment chamber; turning on an evacuation fan in a second tunnel between the air conditioning chamber and the containment chamber, the evacuation fan pulling air out of the containment chamber into the air conditioning chamber, opening a valve in an evacuation vent, the evacuation fan pushing air out of the air conditioning chamber through the evacuation vent into the environment; and continuously running the evacuation fan for a predetermined period of time to evacuate air out of the containment chamber.

3. 发明申请

WO2016094654A1 SELF-TRIGGERED FLOW CYTOMETER 审中-公开
标题翻译：自吸式流量计
公开(公告)号：WO2016094654A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/064989
申请日：2015-12-10
申请人： CYTEK BIOSCIENCES INC.
发明人： JIANG, Wenbin
IPC分类号： G01N21/63
CPC分类号： G01N15/1436 , G01N15/1434 , G01N15/1459 , G01N21/645 , G01N2015/1006 , G01N2015/1486 , G01N2021/6421
摘要： An optical spectrum analyzer (100) having a an excitation light source (103) with a luminated bio-sample (114) carried by a flow path (102). A spectrum dispersive element 213 dispersants lumineses light generated by the bio-sample (114).
摘要翻译：一种具有由流路（102）承载的具有发光的生物样品（114）的激发光源（103）的光谱分析仪（100）。光谱色散元件213分散剂发光由生物样品（114）产生的光。

4. 发明申请

WO2018094301A1 FLOW CYTOMETRY SYSTEMS WITH STEPPER FLOW CONTROL VALVE 审中-公开
公开(公告)号：WO2018094301A1
公开(公告)日：2018-05-24
申请号：PCT/US2017/062444
申请日：2017-11-19
申请人： CYTEK BIOSCIENCES, INC.
发明人： VRANE, David
IPC分类号： B07C5/342 , G01N15/14 , F16K31/00
摘要： A system, method, and apparatus are provided for flow cytometry. In one example, the flow cytometry system includes dual laser devices and dual scatter channels to measure velocity of particles in a core stream of sample fluid. The total flow rate of the sample fluid and the sheath fluid around the sample fluid is controlled, and thus held constant, by a feedback control system controlling a vacuum pump based on differential pressure across ends of a flow channel in the flow cell. A stepper flow control valves are disclosed that apply a physical fluid resistance to a flow of sheath fluid in the flow cytometer. The physical fluid resistance regulates a flow rate of the sheath fluid and thereby regulates a flow rate of sample fluid in the flow cytometer.

5. 发明申请

WO2018022674A1 COMPACT DETECTION MODULE FOR FLOW CYTOMETERS 审中-公开
标题翻译：用于流式细胞仪的紧凑型检测模块
公开(公告)号：WO2018022674A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/043815
申请日：2017-07-25
申请人： CYTEK BIOSCIENCES, INC. , YAN, Ming , HSIEH, Yung-Chieh , VRANE, David , CHASE, Eric
发明人： YAN, Ming , HSIEH, Yung-Chieh , VRANE, David , CHASE, Eric
IPC分类号： G01B9/02 , G01J3/00 , G01J3/45 , G02B17/00 , G02B21/00
摘要： In one embodiment, a flow cytometer is disclosed having a compact light detection module. The compact light detection module includes an image array with a transparent block, a plurality of micro-mirrors in a row coupled to a first side of the transparent block, and a plurality of filters in a row coupled to a second side of the transparent block opposite the first side. Each of the plurality of filters reflects light to one of the plurality of micro-mirrors and passes light of a differing wavelength range and each of the plurality of micro-mirrors reflects light to one of the plurality of filters, such that incident light into the image array zigzags back and forth between consecutive filters of the plurality of filters and consecutive micro-mirrors of the plurality of micro-mirrors. A radius of curvature of each of the plurality of micro-mirrors images the fiber aperture onto the odd filters and collimates the light beam on the even filters.
摘要翻译：在一个实施例中，公开了一种具有紧凑型光检测模块的流式细胞仪。紧凑型光检测模块包括具有透明块的图像阵列，耦合到透明块的第一侧的行中的多个微镜以及耦合到透明块的第二侧的行中的多个滤波器在第一面对面。多个滤光器中的每个滤光器将光反射到多个微镜中的一个并且传递不同波长范围的光，并且多个微镜中的每一个将光反射到多个滤光器中的一个，使得入射到图像阵列在所述多个滤波器的连续滤波器与所述多个微镜的连续微镜之间来回锯齿形。多个微镜中的每一个的曲率半径将光纤孔径成像到奇数滤波器上并且将光束准直到偶数滤波器上。

6. 发明申请

WO2017189783A1 COMPACT MULTI-COLOR FLOW CYTOMETER 审中-公开
标题翻译：紧凑的多色流式细胞仪
公开(公告)号：WO2017189783A1
公开(公告)日：2017-11-02
申请号：PCT/US2017/029724
申请日：2017-04-26
申请人： CYTEK BIOSCIENCES, INC.
发明人： YAN, Ming , CHASE, Eric , VRANE, David , JIANG, Wenbin
IPC分类号： G06F19/00 , G01N15/14 , G01N21/00 , G01N21/76 , G01N21/77
摘要： A system, an apparatus, and a method are provided for a modular flow cytometer with a compact size. In one embodiment, the modular flow cytometry system includes the following: a laser system for emitting laser beams; a flow cell assembly positioned to receive the laser beams at an interrogation region of a fluidics stream where fluoresced cells scatter the laser beams into fluorescent light; a fiber assembly positioned to collect the fluorescent light; and a grating system including a dispersive element and a receiver assembly, wherein the dispersive element is positioned to receive the fluorescent light from the fiber assembly and to direct spectrally dispersed light toward the receiver assembly.
摘要翻译：为具有紧凑尺寸的模块化流式细胞仪提供系统，装置和方法。在一个实施例中，模块化流式细胞术系统包括以下部分：用于发射激光束的激光系统; 流动池组件，所述流动池组件定位成在流体流的询问区域处接收激光束，其中荧光细胞将激光束散射到荧光灯中; 定位成收集荧光的纤维组件; 以及包括色散元件和接收器组件的光栅系统，其中色散元件被定位成接收来自光纤组件的荧光并将光谱分散的光导向接收器组件。

7. 发明申请

WO2022178488A2 INTEGRATED COMPACT CELL SORTER 审中-公开
公开(公告)号：WO2022178488A2
公开(公告)日：2022-08-25
申请号：PCT/US2022/070542
申请日：2022-02-05
申请人： CYTEK BIOSCIENCES, INC.
发明人： KRUEGER, Glen , VRANE, David
IPC分类号： G01N15/14 , G01N21/49 , G01N21/63 , B01L2200/0652 , B01L2300/0654 , B01L2300/0663 , B01L2300/0681 , B01L2300/0829 , B01L2300/1805 , B01L2300/1822 , B01L2300/1844 , B01L2300/1894 , B01L3/0241 , B01L3/502715 , B01L3/502761 , C12M47/04 , G01N15/1436 , G01N2015/0065 , G01N2015/1006 , G01N2015/1409 , G01N2015/149
摘要： A flow cytometry or cell sorting system is disclosed. Under pressure, a fluidics system causes sheath and sample biological fluids to flow. The fluidics system can include a degasser. A flow cell communicates with the fluidics system to receive the sheath fluid, wherein a sample biological fluid flows with cells or particles through the flow cell to be surrounded by the sheath fluid. A deflection chamber under the flow cell receives the drops of sample biological fluid and sheath fluid out of the flow cell to selectively deflect one or more of the drops along one or more deflection paths; and a droplet deposition unit to receive selectively deflected drops in the stream of the sample biological fluid with the one or more biological cells or particles into one or more containers.

8. 发明申请

WO2022170149A1 MAGNETICALLY COUPLED COLLECTING SYSTEM FOR FLOW CYTOMETRY AND CELL SORTER SYSTEMS 审中-公开
公开(公告)号：WO2022170149A1
公开(公告)日：2022-08-11
申请号：PCT/US2022/015383
申请日：2022-02-04
申请人： CYTEK BIOSCIENCES, INC.
发明人： HONARYAR, Babak , VRANE, David , TRUNG, Peter , WANG, Kuncheng , SCHWARTZ, Max
IPC分类号： C12M3/06
摘要： A collecting system with a magnetically coupled sample mover is provided for flow cytometry and cell sorter systems. The collecting system uses magnets in a driver carriage to control the position of other magnets in a follower carriage. The driver carriage can thereby control the position of the follower carriage without physically touching the follower carriage.

9. 发明申请

WO2020033934A3 SMART FLOW CYTOMETERS WITH SELF MONITORING AND SELF VALIDATION 审中-公开
公开(公告)号：WO2020033934A3
公开(公告)日：2020-02-13
申请号：PCT/US2019/046071
申请日：2019-08-10
申请人： CYTEK BIOSCIENCES, INC.
发明人： JIANG, Janine , VRANE, David
IPC分类号： G01N15/02 , G01N15/06 , G01N15/10 , G01N15/14
摘要： In some embodiments, a smart flow cytometer includes a monitoring system to monitor differing operational parameters of the smart flow cytometer to detect an advanced failure of components and an advanced need for maintenance. In others, a smart flow cytometer includes a quality control system including a reservoir of quality control beads to periodically run a validation test with the quality control beads in order to determine the ability of the flow cytometer to generate quality data output from a plurality of light detectors. In some embodiments, a plurality of smart flow cytometers are coupled into communication with a computer communication network; a central repair server system is coupled into communication with the computer communication network and the plurality of smart flow cytometers; wherein each of the plurality of smart flow cytometers includes a monitoring system coupled to monitor differing operational parameters of the smart flow cytometer for possible failure.

10. 发明申请

WO2019226717A1 FAST RECOMPENSATION OF FLOW CYTOMETERY DATA FOR SPILLOVER READJUSTMENTS 审中-公开
公开(公告)号：WO2019226717A1
公开(公告)日：2019-11-28
申请号：PCT/US2019/033419
申请日：2019-05-21
申请人： CYTEK BIOSCIENCES, INC.
发明人： ZHANG, Zhenyu
IPC分类号： G01N15/10
摘要： n one embodiment, a method of performing fast compensation in a flow cytometry experiment is provided. The method includes the following: generating an initial spillover matrix by using a plurality of single stained compensation controls; running a sample through the flow cytometer; generating a measured sample event vector by measuring fluorescence of a plurality of cells passing through the flow cytometer; generating a compensated sample event vector by using the initial spillover matrix and the measured sample event vector; generating an adjusted spillover matrix by finely adjusting the initial spill-over matrix; and calculating a re-compensated event vector by using the adjusted spillover matrix and the measured sample event vector.

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