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    • 4. 发明申请
    • OPTICAL PROXIMITY CORRECTION AWARE INTEGRATED CIRCUIT DESIGN OPTIMIZATION
    • 光临近度校正认知集成电路设计优化
    • WO2011072038A3
    • 2011-09-29
    • PCT/US2010059508
    • 2010-12-08
    • SYNOPSYS INCCHEN QIANGTIRUMALA SRIDHAR
    • CHEN QIANGTIRUMALA SRIDHAR
    • G06F17/50
    • G06F17/5081G03F1/36
    • An EDA method is implemented for modifying a layout file after place and route. The method includes storing a library of shape modifications for cells in the design library used for implementation of the circuit. The library of shape modifications includes the results of process-specific calibration of the shape modifications which indicate adjustment of a circuit parameter caused by applying the shape modifications to the cells. The layout file is analyzed to identify a cell for adjustment of the circuit parameter. A shape modification calibrated to achieve the desired adjustment is selected from the library. The shape modification is applied to the identified cell in the layout file to produce a modified layout file. The modified layout file can be used for tape out, and subsequently for manufacturing of an improved integrated circuit.
    • 实现了EDA方法,用于修改布局文件的放置和路由。 该方法包括将用于单元的形状修改库存储在用于实现电路的设计库中。 形状修改库包括形状修改的过程特定校准的结果,其指示通过将形状修改应用于单元而引起的电路参数的调整。 分析布局文件以识别用于调整电路参数的单元。 从库中选择校准以实现所需调整的形状修改。 形状修改应用于布局文件中的已识别单元,以生成修改后的布局文件。 修改的布局文件可用于磁带输出,随后用于制造改进的集成电路。
    • 5. 发明申请
    • ELECTROCHEMICAL ANALYTE SENSORS USING THERMOSTABLE SOYBEAN PEROXIDASE
    • 电化学分析仪使用热稳定的大豆过氧化物
    • WO9835053A2
    • 1998-08-13
    • PCT/US9802403
    • 1998-02-11
    • HELLER E & COHELLER ADAMKENAUSIS GREGG LCHEN QIANGVREEKE MARK S
    • HELLER ADAMKENAUSIS GREGG LCHEN QIANGVREEKE MARK S
    • C12N15/09C12Q1/00C12Q1/28C12Q1/68G01N27/327
    • C12Q1/6825C12Q1/005Y10S435/817
    • A sensor for the detection and measurement of an analyte in a biofluid. The sensor includes two enzymes. One type of sensor measures the concentration of hydrogen peroxide using a thermostable peroxidase enzyme that is immobilized in a redox hydrogel to form a sensing layer on a working electrode. This sensor also includes a hydrogen peroxide-generating second enzyme which is insulated from the redox hydrogel and electrode. This second enzyme generates hydrogen peroxide in response to the presence of an analyte or analyte-generated compound. The second enzyme may be insulated from the electrode by placement of an electrically insulating layer between the sensing layer and the second enzyme layer. Alternatively, the second enzyme is immobilized in an inorganic polymeric matrix, preferably made using a sol-gel polymerization process. Such matrices include those made of silica. Often, the second enzyme is stabilized by immobilization in a sol-gel. Further stabilization of polyelectrolytic enzymes can be obtained by immobilizing the enzyme with a polyelectrolytic polymer in the sol-gel matrix.
    • 用于检测和测量生物流体中分析物的传感器。 传感器包括两种酶。 一种传感器使用固定在氧化还原水凝胶中的热稳定过氧化物酶测量过氧化氢的浓度,以在工作电极上形成感测层。 该传感器还包括与氧化还原水凝胶和电极绝缘的产生过氧化氢的第二酶。 该第二酶响应于分析物或分析物产生的化合物的存在而产生过氧化氢。 第二酶可以通过在感测层和第二酶层之间放置电绝缘层而与电极绝缘。 或者,将第二酶固定在无机聚合物基质中,优选使用溶胶 - 凝胶聚合方法制备。 这些基质包括由二氧化硅制成的那些。 通常,通过固定在溶胶 - 凝胶中来稳定第二种酶。 聚电解酶的进一步稳定可以通过在溶胶 - 凝胶基质中用聚电解质聚合物固定酶来获得。