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1. 发明申请

WO2013006244A1 BISPECIFIC MONOCLONAL ANTIBODY THERAPEUTICS AGAINST WEST NILE VIRUS WITH IMPROVED CNS PENETRATION 审中-公开
标题翻译：双抗性单克隆抗体治疗与改善CNS渗透的西尼病毒
公开(公告)号：WO2013006244A1
公开(公告)日：2013-01-10
申请号：PCT/US2012/041121
申请日：2012-06-06
申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , CHEN, Qiang , LAI, Huafang , HE, Junyun
发明人： CHEN, Qiang , LAI, Huafang , HE, Junyun
IPC分类号： C12P21/08 , A61K39/00
CPC分类号： C07K16/10 , A61K2039/505 , C07K16/1081 , C07K16/2869 , C07K16/2881 , C07K16/46 , C07K19/00 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/622 , C07K2317/64 , C07K2317/66 , C07K2317/734 , C07K2317/76 , C07K2317/90 , C07K2317/92 , Y02A50/394
摘要： The plant-based production of a therapeutic antibody against West Nile Virus is disclosed.
摘要翻译：公开了针对西尼罗河病毒的治疗性抗体的基于植物的生产。

2. 发明申请

WO2011116056A3 MODELING OF CELL DELAY CHANGE FOR ELECTRONIC DESIGN AUTOMATION 审中-公开
标题翻译：电子设计自动化中细胞延迟变化的建模
公开(公告)号：WO2011116056A3
公开(公告)日：2011-11-24
申请号：PCT/US2011028613
申请日：2011-03-16
申请人： SYNOPSYS INC , TANG QIAN-YING , CHEN QIANG , TIRUMALA SRIDHAR
发明人： TANG QIAN-YING , CHEN QIANG , TIRUMALA SRIDHAR
IPC分类号： G06F19/00 , G06F9/44 , G06F17/50 , G11C29/54
CPC分类号： G06F17/5009 , G06F17/5022 , G06F17/5036 , G06F2217/84
摘要： An integrated circuit design optimization procedure to modify a cell feature, such as gate length, models changes in delay as a result of the modification. In the delay change calculation, a characteristic of an event in cell switching behavior, such as the output short- circuit voltage VSC, is determined for the modified cell, where changes in the determined characteristic correlate with changes in delay of the cell due to the modification. Next, a value for delay of the modified cell is determined as a function of the determined characteristic of the event. The procedure can be applied after placement and routing. A timing-constrained, leakage power reduction is described using the delay change model.
摘要翻译：用于修改单元特征（例如，栅极长度）的集成电路设计优化程序模拟由于修改而引起的延迟变化。在延迟变化计算中，针对修改的单元确定单元切换行为中的事件的特性，例如输出短路电压VSC，其中所确定的特性中的变化与由于修改。接下来，根据所确定的事件特征确定修改小区的延迟值。该过程可以在布置和布线之后应用。使用延迟变化模型来描述时序受限的泄漏功率减小。

3. 发明申请

WO2008027146A3 INJECTOR HAVING TANGENTIALLY ORIENTED PURGE LINE 审中-公开
标题翻译：注射器具有面向导向的直线
公开(公告)号：WO2008027146A3
公开(公告)日：2008-07-31
申请号：PCT/US2007017094
申请日：2007-07-31
申请人： CATERPILLAR INC , STOCKNER ALAN R , COX GLENN B , CHEN QIANG , MCCLURE THOMAS R , MILLER ROBERT L , WILEY STEPHEN M , GONG XIAOHUI
发明人： STOCKNER ALAN R , COX GLENN B , CHEN QIANG , MCCLURE THOMAS R , MILLER ROBERT L , WILEY STEPHEN M , GONG XIAOHUI
IPC分类号： F01N3/025 , F02M43/04 , F02M61/16
CPC分类号： F01N3/0253 , F01N3/2066 , F01N3/30 , F01N2610/08 , F01N2610/1453 , F01N2610/1493 , F02M43/04 , F02M61/162 , F02M67/02 , F02M69/08 , Y02T10/24
摘要： A fluid injector (4-2) for 'an exhaust treatment device (40) is disclosed. The fluid injector may have a housing (70) at least partially forming a fluid chamber (98). The housing may have a central axis (90), and a fluid passagewa (80) configured to supply fluid to the fluid chamber. The supply of fluid may be in a tangential direction relative to the central axis. The injector (42) can provide mixing with pressurized air and can be used to regenerate a particulate trap (53).
摘要翻译：公开了一种用于排气处理装置（40）的流体注射器（4-2）。流体注射器可以具有至少部分地形成流体室（98）的壳体（70）。壳体可以具有中心轴线（90）和被配置为向流体室供应流体的流体通道（80）。流体的供应可以相对于中心轴线处于切向方向。注射器（42）可以提供与加压空气的混合，并且可以用于再生颗粒捕集器（53）。

4. 发明申请

WO2007149681A3 GROUNDING STRATEGY FOR FILTER ON PLANAR SUBSTRATE 审中-公开
公开(公告)号：WO2007149681A3
公开(公告)日：2007-12-27
申请号：PCT/US2007/069801
申请日：2007-05-25
申请人： TDK CORPORATION , CHEN, Qiang, Richard
发明人： CHEN, Qiang, Richard
IPC分类号： H03H7/01 , H01P1/203
摘要： The invention provides a grounding strategy for electronic components. In particular, the present provides ground connections in thin-film electronic components by connecting one group of one or more resonators to one ground connection and connecting a second group of one or more resonators to another ground connection.

5. 发明申请

WO2007149681A2 GROUNDING STRATEGY FOR FILTER ON PLANAR SUBSTRATE 审中-公开
标题翻译：用于平面基板上滤波器的接地策略
公开(公告)号：WO2007149681A2
公开(公告)日：2007-12-27
申请号：PCT/US2007069801
申请日：2007-05-25
申请人： TDK CORP , CHEN QIANG RICHARD
发明人： CHEN QIANG RICHARD
IPC分类号： H03H7/01 , H01P1/203
CPC分类号： H01P1/20381
摘要： The invention provides a grounding strategy for electronic components. In particular, the present provides ground connections in thin-film electronic components by connecting one group of one or more resonators to one ground connection and connecting a second group of one or more resonators to another ground connection.
摘要翻译：本发明为电子元件提供接地策略。特别地，本发明通过将一组一个或多个谐振器连接到一个接地连接并将第二组一个或多个谐振器连接到另一个接地连接来提供薄膜电子部件中的接地连接。

6. 发明申请

WO2014176304A1 ONE-POT SYNTHESIS OF HIGHLY MECHANICAL AND RECOVERABLE DOUBLE-NETWORK HYDROGELS 审中-公开
标题翻译：高效机械和可恢复的双网络水合物的一步法合成
公开(公告)号：WO2014176304A1
公开(公告)日：2014-10-30
申请号：PCT/US2014/035071
申请日：2014-04-23
申请人： THE UNIVERSITY OF AKRON , ZHENG, Jie , CHEN, Qiang , ZHAO, Chao
发明人： ZHENG, Jie , CHEN, Qiang , ZHAO, Chao
IPC分类号： C12C11/02
CPC分类号： C08L33/26 , C08B37/0039 , C08J3/075 , C08J2305/12 , C08J2333/26 , C08J2405/12 , C08J2433/26 , C08L5/00 , C08L5/12 , C08L33/10
摘要： A method of forming a hybrid physically and chemically cross-linked double-network hydrogel with highly recoverable and mechanical properties in a single-pot synthesis is provided. The method comprises the steps of combining the hydrogel precursor reactants into a single pot. The hydrogel precursor reactants include water; a polysaccharide; a methacrylate monomer; an ultraviolet initiator; and a chemical crosslinker. Next the hydrogel precursor reactants are heated to a temperature higher than the melting point of the polysaccharide and this temperature is retained until the polysaccharide is in a sol state. Then the single-pot is cooled to a temperature lower than the gelation point of the polysaccharide and this temperature is retained to form a first network. Thereafter, photo-initiated polymerization of the methacrylate monomer occurs via the ultraviolet initiator to form the second network.
摘要翻译：提供了在单锅合成中形成具有高可回收和机械性质的杂化物理和化学交联双网络水凝胶的方法。该方法包括以下步骤：将水凝胶前体反应物合并成单个罐。水凝胶前体反应物包括水; 多糖; 甲基丙烯酸酯单体; 紫外线引发剂; 和化学交联剂。接下来将水凝胶前体反应物加热到高于多糖的熔点的温度，并保持该温度，直到多糖处于溶胶状态。然后将单釜冷却至低于多糖的凝胶化点的温度，并保持该温度以形成第一网络。此后，通过紫外线引发剂发生甲基丙烯酸酯单体的光引发聚合以形成第二网络。

7. 发明申请

WO2011085289A1 PRODUCTION OF A MONOCLONAL ANTIBODY THERAPEUTIC AGAINST WEST NILE VIRUS IN PLANTS 审中-公开
标题翻译：生产针对植物的西兰病毒的单克隆抗体治疗
公开(公告)号：WO2011085289A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020635
申请日：2011-01-10
申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , CHEN, Qiang , LAI, Huafang
发明人： CHEN, Qiang , LAI, Huafang
IPC分类号： C12N5/04 , A61K39/42 , C12N15/82
CPC分类号： C12N15/8257 , A61K2039/505 , C07K16/1081 , C07K2317/24 , C07K2317/76 , Y02A50/394
摘要： The present invention describes the plant-based production of a therapeutic antibody against West Nile Virus.
摘要翻译：本发明描述了针对西尼罗河病毒的治疗性抗体的基于植物的生产。

8. 发明申请

WO2007013857A1 CONTACT LENS 审中-公开
标题翻译：隐形眼镜
公开(公告)号：WO2007013857A1
公开(公告)日：2007-02-01
申请号：PCT/SG2006/000206
申请日：2006-07-24
申请人： OCULUS LIMITED , NARAYANSWAMY, Babu , CUI, Jian , CHEN, Yong Jun , CHEN, Qiang, Oliver , FAN, Daming , NERURKAR, Meghana Devadutt
发明人： NARAYANSWAMY, Babu , CUI, Jian , CHEN, Yong Jun , CHEN, Qiang, Oliver , FAN, Daming , NERURKAR, Meghana Devadutt
IPC分类号： G02C7/04
CPC分类号： G02C7/046
摘要： The invention relates to a contact lens capable of altering the appearance of the eye of the wearer when the wearer is wearing the contact lens. More particularly, but not exclusively, the contact lens is capable of making the eye appear bigger and brighter. As such, a preferred aspect of the invention includes a contact lens comprising a non-opaque pupil region; a generally annular-shaped iris region having an area and circumferentially surrounding the pupil region; a pattern printed on the iris region, the pattern extending across a portion of the area of the iris region to impart to the iris region at least a perception of a structure of an iris of an eye; and wherein the diameter of the iris region is greater than the diameter of a wearer's iris thereby providing a lens capable of making the eye of the wearer appear bigger when the wearer is wearing the contact lens.
摘要翻译：本发明涉及一种隐形眼镜，其能够在穿戴者穿戴隐形眼镜时改变佩戴者的眼睛的外观。更具体地，但不排他地，隐形眼镜能够使眼睛看起来更大更亮。因此，本发明的优选方面包括：隐形眼镜，其包括非不透明瞳孔区域; 具有区域并且周向围绕瞳孔区域的大致环形的虹膜区域; 印刷在虹膜区域上的图案，图案延伸穿过虹膜区域的一部分区域以赋予虹膜区至少对眼睛虹膜结构的感知; 并且其中虹膜区域的直径大于穿用者虹膜的直径，由此提供当佩戴者佩戴隐形眼镜时能够使佩戴者的眼睛看起来更大的透镜。

9. 发明申请

WO2020247642A1 PLANT-PRODUCED MABS AGAINST CHIKUNGUNYA VIRUS WITH ENHANCED EFFECTOR FUNCTION AND EFFICACY 审中-公开
公开(公告)号：WO2020247642A1
公开(公告)日：2020-12-10
申请号：PCT/US2020/036136
申请日：2020-06-04
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , CHEN, Qiang , HURTADO, Jonathan , SUN, Haiyan , LAI, Huafang
发明人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , CHEN, Qiang , HURTADO, Jonathan , SUN, Haiyan , LAI, Huafang
IPC分类号： A61K39/395 , A61K39/42 , C07K14/415 , C07K16/00 , C07K16/08 , C07K16/46
摘要： Disclosed are monoclonal antibodies against Chikungunya virus having enhanced effector function and efficacy, methods of producing them, and methods of treatment of Chikungunya viral infection using the antibodies.

10. 发明申请

WO2015113055A2 PLANT-DERIVED ANTIBODIES AND DERIVATIVES THAT REDUCE RISK OF ANTIBODY-DEPENDENT ENHANCEMENT (ADE) OF INFECTION 审中-公开
标题翻译：植物衍生的抗体和衍生物，降低感染的抗体依赖性增强（ADE）的风险
公开(公告)号：WO2015113055A2
公开(公告)日：2015-07-30
申请号：PCT/US2015/013115
申请日：2015-01-27
申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , CHEN, Qiang , LAI, Huafang , HURTADO, Jonathan
发明人： CHEN, Qiang , LAI, Huafang , HURTADO, Jonathan
IPC分类号： A01H5/00 , C12N15/82
CPC分类号： C12N15/8258 , A61K2039/505 , C07K16/1081 , C07K2317/13 , C07K2317/35 , C07K2317/41 , C07K2317/622 , C07K2317/76 , C12N15/8205 , Y02A50/386 , Y02A50/394
摘要： The present invention describes the plant-based production of a therapeutic antibody.
摘要翻译：本发明描述了治疗性抗体的基于植物的生产。

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