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1. 发明申请

WO2009063399A3 TISSUE TEMPERATURE INDICATING ELEMENT FOR ULTRASOUND THERAPY 审中-公开
标题翻译：组织温度指示超声治疗的元素
公开(公告)号：WO2009063399A3
公开(公告)日：2010-08-19
申请号：PCT/IB2008054718
申请日：2008-11-11
申请人： KONINKL PHILIPS ELECTRONICS NV , HALL CHRISTOPHER S , KURT RALPH
发明人： HALL CHRISTOPHER S , KURT RALPH
IPC分类号： A61N7/02 , C09K19/38 , C09K19/52 , G01K11/16
CPC分类号： A61N7/02 , A61B2017/00084 , C09K19/38 , C09K19/408 , C09K19/52 , G01K11/16 , G01K11/165
摘要： The present invention relates to a hydrogel-containing temperature indicating element for use in ultrasound therapy. The temperature indicating element of the present invention and the therapeutic device and method making use of the same enable in some embodiments an automated adaptation of the power output as a function of the tissue temperature, avoiding therefore overheating or burning of the skin.
摘要翻译：本发明涉及一种用于超声治疗的含水凝胶温度指示元件。本发明的温度指示元件和使用其的治疗装置和方法在一些实施例中能够根据组织温度自动调整功率输出，从而避免皮肤过热或燃烧。

2. 发明申请

WO2009001266A3 ACOUSTIC OFFSET FOR TRANSDUCER 审中-公开
标题翻译：声音偏移传感器
公开(公告)号：WO2009001266A3
公开(公告)日：2009-11-05
申请号：PCT/IB2008052450
申请日：2008-06-20
申请人： KONINKL PHILIPS ELECTRONICS NV , HALL CHRISTOPHER S , RAJU BALASUNDAR , AZEVEDO JOSE M I , CHIN CHIEN T , SHI WILLIAM T
发明人： HALL CHRISTOPHER S , RAJU BALASUNDAR , AZEVEDO JOSE M I , CHIN CHIEN T , SHI WILLIAM T
IPC分类号： A61B17/22 , A61N7/00
CPC分类号： A61B17/2251 , A61B2017/2253
摘要： The invention is related to a standoff comprising an acoustic coupling medium for use with an ultrasound transducer, comprising a first portion of tubular shape having a constant cross sectional area with an axis defining the direction of sound propagation and being adapted to be interfaced to the transducer, and a second portion of tapered shape being coaxial to the first portion. The second portion has a proximal end connected to the first, wherein the cross sectional area at a distal end of the second portion is smaller than the cross sectional area at the proximal end. The invention is further related to an envelope which is adapted to enclose the first and/or second portion of the standoff. The invention provides an improved acoustic standoff which is adapted for small and/or superficial structures.
摘要翻译：本发明涉及包括用于与超声换能器一起使用的声耦合介质的隔离件，其包括管状形状的第一部分，其具有恒定的横截面积，轴线限定声音传播的方向，并且适于与换能器和与第一部分同轴的锥形形状的第二部分。第二部分具有连接到第一部分的近端，其中第二部分的远端处的横截面面积小于近端处的横截面面积。本发明还涉及一种适于包围支架的第一和/或第二部分的外壳。本发明提供了一种适于小型和/或表面结构的改进的隔音。

3. 发明申请

WO2009063399A2 TISSUE TEMPERATURE INDICATING ELEMENT FOR ULTRASOUND THERAPY 审中-公开
标题翻译：组织温度指示超声治疗的元素
公开(公告)号：WO2009063399A2
公开(公告)日：2009-05-22
申请号：PCT/IB2008/054718
申请日：2008-11-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALL, Christopher, S. , KURT, Ralph
发明人： HALL, Christopher, S. , KURT, Ralph
IPC分类号： A61N7/02 , G01K11/16
CPC分类号： A61N7/02 , A61B2017/00084 , C09K19/38 , C09K19/408 , C09K19/52 , G01K11/16 , G01K11/165
摘要： The present invention relates to a hydrogel-containing temperature indicating element for use in ultrasound therapy. The temperature indicating element of the present invention and the therapeutic device and method making use of the same enable in some embodiments an automated adaptation of the power output as a function of the tissue temperature, avoiding therefore overheating or burning of the skin.
摘要翻译：本发明涉及一种用于超声治疗的含水凝胶温度指示元件。本发明的温度指示元件和使用其的治疗装置和方法在一些实施例中能够根据组织温度自动调整功率输出，从而避免皮肤过热或燃烧。

4. 发明申请

WO2009001243A1 APPARATUS FOR CONTROLLED DELIVERY OF MOLECULES USING A CONTROLLED INJECTION SYSTEM 审中-公开
标题翻译：用控制注射系统控制输送分子的装置
公开(公告)号：WO2009001243A1
公开(公告)日：2008-12-31
申请号：PCT/IB2008/052373
申请日：2008-06-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALL, Christopher, S. , RAJU, Balasundar, I. , CHIN, Chien, T. , SHI, William, T.
发明人： HALL, Christopher, S. , RAJU, Balasundar, I. , CHIN, Chien, T. , SHI, William, T.
IPC分类号： A61M37/00 , A61K41/00
CPC分类号： A61M37/0092 , A61K41/0033 , A61M5/16827
摘要： Apparatus for controlled delivery of molecules at a predetermined region of interest within a fluid- filled cavity or vessel by means of ultrasound activatable particles. Said apparatus comprises a system for locating the region of interest (1), a first injection system (4) for injecting said ultrasound activatable particles into said cavity or vessel, wherein said first injection system is adapted to adjust the flow rate of said ultrasound activatable particles and a second injection system (4) for injecting said molecules into said cavity or vessel, wherein said second injection system is adapted to adjust the flow rate of said molecules. The apparatus further comprises a delivery system (1) for delivering said molecules by activating the ultrasound activatable particles at the region of interest, a detection system for determining the delivery of the molecules at the region of interest and a controller (7) for controlling the first and second injection system and the delivery system in response to the detection system.
摘要翻译：用于通过超声可激活颗粒在流体填充的空腔或容器内的预定感兴趣区域处控制传递分子的装置。所述装置包括用于定位所述感兴趣区域（1）的系统，用于将所述超声可激活颗粒注入所述空腔或容器中的第一注射系统（4），其中所述第一注射系统适于调节所述超声可激活的颗粒和用于将所述分子注入所述空腔或容器中的第二注射系统（4），其中所述第二注射系统适于调节所述分子的流速。该装置还包括用于通过激活感兴趣区域上的超声可激活颗粒来递送所述分子的递送系统（1），用于确定感兴趣区域中分子递送的检测系统和用于控制第一和第二注射系统以及响应于检测系统的递送系统。

5. 发明申请

WO2008075304A1 INTEGRATED SPECT IMAGING AND ULTRASOUND THERAPY SYSTEM 审中-公开
标题翻译：一体化SPECT成像和超声治疗系统
公开(公告)号：WO2008075304A1
公开(公告)日：2008-06-26
申请号：PCT/IB2007/055240
申请日：2007-12-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALL, Christopher S. , SOKKA, Shunmugavelu , RAJU, Balasundara I.
发明人： HALL, Christopher S. , SOKKA, Shunmugavelu , RAJU, Balasundara I.
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B6/037
摘要： A method and apparatus for the integration of an ultrasound transducer with a SPECT imaging system is disclosed. The ultrasound transducer allows the delivery of particle-born drug therapies or thermally active therapies at the same site detected with SPECT imaging. The system includes a SPECT imaging subsystem; an ultrasound transducer for producing a signal representative of applied ultrasound and signally coupled to the SPECT imaging subsystem; and co-registering means for co-registering the signal representative of applied ultrasound in a coordinate system of SPECT imaging subsystem. The SPECT subsystem may be replaced with a SPECT/CT combined system to provide morphology that allows for treatment planning. In another embodiment, the ultrasound transducer can be used intermittently with the sequential gathering of SPECT images for tracking time-varying properties of the binding of specific SPECT contrast agents to biomarkers of disease. In this way, the ultrasound and SPECT imaging devices form a novel combination to improve patient care through improved spatial registration, therapy planning, and workflow.
摘要翻译：公开了一种用于将超声换能器与SPECT成像系统集成的方法和装置。超声换能器允许在用SPECT成像检测的相同部位输送粒子出生的药物疗法或热活性疗法。该系统包括一个SPECT成像子系统; 超声换能器，用于产生代表施加的超声波并且信号耦合到SPECT成像子系统的信号; 以及用于在SPECT成像子系统的坐标系中共同对应表示应用的超声波的信号的共同配准装置。可以用SPECT / CT组合系统替换SPECT子系统，以提供允许治疗计划的形态。在另一个实施例中，可以间歇地使用超声换能器与SPECT图像的顺序收集，以跟踪特定SPECT造影剂与疾病生物标志物的结合的时变特性。以这种方式，超声和SPECT成像装置形成了一种新颖的组合，通过改进空间注册，治疗计划和工作流程来改善患者的护理。

6. 发明申请

WO2008023287A2 DEVICE CONTAINING A FLUID REFRACTING ULTRASOUND MODALITY 审中-公开
标题翻译：含有流体超薄超声波模型的装置
公开(公告)号：WO2008023287A2
公开(公告)日：2008-02-28
申请号：PCT/IB2007051329
申请日：2007-04-12
申请人： KONINKL PHILIPS ELECTRONICS NV , SUIJVER JAN FREDERIK , FERNANDEZ ANNA T , HALL CHRISTOPHER S
发明人： SUIJVER JAN FREDERIK , FERNANDEZ ANNA T , HALL CHRISTOPHER S
IPC分类号： G10K11/30
CPC分类号： G10K11/30
摘要： An acoustic device is disclosed having a variably refracting acoustic fluid interface including the boundary between two separate fluid media, means for directing acoustic waves onto the interface, and an acoustic generator or transducer located in one of the fluid media with the acoustic generator having an impedance that is substantially equal to the one said fluid media to minimize signal loss and reflection.
摘要翻译：公开了一种声学装置，其具有包括两个单独流体介质之间的边界的可变折射声学流体界面，用于将声波引导到界面上的装置，以及位于一个流体介质中的声发生器或换能器，声发生器具有阻抗其基本上等于所述流体介质以最小化信号损失和反射。

7. 发明申请

WO2007125500A3 METHOD AND APPARATUS FOR ELEVATION FOCUS CONTROL OF ACOUSTIC WAVES 审中-公开
标题翻译：用于高音重点控制声波的方法和装置
公开(公告)号：WO2007125500A3
公开(公告)日：2008-01-10
申请号：PCT/IB2007051582
申请日：2007-04-27
申请人： KONINKL PHILIPS ELECTRONICS NV , HALL CHRISTOPHER S , CHIN CHIEN TING , SUIJVER FREEK , HENDRIKS BERNARDUS H W , KUIPER STEIN
发明人： HALL CHRISTOPHER S , CHIN CHIEN TING , SUIJVER FREEK , HENDRIKS BERNARDUS H W , KUIPER STEIN
IPC分类号： G10K11/30
CPC分类号： G10K11/30
摘要： An acoustic probe (100) includes an acoustic transducer (20) including a plurality of acoustic transducer elements arranged in a one-dimensional array; and a variably- refracting acoustic lens (10) coupled to the acoustic transducer. The variably-refracting acoustic lens has at least a pair of electrodes (150, 160) adapted to adjust the focus of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. In one embodiment, the variably-refracting acoustic lens includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100）包括声换能器（20），其包括以一维阵列排列的多个声换能器元件; 以及耦合到声换能器的可变折射声透镜（10）。可变折射声透镜具有至少一对电极（150,160），其适于响应于施加在电极上的选定电压来调节可变折射声透镜的焦点。在一个实施例中，可变折射声透镜包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

8. 发明申请

WO02060524A2 ENHANCED ULTRASOUND DETECTION WITH TEMPERATURE DEPENDENT CONTRAST AGENTS 审中-公开
标题翻译：增强超声波检测与温度相关对比剂
公开(公告)号：WO02060524A2
公开(公告)日：2002-08-08
申请号：PCT/US0202631
申请日：2002-01-30
申请人： BARNES JEWISH HOSPITAL , LANZA GREGORY M , WICKLINE SAMUEL A , HALL CHRISTOPHER S
发明人： LANZA GREGORY M , WICKLINE SAMUEL A , HALL CHRISTOPHER S
IPC分类号： G01R33/28 , A61B5/055 , A61B8/00 , A61K9/133 , A61K49/00 , A61K49/04 , A61K49/22 , A61K51/00 , A61N
CPC分类号： A61K49/223 , A61K49/226 , Y10S514/937 , Y10S514/938
摘要： Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are disclosed. The methods and devices can be used for enhanced imaging alone or in conjunction with drug delivery, with therapeutic approaches such as hyperthermia or cryotherapy or with other imaging modalities.
摘要翻译：公开了基于与超声目标结合的温度依赖性造影剂的改变温度和超声反射率的用于增强超声检测的方法和装置。所述方法和装置可用于单独增强成像或与药物递送联合使用，具有治疗方法如热疗或冷冻治疗或其它成像方式。

9. 发明申请

WO2009007900A3 ULTRASONIC ASSEMBLY WITH ADJUSTABLE FLUID LENS 审中-公开
标题翻译：带可调流体透镜的超声波组装
公开(公告)号：WO2009007900A3
公开(公告)日：2009-03-26
申请号：PCT/IB2008052716
申请日：2008-07-07
申请人： KONINKL PHILIPS ELECTRONICS NV , HALL CHRISTOPHER S , FERNANDEZ ANNA T , SUIJVER JAN F
发明人： HALL CHRISTOPHER S , FERNANDEZ ANNA T , SUIJVER JAN F
IPC分类号： A61B7/02
CPC分类号： A61N7/022 , A61B2017/00243 , A61N2007/0056 , G10K11/30
摘要： An ultrasonic assembly suited for attachment to a catheter, e.g. for medical treatment. The ultrasonic assembly includes an adjustable ultrasonic focus mechanism arranged in connection with the ultrasonic transducer to adjust focus of ultrasonic waves generated by the transducer. The ultrasonic focus mechanism includes a fluid focus lens with at least two fluids separated by an interface such that ultrasonic waves are substantially reflected at the interface. At least two electrodes are arranged in connection with the fluid focus lens so as to allow adjustment of the interface shape, e.g. a curvature of the interface, when a voltage is applied to the electrodes. In preferred embodiments the electrodes are arranged so as to allow adjustment of the fluid focus lens in an elevation direction as well as in a radial direction. In simple embodiments with rotational symmetric geometry with the transducer positioned in the centre of the fluid focus lens, ultrasonic waves can be focused in an annular ring. This is e.g. suitable for ablative or coagulative necrotic treatment of human tissue, e.g. for atrial fibrillation treatment. In some embodiments, the assembly has a number of separate individually adjustable fluid focus lens compartments allowing a more detailed control of the ultrasonic focus pattern.
摘要翻译：适合于附接到导管的超声波组件，例如，为了医疗。超声波组件包括与超声波换能器连接设置的可调节超声波聚焦机构，以调节换能器产生的超声波的聚焦。超声波聚焦机构包括流体聚焦透镜，其具有被界面分开的至少两种流体，使得超声波在界面处基本上被反射。至少两个电极与流体聚焦透镜相关联地布置，以便允许调节界面形状。当电压施加到电极时界面的曲率。在优选实施例中，电极布置成允许在仰角方向以及径向方向上调节流体聚焦透镜。在转换器位于流体聚焦透镜中心的旋转对称几何结构的简单实施例中，超声波可以聚焦在圆环中。这是例如适用于人体组织的烧蚀性或凝固性坏死治疗，例如用于心房纤颤治疗。在一些实施例中，该组件具有许多单独的可单独调节的流体聚焦透镜隔室，从而允许更详细地控制超声聚焦图案。

10. 发明申请

WO2009027920A2 AN ULTRASOUND DEVICE FOR DETECTING PRESENCE OR ABSENCE OF CAVITATION EVENTS 审中-公开
标题翻译：用于检测存在或不存在空隙事件的超声波装置
公开(公告)号：WO2009027920A2
公开(公告)日：2009-03-05
申请号：PCT/IB2008/053397
申请日：2008-08-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALL, Christopher, S. , FERNANDEZ, Anna, T. , SUIJVER, Jan, F.
发明人： HALL, Christopher, S. , FERNANDEZ, Anna, T. , SUIJVER, Jan, F.
IPC分类号： A61B6/12 , A61B17/22
CPC分类号： A61B17/22004 , A61B8/00 , A61B17/22029 , A61B17/225 , A61B2017/00106 , A61B2017/22009
摘要： This invention relates to an ultrasound device for detecting presence or absence of cavitation events. An ultrasound transducer receives emitted and reflected ultrasound waves from tissues within a specific target volume and the received ultrasound waves are subsequently converted into a detection signal. A control unit then processes the detected signal for determining whether a cavitation event is detected. A liquid lens having an adjustable focal point is placed in front of the ultrasound transducer such that the received ultrasound waves go through the liquid lens prior to be received by the ultrasound transducer. The lens is controlled by the control unit such that in response to a detection of a cavitation event the focal position of the lens is adjusted substantially closer to the spatial location of the detected cavitation event.
摘要翻译：本发明涉及用于检测气蚀事件的存在或不存在的超声波装置。超声波换能器从特定目标体积内的组织接收发射和反射的超声波，并且接收的超声波随后被转换成检测信号。控制单元然后处理检测到的信号，以确定是否检测到空化事件。具有可调焦点的液体透镜被放置在超声波换能器的前面，使得接收的超声波在被超声换能器接收之前通过液体透镜。透镜由控制单元控制，使得响应于空化事件的检测，透镜的焦点位置基本上更接近于检测到的气蚀事件的空间位置。

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