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1. 发明申请

WO2010119363A1 TUMOR TREATMENT USING ULTRASOUND CAVITATION 审中-公开
标题翻译：使用超声波治疗肿瘤治疗
公开(公告)号：WO2010119363A1
公开(公告)日：2010-10-21
申请号：PCT/IB2010/051456
申请日：2010-04-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , CHIN, Chien Ting , HALL, Christopher Stephen , KLIBANOV, Alexander L.
发明人： CHIN, Chien Ting , HALL, Christopher Stephen , KLIBANOV, Alexander L.
IPC分类号： A61N7/00 , A61B17/22
CPC分类号： A61N7/00 , A61B8/481 , A61B2017/22008 , A61N2007/0039
摘要： Growth in body tissue is slowed, arrested or reversed. In one aspect, this is accomplished by providing bubbles (S315), and delivering, to cause temporary change in physiology that at least one of retards, arrests and reverses said growth, a series of one or more pulses (206) of energy to respective focal points (213) at the site of the growth. In another aspect, temporary change in physiology, such as transient vasospasm (216) in vasculature of a neoplasm, is induced via the mechanical, non-thermal effects of fluid cavitation caused by the pulses. The bubbles, for facilitating the cavitation, in some embodiments, are afforded by administration of a microbubble agent to the host.
摘要翻译：身体组织的增长减慢，被阻止或逆转。在一个方面，这是通过提供气泡（S315）和递送，以引起生理学的暂时改变，使至少一个延迟，阻止和逆转所述生长，将一系列一个或多个能量脉冲（206）转换成相应的联络点（213）在现场的增长。另一方面，通过由脉冲引起的流体空化的机械非热效应来诱导生理学的暂时性变化，例如肿瘤脉管系统中的瞬时血管痉挛（216）。在一些实施方案中，用于促进气蚀的气泡通过向主体施用微泡剂来提供。

2. 发明申请

WO2008065561A1 APPARATUS FOR 3D ULTRASOUND IMAGING AND THERAPY 审中-公开
标题翻译： 3D超声成像和治疗设备
公开(公告)号：WO2008065561A1
公开(公告)日：2008-06-05
申请号：PCT/IB2007/054507
申请日：2007-11-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , RAJU, Balasundara , HALL, Christopher , CHIN, Chien Ting , SHI, William T.
发明人： RAJU, Balasundara , HALL, Christopher , CHIN, Chien Ting , SHI, William T.
IPC分类号： A61B8/08 , A61M37/00 , A61N7/02 , B06B1/06 , A61N7/00
CPC分类号： A61B8/08 , A61B8/0808 , A61B8/0833 , A61B8/4483 , A61B8/463 , A61B8/483 , A61B2090/378 , A61M37/0092 , A61N7/02 , B06B1/0625 , B06B1/0637
摘要： An apparatus for application of three-dimensional ultrasound imaging and therapy comprising a two-dimensional ultrasound imaging array of transducer elements having an image signal transmitter and receiver that forms, steers and selectively focuses ultrasound beams to a three-dimensional moving or stationary spatial volume; one or more two- dimensional ultrasound therapy arrays of transducer elements, each array having a therapy signal transmitter that forms, steers and selectively focuses and delivers ultrasound therapy to the volume; wherein the location of the array of imaging and therapy transducer elements are known relative to one another; and a controller that controls the image transmitter and receiver to provide three-dimensional images of the volume and simultaneously independently controls each of the one or more therapy transmitters to deliver therapy to the volume. Also disclosed is a method of delivering ultrasound therapy to a biological tissue in a three-dimensional moving or stationary spatial volume utilizing the apparatus.
摘要翻译：一种用于应用三维超声成像和治疗的装置，包括具有图像信号发射器和接收器的换能器元件的二维超声成像阵列，所述图像信号发射器和接收器形成，控制和选择性地将超声波束聚焦到三维移动或固定空间体积; 换能器元件的一个或多个二维超声治疗阵列，每个阵列具有治疗信号发射器，其形成，转向和选择性地聚焦并将超声治疗递送到所述体积; 其中成像和治疗换能器元件阵列的位置相对于彼此是已知的; 以及控制器，其控制所述图像发射器和接收器以提供所述体积的三维图像，并且同时独立地控制所述一个或多个治疗发射器中的每一个以向所述体积传递治疗。还公开了一种利用该装置在三维移动或静止空间体积中向生物组织递送超声治疗的方法。

3. 发明申请

WO2010020938A1 ULTRASOUND ENHANCED STEM CELL DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：超声波增强型干细胞递送装置及方法
公开(公告)号：WO2010020938A1
公开(公告)日：2010-02-25
申请号：PCT/IB2009/053625
申请日：2009-08-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , UNIVERSITY OF BONN , HALL, Christopher, Stephen , CHIN, Chien, Ting , TIEMANN, Klaus , GHANEM, Alexander
发明人： HALL, Christopher, Stephen , CHIN, Chien, Ting , TIEMANN, Klaus , GHANEM, Alexander
IPC分类号： A61M37/00 , A61B8/00 , A61B17/32 , A61B7/00
CPC分类号： A61M37/0092 , A61B5/416 , A61B5/4839 , A61B8/481 , A61B2017/22008
摘要： A method of delivering cell sized objects to a targeted organ or tissue of interest comprises: introducing (64, 70) the cell sized objects into the bloodstream; introducing (50, 70) microbubbles into the bloodstream; and locally agitating (56, 76) the introduced microbubbles, the agitating being substantially localized to the targeted organ or tissue of interest, the local agitating of the introduced microbubbles enhancing transendothelial migration of the cell sized objects into the targeted organ or tissue of interest. An apparatus for performing said method comprises: an intravascular delivery device (20, 22, 24) configured to deliver the cell sized objects and microbubbles into the bloodstream; an ultrasound system (30, 32, 34, 36); and a therapy controller (44) configured to control delivery of the cell-sized objects and the microbubbles into the bloodstream and ultrasonic agitation of the intravascular microbubbles in the targeted organ or tissue of interest.
摘要翻译：将细胞大小的物体递送到感兴趣的靶器官或组织的方法包括：将细胞大小的物体引入（64,70）到血流中; 将（50,70）微泡引入血液中; 并且局部搅动引入的微泡（56,76），所述搅拌基本上定位于所关注的目标器官或组织，所述引入的微泡的局部搅动增强细胞大小物体的经内皮迁移进入目标器官或感兴趣的组织。用于执行所述方法的装置包括：血管内输送装置（20,22,24），其配置成将细胞大小的物体和微泡输送到血流中; 超声系统（30,32,34,36）; 以及治疗控制器（44），其被配置为控制细胞大小的物体和微泡传递到血流中并且超声搅动目标器官或目的组织中的血管内微泡。

4. 发明申请

WO2010010473A1 ULTRASOUND MEDIATED DRUG DELIVERY 审中-公开
标题翻译：超声介质药物递送
公开(公告)号：WO2010010473A1
公开(公告)日：2010-01-28
申请号：PCT/IB2009/052449
申请日：2009-06-09
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , SHI, William , CHIN, Chien, Ting , HALL, Christopher , RAJU, Balasundara , BOHMER, Marcel
发明人： SHI, William , CHIN, Chien, Ting , HALL, Christopher , RAJU, Balasundara , BOHMER, Marcel
IPC分类号： A61M37/00
CPC分类号： A61K41/0028 , A61K9/0009 , A61K9/0019 , A61K49/223 , A61M37/0092
摘要： Described is a method for the delivery of a therapeutic agent to a mammal, particularly a human person, comprising (i) the administration of ultrasound particles that undergo a physical change when subjected to ultrasound; (ii) the administration of the therapeutic agent in an ultrasound dosage form allowing release of the therapeutic agent to be affected by the application of ultrasound, (iii) the application of ultrasound so as to affect a physical change in at least some of the ultrasound particles, and (iv) the application of ultrasound so as to stimulate release of the therapeutic agent. According to the invention the ultrasound particles are subjected to detection of their acoustic responses via echoes and/or emissions. The information thus obtained is processed and the processed information is used to adapt or adjust the ultrasound-mediated delivery of the therapeutic agent. This can be carried out using a single set of particles (that serve both as ultrasound imaging tracers and as drug delivery vehicles) or by applying separate sets of particles.
摘要翻译：描述了用于将哺乳动物，特别是人的治疗剂递送的方法，包括（i）施用经受超声的物理变化的超声波颗粒; （ii）以超声波剂量形式施用治疗剂，允许释放待施用超声波的治疗剂，（iii）施加超声波以影响至少一些超声波的物理变化颗粒，以及（iv）超声波的应用，以刺激治疗剂的释放。根据本发明，超声波颗粒经由回波和/或发射来检测其声响应。处理如此获得的信息，并且使用处理的信息来适应或调整超声介导的治疗剂的递送。这可以使用单组颗粒（既用作超声成像示踪剂又作为药物递送载体）或通过应用单独的颗粒组来进行。

5. 发明申请

WO2009063421A1 METHOD AND APPARATUS FOR POSITIONAL TRACKING OF A THERAPEUTIC ULTRASOUND TRANSDUCER 审中-公开
标题翻译：用于治疗超声波传感器的位置跟踪的方法和装置
公开(公告)号：WO2009063421A1
公开(公告)日：2009-05-22
申请号：PCT/IB2008/054767
申请日：2008-11-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HALL, Christopher, Stephen , CHIN, Chien, Ting , RAJU, Balasundara , SHI, William, Tao , SHECHTER, Guy
发明人： HALL, Christopher, Stephen , CHIN, Chien, Ting , RAJU, Balasundara , SHI, William, Tao , SHECHTER, Guy
IPC分类号： A61N7/02 , A61B19/00
CPC分类号： A61N7/02 , A61B34/20 , A61B34/25 , A61B2017/00123 , A61B2090/372 , A61M37/0092 , A61N2007/0008
摘要： A therapeutic ultrasound tracking system (10) includes a first and second plurality of tracking elements ((14, 16, 18),(20,22,24)), a tracking generator (26), and a system controller (28). The first plurality of tracking elements (14, 16, 18) is disposed in a first position and orientation with respect to each another and with respect to an energy emission surface (30) of a therapeutic ultrasound probe (12). The second plurality of tracking elements (20,22,24) is adapted to be coupled to a patient (42) in a second position and orientation with respect to each other and with respect to a target region of the patient which is to receive a therapeutic treatment. The tracking generator (26) emits tracking energy for use in connection with the first and second plurality of tracking elements. The system controller (28) detects whether the probe (12) is positioned within an allowable position and orientation with respect to the target region, and (i) responsive to detecting the probe being within the allowable position and orientation, the system controller enables an energization of the probe to perform one of (i)(a) commence the therapeutic treatment and (i)(b) continue the therapeutic treatment, and (ii) responsive to not detecting the probe being within the allowable position and orientation, the system controller disables the energization of the probe for the therapeutic treatment.
摘要翻译：治疗性超声跟踪系统（10）包括第一和第二多个跟踪元件（（14,16,18），（20,22,24）），跟踪发生器（26）和系统控制器（28）。第一组多个跟踪元件（14,16,18）相对于彼此并且相对于治疗性超声波探头（12）的能量发射表面（30）设置在第一位置和方向上。第二组多个跟踪元件（20,22,24）适于以相对于彼此并且相对于要接收患者的目标区域的第二位置和取向联接到患者（42）治疗方法。跟踪发生器（26）发射用于与第一和第二多个跟踪元件结合使用的跟踪能量。系统控制器（28）检测探头（12）是否位于相对于目标区域的允许位置和方位之内，以及（i）响应于探测器在允许的位置和方向上的检测，系统控制器（i）（a）中的一个的通电开始治疗处理，（i）（b）继续治疗，以及（ii）响应于不检测探针在允许的位置和方向内，系统控制器禁用用于治疗治疗的探针通电。

6. 发明申请

WO2007125500A3 METHOD AND APPARATUS FOR ELEVATION FOCUS CONTROL OF ACOUSTIC WAVES 审中-公开
标题翻译：用于高音重点控制声波的方法和装置
公开(公告)号：WO2007125500A3
公开(公告)日：2008-01-10
申请号：PCT/IB2007051582
申请日：2007-04-27
申请人： KONINKL PHILIPS ELECTRONICS NV , HALL CHRISTOPHER S , CHIN CHIEN TING , SUIJVER FREEK , HENDRIKS BERNARDUS H W , KUIPER STEIN
发明人： HALL CHRISTOPHER S , CHIN CHIEN TING , SUIJVER FREEK , HENDRIKS BERNARDUS H W , KUIPER STEIN
IPC分类号： G10K11/30
CPC分类号： G10K11/30
摘要： An acoustic probe (100) includes an acoustic transducer (20) including a plurality of acoustic transducer elements arranged in a one-dimensional array; and a variably- refracting acoustic lens (10) coupled to the acoustic transducer. The variably-refracting acoustic lens has at least a pair of electrodes (150, 160) adapted to adjust the focus of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. In one embodiment, the variably-refracting acoustic lens includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100）包括声换能器（20），其包括以一维阵列排列的多个声换能器元件; 以及耦合到声换能器的可变折射声透镜（10）。可变折射声透镜具有至少一对电极（150,160），其适于响应于施加在电极上的选定电压来调节可变折射声透镜的焦点。在一个实施例中，可变折射声透镜包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

7. 发明申请

WO2009001297A1 METHOD AND APPARATUS FOR STEERING ULTRASOUND THERAPY BEAM 审中-公开
标题翻译：用于转向超声治疗束的方法和装置
公开(公告)号：WO2009001297A1
公开(公告)日：2008-12-31
申请号：PCT/IB2008/052516
申请日：2008-06-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , RAJU, Balasundara , HALL, Christopher Stephen , CHIN, Chien Ting , SHI, William Tao
发明人： RAJU, Balasundara , HALL, Christopher Stephen , CHIN, Chien Ting , SHI, William Tao
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61N2007/0078
摘要： An apparatus and methodology for medically treating at least one region of interest of a patient is disclosed utilizing an ultrasound therapy array transducer for generating a therapy beam of given amplitude at one or more focal point locations of the at least one region of interest; a memory storage device for storing information regarding transducer beam amplitude as a function of focal point location of the beams, the device including a processor for computing beam amplitudes as a function of focal location in real time; a positioning system that is connected to the transducer for translating or rotating the position of the transducer, the positioning system being capable of changing the position of the transducer by utilizing electronic beam steering and/or mechanical re-positioning; a controller for determining whether mechanical repositioning of the transducer is needed, the controller being connected to the positioning system and being capable of causing translation or rotation of the transducer position; a user interface that couples to the controller, the user interface being capable of receiving input from the user of the desired size, shape and location of the at least one region of interest; and optionally a signaling device connected to the controller for indicating to the user that mechanical re -positioning of the transducer is needed.
摘要翻译：公开了一种用于医疗治疗患者的至少一个感兴趣区域的装置和方法，其利用超声治疗阵列换能器来产生在所述至少一个感兴趣区域的一个或多个焦点位置处的给定幅度的治疗束; 存储器存储装置，用于存储关于作为所述波束的焦点位置的函数的换能器波束幅度的信息，所述装置包括用于实时地计算作为焦点位置的函数的波束幅度的处理器; 定位系统，其连接到所述换能器，用于平移或旋转所述换能器的位置，所述定位系统能够通过利用电子束转向和/或机械重新定位来改变所述换能器的位置; 用于确定是否需要机械重新定位换能器的控制器，所述控制器连接到所述定位系统并且能够引起所述换能器位置的平移或旋转; 耦合到所述控制器的用户界面，所述用户界面能够从所述用户接收所述至少一个感兴趣区域的期望大小，形状和位置的输入; 以及可选地连接到控制器的信令装置，用于向用户指示换能器的机械重新定位是必需的。

8. 发明申请

WO2008135922A1 METHODS AND APPARATUSES OF MICROBEAMFORMING WITH ADJUSTABLE FLUID LENSES 审中-公开
标题翻译：具有可调节流体镜片的微球的方法和装置
公开(公告)号：WO2008135922A1
公开(公告)日：2008-11-13
申请号：PCT/IB2008/051686
申请日：2008-04-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALL, Christopher Stephen , CHIN, Chien Ting , SUIJVER, Jan Frederik , HENDRIKS, Bernardus Hendrikus Wilhelmus , KUIPER, Stein
发明人： HALL, Christopher Stephen , CHIN, Chien Ting , SUIJVER, Jan Frederik , HENDRIKS, Bernardus Hendrikus Wilhelmus , KUIPER, Stein
IPC分类号： G10K11/30
CPC分类号： G10K11/30
摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

9. 发明申请

WO2009007868A1 IN VIVO EXPRESSION ANALYSIS USING ULTRASOUND-INDUCED TRANSFECTION OF REPORTER CONSTRUCTS 审中-公开
标题翻译：使用超声波诱导的报告器结构转移的体检表达分析
公开(公告)号：WO2009007868A1
公开(公告)日：2009-01-15
申请号：PCT/IB2008/052572
申请日：2008-06-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SANTO, Evan Edward , DIMITROVA, Nevenka , CHIN, Chien Ting
发明人： SANTO, Evan Edward , DIMITROVA, Nevenka , CHIN, Chien Ting
IPC分类号： C12Q1/68
CPC分类号： C12N15/1086 , C12Q1/6897 , C12Q2565/101
摘要： The invention features compositions and methods for in vivo expression analysis. The data presented herein demonstrates that ultrasound-enhanced delivery and/or expression of a composition for expression analysis comprising microbubbles vectors as well as a genetic payload, comprising a "always-on" promoter, a "reference" reporter gene, a "query" promoter and an "answer" reporter gene, enables in vivo analysis of gene expression both without requiring prior preparation (especially genetic modification) of the test subject (animal or patient) and without causing long term or systemic effects on the subject. Such an invention can be used, for example, to query the epigenotypic or phenotypic response of the individual subject to a foreign effector substance such as a pyrogen, pharmaceutical compound, pharmaceutical lead compound, an allergen, an autoimmunogene, a toxin, a polyclonal antibody, a monoclonal antibody, an antigen, a lipid, a carbohydrate, a peptide, a protein, a protein-complex, an amino acid, a fatty acid, a nucleotide, DNA, RNA, PNA, siRNA and micro RNA.
摘要翻译：本发明的特征在于用于体内表达分析的组合物和方法。本文提供的数据表明包括微泡载体以及遗传有效载荷的用于表达分析的组合物的超声增强递送和/或表达，包括“始终在上”启动子，“参考”报告基因，“查询” 启动子和“答案”报告基因，能够在不需要测试对象（动物或患者）的事先准备（特别是遗传修饰）的情况下进行基因表达的体内分析，并且不会对受试者造成长期或全身影响。这样的发明可以用于例如查询个体受试者对外源性效应物质如热原，药物化合物，药物引导化合物，变应原，自身免疫原，毒素，多克隆抗体的表型表型或表型反应，单克隆抗体，抗原，脂质，碳水化合物，肽，蛋白质，蛋白质复合物，氨基酸，脂肪酸，核苷酸，DNA，RNA，PNA，siRNA和微RNA。

10. 发明申请

WO2007125500A2 METHOD AND APPARATUS FOR ELEVATION FOCUS CONTROL OF ACOUSTIC WAVES 审中-公开
标题翻译：用于高音重点控制声波的方法和装置
公开(公告)号：WO2007125500A2
公开(公告)日：2007-11-08
申请号：PCT/IB2007/051582
申请日：2007-04-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HALL, Christopher, S. , CHIN, Chien, Ting , SUIJVER, Freek , HENDRIKS, Bernardus, H., W. , KUIPER, Stein
发明人： HALL, Christopher, S. , CHIN, Chien, Ting , SUIJVER, Freek , HENDRIKS, Bernardus, H., W. , KUIPER, Stein
CPC分类号： G10K11/30
摘要： An acoustic probe (100) includes an acoustic transducer (20) including a plurality of acoustic transducer elements arranged in a one-dimensional array; and a variably- refracting acoustic lens (10) coupled to the acoustic transducer. The variably-refracting acoustic lens has at least a pair of electrodes (150, 160) adapted to adjust the focus of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. In one embodiment, the variably-refracting acoustic lens includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100）包括声换能器（20），其包括以一维阵列排列的多个声换能器元件; 以及耦合到声换能器的可变折射声透镜（10）。可变折射声透镜具有至少一对电极（150,160），其适于响应于施加在电极上的选定电压来调节可变折射声透镜的焦点。在一个实施例中，可变折射声透镜包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

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