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1. 发明申请

WO2018022674A1 COMPACT DETECTION MODULE FOR FLOW CYTOMETERS 审中-公开
标题翻译：用于流式细胞仪的紧凑型检测模块
公开(公告)号：WO2018022674A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/043815
申请日：2017-07-25
申请人： CYTEK BIOSCIENCES, INC. , YAN, Ming , HSIEH, Yung-Chieh , VRANE, David , CHASE, Eric
发明人： YAN, Ming , HSIEH, Yung-Chieh , VRANE, David , CHASE, Eric
IPC分类号： G01B9/02 , G01J3/00 , G01J3/45 , G02B17/00 , G02B21/00
摘要： In one embodiment, a flow cytometer is disclosed having a compact light detection module. The compact light detection module includes an image array with a transparent block, a plurality of micro-mirrors in a row coupled to a first side of the transparent block, and a plurality of filters in a row coupled to a second side of the transparent block opposite the first side. Each of the plurality of filters reflects light to one of the plurality of micro-mirrors and passes light of a differing wavelength range and each of the plurality of micro-mirrors reflects light to one of the plurality of filters, such that incident light into the image array zigzags back and forth between consecutive filters of the plurality of filters and consecutive micro-mirrors of the plurality of micro-mirrors. A radius of curvature of each of the plurality of micro-mirrors images the fiber aperture onto the odd filters and collimates the light beam on the even filters.
摘要翻译：在一个实施例中，公开了一种具有紧凑型光检测模块的流式细胞仪。紧凑型光检测模块包括具有透明块的图像阵列，耦合到透明块的第一侧的行中的多个微镜以及耦合到透明块的第二侧的行中的多个滤波器在第一面对面。多个滤光器中的每个滤光器将光反射到多个微镜中的一个并且传递不同波长范围的光，并且多个微镜中的每一个将光反射到多个滤光器中的一个，使得入射到图像阵列在所述多个滤波器的连续滤波器与所述多个微镜的连续微镜之间来回锯齿形。多个微镜中的每一个的曲率半径将光纤孔径成像到奇数滤波器上并且将光束准直到偶数滤波器上。

2. 发明申请

WO1998019528A1 CELL WASH APPARATUS AND METHOD 审中-公开
标题翻译：电池洗衣机和方法
公开(公告)号：WO1998019528A1
公开(公告)日：1998-05-14
申请号：PCT/US1997012130
申请日：1997-06-19
申请人： CHASE, Eric , NORTH, Howard, L., Jr. , SCHULTE, Harvey
IPC分类号： A01N01/02
CPC分类号： G01N1/40 , B04B5/0407 , B04B5/0442 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： An apparatus and method are disclosed to wash blood cells in a discrete manner that is compatible with automated sample preparation systems. The test tube containing the cells to be washed is mounted on a rotatable spindle. The spindle includes central passageways for the introduction of wash fluid and air into the test tube, and radial exit passageways at the bottom of the spindle. The test tube is first spun about its vertical axis to centrifuge cells against the inner wall of the test tube. A vacuum is then applied to the exit passageways so cell supernatant is aspirated out through the exit passageways. Wash fluid is then introduced into the test tube, and aspirated out through the exit passageways, thereby washing the cells. Rotational acceleration and deceleration of the test tube then resuspends the cells in wash fluid.
摘要翻译：公开了以与自动化样品制备系统相容的离散方式洗涤血细胞的装置和方法。将含有要洗涤的电池的试管安装在可旋转的主轴上。主轴包括用于将洗涤流体和空气引入试管的中心通道，以及主轴底部的径向出口通道。试管首先围绕其垂直轴旋转，将细胞离心到试管的内壁。然后将真空施加到出口通道，使得细胞上清液通过出口通道被吸出。然后将洗涤液引入试管中，并通过出口通道吸出，从而洗涤细胞。然后试管的旋转加速和减速将细胞重新悬浮在洗涤液中。

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